lncRNAs are involved in many biological processes, and their mutations and disorders are closely related to many diseases. Identification of LncRNA-Disease Associations (LDAs) helps us understand the pathogenesis of d...
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ISBN:
(数字)9781665468190
ISBN:
(纸本)9781665468206
lncRNAs are involved in many biological processes, and their mutations and disorders are closely related to many diseases. Identification of LncRNA-Disease Associations (LDAs) helps us understand the pathogenesis of diseases and improve their diagnosis and treatment. However, experiments to determine LDAs are expensive, so it is essential to exploit effective computational methods to screen possible LDAs. In this study, we developed an LDA prediction model (LDA-DLPU) based on deep learning and positive-unlabeled (PU) learning. First, LDA-DLPU extracted features of lncRNAs and diseases based on singular value decomposition and regression model. Second, it selected negative LDAs based on PU learning and graph autoencoder. Finally, it classified unknown lncRNA-disease pairs based on deep neural network. LDA-DLPU obtained the best performance on two datasets. We predict that BCYRN1 and IFNG-AS1 may associate with leukemia.
Recovery type a posteriori error estimators are popular, particularly in the engineering community, for their computationally inexpensive, easy to implement, and generally asymptotically exactness. Unlike the residual...
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In this paper, we propose a novel two-relaxation-time regularized lattice Boltzmann (TRTRLB) model for simulating weakly compressible isothermal flows. A free relaxation parameter, τs,2, is employed to relax the regu...
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The Roe's flux difference splitting scheme has been a popular shock-capturing method in computational fluid dynamics due to its high resolution for various discontinuities. However, it fails to satisfy the entropy...
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In this paper, we present a novel enhancement to the conventional hr-adaptive finite element methods for parabolic equations, integrating traditional h-adaptive and r-adaptive methods via neural networks. A major chal...
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A robust C0-continuous nonconforming virtual element method (VEM) is developed for a boundary value problem arising from strain gradient elasticity in two dimensions, with the family of polygonal meshes satisfying a v...
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In this paper, we develop a two-relaxation-time regularized lattice Boltzmann (TRT-RLB) model for simulating weakly compressible isothermal flows, which demonstrates superior stability and accuracy over existing model...
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We derive optimal order a posteriori error estimates in the L∞(L2) and L1(L2)-norms for the fully discrete approximations of time fractional parabolic differential equations. For the discretization in time, we use th...
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作者:
Huang, LinghanShu, ShiYang, Ying
Guangxi Guilin541004 China School of Mathematics and Computational Science
Xiangtan University Hunan Key Laboratory for Computation and Simulation in Science and Engineering Key Laboratory of Intelligent Computing and Information Processing Ministry of Education Hunan Xiangtan411105 China
Guangxi541004 China
The Poisson-Boltzmann equation is a nonlinear elliptic equation with Dirac distribution sources, which has been widely applied to the prediction of electrostatics potential of biological biomolecular systems in soluti...
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In this paper, a new two-relaxation-time regularized (TRT-R) lattice Boltzmann (LB) model for convection-diffusion equation (CDE) with variable coefficients is proposed. Within this framework, we first derive a TRT-R ...
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