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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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NATURE GENETICS 2022年第5期54卷 560-+页

作者： Mahajan, Anubha Spracklen, Cassandra N. Zhang, Weihua Ng, Maggie C. Y. Petty, Lauren E. Kitajima, Hidetoshi Yu, Grace Z. Rueger, Sina Speidel, Leo Kim, Young Jin Horikoshi, Momoko Mercader, Josep M. Taliun, Daniel Moon, Sanghoon Kwak, Soo-Heon Robertson, Neil R. Rayner, Nigel W. Loh, Marie Kim, Bong-Jo Chiou, Joshua Miguel-Escalada, Irene Parolo, Pietro della Briotta Lin, Kuang Bragg, Fiona Preuss, Michael H. Takeuchi, Fumihiko Nano, Jana Guo, Xiuqing Lamri, Amel Nakatochi, Masahiro Scott, Robert A. Lee, Jung-Jin Huerta-Chagoya, Alicia Graff, Mariaelisa Chai, Jin-Fang Parra, Esteban J. Yao, Jie Bielak, Lawrence F. Tabara, Yasuharu Hai, Yang Steinthorsdottir, Valgerdur Cook, James P. Kals, Mart Grarup, Niels Schmidt, Ellen M. Pan, Ian Sofer, Tamar Wuttke, Matthias Sarnowski, Chloe Gieger, Christian Nousome, Darryl Trompet, Stella Long, Jirong Sun, Meng Tong, Lin Chen, Wei-Min Ahmad, Meraj Noordam, Raymond Lim, Victor J. Y. Tam, Claudia H. T. Joo, Yoonjung Yoonie Chen, Chien-Hsiun Raffield, Laura M. Lecoeur, Cecile Prins, Bram Peter Nicolas, Aude Yanek, Lisa R. Chen, Guanjie Jensen, Richard A. Tajuddin, Salman Kabagambe, Edmond K. An, Ping Xiang, Anny H. Choi, Hyeok Sun Cade, Brian E. Tan, Jingyi Flanagan, Jack Abaitua, Fernando Adair, Linda S. Adeyemo, Adebowale Aguilar-Salinas, Carlos A. Akiyama, Masato Anand, Sonia S. Bertoni, Alain Bian, Zheng Bork-Jensen, Jette Brandslund, Ivan Brody, Jennifer A. Brummett, Chad M. Buchanan, Thomas A. Canouil, Mickael Chan, Juliana C. N. Chang, Li-Ching Chee, Miao-Li Chen, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengming Chuang, Lee-Ming Cushman, Mary Das, Swapan K. de Silva, H. Janaka Dedoussis, George Dimitrov, Latchezar Doumatey, Ayo P. Du, Shufa Duan, Qing Eckardt, Kai-Uwe Emery, Leslie S. Evans, Daniel S. Evans, Michele K. Fischer, Krista Floyd, James S. Ford, Ian Fornage, Myriam Franco, Oscar H. Frayling, Timothy M. Freedman, Barry, I Fuchsberger, Christian Genter, Pauline Gerstein, Hertzel C. Giedraitis, Vilmantas Gonzalez-Villalpando, Clicerio Gonzalez-Villalpando, M Univ Oxford Oxford Ctr Diabet Endocrinol & Metab Radcliffe Dept Med Oxford England Univ Oxford Wellcome Ctr Human Genet Nuffield Dept Med Oxford England Univ North Carolina Chapel Hill Dept Genet Chapel Hill NC USA Univ Massachusetts Dept Epidemiol & Biostat Amherst MA 01003 USA Imperial Coll London Dept Epidemiol & Biostat London England London North West Healthcare NHS Trust Dept Cardiol Ealing Hosp London England Vanderbilt Univ Sch Med Vanderbilt Genet Inst Div Genet Med Nashville TN USA Wake Forest Sch Med Ctr Genom & Personalized Med Res Winston Salem NC 27101 USA Wake Forest Sch Med Dept Biochem Winston Salem NC 27101 USA Tohoku Univ Adv Res Ctr Innovat Next Generat Med INGEM Sendai Miyagi Japan Tohoku Univ Dept Integrat Genom Tohoku Med Megabank Org Sendai Miyagi Japan Tohoku Univ Tohoku Univ Hosp Canc Ctr Sendai Miyagi Japan Univ Helsinki Inst Mol Med Finland FIMM Helsinki Finland UCL Genet Inst London England Francis Crick Inst London England Natl Inst Hlth Dept Precis Med Div Genome Sci Cheongju South Korea RIKEN Ctr Integrat Med Sci Lab Genom Diabet & Metab Yokohama Kanagawa Japan Broad Inst Harvard & MIT Programs Metab Cambridge MA USA Broad Inst Harvard & MIT Program Med Cambridge MA USA Massachusetts Gen Hosp Diabet Unit Boston MA 02114 USA Massachusetts Gen Hosp Ctr Genom Med Boston MA 02114 USA Harvard Med Sch Boston MA 02115 USA Univ Michigan Dept Biostat Ann Arbor MI 48109 USA Univ Michigan Ctr Stat Genet Ann Arbor MI 48109 USA Seoul Natl Univ Hosp Dept Internal Med Seoul South Korea Wellcome Sanger Inst Dept Human Genet Hinxton England Helmholtz Zentrum Munchen Inst Translat Genom German Res Ctr Environm Hlth Neuherberg Germany Nanyang Technol Univ Lee Kong Chian Sch Med Singapore Singapore ASTAR Translat Lab Genet Med TLGM Singapore Singapore Natl Univ Singapore NUS Singapore Singapore Univ Calif San Diego Biomed Sci Grad Studies Program La Jolla CA 92093 USA Barcelona Inst Sci & Technol Ctr

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

关键词： Genome-wide association studies Type 2 diabetes Biomedicine general human Genetics Cancer Research Agriculture Gene Function Animal Genetics and Genomics

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Mapping the human genetic architecture of COVID-19

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NATURE 2021年第7889期600卷 472-+页

作者： Niemi, Mari E. K. Karjalainen, Juha Daly, Mark Ganna, Andrea Mehtonen, Juha Cordioli, Mattia Kaunisto, Mari Pigazzini, Sara Donner, Kati Kivinen, Katja Palotie, Aarno Daly, Mark J. Liao, Rachel G. Kanai, Masahiro Veerapen, Kumar Minica, Camelia Trankiem, Amy Balaconis, Mary K. Nguyen, Huy Solomonson, Matthew Francioli, Laurent Wang, Qingbo Green, Robert C. Bryant, Sam Finucane, Hilary Martin, Alicia R. Zhou, Wei Nkambule, Lindokuhle Karczewski, Konrad J. Atkinson, Elizabeth G. Tsuo, Kristin Baya, Nikolas Turley, Patrick Gupta, Rahul Walters, Raymond K. Palmer, Duncan S. Sarma, Gopal Cheng, Nathan Lu, Wenhan Churchhouse, Claire Goldstein, Jacqueline, I King, Daniel Seed, Cotton Neale, Benjamin M. Satterstrom, F. Kyle Pathak, Gita A. Wendt, Frank R. Polimanti, Renato Andrews, Shea J. Sloofman, Laura Sealfon, Stuart C. Fernandez-Cadenas, Israel Schulte, Eva C. Protzer, Ulrike Striano, Pasquale Coviello, Domenico A. Zara, Federico Salpietro, Vincenzo Iacomino, Michele Scudieri, Paolo Bocciardi, Renata Minetti, Carlo Vari, Maria Stella Madia, Francesca Marouli, Eirini Kanoni, Stavroula Moutsianas, Loukas Karim, Mohd Anisul Ghoussaini, Maya Schwartzentruber, Jeremy Dunham, Ian Savage, Jeanne Posthuma, Danielle Tissink, Elleke Uffelmann, Emil Butler-Laporte, Guillaume Richards, J. Brent Nakanishi, Tomoko Morrison, David R. Forgetta, Vincenzo Ghosh, Biswarup Laurent, Laetitia Henry, Danielle Abdullah, Tala Adeleye, Olumide Mamlouk, Noor Kimchi, Nofar Afrasiabi, Zaman Rezk, Nardin Vulesevic, Branka Bouab, Meriem Guzman, Charlotte Petitjean, Louis Tselios, Chris Xue, Xiaoqing Afilalo, Jonathan Adra, Darin Kim, Han-Na Okada, Yukinori Byun, Jinyoung Han, Younghun Uddin, Mohammed Jashim Smith, George Davey Willer, Cristen J. Buxbaum, Joseph D. Sloofman, Laura G. Collins, Brett L. Levy, Tess Underwood, Slayton J. Britvan, Bari Keller, Katherine Tang, Lara Peruggia, Michael Hiester, Liam L. Niblo, Kristi Aksentijevich, Alexandra Labkowsky, Alexander Karp, Avromie Zlatopolsky, Menachem Arora, Jatin Raychaudhuri, Soumya Mercader, Univ Helsinki Inst Mol Med Finland FIMM Helsinki Finland Broad Inst MIT & Harvard Cambridge MA 02142 USA Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Massachusetts Gen Hosp Broad Inst MIT & Harvard Cambridge MA USA Yale Univ New Haven CT USA Icahn Sch Med Mt Sinai New York NY USA St Pau Hosp Biomed Res Inst St Pau IIB St Pau Stroke Pharmacogen & Genet Inmungen CoV2 Barcelona Spain Tech Univ Munich Inst Virol Munich Germany Helmholtz Zentrum Munchen Munich Germany Univ Munich Inst Psychiat Phen & Genom Med Ctr Munich Germany Univ Munich Dept Psychiat Med Ctr Munich Germany Ist Giannina Gaslini IRCCS Genoa Italy Univ Genoa Dept Neurosci Rehabil Ophthalmol Genet Maternar & Genoa Italy Queen Mary Univ London London England Open Targets Wellcome Genome Campus Hinxton England Vrije Univ Amsterdam Ctr Neurogen & Cognit Res Amsterdam Neurosci Dept Complex Trait Genet Amsterdam Netherlands McGill Univ Jewish Gen Hosp Lady Davis Inst Montreal PQ Canada Sungkyunkwan Univ Kangbuk Samsung Hosp Med Res Inst Sch Med Suwon South Korea Osaka Univ Grad Sch Med Osaka Japan Baylor Coll Med Houston TX 77030 USA Mohammed Bin Rashid Univ Med & Hlth Sci Dubai U Arab Emirates Univ Bristol MRC Integrat Epidemiol Unit IEU Bristol Avon England Michigan Med Div Cardiovasc Med Dept Internal Med Ann Arbor MI USA Univ Michigan Dept Human Genet Med Sch Ann Arbor MI 48109 USA Univ Michigan Dept Computat Med & Bioinformat Med Sch Ann Arbor MI 48109 USA Icahn Sch Med Mt Sinai Dept Psychiat Seaver Autism Ctr Res & Treatment New York NY 10029 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Univ Calif Los Angeles David Geffen Sch Med Los Angeles CA 90095 USA Inst Pasteur Paris France Harvard Sch Publ Hlth Boston MA USA Univ Queensland Inst Mol Biosci Brisbane Qld Australia Wellcome Sanger Inst Wellcome Genome Campus Hinxton England European Bioinformat Inst EMBL EBI European Mol Biol Lab We

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19(1,2), host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases(3-7). They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.

关键词： Genetics Genome-wide association studies SARS-CoV-2 Viral infection Science humanities and Social Sciences multidisciplinary

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROSCIENCE 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Multidimensional Signals and Analytic Flexibility: Estimating Degrees of Freedom in human-Speech Analyses

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ADVANCES IN METHODS AND PRACTICES IN PSYCHOLOGICAL SCIENCE 2023年第3期6卷

作者： Coretta, Stefano Casillas, Joseph V. Roessig, Simon Franke, Michael Ahn, Byron Al-Hoorie, Ali H. Al-Tamimi, Jalal Alotaibi, Najd E. AlShakhori, Mohammed K. Altmiller, Ruth M. Arantes, Pablo Athanasopoulou, Angeliki Baese-Berk, Melissa M. Bailey, George Sangma, Cheman Baira A. Beier, Eleonora J. Benavides, Gabriela M. Benker, Nicole BensonMeyer, Emelia P. Benway, Nina R. Berry, Grant M. Bing, Liwen Bjorndahl, Christina Bolyanatz, Mariska Braver, Aaron Brown, Violet A. Brown, Alicia M. Brugos, Alejna Buchanan, Erin M. Butlin, Tanna Buxo-Lugo, Andres Caillol, Coline Cangemi, Francesco Carignan, Christopher Carraturo, Sita Caudrelier, Tiphaine Chodroff, Eleanor Cohn, Michelle Cronenberg, Johanna Crouzet, Olivier Dagar, Erica L. Dawson, Charlotte Diantoro, Carissa A. Dokovova, Marie Drake, Shiloh Du, Fengting Dubuis, Margaux Dueme, Florent Durward, Matthew Egurtzegi, Ander Elsherif, Mahmoud M. Esser, Janina Ferragne, Emmanuel Ferreira, Fernanda Fink, Lauren K. Finley, Sara Foster, Kurtis Foulkes, Paul Franzke, Rosa Frazer-McKee, Gabriel Fromont, Robert Garcia, Christina Geller, Jason Grasso, Camille L. Greca, Pia Grice, Martine Grose-Hodge, Magdalena S. Gully, Amelia J. Halfacre, Caitlin Hauser, Ivy Hay, Jen Haywood, Robert Hellmuth, Sam Hilger, Allison I. Holliday, Nicole Hoogland, Damar Huang, Yaqian Hughes, Vincent Icardo Isasa, Ane Ilchovska, Zlatomira G. Jeon, Hae-Sung Jones, Jacq Junges, Magat N. Kaefer, Stephanie Kaland, Constantijn Kelley, Matthew C. Kelly, Niamh E. Kettig, Thomas Khattab, Ghada Koolen, Ruud Krahmer, Emiel Krajewska, Dorota Krug, Andreas Kumar, Abhilasha A. Lander, Anna Lentz, Tomas O. Li, Wanyin Li, Yanyu Lialiou, Maria Lima, Ronaldo M., Jr. Lo, Justin J. H. Lopez Otero, Julio Cesar Mackay, Bradley MacLeod, Bethany Mallard, Mel McConnellogue, Carol-Ann Mary Moroz, George Murali, Mridhula Nalborczyk, Ladislas Nenadic, Filip Nieder, Jessica Nikolic, Dusan Nogueira, Francisco G. S. Offerman, Heather M. Passoni, Elisa Pelissier, Maud Perry, Scott J. Pfiffner, Alexandra M. Proctor, Michael Rhodes, Univ Edinburgh Dept Linguist & English Language Edinburgh Scotland Rutgers State Univ Dept Spanish & Portuguese New Brunswick NJ USA Cornell Univ Dept Linguist Ithaca NY USA Univ Tubingen Dept Gen & Computat Linguist Tubingen Germany Princeton Univ Program Linguist Princeton NJ USA Royal Commiss Jubail & Yanbu Jubail English Language & Preparatory Year Inst Jubail Ind City Saudi Arabia Univ Paris Cite CNRS Lab Linguist Formelle Paris France Newcastle Univ Sch Educ Commun & Language Sci Newcastle Upon Tyne England Univ Arizona Dept Linguist Tucson AZ USA Washington Univ St Louis Psychol & Brain Sci St Louis MO USA Univ Fed Sao Carlos Dept Letras Sao Carlos Brazil Univ Calgary Sch Languages Linguist Literatures & Cultures Calgary AB Canada Univ Oregon Dept Linguist Eugene OR USA Univ York Dept Language & Linguist Sci York England Univ Calif Davis Dept Psychol Davis CA USA Univ Munich Inst Phonet & Speech Proc Munich Germany Univ Penn Dept Linguist Philadelphia PA USA Syracuse Univ Dept Commun Sci & Disorders Syracuse NY USA Villanova Univ Dept Spanish Villanova PA USA Univ Birmingham Dept English Language & Linguist Birmingham England Carnegie Mellon Univ Dept Philosophy Pittsburgh PA USA Occidental Coll Department Spanish & French Studies Los Angeles CA USA Texas Tech Univ English Lubbock TX USA Univ Arizona Dept Spanish & Portuguese Tucson AZ USA Simmons Univ Div Math & Comp Sci Boston MA USA Harrisburg Univ Sci & Technol Analyt Harrisburg PA USA SUNY Buffalo Dept Psychol Buffalo NY USA Univ Paris Cite CLILLAC ARP Paris France Univ Cologne IfL Phonet Cologne Germany UCL Dept Speech Hearing & Phonet Sci London England Basque Ctr Cognit Brain & Language Donostia San Sebastian Spain Univ Calif Davis Dept Linguist Davis CA USA Univ Nantes CNRS Lab Linguist Nantes UMR6310 Nantes France Univ Texas Arlington Dept Linguist Arlington TX USA Univ Texas Arlington TESOL Arlington TX USA Newcastle Univ Sch Psychol Newc

Recent empirical studies have highlighted the large degree of analytic flexibility in data analysis that can lead to substantially different conclusions based on the same data set. Thus, researchers have expressed their concerns that these researcher degrees of freedom might facilitate bias and can lead to claims that do not stand the test of time. Even greater flexibility is to be expected in fields in which the primary data lend themselves to a variety of possible operationalizations. The multidimensional, temporally extended nature of speech constitutes an ideal testing ground for assessing the variability in analytic approaches, which derives not only from aspects of statistical modeling but also from decisions regarding the quantification of the measured behavior. In this study, we gave the same speech-production data set to 46 teams of researchers and asked them to answer the same research question, resulting in substantial variability in reported effect sizes and their interpretation. Using Bayesian meta-analytic tools, we further found little to no evidence that the observed variability can be explained by analysts' prior beliefs, expertise, or the perceived quality of their analyses. In light of this idiosyncratic variability, we recommend that researchers more transparently share details of their analysis, strengthen the link between theoretical construct and quantitative system, and calibrate their (un)certainty in their conclusions.

关键词： crowdsourcing science data analysis scientific transparency speech acoustic analysis

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

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AUTOPHAGY 2016年第1期12卷 1-222页

作者： Klionsky, Daniel J. Abdelmohsen, Kotb Abe, Akihisa Abedin, Md Joynal Abeliovich, Hagai Arozena, Abraham Acevedo Adachi, Hiroaki Adams, Christopher M. Adams, Peter D. Adeli, Khosrow Adhihetty, Peter J. Adler, Sharon G. Agam, Galila Agarwal, Rajesh Aghi, Manish K. Agnello, Maria Agostinis, Patrizia Aguilar, Patricia V. Aguirre-Ghiso, Julio Airoldi, Edoardo M. Ait-Si-Ali, Slimane Akematsu, Takahiko Akporiaye, Emmanuel T. Al-Rubeai, Mohamed Albaiceta, Guillermo M. Albanese, Chris Albani, Diego Albert, Matthew L. Aldudo, Jesus Alguel, Hana Alirezaei, Mehrdad Alloza, Iraide Almasan, Alexandru Almonte-Beceril, Maylin Alnemri, Emad S. Alonso, Covadonga Altan-Bonnet, Nihal Altieri, Dario C. Alvarez, Silvia Alvarez-Erviti, Lydia Alves, Sandro Amadoro, Giuseppina Amano, Atsuo Amantini, Consuelo Ambrosio, Santiago Amelio, Ivano Amer, Amal O. Amessou, Mohamed Amon, Angelika An, Zhenyi Anania, Frank A. Andersen, Stig U. Andley, Usha P. Andreadi, Catherine K. Andrieu-Abadie, Nathalie Anel, Alberto Ann, David K. Anoopkumar-Dukie, Shailendra Antonioli, Manuela Aoki, Hiroshi Apostolova, Nadezda Aquila, Saveria Aquilano, Katia Araki, Koichi Arama, Eli Aranda, Agustin Araya, Jun Arcaro, Alexandre Arias, Esperanza Arimoto, Hirokazu Ariosa, Aileen R. Armstrong, Jane L. Arnould, Thierry Arsov, Ivica Asanuma, Katsuhiko Askanas, Valerie Asselin, Eric Atarashi, Ryuichiro Atherton, Sally S. Atkin, Julie D. Attardi, Laura D. Auberger, Patrick Auburger, Georg Aurelian, Laure Autelli, Riccardo Avagliano, Laura Avantaggiati, Maria Laura Avrahami, Limor Awale, Suresh Azad, Neelam Bachetti, Tiziana Backer, Jonathan M. Bae, Dong-Hun Bae, Jae-Sung Bae, Ok-Nam Bae, Soo Han Baehrecke, Eric H. Baek, Seung-Hoon Baghdiguian, Stephen Bagniewska-Zadworna, Agnieszka Bai, Hua Bai, Jie Bai, Xue-Yuan Bailly, Yannick Balaji, Kithiganahalli Narayanaswamy Balduini, Walter Ballabio, Andrea Balzan, Rena Banerjee, Rajkumar Banhegyi, Gabor Bao, Haijun Barbeau, Benoit Barrachina, Maria D. Barreiro, Esther Bartel, Bonnie Bartolome, Alberto Bassham, Diane C. Bassi, Ma ASTAR Inst Mol & Cell Biol Singapore Singapore Adam Mickiewicz Univ Dept Gen Bot Inst Expt Biol Fac Biol Poznan Poland Aarhus Univ Hosp Dept Nucl Med DK-8000 Aarhus Denmark PET Ctr Aarhus Denmark Aarhus Univ Dept Biomed Aarhus Denmark Aarhus Univ Dept Clin Med Aarhus Denmark Aarhus Univ Dept Mol Biol & Genet Aarhus Denmark Aarhus Univ Med Res Lab Inst Clin Med Aarhus Denmark Alberystwyth Univ Inst Biol Environm & Rural Sci Aberystwyth Dyfed Wales Acad Sinica Inst Biol Chem Taipei 115 Taiwan Acad Sinica Inst Biomed Sci Taipei 115 Taiwan Acad Sinica Inst Mol Biol Taipei 115 Taiwan Univ Amsterdam Acad Med Ctr Dept Gastroenterol & Hepatol Meibergdreef 9 NL-1105 AZ Amsterdam Netherlands Univ Amsterdam Acad Med Ctr Dept Cell Biol & Histol Meibergdreef 9 NL-1105 AZ Amsterdam Netherlands Aix Marseille Univ CNRS IBDM UMR 7288 Campus Luminy Marseille France Aix Marseille Univ CNRS IRD198 UMR 7278INSERM U1095Med Fac Marseille France Aix Marseille Univ U2M Ctr Immunol Marseille Luminy Marseille France Ajou Univ Coll Pharm Gyeonggido South Korea Ajou Univ Sch Med Dept Microbiol Gyeonggi Do South Korea Akershus Univ Hosp Oslo Norway Akita Univ Grad Sch Med Akita 010 Japan Al Jalila Fdn Res Ctr Dubai U Arab Emirates Albany Med Coll Ctr Neuropharmacol & Neurosci Albany NY 12208 USA Albert Einstein Canc Ctr New York NY USA Albert Einstein Coll Med Bronx NY 10467 USA Albert Einstein Coll Med Dept Dev & Mol Biol Bronx NY 10467 USA Albert Einstein Coll Med Dept Dev & Mol Biol Inst Aging Studies Bronx NY 10467 USA Albert Einstein Coll Med Dept Med Bronx NY 10467 USA Albert Einstein Coll Med Dept Mol Pharmacol Bronx NY 10467 USA Albert Einstein Coll Med Dept Pathol Bronx NY 10467 USA Albert Einstein Coll Med Dept Biochem Bronx NY 10467 USA Albert Einstein Coll Med Dept Med Bronx NY 10467 USA Albert Einstein Coll Med Dept Med Endocrinol Bronx NY 10467 USA Albert Einstein Coll Med Dept Mol Pharmacol Bronx NY 10467 USA Alber

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