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Beta-elemene inhibits the growth of KDM6A-null bladder cancer cells by suppressing the epithelial-mesenchymal transition

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Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 15-24页

作者： Ruonan Zhang Jiao Feng Yintao Zheng Qianru Zhu Bo Xiang Qibiao Wu Xinbing Sui The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health Cancer Research Institute and School of Basic Medical SciencesCentral South UniversityChangsha 410008HunanChina School of Pharmacy Hangzhou Normal UniversityHangzhou 311121ZhejiangChina Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou 311121ZhejiangChina Department of Gastrointestinal and Pancreatic Surgery Key Laboratory of Gastroenterology of Zhejiang ProvinceZhejiang Provincial People’s HospitalHangzhou 310014ZhejiangChina School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 311402ZhejiangChina State Key Laboratory of Quality Research in Chinese Medicines Faculty of Chinese MedicineMacao University of Science and TechnologyMacao 999078China

Background:Bladder cancer is a highly prevalent and lethal malignant tumor characterized by frequent mutations/deletions of lysine-specific demethylase 6A(KDM6A),which is suggested to be a key event in cancer progression and ***-elemene has been shown to inhibit metastasis and growth of various tumors,but its effect on KDM6A-null bladder cancer cells remains ***:This study aimed to investigate the potential and molecular mechanism ofβ-elemene in inhibiting the growth of KDM6A-null bladder ***:This study examined the migration ability and viability of RT-4(KDM6A wild-type)and KU19-19(KDM6A-null)cell lines using wound healing assay and CCK-8,*** inhibitory effect ofβ-elemene on KU19-19 cell migration was evaluated using transwell and immunofluorescence assays,and the expression of transfer-related proteins and genes was analyzed through western blot and qRT-PCR,*** docking was performed to predict the targeting ofβ-elemene,and the effects were confirmed in KDM6Aknockdown RT-4 ***,the therapeutic effect ofβ-elemene on bladder cancer was tested in animal ***:The study observed that loss of KDM6A increased bladder cancer cell migration,with KU19-19 exhibiting significantly stronger migration than *** investigation revealed thatβ-elemene effectively inhibited KU19-19 cell migration,likely through targeting EZH2 as determined by molecular *** of KDM6A inhibited KU19-19 metastasis,while knockdown of KDM6A in RT-4 cells enhanced cell migration,which was reversed byβ-elemene ***,in vivo testing revealed a significant suppression of KU19-19 cell growth withβ-elemene administered at a dosage of 100 mg/***:β-elemene has the potential to suppress the growth of KDM6A-null bladder cancer by inhibiting epithelial-mesenchymal transition(EMT),which could make it a promising therapeutic option for patients with KDM6A-null bladder cancer.

关键词： β-Elemene Lysine-specific demethylase 6A(KDM6A) Bladder cancer Metastasis Epithelial-mesenchymal transition(EMT)

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Opportunities of prebiotics for the intestinal health of monogastric animals

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Animal Nutrition 2020年第4期6卷 379-388页

作者： Md A.K.Azad Jing Gao Jie Ma Tiejun Li Bie Tan Xingguo Huang Jie Yin College of Animal Science and Technology Hunan Agricultural UniversityHunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryChangsha410128China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionChangsha410125China University of Chinese Academy of Sciences Beijing100049China

The goal of prebiotic applications from different sources is to improve the gut ecosystem where the host and microbiota can benefit from *** has already been recognized that prebiotics have potential roles in the gut ecosystem because gut microbiota ferment complex dietary macronutrients and carry out a broad range of functions in the host body,such as the production of nutrients and vitamins,protection against pathogens,and maintenance of immune system *** gut ecosystem is very crucial and can be affected by numerous factors consisting of dietary constituents and commensal *** review focuses on recent scientific evidence,confirming a beneficial effect of prebiotics on animal health,particularly in terms of protection against pathogenic bacteria and increasing the number of beneficial bacteria that may improve epithelial cell barrier *** has also been reviewed that modification of the gut ecosystem through the utilization of prebiotics significantly affects the intestinal health of ***,the identification and characterization of novel potential prebiotics remain a topical issue and elucidation of the metagenomics relationship between gut microbiota alteration and prebiotic substances is necessary for future prebiotic studies.

关键词： Prebiotics Gut microbiota Intestinal health Short-chain fatty acids

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Graphene Oxide Reinforced High-Performance Three-Dimensional Superhydrophobic Hybrid Hydrogel Geopolymer Composites

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SSRN 2024年

作者： Li, Yi Zhong, Zhaowen Ma, Xiongying Gan, Yuxiang Kang, Xin Chen, Renpeng Key Laboratory of Building Safety and Energy Efficiency The Ministry of Education Hunan University Changsha410082 China National Center for International Research Collaboration in Building Safety and Environment Hunan University Changsha410082 China College of Civil Engineering Hunan University Changsha410082 China Hunan Provincial Engineering Research Center for Advanced Technology Intelligent Equipment for Underground Space Development China Zachry Department of Civil and Environmental Engineering Texas A&M University College StationTX77843 United States

High-performance geopolymers boast a low carbon footprint for construction, but their inherent hydrophilicity leads to water accumulation and internal corrosion damage. Hydrophobic modification of geopolymers significantly improves the corrosion resistance, however, potential strength reductions remains unsolved. This study aimed to counteract the detrimental influence of the hydrophobic aluminosilicate hydrate gel on mechanical properties while maintaining the superhydrophobic performance. We achieved this by incorporating a novel composite modifier with the polymethyl hydrosiloxane (PMHS) as the primary hydrophobic modifier. The addition of single-layer graphene oxide (GO) is used for effective pore filling, mechanical reinforcement, and nano-hydrophobic particles due to its excellent dispersion , enhanced reactivity and superior mechanical properties. This synergistic combination enabled the successful fabrication of a high-performance geopolymer composite characterized by exceptional mechanical strength, three-dimensional superhydrophobicity, and enhanced chemical stability. The graphene oxide reinforced high-performance three-dimensional superhydrophobic hybrid hydrogel geopolymer composites maintained high compressive strength while achieving a water contact angle of 153 ° and a water absorption rate of only 1.7%. Remarkably, the geopolymer retains its high hydrophobicity even after 24 hours in an acid-base solution, with a contact angle exceeding 140° and water absorption rates lower than 4%. © 2024, The Authors. All rights reserved.

关键词： Geopolymers

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Natural variations in TT8 and its neighboring STK confer yellow seed with elevated oil content in Brassica juncea

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Proceedings of the National Academy of Sciences of the United States of America 2025年第5期122卷 e2417264122页

作者： Qian, Lunwen Yang, Liu Liu, Xianjun Wang, Tianyi Kang, Lei Chen, Hao Lu, Yin Zhang, Yukun Yang, Shujie You, Liang Yao, Min Xiang, Xingru Cui, Kan Guo, Ying Yang, Bin Yan, Mingli Xia, Shitou Meng, Jinling Lin, Tao Mason, Annaliese S. Snowdon, Rod J. Liu, Zhongsong College of Agronomy Hunan Agricultural University Changsha 410128 China Molecular Rapeseed Breeding Team Yuelushan Laboratory Changsha 410128 China Smartgenomics Technology Institute Tianjin 301700 China Hunan Provincial Key Laboratory of Phytohormones and Growth Development College of Bioscience and Biotechnology Hunan Agricultural University Changsha 410128 China National Key Laboratory of Crop Genetic Improvement Key Laboratory of Rapeseed Genetic Improvement Ministry of Agriculture China Huazhong Agricultural University Wuhan 430072 China College of Horticulture China Agricultural University Beijing 100193 China Plant Breeding Department The University of Bonn Bonn 53115 Germany Department of Plant Breeding Justus Liebig University Giessen Giessen 35392 Germany

Seed color is a critical quality trait in numerous plant species. In oilseed Brassica crops, including rapeseed and mustard, yellow seeds are distinguished by their significantly higher oil content and faster germination rates compared to black or brown counterparts. Despite the agronomic significance of the yellow seeds being a prime breeding target, the mechanisms underlying elevated oil content remain obscure. In this study, we assembled the first telomere-to-telomere (T2T) genome of B. juncea and further investigated the genetic regulation, molecular mechanism, and the evolutionary history of yellow seeds in B. juncea. Through an analysis of allelic variation in the TRANSPARENT TESTA 8 (TT8) genes across 1,002 worldwide B. juncea accessions, we traced the single origin of yellow seeds to approximately 2,300 y ago in Southwestern China. Furthermore, we discovered the MADS-box gene SEEDSTICK (STK) coevolved with TT8, and they coordinately regulated seed size, oil accumulation, and seed coat proportion in B. juncea. These findings open broad avenues for targeted breeding of yellow-seeded Brassica crops with elevated oil content. Copyright © 2025 the Author(s).

关键词： co-evolution haplotype oil content STK TT8

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D-Alanine functionalized Iridium(III) complexes as two-photon photo-antibiotics for bacteria-specific ablation in infected macrophages

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European Journal of Medicinal Chemistry 2025年 294卷 117758页

作者： Shu, Jun Jiang, Hui Lin, Minwei Liang, Jinzhe Zhao, Yukun Luo, Diqing Wang, Jinquan Chao, Hui MOE Key Laboratory of Bioinorganic and Synthetic Chemistry State Key Laboratory of Anti-Infective Drug Discovery and Development Guangdong Basic Research Center of Excellence for Functional Molecular Engineering School of Chemistry Sun Yat-Sen University Guangzhou 510006 China Department of Dermatology The First Affiliated Hospital Sun Yat-Sen University Guangzhou 510275 China Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations School of Bioscience and Biopharmaceutics Guangdong Pharmaceutical University Guangzhou 510006 China MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule School of Chemistry and Chemical Engineering Hunan University of Science and Technology Xiangtan 400201 China

The prevalence of bacterial resistance, driven by extensive antibiotic overuse, significantly threatens patient safety. Consequently, it is urgent and helpful for the clinician to develop new antibacterial therapy techniques. In this study, we designed a novel photodynamic antibacterial therapeutic strategy by functionalizing D-alanine on Iridium(III) complexes. The synergistic D-alanine metabolic labeling function and two-photon photodynamic eradication capacity of Ir(III) complexes enable bacterial imaging and elimination of bacterial pathogens within host cells. These two-photon photoantibiotics effectively inhibit bacterial biofilm formation and efficiently eliminate intracellular bacterial infections in macrophages, enabling real-time dynamic monitoring of antimicrobial efficacy. Furthermore, both in vitro and in vivo experiments demonstrated superior antibacterial performance compared to conventional antibiotics alone. © 2025 Elsevier Masson SAS

关键词： Bacterial resistance Iridium Medicinal inorganic chemistry Photo-antibiotics Two-photon

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Numerical investigation of bolt anchorage with tension force and shear force

Numerical investigation of bolt anchorage with tension force...

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作者： Yu Chen Yongde Li Hunan Provincial Key Laboratory of Hydropower Development Key Technology China Construction Fifth Engineering Division Corp. Ltd

The bolt anchorage with tension force and shear force are studied numerically by FLAC3 D modelling.A tri-linear material model was utilized for the bolt steels in order to simulate the strain hardening behaviour of the *** numerical modelling show that different types of bolts have similar load capacities,while their deformation capacities are *** numerical results match the laboratory test *** different deformation capacities of rock bolts are attributed to their different bonding conditions and stretching *** axial load in the rebar bolt reduces exponentially from the loading point close to the joint to the bolt *** axial load in the D-Bolt has its maximum at the joint and reduces slowly as the distance from the joint increases.

关键词： Numerical investigation of bolt anchorage with tension force and shear force

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Dietary polyphenols in lipid metabolism: A role of gut microbiome

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Animal Nutrition 2020年第4期6卷 404-409页

作者： Jie Ma Yongmin Zheng Wenjie Tang Wenxin Yan Houfu Nie Jun Fang Gang Liu College of Bioscience and Biotechnology College of Animal Science and TechnologyHunan Agricultural UniversityHunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryChangshaHunanChina Key Laboratory of Agro-Ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangshaHunanChina Sichuan Academy of Animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengduChina Agricultural and Rural Office of Chunkou Town LiuyangHunanChina

Polyphenols are a class of non-essential phytonutrients,which are abundant in fruits and *** polyphenols or foods rich in polyphenols are widely recommended for metabolic ***,polyphenols(i.e.,catechins,resveratrol,and curcumin)are increasingly recognized as a regulator of lipid metabolism in *** mechanisms,at least in part,may be highly associated with gut *** review mainly discussed the beneficial effects of dietary polyphenols on lipid *** potential mechanisms of gut microbiome are focused on the effect of dietary polyphenols on gut microbiota compositions and how gut microbiota affect polyphenol ***,dietary polyphenols may be a useful nutritional strategy for manipulation of lipid metabolism or obesity care.

关键词： Polyphenols Lipid metabolism Obesity Gut microbiota

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Mofs/Biomass-Derived Carbon as a High-Performance Anode for Phosphorus Removal

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SSRN 2024年

作者： Chen, Xing Song, Xiang Wenqing, Chen Ao, TianQi Qiulin, Yang Lili, Zhao College of Architecture and Environment Sichuan University Chengdu610065 China State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu610065 China College of Water Resource and Hydropower Sichuan University Chengdu610065 China Sichuan Development Environmental Science and Technology Research Institute Co. Ltd Chengdu610094 China Sichuan Provincial Industrial Wastewater Pollution Control and Low Carbon Resource Utilization Engineering Technology Research Center Chengdu610094 China

Capacitive deionization (CDI) is considered an emerging electrochemical technology for phosphorus removal. Electrode materials are critical to achieving cost-efficient phosphorus elimination. Metal-organic frameworks (MOFs)-derived carbon has been recognized as a promising material for phosphorus removal, but potential metal particle agglomeration, poor conductivity, and the high cost largely thwarted its application. Nitrogen (N) doping facilitates the dispersion of metal particles in the carbon matrix as well as enhances the conductivity. Fortunately, N in biomass could also be inherited by the derived carbon material even after carbonization, contributing to addressing problems such as metal particle agglomeration and poor conductivity, as well as reducing costs and boosting resource utilization. Herein, Zirconium-nitrogen co-doped carbon (N@Zr/C) was fabricated by in-situ growth of Zr-MOFs on biomass followed by pyrolysis. Apparently, the conductivity and phosphorus removal performance were remarkably enhanced with the introduction of biomass. Under 1.2 V condition, the N@Zr/C electrode exhibited an optimal electrosorption capacity of 32.30 mg P/g. Meanwhile, the corresponding electrosorption was comprehensively clarified through Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). This study shows that N@Zr/C electrodes can be expected to achieve efficient phosphorus removal by CDI. © 2024, The Authors. All rights reserved.

关键词： Organometallics

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Direct measurement of the 19F(p,αγ)16O reaction in JUNA 16

Direct measurement of the 19F(p,αγ)16O reaction in JUNA

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16th Symposium on Nuclei in the Cosmos, NIC-XVI 2021

作者： Zhang, L.Y. Su, J. He, J.J. Wiescher, M. deBoer, R.J. Kahl, D. Chen, Y.J. Li, X.Y. Wang, J.G. Zhang, L. Cao, F.Q. Zhang, H. Zhang, Z.C. Jiao, T.Y. Sheng, Y.D. Wang, L.H. Song, L.Y. Jiang, X.Z. Li, Z.M. Li, E.T. Wang, S. Lian, G. Li, Z.H. Tang, X.D. Zhao, H.W. Sun, L.T. Wu, Q. Li, J.Q. Cui, B.Q. Chen, L.H. Ma, R.G. Guo, B. Xu, S.W. Li, J.Y. Qi, N.C. Sun, W.L. Guo, X.Y. Zhang, P. Chen, Y.H. Zhou, Y. Zhou, J.F. He, J.R. Shang, C.S. Li, M.C. Zhou, X.H. Zhang, Y.H. Zhang, F.S. Hu, Z.G. Xu, H.S. Cheng, J.P. Liu, W.P. Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and Technology Beijing Normal University Beijing100875 China The Joint Institute for Nuclear Astrophysics Department of Physics University of Notre Dame Notre DameIN46556 United States Bucharest-Magurele077125 Romania Institute of Modern Physics Chinese Academy of Sciences Lanzhou730000 China China Institute of Atomic Energy Beijing102413 China College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen518060 China Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space Sciences Shandong University Weihai264209 China Yalong River Hydropower Development Company Chengdu610051 China Beijing Radiation Center Beijing100875 China

The 19F(p, αγ)16O reaction is of crucial importance for Galactic 19F abundances and CNO cycle loss in first generation Population III stars. Due to its extremely small cross sections, the 19F(p, αγ)16O reaction has not been measured in the low energy part of the Gamow window(70-200 keV). As a day-one campaign, the experiment was performed under the extremely low cosmic-ray-induced background environment of the China JinPing Underground laboratory(CJPL), one of the deepest underground laboratories in the world. The γ-ray yields were measured over Ec.m.=72.4-344 keV, covering the full Gamow window for the first time. The direct experimental data will help people to expound the fluorine over-abundances, energy generation, as well as heavy-element nuclosynthesis scenario in asymptotic giant branch (AGB) stars, with the astrophysical model on the firm ground. © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://***/licenses/by/4.0/).

关键词： Cosmology

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Eco-friendly fabrication of photothermal, UV-resistant, and anti-oxidative coating on cotton fabric by enzymatic polymerization

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Surfaces and Interfaces 2025年 68卷

作者： Zheng, Guolin He, Wentao Cheng, Haonan Bao, Xinjun Zhang, Anlin Wang, Kun He, Bin Zhou, Hengshu College of Textile and Fashion Intelligent Textile Institute of Innovation Hunan Institute of Engineering Hunan Xiangtan 411104 China Key Laboratory of Intelligent Textile processing Technology College of Hunan Province Hunan Xiangtan 411104 China Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations Changsha Medical University Provincial First-Class Applied Discipline (Pharmacy) Changsha 410219 China

The protective coating on textiles has attracted tremendous interest since the outbreak of COVID-19, prompting significant advancements in protective textiles. Herein, the laccase-platinum nanozyme (Lac-Pt) was selected for the first time to catalyze the self-polymerization of epicatechin, in which the polyepicatechin (PEC) was coated on cotton fabric by in-situ deposition, labeled as CF@PEC. The PEC coating on cotton fabric was confirmed through scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and energy-dispersive X-ray spectroscopy (EDX). Moreover, the self-polymerization mechanism of EC was demonstrated by UV-visible spectra, hydrogen proton nuclear magnetic resonance (¹H NMR), X-ray photoelectron spectroscopy (XPS), and FTIR. The laccase and platinum nanozyme possess the synergies during catalyzing the polymerization of EC. CF@PEC exhibits good photothermal effect (photothermal temperature of 60.3°C), UV protection ability (UPF of 95.6), and anti-oxidative performance (94.4 ± 0.3%). In addition, CF@PEC can maintain UV protection ability after undergoing 20 washing cycles. Notably, the Lac-Pt used to create the multifunctional coating not only preserves the strength of the cotton fabric, but also reduces wastewater production. Briefly, this work renders a promising strategy to prepare the protective coating, which may open a sustainable and efficient avenue to room-temperature thermal therapy and can provide heat to the body in cold environments. © 2025 Elsevier B.V.

关键词： Epicatechin Laccase Protective coating Textiles

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