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IET International Radar Conference 2023, IRC 2023

作者： Liu, Rui Wei, Xiaoxiao Key Laboratory of Advanced Marine Communication and Information Technology Ministry of Industry and Information Technology AVIC United Technology Center for Electromagnetic Spectrum Collaborative Detection and Intelligent Cognition College of Information and Communication Engineering Harbin Engineering University No. 145 Nantong St. Harbin China

ISBN: (纸本)9781839539954

To address the issue of high computational complexity in traditional polarized sensitive arrays for estimating signal direction of arrival (DOA) and polarization parameters, a compression structure has been proposed. The proposed structure involves the addition of a compression network in front of the front-end chains. The compression matrix generated by this network consists of complex Gaussian distributed elements. The compression matrix reduces the dimension of the sample covariance matrix, thereby reducing the complexity of the computation process. The proposed structure achieves higher accuracy in DOA and polarization parameter estimation for a given number of front-end circuit chains. Compared to traditional polarized sensitive arrays, this structure significantly reduces the computational burden in the estimation process, improving the efficiency of DOA and polarization parameter estimation. Numerical simulation results validated the effectiveness of the proposed structure. © The Institution of Engineering & technology 2023.

关键词： Covariance matrix

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内源性双miRNA触发响应的DNA纳米结构动态自组装用于原位递送siRNA

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Science China Materials 2023年第7期66卷 2938-2946页

作者：钟武坤黄蕾林玉红邢超卢春华 MOE Key Laboratory for Analytical Science of Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350116China Institute of Nanobiomaterials and Immunology School of Life ScienceTaizhou UniversityTaizhou 318000China Fujian Key Laboratory of Functional Marine Sensing Materials Center for Advanced Marine Materials and Smart SensorsMinjiang UniversityFuzhou 350108China

通过多重miRNA触发的原位siRNA递送治疗策略可以有效提高对癌细胞的精确治疗.基于DNA纳米结构的可编程性、特异性分子识别、易于功能化修饰和良好生物相容性的特点,我们设计了一个3D DNA纳米治疗平台,用于实现双miRNA触发响应的siRNA原... 详细信息

通过多重miRNA触发的原位siRNA递送治疗策略可以有效提高对癌细胞的精确治疗.基于DNA纳米结构的可编程性、特异性分子识别、易于功能化修饰和良好生物相容性的特点,我们设计了一个3D DNA纳米治疗平台,用于实现双miRNA触发响应的siRNA原位递送.这种3D DNA纳米结构(TY1Y2)是由DNA四面体支架、两组Y型DNA(Y1和Y2)和EpCAM核酸适体通过自组装构建而成的.TY1Y2被特异性内化至靶标癌细胞后,能够被两个内源性miRNA(miR-21和miR-122)触发,从而产生强的荧光共振能量转移信号,用于双miRNAs成像.同时,治疗性的siRNA(siSurvivin和siBcl2)也可以通过链置换反应从TY1Y2中产生并进行原位释放,实现癌细胞的协同基因治疗.这种3D DNA纳米结构将内源性生物标记物的特异性成像和治疗性基因的原位递送整合为一个多功能纳米平台,在癌症诊断和治疗方面显示出广阔的应用前景.

关键词： DNA tetrahedra dynamic assembly miRNA in-situ delivery cell imaging gene therapy

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A fast instantaneous frequency estimation for underwater acoustic target feature extraction 2

A fast instantaneous frequency estimation for underwater aco...

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2021 2nd International Conference on Signal Processing and Computer Science, SPCS 2021

作者： Ma, Yanxin Zhang, Yifan Zhu, Jiahua Xu, Ke Cai, Yujin College of Meteorology and Oceanology National University of Defense Technology Hunan Changsha410073 China Hunan Key Laboratory for Marine Detection Technology Hunan Changsha410073 China College of Electronic Science National University of Defense Technology Hunan Changsha410073 China

Traditional auditory features merely present the amplitude characteristics of target signals in frequency domain. Such features are susceptible to environmental noise, resulting in significant degradation of recognition stability. Inspired by instantaneous information applied in speech signal processing field, this paper proposed a feature extraction method using sub-based instantaneous frequency. A fast instantaneous frequency information extraction algorithm is proposed with the normalized Gammatone filterbanks. Experiments confirm that the proposed feature extraction method can effectively maintain the recognition accuracy under low SNR conditions while reduce the computation cost. © 2021 Institute of Physics Publishing. All rights reserved.

关键词： Frequency domain analysis

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Enlightenment of the Mariana Fore-arc Sedimentary Basin Evolution to the Subduction Process

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Acta Geologica Sinica(English Edition) 2022年第1期96卷 71-80页

作者： XING Lei LI Qianqian MENG Qingwei LIU Huaishan WEI Jia LU Boran ZHOU Heng Key Lab of Submarine Geosciences and Prospecting Techniques Ministry of EducationOcean University of ChinaQingdaoShandong 266100China Evaluation and Detection Technology Laboratory of Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China Chinese Academy of Geological Sciences Beijing 100037China Qingdao Institute of Marine Geology China Geological SurveyMinistry of Natural ResourcesQingdaoShandong 266071China BGP International CNPCZhuozhouHebei 072750China

The Mariana subduction structure is a hot topic in ocean-ocean subduction zone research,and its subduction mechanism has attracted wide attention from experts and scholars in China and *** on the multi-channel seismic data of survey line MGL1204 in the Mariana fore-arc and DSDP ocean drilling data,this paper studies the development and evolution characteristics of the structure and strata in the Cenozoic Mariana fore-arc sedimentary *** Cenozoic strata are divided into six seismic sequences,with the possible era of each seismic sequence discerned,and the relationship between fault development and earthquakes *** episodic activity of the volcanic chain of the Mariana island arc is thought to control the tectonic and stratigraphic development pattern of the Cenozoic sedimentary basin in the *** 16°N-19°N and 146°E-151°E,the maximum thickness of the sedimentary center of the Cenozoic fore-arc sedimentary basin in Mariana is about 2360 *** faults are developed in the area and some broke to the seabed,indicating that the Mariana island arc is still in the post-arc expansion *** application of multi-channel seismic sections in structural and stratigraphic evolution study is an important means to elucidating the Mariana subduction mechanism.

关键词： subduction system fore-arc basin sedimentary evolution subduction mechanism Mariana

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Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy

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Science China(Life Sciences) 2023年第9期66卷 2152-2166页

作者： Shiyue Du Sheng Zeng Li Song Hongying Ma Rui Chen Junyu Luo Xu Wang Tingbin Ma Xuan Xu Hao Sun Ping Yi Jifeng Guo Yaling Huang Mugen Liu Tao Wang Wei-Ping Liao Luoying Zhang Jing Yu Liu Beisha Tang Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and Technology(HUST)Wuhan 430074China Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Geriatrics The Second Xiangya HospitalCentral South UniversityChangsha 410011China National Reference Laboratory of Veterinary Drug Residues and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Neurology Union Hospital of HUSTWuhan 430022China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of ChinaGuangzhou Medical UniversityGuangzhou 510260China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China

Focal epilepsy accounts for 60% of all forms of epilepsy, but the pathogenic mechanism is not well understood. In this study,three novel mutations in NPRL3(nitrogen permease regulator-like 3), c.937_945del, c.1514dup C and 6,706-bp genomic DNA(g DNA) deletion, were identified in three families with focal epilepsy by linkage analysis, whole exome sequencing(WES) and Sanger sequencing. NPRL3 protein is a component of the GATOR1 complex, a major inhibitor of m TOR signaling. These mutations led to truncation of the NPRL3 protein and hampered the binding between NPRL3 and DEPDC5, which is another component of the GATOR1 complex. Consequently, the mutant proteins enhanced m TOR signaling in cultured cells, possibly due to impaired inhibition of m TORC1 by GATOR1. Knockdown of nprl3 in Drosophila resulted in epilepsy-like behavior and abnormal synaptic development. Taken together, these findings expand the genotypic spectrum of NPRL3-associated focal epilepsy and provide further insight into how NPRL3 mutations lead to epilepsy.

关键词： focal epilepsy NPRL3 GATOR1 mTOR abnormal synaptic development

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BOTTOM REVERBERATION SUPPRESSION USING DELAY-DOPPLER DECONVOLUTION FOR THE detection OF LOW-SPEED SMALL TARGETS IN VERY SHALLOW WATER 28

BOTTOM REVERBERATION SUPPRESSION USING DELAY-DOPPLER DECONVO...

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28th International Congress on Sound and Vibration, ICSV 2022

作者： Yacong, Zhao Xionghou, Liu Chao, Sun Jie, Zhuo Yixin, Yang School of Marine Science and Technology Northwestern Polytechnical University Shaanxi Xi'an710072 China Shaanxi Key Laboratory of Underwater Information Technology Shaanxi Xi'an710072 China Science and Technology on Near-Surface Detection Laboratory Wuxi214035 China

ISBN: (纸本)9789811850707

In the scenarios of detecting the underwater low-speed small targets (e.g., frogmen or UUVs) in the very shallow water environment (e.g., harbor or shoal where the water depth is about several meters), much attention has been attracted on reverberation suppression. Based on the Doppler difference between the moving target echoes and the bottom reverberation dominant in the very shallow water, the traditional matched filtering may realize the separation of the bottom reverberation and the target echoes. However, the Doppler incurred by low-speed small targets is quite small, so the performance on the bottom reverberation suppression seriously degrades due to the limitation of Doppler resolution of the traditional approach. Therefore, it is urgent to improve its Doppler resolution to separate low-speed small targets out from the nearly static bottom reverberation. Generally, the reverberation and the target echoes can be considered as the weighted sum of the copies of transmitted signal with different delay and Doppler, which indicates that "the cross-ambiguity function of the received echo is approximately the two-dimensional convolution of the auto-ambiguity function of transmitted signal and the generalized "target" reflectivity density function (i.e., the weighted sum of the 2-D Dirac Delta function convolved with different delays and Doppler shifts)". In this paper, regarding the auto-ambiguity function of the transmitted signal as the 2-D point spread function (PSF), an iterative deconvolution algorithm called the Richardson-Lucy (R-L) algorithm is exploited to deblur the conventional delay-Doppler output. This processing can obtain approximately the generalized "target" reflectivity density function similar to the thumbtacks, which can significantly improve the resolution of the delay and Doppler of the raw output, and separate the slow-speed small targets submerged by the bottom reverberation. Simulations show the effectiveness and superiority of the proposed

关键词： Reflection

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Advancements in research and current applications of

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The European Physical Journal Special Topics 2025年 1-29页

作者： Zhou, Zhengrong Zhang, Hongwei Huang, Rongjin He, Feng Xu, Dong Yan, Xiuwen Li, Laifeng Technical Institute of Physics and Chemistry Key Laboratory of Cryogenic Science and Technology Chinese Academy of Sciences Beijing China Hunan Key Laboratory of High-Performance Intelligent Sensor and Detection System The 48th Research Institute of CETC Changsha China Hunan National Defense Key Laboratory of Thin Film Sensing Technology The 48th Research Institute of CETC Changsha China School of Future Technology University of Chinese Academy of Sciences Beijing China

In recent years, superconducting quantum interference devices (SQUIDs) based on the Josephson effect have undergone significant advancements. As one of the most sensitive and precise instruments for measuring magnetic fields, SQUIDs are widely used in low-frequency communications, biomagnetic measurements, aerial magnetometry, nondestructive testing, magnetic measurement microscopy, and other fields. The development of SQUIDs involves theories and technologies such as electromagnetic theory, superconductivity, semiconductor technology, thin film fabrication technology, packaging technology, electronic circuits, and cryogenics, reflecting a product of multidisciplinary integration. This paper reviews and summarizes the principles, types, processes, system structures, and current research status of SQUIDs while anticipating future developments in this field.

关键词：

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Dynamics Modeling of a Three-Legged Sea Floor Drill Rig Hard-Landing and Analysis of Influence of Landing Conditions on its Responses

SSRN

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SSRN 2024年

作者： Liu, Peng Jin, Yongping Liu, Deshun Wan, Buyan Liu, Guangping National-Local Joint Engineering Laboratory of Marine Mineral Resources Exploration Equipment and Safety Technology Hunan University of Science and Technology Xiangtan City411201 China Hunan Provincial Key Laboratory of Marine Resources Exploration Technology and Equipment Hunan University of Science and Technology Xiangtan City411201 China

Touchdown is a decisive step in the underwater deployment of the sea floor drill rig (SFDR), but the related research is still in its infancy. Therefore, a spatial seven degrees of freedom (DoF) dynamic model of the three-legged SFDR "Seabull Ⅱ" hard landing was established, and a simulation platform was built. In addition, the influence of landing conditions on the dynamic responses was understood through orthogonal experiments, which indicates that: (a) The maxima of outrigger axial-force-loads are mainly affected by the sediments elastic coefficient;the maximum of connecting strut lateral-force-load is mainly affected by the slope of the landing surface (SLS). (b) The acceleration-load is not a point that requires special attention for SFDR hard landing. (c) For control strategies, it is recommended to set the release height from seabed (RHFS) at 2 to 3 meters, and to choose a smaller leg-opening-angle (LOA) based on the actual sea condition and seabed environment. (d) For the optimal design of the SFDR supporting system, it is advisable to increase the friction coefficient between the footpad and sediments by changing the structure and surface characteristics of the footpad, as well as to add a function of variable support area to the footpad. © 2024, The Authors. All rights reserved.

关键词： Simulation platform

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Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

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Science China Chemistry 2024年第8期67卷 2497-2523页

作者： Yuan Zeng Shuhan Zhang Yuecong Guo Yalin Cong Xu Ding Peihua Li Yunxiang Lin Wenzhi Ren Hui Su Weigang Sun Liuxin Xu Guikai Zhang Shihua Chen Yu Chen Weiren Cheng Shengqi Chu Yong Guan Jinru Han Jie Lin Hengjie Liu Zheyi Liu Pan Luo Fanchun Meng Sicong Qiao Zongyin Song Ying Wang Zhao Wu Chenyu Yang Meng Yang Shirui Yang Zi Yin Zhibin Yin Pengjun Zhang Hongyu Zhang Pingping Zheng Jia Zhou Wanlin Zhou Pengfei An He Cheng Chunhai Fan Xingjiu Huang Yong Lei Lina Li Mu Li Qinghua Liu Shuming Peng Li Song Zhihu Sun Yangchao Tian Fangjun Wang Lihua Wang Liming Wang Shiqiang Wei Aiguo Wu Chunlei Xiao Xueming Yang Panchao Yin Jing Zhang Mingxin Zhang Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science LaboratoryNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410081China State Key Laboratory of Luminescent Materials and Devices South China Advanced Institute for Soft Matter Science and TechnologySouth China University of TechnologyGuangzhou 510640China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Advanced Science Facilities Shenzhen 518107China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Acade

With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron *** further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.

关键词： large scientific facilities synchrotron radiation FEL light sources neutron sources spectroscopic analysis methods X-ray imaging techniques structural information chemical dynamics

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Facile fabrication of self-healing silicone-based poly(urea-thiourea)/tannic acid composite for anti-biofouling

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Journal of Materials Science & technology 2022年第29期124卷 1-13页

作者： Jiawen Sun Chao Liu Jizhou Duan Jie Liu Xucheng Dong Yimeng Zhang Ning Wang Jing Wang Baorong Hou Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100039China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China College of Resources and Environment Hunan Agricultural UniversityChangsha 410128China

A novel silicone-based poly(urea-thiourea)/tannic acid composite(PDMS-P(Ua-TUa)-TA)with excellent mechanical,self-healing and antifouling properties is *** multiple dynamic hydrogen bonds formed by thiourea groups,urea groups,and tannic acid(TA)molecules ensured a tough elastomer(ultimate strength:2.47 MPa)with high stretchability(~1000%).TA molecules as partial hydrogen bonding cross-linking sites interacted rapidly with urea and thiourea groups before the migration of polymer chains,resulting in fast and efficient *** on the film completely disappeared within12 min,and the repair efficiency of strength was up to 98.4%within 3 h under ambient *** behavior was also evaluated in artificial seawater and the healing efficiency(HE)was 95.1%.Furthermore,TA uniformly dispersed in the polymer matrix provides good antibacterial and anti-diatom properties,as well as strong adhesion to the substrate(~2.2 MPa).laboratory bioassays against marine bacteria adhesion(~96%,~95%and~93%reduction for ***.,***,and ***,respectively)and diatom attachment(~84%reduction)demonstrated an outstanding antifouling property of the PDMSP(Ua-TUa)-*** work provides a promising pathway towards the development of high-performance silicone-based coatings for marine anti-biofouling.

关键词： Poly(dimethylsiloxane) Poly(urea-thiourea) Self-healing Hydrogen bonding marine antifouling Tannic acid

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