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SMALL STRUCTURES 2024年第11期5卷

作者： Je, Hyeongmin Won, Sukyoung Wie, Jeong Jae Kim, Sanha Korea Adv Inst Sci & Technol Dept Mech Engn 291 Daehak Ro Daejeon 34141 South Korea Hanyang Univ Dept Organ & Nano Engn 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Res Inst Ind Sci 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Human Tech Convergence Program 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Dept Chem Engn 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Inst Nano Sci & Technol 222 Wangsimni Ro Seoul 04763 South Korea SUNY Syracuse Coll Environm Sci & Forestry Dept Chem Engn 1 Forestry Dr Syracuse NY 13210 USA SUNY Syracuse Michael M Szwarc Polymer Res Inst Coll Environm Sci & Forestry 1 Forestry Dr Syracuse NY 13210 USA

Untethered magnetic actuation is an attractive technique for controlling a batch of micrometer-sized soft robots. Recent advancements have enabled each robot to follow its path independently using a single magnetic device. However, applications of magnetic soft microrobots are mostly biased toward the biomedical field. In this study, thermoplastic polyurethane-Fe3O4 nanocomposite soft spinning microrobots, that is, spinbots that actuate on a tabletop magnetic stirrer, were utilized as innovative precision manufacturing tools for spatially selective precision polishing and cleaning. The pivot motion of the revolving spinbots, which involves repetitive sweeping during rotation cycles, is explored. This sweeping action physically removes nanometer-sized surface contaminants from the workpiece, achieving a cleaning efficiency of 99.6%. Multiple spinbots, up to 42 in total, simultaneously operated along their own orbital pathways on three vertically stacked wafers, thereby demonstrating an unprecedented cleaning method. In addition, the spinbots precisely removed materials from the workpiece using a three-body abrasion mechanism. Furthermore, the spinbots contributed to precise material removal, resulting in remarkable surface polishing (R a approximate to 1.8 nm). This novel polishing system, which uses the collective behavior of multiple spinbots on a tabletop magnetic stirrer, is 1000-fold lighter than current state-of-the-art equipment aimed at achieving similar levels of fine finishing. Polyurethane-Fe3O4 nanocomposite microrobots, called spinbots, are utilized for precise polishing and cleaning. Multiple microrobots pivot along their trajectories which can sweep to remove nanometer-sized surface contaminants, achieve 99.6% cleaning efficiency, or polish a copper with a fine surface of R a approximate to 1.8 nm. More than 40 spinbots can operate simultaneously on vertically stacked wafers and are spatially restricted when necessary. image (c) 2024 WILEY-VCH GmbH

关键词： cleaning magnetic actuation microrobots polishing untethered miniaturized robots

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Applications of biomass-derived solvents in biomass pretreatment - Strategies, challenges, and prospects

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BIORESOURCE techNOLOGY 2023年 368卷 128280页

作者： Meng, Xianzhi Wang, Yunxuan Conte, Austin J. Zhang, Shuyang Ryu, Jiae Wie, Jeong Jae Pu, Yunqiao Davison, Brian H. Yoo, Chang Geun Ragauskas, Arthur J. Univ Tennessee Dept Chem & Biomol Engn Knoxville TN 37996 USA State Univ New York Coll Environm Sci & Forestry Dept Chem Engn Syracuse NY 13210 USA Hanyang Univ Dept Organ & Nano Engn Seoul 04763 South Korea Hanyang Univ Human Tech Convergence Program Seoul 04763 South Korea Hanyang Univ Dept Chem Engn Seoul 04763 South Korea Hanyang Univ Inst Nano Sci & Technol Seoul 04763 South Korea Michael M Szwarc Polymer Res Inst Syracuse NY 13210 USA Oak Ridge Natl Lab ORNL Biosci Div Oak Ridge TN 37831 USA Oak Ridge Natl Lab ORNL Joint Inst Biol Sci Oak Ridge TN 37831 USA Univ Tennessee Inst Agr Ctr Renewable Carbon Dept Forestry Wildlife & Fisheries Knoxville TN 37996 USA

Biomass pretreatment is considered a key step in the 2nd generation biofuel production from lignocellulosic biomass. Research on conventional biomass pretreatment solvents has mainly been focused on carbohydrate conversion efficiency, while their hazardousness and/or carbon intensity were not comprehensively considered. Recent sustainability issues request further consideration for eco-friendly and sustainable alternatives like biomass-derived solvents. Carbohydrate and lignin-derived solvents have been proposed and investigated as green alternatives in many biomass processes. In this review, the applications of different types of biomass pretreatment solvents, including organic, ionic liquid, and deep eutectic solvents, are thoroughly discussed. The role of water as a co-solvent in these pretreatment processes is also reviewed. Finally, current research challenges and prospects of utilizing biomass-derived pretreatment solvents for pretreatment are discussed. Given bio-ethanol's market potential and increasing public awareness about environmental concerns, it will be a priority adopting sustainable and green biomass pretreatment solvents in biorefinery.

关键词： Pretreatment Biomass-derived solvent Organosolv Ionic liquid Deep eutectic solvent

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Correlation between frictional heat and triboelectric charge: In operando temperature measurement during metal-polymer physical contact

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NANO ENERGY 2022年第PartA期103卷

作者： Lee, Dong Woo Kong, Dae Sol Kim, Jong Hun Park, Sang Hyeok Hu, Ying Chieh Ko, Young Joon Jeong, Chan Bae Lee, Seoku Choie, Joong Il Jake Lee, Gwan-Hyoung Lee, Minbaek Wie, Jeong Jae Chang, Ki Soo Park, Jeong Young Jung, Jong Hoon Inha Univ Dept Phys Incheon 22212 South Korea Seoul Natl Univ Dept Mat Sci & Engn Seoul 08826 South Korea Korea Basic Sci Inst Div Sci Instrumentat & Management Daejeon 34133 South Korea Inha Univ Program Environm & Polymer Engn Incheon 22212 South Korea Inst Basic Sci IBS Ctr Nanomat & Chem React Daejeon 34141 South Korea Seoul Natl Univ Res Inst Adv Mat RIAM Seoul 08826 South Korea Seoul Natl Univ Inst Engn Res Seoul 08826 South Korea Seoul Natl Univ Inst Appl Phys Seoul 08826 South Korea Hanyang Univ Dept Organ & Nano Engn Seoul 04763 South Korea Hanyang Univ Human Tech Convergence Program Seoul 04763 South Korea Korea Adv Inst Sci & Technol KAIST Dept Chem Daejeon 34141 South Korea

In operando techniques have emerged to elucidate the fundamental mechanism of triboelectrification via relevant physical quantity measurement during the physical contact of two materials. Here, a correlation between fric-tional heat and triboelectric charge is reported in a metal-polymer triboelectric nanogenerator through the in operando temperature measurement. Fluorine-doped tin oxide (FTO) metal is slid back-and-forth under different contact pressures across polydimethylsiloxane (PDMS) polymers having different degrees of crosslinking, i.e., mixing ratio. Both the triboelectric charge and temperature variation increase and become saturated with different time-constants. Notably, the saturated triboelectric charge increases, while the saturated temperature decreases, with increasing mixing ratio. In contrast, both saturated triboelectric charge and temperature increase with increasing contact pressure. X-ray photoemission spectroscopy reveals that chemical bonds are modified inhomogeneously at the surface, and that charged materials are transferred from PDMS to FTO in accordance with the mixing ratio-and sliding time-dependent triboelectric charges. Frictional heat plays a distributive role in bond rupture and temperature variation, depending on the activation energy and frictional coefficient of PDMS. In operando temperature variation measurement provides important information on the specific bonds for tri-boelectrification and detailed charge-transfer process during physical contact.

关键词： In operando measurement Frictional heat Triboelectric charge Temperature variation Activation energy Young?s modulus

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Synergistic Effect of Excited State Property and Aggregation Characteristic of Organic Semiconductor on Efficient Hole-Transportation in Perovskite Device

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ADVANCED FUNCTIONAL MATERIALS 2021年第5期31卷 2007180-2007180页

作者： Jo, Bonghyun Park, Hansol Kamaraj, Eswaran Lee, Sewook Jung, Bumho Somasundaram, Sivaraman Jeon, Gyeong G. Lee, Kyu-Tae Kim, Namdoo Kim, Jong H. Kim, Bong-Gi Ahn, Tae Kyu Park, Sanghyuk Park, Hui Joon Hanyang Univ Dept Organ & Nano Engn Seoul 04763 South Korea Sungkyunkwan Univ Dept Energy Sci Suwon 16419 South Korea Hanyang Univ Human Tech Convergence Program Seoul 04763 South Korea Kongju Natl Univ Dept Chem Kong Ju 32588 South Korea Ajou Univ Dept Mol Sci & Technol Suwon 16499 South Korea Inha Univ Dept Phys Incheon 22212 South Korea Konkuk Univ Dept Organ & Nano Syst Engn Seoul 05029 South Korea

Intrinsic characteristics of organic semiconductor-based hole transport materials (HTMs) such as facile synthesizability, energy level tunability, and charge transport capability have been highlighted as crucial factors determining the performances of perovskite photovoltaic (PV) cells. However, their properties in the excited state have not been actively studied, although PVs are operated under solar illumination. Here, the characteristics of organic HTMs in their excited state such as transition dipole moment can be a decisive factor that can improve built-in potential of PVs, consequently enhancing their charge extraction property as well as reducing carrier recombination. Moreover, the aggregation property of organic semiconductors, which has been an essential factor for high-performance organic HTMs to improve their carrier transport property, can induce a synergistic effect with their excited state property for the high-efficiency perovskite PVs. Additionally, it is also confirmed that their optical bandgaps, manipulated to have their absorption in the UV region, are beneficial to block UV light that degrades the quality of perovskite, consequently improving the stability of perovskite PV in p-i-n configuration. As a proof-of-concept, a model system, composed of triarylamine and imidazole-based organic HTMs, is designed, and it is believed that this strategy paves a way toward high-performance and stable perovskite PV devices.

关键词： built-in potential excited state dipole moment molecular aggregation perovskite photovoltaic cell

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Multi-Functional Locomotion of Collectively Assembled Shape-Reconfigurable Electronics

SSRN

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SSRN 2023年

作者： Cho, Woongbi Kang, Dong Jun Hahm, Min Jeong Jeon, Jisoo Kim, Dong-Gyun Kim, Yong Seok Han, Tae Hee Wie, Jeong Jae Department of Organic and Nano Engineering Hanyang University 222 Wangsimni-ro Seongdong-gu Seoul04763 Korea Republic of Human-Tech Convergence Program Hanyang University 222 Wangsimni-ro Seongdong-gu Seoul04763 Korea Republic of Program in Environmental and Polymer Engineering Inha University 100 Inha-ro Michuhol-gu Incheon22212 Korea Republic of Advanced Materials Division Korea Research Institute of Chemical Technology 141 Gajeong-ro Yuseong-gu Daejeon34114 Korea Republic of Department of Chemical Engineering Hanyang University 222 Wangsimni-ro Seongdong-gu Seoul04763 Korea Republic of Institute of Nano Science and Technology Hanyang University 222 Wangsimni-ro Seongdong-gu Seoul04763 Korea Republic of Department of Chemical Engineering State University of New York College of Environmental Science and Forestry SyracuseNY13210 United States The Michael M. Szwarc Polymer Research Institute State University of New York College of Environmental Science and Forestry SyracuseNY13210 United States

Beyond typical flexible electronics, stimuli-responsive shape-reconfigurable electronics are great candidates for the next-generation miniaturized electronics, carrying out complex missions by morphing their geometry and transferring their bodies to the desired positions. To achieve shape-reconfigurable electronics, it is essential to give shape-programmability as well as high electrical conductivity for polymeric materials. However, this is difficult to achieve due to a trade-off relationship between the shape-reconfigurability and the electrical conductivity of polymer composites that embed conductive fillers. Herein, we introduced highly conductive and physical intelligence-encoded polymeric composites based on MXene/liquid crystal elastomer (LCE) bilayer (MLB), for shape-reconfigurable electronics performing on-demand and reversible 3D morphing and locomotion. The MLB demonstrated remarkable photo-/electro-thermally driven bending and twisting performance under near-infrared (NIR) light with 0.4 W cm-2 and voltage application of 3.5 V without delamination, originating from both high photothermal conversion efficiency and electrical conductivity of ~5,300 S cm-1. The MLB also proved structural durability after 1000 cycles of bending originating from the stable interface induced by hydrogen bonding between MXene and LCE. Macroscopic collective assembly of the MLBs enabled dynamic locomotion inspired by nature. Collectively assembled MLBs demonstrated crawling, rotating, jumping, and sling-shooting by engineering the symmetricity of assembled structure and introducing snap-through instability. © 2023, The Authors. All rights reserved.

关键词： Flexible electronics

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A Microphase Separation Strategy for the Infrared Transparency-Thermomechanical Property Conundrum in Sulfur-Rich Copolymers

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ADVANCED OPTICAL MATERIALS 2023年第5期11卷

作者： Hwang, Jae Hyuk Kim, Sang Hwa Cho, Woongbi Lee, Woohwa Park, Sungmin Kim, Yong Seok Lee, Jong-Chan Lee, Kyung Jin Wie, Jeong Jae Kim, Dong-Gyun Korea Res Inst Chem Technol Adv Mat Div 141 Gajeong Ro Daejeon 34114 South Korea Seoul Natl Univ Inst Chem Proc Sch Chem & Biol Engn 599 Gwanak Ro Seoul 08826 South Korea Chungnam Natl Univ Dept Chem Engn & Appl Chem 99 Daehak Ro Daejeon 34134 South Korea Hanyang Univ Dept Organ & Nano Engn 222 Wangsimni Ro Seoul 04763 South Korea Univ Sci & Technol KRICT Sch Adv Mat & Chem Engn 217 Gajeong Ro Daejeon 34114 South Korea Hanyang Univ Human Tech Convergence Program 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Inst Nano Sci & Technol 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Dept Chem Engn 222 Wangsimni Ro Seoul 04763 South Korea SUNY Syracuse Michael M Szwarc Polymer Res Inst Coll Environm Sci & Forestry Syracuse NY 13210 USA

With intrinsic optical and dynamic properties of polysulfide chains, inverse vulcanized copolymers have demonstrated immense potential for infrared (IR) optical applications. However, preparing highly IR-transparent sulfur-rich copolymers without sacrificing their thermomechanical properties remains challenging. To overcome the trade-off relationship between IR optical and thermomechanical properties, an in situ microphase separation strategy for the inverse vulcanization of elemental sulfur utilizing self-crosslinkable 1,3,5-trivinylbenzene (TVB) is presented. Even with 80 wt% sulfur content, the microphase-separated TVB-rich domain self-reinforces the copolymer with a noteworthy modulus of approximate to 2.0 GPa and a high glass transition temperature (T-g) of 92.6 degrees C, while still exhibiting outstanding IR optical properties. This work is expected to provide insights into the fundamental structure-property relationships of sulfur-rich copolymers and pave the way for various practical applications.

关键词： infrared imaging microphase separation sulfur-rich copolymers thermomechanical property

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Controlling Vanadate Nanofiber Interlayer via Intercalation with Conducting Polymers: Cathode Material Design for Rechargeable Aqueous Zinc Ion Batteries

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ADVANCED FUNCTIONAL MATERIALS 2021年第26期31卷 2100005-2100005页

作者： Kim, Jichang Lee, Se Hun Park, Changyong Kim, Hyung-Seok Park, Jae-Ho Chung, Kyung Yoon Ahn, Heejoon Hanyang Univ Dept Organ & Nano Engn Human Tech Convergence Program 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Inst Nano Sci & Technol 222 Wangsimni Ro Seoul 04763 South Korea Korea Inst Sci & Technol Ctr Energy Storage Res 5 Hwarang Ro 14 Gil Seoul 02792 South Korea Kyung Hee Univ KHU KIST Dept Converging Sci & Technol Seoul 02447 South Korea Korea Univ Dept Mat Sci & Engn 145 Anam Ro Seoul 02841 South Korea Korea Univ Sci & Technol KIST Sch Div Energy & Environm Technol 5 Hwarang Ro 14 Gil Seoul 02792 South Korea

Aqueous zinc ion batteries (ZIBs) are promising energy storage devices due to the high ionic conductivity of the aqueous electrolyte as well as the safety, eco-friendliness, and low cost. Vanadium oxide-based materials are attractive cathode materials for aqueous ZIBs because of their high capacity from their layered structure and multiple valences. However, it is difficult to achieve high cycle stability and rate capability due to the low electrical conductivity and trapping of diffused electrolyte cations within the crystal structure, limiting the commercialization of aqueous ZIBs. In this study, the authors propose a facile sonochemical method for controlling the interlayer of the vanadate nanofiber crystal structure using poly(3,4-ethylene dioxythiophene) (PEDOT) to overcome the shortcomings of vanadium oxide-based materials. In addition, the electrochemical correlation between the interplanar distance of the expanded vanadate layers by the insertion of PEDOT and the behavior of Zn2+ ions is investigated. As a result, the intercalation of the conducting polymer increases the electron pathway and extends the distance of the vanadate layers, which helps to increase the number of active sites inside the vanadate and accelerate the zinc ion intercalation/de-intercalation process. Their findings may guide research on the next generation of ZIBs that can replace lithium ion batteries.

关键词： aqueous zinc‐ ion batteries conducting polymers intercalation nanofibers sonochemical methods vanadate

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Highly Sensitive and Cost-Effective Polymeric-Sulfur-Based Mid-Wavelength Infrared Linear Polarizers with Tailored Fabry-Perot Resonance

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ADVANCED MATERIALS 2023年第7期35卷 2209377-2209377页

作者： Cho, Woongbi Hwang, Jehwan Lee, Sang Yeon Park, Jaeseo Han, Nara Lee, Chi Hwan Kang, Sang-Woo Urbas, Augustine Kim, Jun Oh Ku, Zahyun Wie, Jeong Jae Hanyang Univ Dept Organ & Nano Engn 222 Wangsimmni roSeongdong gu Seoul 04763 South Korea Purdue Univ Weldon Sch Biomed Engn W Lafayette IN 47907 USA Inha Univ Dept Polymer Sci & Engn 100 Inha roMichuhol gu Incheon 22212 South Korea Korea Res Inst Stand & Sci Adv Instrumentat Inst 267 Gajeong roYuseong gu Daejeon 34113 South Korea Univ Sci & Technol UST Precis Measurement 267 Gajeong roYuseong gu Daejeon 34113 South Korea Inha Univ Program Environm & Polymer Engn 100 Inha roMichuhol gu Incheon 22212 South Korea SUNY Coll Environm Sci & Forestry Dept Chem Engn Syracuse NY 13210 USA Purdue Univ Sch Mech Engn W Lafayette IN 47907 USA Purdue Univ Sch Mat Engn W Lafayette IN 47907 USA Purdue Univ Birck Nanotechnol Ctr W Lafayette IN 47907 USA Air Force Res Lab Wright Patterson AFB Mat & Mfg Directorate Dayton OH 45433 USA Hanyang Univ Human Tech Convergence Program 222 Wangsimmni roSeongdong gu Seoul 04763 South Korea Hanyang Univ Inst Nano Sci & Technol 222 Wangsimmni roSeongdong gu Seoul 04763 South Korea Hanyang Univ Dept Chem Engn 222 Wangsimmni roSeongdong gu Seoul 04763 South Korea SUNY Coll Environm Sci & Forestry Michael M Szwarc Polymer Res Inst Syracuse NY 13210 USA

Inverse-vulcanized polymeric sulfur has received considerable attention for application in waste-based infrared (IR) polarizers with high polarization sensitivities, owing to its high transmittance in the IR region and thermal processability. However, there have been few reports on highly sensitive polymeric sulfur-based polarizers by replication of pre-simulated dimensions to achieve a high transmission of the transverse magnetic field (T-TM) and extinction ratio (ER). Herein, a 400-nanometer-pitch mid-wavelength infrared bilayer linear polarizer with self-aligned metal gratings is introduced on polymeric sulfur gratings integrated with a spacer layer (SM-polarizer). The dimensions of the SM-polarizer can be closely replicated using pre-simulated dimensions via a systematic investigation of thermal nanoimprinting conditions. Spacer thickness is tailored from 40 to 5100 nm by adjusting the concentration of polymeric sulfur solution during spin-coating. A tailored spacer thickness can maximize T-TM in the broadband MWIR region by satisfying Fabry-Perot resonance. The SM-polarizer yields T-TM of 0.65, 0.59, and 0.43 and ER of 3.12 x 10(3), 5.19 x 10(3), and 5.81 x 10(3) at 4 mu m for spacer thicknesses of 90, 338, and 572 nm, respectively. This demonstration of a highly sensitive and cost-effective SM-polarizer opens up exciting avenues for infrared polarimetric imaging and for applications in polarization manipulation.

关键词： Fabry-Perot resonance inverse vulcanization linear polarizer mid-wavelength infrared polymeric sulfur

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Correction to: Design framework for a seamless smart glove using a digital knitting system

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Fashion and Textiles 2021年第1期8卷 1-1页

作者： Song, Yewon Lee, Seulah Choi, Yuna Han, Sora Won, Hyuna Sung, Tae-Hyun Choi, Youngjin Bae, Jihyun PhD Candidate Department of Electrical Engineering Hanyang University Seoul South Korea Post Doctoral Researcher Department of Electrical and Electronic Engineering Hanyang University Ansan South Korea Graduate Student Department of Electrical and Electronic Engineering Hanyang University Ansan South Korea Graduate Student Human-Tech Convergence Program Department of Clothing & Textiles Hanyang University Seoul South Korea Professor Department of Electrical Engineering Hanyang University Seoul South Korea Professor Department of Electrical and Electronic Engineering Hanyang University Ansan South Korea Associate Professor Human-Tech Convergence Program Department of Clothing & Textiles Hanyang University Seoul South Korea

An amendment to this paper has been published and can be accessed via the original article.

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Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

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MOLECULAR CELL 2020年第3期78卷 506-+页

作者： Zhang, Xiaotian Jeong, Mira Huang, Xingfan Wang, Xue Qing Wang, Xinyu Zhou, Wanding Shamim, Muhammad S. Gore, Haley Himadewi, Pamela Liu, Yushuai Bochkov, Ivan D. Reyes, Jaime Doty, Madison Huang, Yung-Hsin Jung, Haiyoung Heikamp, Emily Aiden, Aviva Presser Li, Wei Su, Jianzhong Aiden, Erez Lieberman Goodell, Margaret A. Baylor Coll Med Stem Cells & Regenerat Med Ctr Houston TX 77030 USA Baylor Coll Med Ctr Cell & Gene Therapy Houston TX 77030 USA Baylor Coll Med Ctr Genome Architecture Houston TX 77030 USA Van Andel Inst Ctr Epigenet Grand Rapids MI 49503 USA Wenzhou Med Univ Inst Biomed Big Data Wenzhou Peoples R China Baylor Coll Med Med Student Training Program Houston TX 77030 USA Rice Univ Ctr Theoret Biol Phys Houston TX USA Rice Univ Dept Comp Sci Houston TX USA Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Sch Hlth Profess Mol Genet Technol Program Houston TX 77030 USA Baylor Coll Med Dev Biol Program Houston TX 77030 USA Korea Res Inst Biosci & Biotechnol Immunotherapy Convergence Res Ctr Daejeon South Korea Baylor Coll Med Dept Pediat Houston TX 77030 USA Univ Calif Irvine Dept Bioinformat Biol Chem Irvine CA USA Baylor Coll Med Dept Mol & Cellular Biol Houston TX 77030 USA Shanghai Tech Univ Shanghai Inst Adv Immunochem Studies Shanghai Peoples R China Univ Washington Seattle WA 98195 USA

Higher-order chromatin structure and DNA methylation are implicated in multiple developmental processes, but their relationship to cell state is unknown. Here, we find that large (>7.3 kb) DNA methylation nadirs (termed "grand canyons") can form long loops connecting anchor loci that may be dozens of megabases (Mb) apart, as well as inter-chromosomal links. The interacting loci cover a total of similar to 3.5 Mb of the human genome. The strongest interactions are associated with repressive marks made by the Polycomb complex and are diminished upon EZH2 inhibitor treatment. The data are suggestive of the formation of these loops by interactions between repressive elements in the loci, forming a genomic subcompartment, rather than by cohesion/CTCF-mediated extrusion. Interestingly, unlike previously characterized subcompartments, these interactions are present only in particular cell types, such as stem and progenitor cells. Our work reveals that H3K27me3-marked large DNA methylation grand canyons represent a set of very-long-range loops associated with cellular identity.

关键词： 3D genomics stem cells self-renewal DNA methylation Polycomb DNA methylation canyon CpG hematopoietic chromosomal looping

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