检索结果-内蒙古大学图书馆

Network and Systems Medicine 2021年第1期4卷 2-50页

作者： Zanin, Massimiliano Aitya, Nadim A.A. Basilio, José Baumbach, Jan Benis, Arriel Behera, Chandan K. Bucholc, Magda Castiglione, Filippo Chouvarda, Ioanna Comte, Blandine Dao, Tien-Tuan Ding, Xuemei Pujos-Guillot, Estelle Filipovic, Nenad Finn, David P. Glass, David H. Harel, Nissim Iesmantas, Tomas Ivanoska, Ilinka Joshi, Alok Boudjeltia, Karim Zouaoui Kaoui, Badr Kaur, Daman Maguire, Liam P. McClean, Paula L. McCombe, Niamh De Miranda, João Luís Moisescu, Mihnea Alexandru Pappalardo, Francesco Polster, Annikka Prasad, Girijesh Rozman, Damjana Sacala, Ioan Sanchez-Bornot, Jose M. Schmid, Johannes A. Sharp, Trevor Solé-Casals, Jordi Spiwok, Vojtěch Spyrou, George M. Stalidzans, Egils Stres, Blaa Sustersic, Tijana Symeonidis, Ioannis Tieri, Paolo Todd, Stephen Van Steen, Kristel Veneva, Milena Wang, Da-Hui Wang, Haiying Wang, Hui Watterson, Steven Wong-Lin, Kongfatt Yang, Su Zou, Xin Schmidt, Harald H.H.W. Centro de Tecnología Biomédica Universidad Politécnica de Madrid Madrid Spain Intelligent Systems Research Centre School of Computing Engineering and Intelligent Systems Ulster University Ulster United Kingdom Center for Physiology and Pharmacology Institute of Vascular Biology and Thrombosis Research Medical University of Vienna Vienna Austria TUM School of Life Sciences Weihenstephan Technical University of Munich Freising Germany Holon Israel CNR National Research Council IAC Institute for Applied Computing Rome Italy Lab of Computing Medical Informatics and Biomedical Imaging Technologies School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece Université Clermont Auvergne INRAE UNH Plateforme d'Exploration du Métabolisme MetaboHUB Clermont Clermont-Ferrand France Université de Technologie de Compiègne Compiègne France Labex MS2T Control of Technological Systems-of-Systems CNRS and Université de Technologie de Compiègne Compiègne France Faculty of Engineering University of Kragujevac Kragujevac Serbia Kragujevac Serbia Steinbeis Advanced Risk Technologies Institute Doo Kragujevac Kragujevac Serbia Pharmacology and Therapeutics School of Medicine Galway Neuroscience Centre National University of Ireland Galway Ireland School of Computing Ulster University Ulster United Kingdom Holon Israel Department of Mathematics and Natural Sciences Kaunas University of Technology Kaunas Lithuania Faculty of Computer Science and Engineering Ss. Cyril and Methodius University Skopje Macedonia Medicine Faculty Université Libre de Bruxelles CHU de Charleroi Charleroi Belgium Northern Ireland Centre for Stratified Medicine Biomedical Sciences Research Institute Ulster University Ulster United Kingdom Escola Superior de Tecnologia e Gestão Instituto Politécnico de Portalegre Portalegre Portugal Instituto Superior Técnico Universidade de Lisboa Lisboa Portugal Faculty of Automatic Control and Computers University Politehnica of B

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. These include both modeling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. Results: This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for digging into the topic. © Massimiliano Zanin et al., 2021;Published by Mary Ann Liebert, Inc. 2021.

关键词： Semantics

来源：评论

学校读者我要写书评

暂无评论

P113 Investigating the neural correlates of brain modulation

引用

Clinical Neurophysiology 2020年第4期131卷 e75-e76页

作者： Semprini, M. Barban, F. Bonassi, G. Carè, M. Pelosin, E. Mantini, D. Chiappalone, M. Avanzino, L. Istituto Italiano di Tecnologia Rehab Technologies IIT-INAIL Lab Genova Italy University of Genoa Experimental Medicine-Human Physiology Genoa Italy University of Genoa Department of Neuroscience and Rehabilitation Genoa Italy IRCCS San Martino Teaching Hospital Genoa Italy IRCCS San Camillo Hospital Venice Italy KU Leuven Research Center for Motor Control and Neuroplasticity Leuven Belgium

来源：评论

学校读者我要写书评

暂无评论

Small P values may not yield robust findings:an example using REST-meta-PD

引用

Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

来源：评论

学校读者我要写书评

暂无评论

Analysis of impaired LTP in schizophrenia using an extended mathematical model of a tripartite synapse 22

Analysis of impaired LTP in schizophrenia using an extended ...

引用

22nd Iranian Conference on Biomedical Engineering, ICBME 2015

作者： Mahdavi, Ali Bahrami, Fariba Janahmadi, Mahyar CIPCE Human Motor Control and Computational Neuroscience Lab School of ECE College of Engineering University of Tehran Tehran Iran CIPCE Direc. of Human Motor Control and Computational Neuroscience Lab School of ECE College of Engineering University of Tehran Tehran Iran Neuroscience Research Center Medical School Shahid Beheshti University of Medical Sciences Tehran Iran

ISBN: (纸本)9781467393515

One of the biological models presented in recent years to express the neuropathology of schizophrenia is based on an inactivated pathologic astrocyte in the tripartite synapse. In this study we developed a mathematical model of a tripartite synapse capable of expressing the pathologic behavior of the synapse under the aforementioned condition. Our results indicate that under pathologic conditions, there are increased nitric oxide (NO) feedback and decreased D-serine in the tripartite synapse that eventually lead to NMDAR hypofunction and subsequently abolishing of long term potentiation (LTP). Increased NO and lack of astrocytic glutamate in the synaptic cleft, which are happened after some intracellular processes, lead to increased release of glutamate from presynaptic neuron. Increased glutamate and at the same time lack of sufficient D-serine lead to fluctuations in NMDAR current with reduced amplitude and also reduced number of spikes and lower frequency in the postsynaptic potential. In other words, impaired synaptic neurotransmission, together with excessive NO-dependent phosphorylation of NMDA receptors, cause dysregulation of the NMDARs. Our results indicate that there is a mutual interaction between irregularities that lead to hypofunction of NMDARs. NMDAR activity is significantly degraded and there is not any stable and persistent LTP in the pathologic tripartite synapse. Based on our results, impairment of LTP is because of increase in the phosphorylation of CaMKII and unusual and severe oscillations with high amplitude and high frequency in the phosphorylated CaMKII concentration. Perhaps the reported deficiencies in the learning and memory and even other cognitive symptoms of schizophrenia are caused by the impaired LTP and the other mentioned impairments in the tripartite synapse especially D-serine shortage, the inactivated astrocyte and abnormalities occurred in the glutamatergic neurotransmission that are likely responsible for hypofunction of NMDA

关键词： Nitric oxide

来源：评论

学校读者我要写书评

暂无评论

Evaluating unified spatial and temporal muscle synergy modules - In different types of point to point hand motion in vertical planes 22

Evaluating unified spatial and temporal muscle synergy modul...

引用

22nd Iranian Conference on Biomedical Engineering, ICBME 2015

作者： Dehghani, Sedigheh Bahrami, Fariba CIPCE Human Motor Control and Computational Neuroscience Laboratory School of ECE College of Engineering University of Tehran Tehran Iran

ISBN: (纸本)9781467393515

The central nervous system (CNS) uses an abundant set of joints and muscles to ensure both flexible and stable movements. How the CNS faces the complexity of control problem is not still clear. Modular control is one of the most attractive hypotheses in motor control. In this hypothesis, some motor primitives are considered as the building blocks that can be combined to present a vast repertoire of movements. Thus, the CNS recruit the modules through lower DOF. In this study a new algorithm of sample-based nonnegative matrix tri-factorization (NM3F) is used to extract spatial and temporal muscle synergy modules from muscle EMG data for three different types of point to point reaching (simple straight, reversal and via-point) in vertical planes. After extracting different features of the muscle synergies, physiological interpretation of these features will be discussed. © 2015 IEEE.

关键词： Muscle

来源：评论

学校读者我要写书评

暂无评论

Hypofunction of NMDA Receptors Due to the Hyperactivation of Dopamine Receptors in the Hippocampal Synapses of Schizophrenia Based on a Mathematical Model

Hypofunction of NMDA Receptors Due to the Hyperactivation of...

引用

Iranian Conference on Biomedical Engineering

作者： Ali Mahdavi Fariba Bahrami Mina Mirjalili Mahyar Janahmadi CIPCE Human Motor Control and Computational Neuroscience Lab School of ECE College of Engineering University of Tehran CIPCE Director of Human Motor Control and Computational Neuroscience Lab School of ECE College of Engineering University of Tehran Neuroscience Research Center Medical school Shahid Beheshti University of Medical Sciences

ISBN: (纸本)9781467393522

Glutamate and dopamine hypothesizes are known in the pathophysiology of schizophrenia. Some recent experiments suggest that there is an interaction between them. We proposed a mathematical model for some of the abnormalities of schizophrenia in the synaptic level. First, we developed a healthy single tripartite synapse and after that the model according to the schizophrenia was impaired. The tripartite synapse is consisted of one presynaptic and one postsynaptic neuron and a glial component that is the astrocyte. In our developed model, the dynamics of dopamine and NMDAR current are added to a basic tripartite synapse. The results of pathologic model indicate that there is a strong connection between these two hypothesizes so that the NMDA receptors are highly affected from dopamine neurotransmission and hyperactive dopamine receptors. The increased activity of dopamine receptors lead to change in the intracellular processes of postsynaptic neuron such as IP_3, Ca~(2+) and calmodulin. Increasing the calmodulin concentration reduces the NMDAR opening time and in general, it inhibits this receptor so that it leads to the conversion of postsynaptic voltage mode from bursting to single spiking. Our analysis of results indicates that the decreased fluctuations of NMDAR current are caused by dysfunction of dopamine neurotransmission. Our results in the synaptic level using a mathematical model express that hyperfunction of dopaminergic system may lead to the hypofunction of glutamatergic system. It is likely that such a disorder also occurs in schizophrenia synapses.

关键词： Schizophrenia Dopamine receptors NMDA receptors Mathematical Model Single Tripartite Synapse

来源：评论

学校读者我要写书评

暂无评论

Analysis of Impaired LTP in Schizophrenia Using an Extended Mathematical Model of a Tripartite Synapse

Analysis of Impaired LTP in Schizophrenia Using an Extended ...

引用

Iranian Conference on Biomedical Engineering

作者： Ali Mahdavi Fariba Bahrami Mahyar Janahmadi CIPCE Human Motor Control and Computational Neuroscience Lab School of ECE College of Engineering University of Tehran CIPCE Director of Human Motor Control and Computational Neuroscience Lab School of ECE College of Engineering University of Tehran Neuroscience Research Center Medical school Shahid Beheshti University of Medical Sciences

ISBN: (纸本)9781467393522

关键词： Schizophrenia LTP Mathematical Model Single Tripartite Synapse

来源：评论

学校读者我要写书评

暂无评论

Evaluating unified spatial and temporal muscle synergy modules - In different types of point to point hand motion in vertical planes

Evaluating unified spatial and temporal muscle synergy modul...

引用

Iranian Conference on Biomedical Engineering

作者： Sedigheh Dehghani Fariba Bahrami CIPCE Human Motor Control and Computational Neuroscience Laboratory School of ECE College of Engineering University of Tehran

ISBN: (纸本)9781467393522

关键词： Module Temporal Spatial human motor control EMG decomposition

来源：评论

学校读者我要写书评

暂无评论

Allocentric spatial navigation impairment in schizophrenic subject: A model-based study

Allocentric spatial navigation impairment in schizophrenic s...

引用

Iranian Conference on Electrical Engineering (ICEE)

作者： Mohammad Mohammadi Ali Mahdavi Shiva G. Farashahi Fariba Bahrami Human Motor Control and Computational Neuroscience University of Tehran Tehran Iran Dartmouth College Department of Psychological and Brain Sciences Hanover NH USA

Experimental studies revealed spatial navigation impairments in schizophrenic patients. Both human and animal subjects exhibited diminished navigation performances compared to control ones. In brain, hippocampus is believed to be more involved in navigation and memory. In the pathology of schizophrenia, neural mechanisms especially synaptic transmission of hippocampal neurons change and functionalities of hippocampus decline. In present paper we used a computational model of CA3 area in the hippocampus and showed how underlying impairments in neural mechanisms observed in schizophrenia lead to navigation problems. To show the effect of schizophrenia on the navigation impairment, we used the place field concept. Based on our simulation results, after inducing neuropathology of schizophrenia into the model, place fields encoded the spatial information with lower resolution. These results can explain mechanism underlying observed navigation impairment in schizophrenic patients.

关键词： Navigation Hippocampus Neurons Firing computational modeling Mathematical model Pathology

来源：评论

学校读者我要写书评

暂无评论

26th Annual computational neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

引用

BMC neuroscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：