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Fostering second-hand luxury purchases through social media influencers: insights from young adults in Taiwan

YOUNG CONSUMERS 2025年第4期26卷 606-628页

作者： Nguyen, Dung Minh Nguyen, Trieu Natl Kaohsiung Univ Sci & Technol Coll Management Kaohsiung Taiwan Natl Kaohsiung Univ Sci & Technol IMBA Program Kaohsiung Taiwan

PurposeBased on signaling theory, this study aims to examine the impact of three influencer-related attributes (i.e. credibility, homophily and popularity) on consumers' emotional responses (i.e. pride and hope) and their intention to buy second-hand luxury (SHL) ***/methodology/approachWith the data obtained from 409 young YouTube users in Taiwan, the proposed hypotheses were examined using partial least squares-structural equation modeling (PLS-SEM) and fuzzy-set qualitative comparative analysis (fsQCA).FindingsThe PLS-SEM results showed that influencer-related attributes significantly trigger consumer pride and hope, which in turn stimulate their purchase intention toward SHL products. The fsQCA results supplemented the PLS-SEM findings, indicating four configurations boosting purchase ***/valueAlthough scholars are increasingly interested in SHL goods due to their eco-friendly appeal, there remains an untapped opportunity to harness the potential of social media influencers in driving consumer purchases within this realm. The findings enrich the literature on influencer marketing and SHL purchases and offer practical implications for brands and advertisers in creating impactful influencer marketing strategies to influence consumers' purchase behavior and foster a culture of sustainable consumption.

关键词： Social media influencer Second-hand luxury Pride Hope Sustainable consumption

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The material properties of mitotic chromosomes

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CURRENT OPINION IN STRUCTURAL BIOLOGY 2023年第1期81卷 102617页

作者： Spicer, Maximilian F. D. Gerlich, Daniel W. Austrian Acad Sci Vienna Bioctr VBC Inst Mol Biotechnol IMBA A-1030 Vienna Austria Univ Vienna Vienna Bioctr Doctoral Sch PhD Program A-1030 Vienna Austria Med Univ Vienna A-1030 Vienna Austria

Chromosomes transform during the cell cycle, allowing tran-scription and replication during interphase and chromosome segregation during mitosis. Morphological changes are thought to be driven by the combined effects of DNA loop extrusion and a chromatin solubility phase transition. By extruding the chromatin fibre into loops, condensins enrich at an axial core and provide resistance to spindle pulling forces. Mitotic chromosomes are further compacted by deacetylation of histone tails, rendering chromatin insoluble and resistant to penetration by microtubules. Regulation of surface properties by Ki-67 allows independent chromosome movement in early mitosis and clustering during mitotic exit. Recent progress has provided insight into how the extraordinary material properties of chromatin emerge from these activities, and how these properties facilitate faithful chromosome segregation.

关键词： Mitosis Chromosomes Chromatin Condensin Phase separation

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Fostering green customer citizenship behavioral intentions through green hotel practices: the roles of pride, moral elevation, and hotel star ratings

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Journal of Sustainable Tourism 2025年第1期33卷 122-142页

作者： Tran, Dat Van Nguyen, Dung Minh Nguyen, Trieu Head of Marketing Department Ho Chi Minh University of Banking Ho Chi Minh city Viet Nam College of Management National Kaohsiung University of Science and Technology Kaohsiung Taiwan IMBA program College of Management National Kaohsiung University of Science and Technology Kaohsiung Taiwan

In the past decade, hotels have increasingly adopted green practices due to heightened customers’ environmental concerns and a commitment to fostering sustainability. While the literature on green hotel practices is abundant, understanding customers’ extra-role behaviors in response to these practices remains a complex and underexplored area. This study, based on social exchange theory, examines how perceptions of green hotel practices boost customer citizenship behavioral intentions (green CCBi). It further explores the mediating mechanisms of pride and moral elevation and the moderating mechanism of hotel star ratings in this association. The proposed hypotheses were tested utilizing a multi-method quantitative approach with data collected from hotel guests in Taiwan. Findings from the survey (N = 407) reveal that green practices have a positive and direct effect on green CCBi and have indirect effects through pride and moral elevation. Furthermore, the impacts of green hotel practices on green CCBi, pride, and moral elevation are stronger for higher-star-rated hotels. These findings are reinforced by the results of the two experiments (N = 492). The insights guide hotel managers and policymakers in crafting more effective green strategies to evoke customers’ positive emotions and voluntary behavior among customers. © 2024 Informa UK Limited, trading as Taylor & Francis Group.

关键词： green customer citizenship behavioral intentions Green hotel practices hotel star ratings moral elevation pride

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It takes two to untangle Combined stimulation of adult : neurogenesis reverts AD symptoms

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CELL STEM CELL 2023年第4期30卷 333-334页

作者： Gabarro-Solanas, Rut Urban, Noelia Austrian Acad Sci IMBA Inst Mol Biotechnol Vienna Bioctr VBC Dr Bohr Gasse 3 A-1030 Vienna Austria Univ Vienna Doctoral Sch Vienna Bioctr PhD Program A-1030 Vienna Austria Med Univ Vienna A-1030 Vienna Austria

Alzheimer's disease (AD) is associated with reduced adult hippocampal neurogenesis and impaired hippo-campal-dependent behaviors. Li et al.1 report that stimulating adult neurogenesis combined with new-born neuron activation ameliorates behavioral symptoms and plaque deposition in AD mouse models. This supports boosting adult neurogenesis as a potential therapeutic approach for AD-related cognitive decline.

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What will make Generation Y and Generation Z to continue to use online food delivery services: a uses and gratifications theory perspective

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Journal of Hospitality & Leisure Marketing 2024年第4期33卷 415-442页

作者： Trieu Nguyen Dung Minh Nguyen a IMBA program College of Management National Kaohsiung University of Science and Technology Kaohsiung Taiwan b College of Management National Kaohsiung University of Science and Technology Kaohsiung Taiwan

ABSTRACTThe rapid growth of online food delivery (OFD) services presents new opportunities and challenges for OFD stakeholders, emphasizing the strategic importance of retaining customers. However, the existing OFD continuance literature lacks diverse theoretical approaches and customer segment-specific knowledge, limiting a comprehensive understanding of post-pandemic customer behavior. This study leverages the uses and gratifications (U&G) theory to delve into customers’ expectations and motivations for continuing to use OFD, with a particular focus on the possible differences between Generation Y and Generation Z customers. By applying a mixed-method approach, the results identified six gratifications of OFD continuance usage, classified into three groups: utilitarian, hedonic, and social gratifications. Generation Y and Z assign varying levels of importance to the identified gratifications. The study enriches the current OFD literature by demonstrating the explanatory prowess of U&G theory to the continuance phenomenon and provides practical suggestions for OFD stakeholders to cultivate competitiveness and sustainable growth.摘要在线食品配送服务的快速增长为食品配送利益相关者带来了新的机遇和挑战, 强调了留住客户的战略重要性. 然而, 现有的OFD持续性文献缺乏多样的理论方法和特定于客户细分市场的知识, 限制了对疫情后客户行为的全面理解. 本研究利用使用和满足 (U&G) 理论深入研究客户继续使用OFD的期望和动机, 特别关注Y世代和Z世代客户之间可能存在的差异. 通过应用混合方法, 结果确定了OFD持续使用的六种满意度, 分为三组: 功利性满意度、享乐性满意度和社会满意度. Y世代和Z世代对所确定的满足感具有不同程度的重要性. 该研究通过展示U&G理论对持续现象的解释能力, 丰富了当前的对外直接投资文献, 并为对外直接投资利益相关者培养竞争力和可持续增长提供了实践建议.

关键词： Online food delivery service uses and gratifications theory generation continuance mixed-method approach

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Virus-like transposons cross the species barrier and drive the evolution of genetic incompatibilities

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SCIENCE 2023年第6652期380卷 1336-+页

作者： Widen, Sonya A. A. Bes, Israel Campo Koreshova, Alevtina Pliota, Pinelopi Krogull, Daniel Burga, Alejandro Inst Mol Biotechnol Austrian Acad Sci IMBA Vienna Bioctr VBC A-1030 Vienna Austria Univ Vienna Doctoral Sch Vienna Bioctr PhD Program A-1030 Vienna Austria Med Univ Vienna A-1030 Vienna Austria Barcelona Inst Sci & Technol Ctr Genom Regulat CRG Barcelona 08003 Spain

INTRODUCTION When we think of DNA, we think of inheritance from parent to offspring. However, DNA can also be transmitted between individuals that are not related and even between individuals belonging to different species in a process known as horizontal gene transfer (HGT). Although best characterized in bacteria, a growing body of evidence indicates that HGT can also take place in a wide range of eukaryotes, including fungi, plants, and animals. However, one of the most fascinating aspects of HGT, the mechanism of transfer in metazoans, remains largely *** Many microorganisms can take up DNA from their environment, and some have even evolved specialized machinery to transfer DNA between peers. In sharp contrast, transfer of DNA between multicellular organisms poses a greater logistical challenge. For HGT to take place, DNA must first find its way out of the donor species, come in close contact with the germ line of a second species (which is physically and molecularly guarded), and, finally, integrate into the genome of the new host. Viruses have long been hypothesized to mediate HGT because of their known ability to take up DNA sequences from their hosts, integrate into genomes, and infect different species. However, evidence is sparse and mostly limited to highly specialized viral symbionts that have co-evolved in the genomes of parasitoid *** While studying nematodes, we discovered one of the long-sought vectors of HGT in eukaryotes: Maverick elements. Mavericks, also known as Polintons, are unique because they share features of both transposons and viruses. Like transposons, Mavericks are flanked by terminal inverted repeats and can readily jump and insert into genomes. Like viruses, they code for a large number of proteins, including a type-B DNA polymerase, a retroviral-like integrase, as well as major and minor capsid proteins. We discovered that two new nematode gene families, wosp proteases and krma kinases, are preferenti

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A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary

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GENETICS 2022年第1期220卷 iyab179页

作者： ElMaghraby, Mostafa F. Tirian, Laszlo Senti, Kirsten-Andre Meixner, Katharina Brennecke, Julius Austrian Acad Sci IMBA Vienna BioCtr VBC Inst Mol Biotechnol A-1030 Vienna Austria Univ Vienna Doctoral Sch Vienna BioCtr PhD Program A-1030 Vienna Austria Med Univ Vienna A-1030 Vienna Austria

Argonaute proteins of the PIWI clade complexed with PIWI-interacting RNAs (piRNAs) protect the animal germline genome by silencing transposable elements. One of the leading experimental systems for studying piRNA biology is the Drosophila melanogaster ovary. In addition to classical mutagenesis, transgenic RNA interference (RNAi), which enables tissue-specific silencing of gene expression, plays a central role in piRNA research. Here, we establish a versatile toolkit focused on piRNA biology that combines germline transgenic RNAi, GFP marker lines for key proteins of the piRNA pathway, and reporter transgenes to establish genetic hierarchies. We compare constitutive, pan-germline RNAi with an equally potent transgenic RNAi system that is activated only after germ cell cyst formation. Stage-specific RNAi allows us to investigate the role of genes essential for germline cell survival, for example, nuclear RNA export or the SUMOylation pathway, in piRNA-dependent and independent transposon silencing. Our work forms the basis for an expandable genetic toolkit provided by the Vienna Drosophila Resource Center.

关键词： Drosophila oogenesis germline Gal4-UAS piRNA pathway transposable elements RNAi RNA export SUMO

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Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery

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NATURE STRUCTURAL & MOLECULAR BIOLOGY 2022年第2期29卷 130-+页

作者： Andreev, Veselin, I Yu, Changwei Wang, Juncheng Schnabl, Jakob Tirian, Laszlo Gehre, Maja Handler, Dominik Duchek, Peter Novatchkova, Maria Baumgartner, Lisa Meixner, Katharina Sienski, Grzegorz Patel, Dinshaw J. Brennecke, Julius Austrian Acad Sci IMBA Vienna BioCtr VBC Inst Mol Biotechnol Vienna Austria Univ Vienna Doctoral Sch Vienna BioCtr PhD Program Vienna Austria Med Univ Vienna Vienna Austria Mem Sloan Kettering Canc Ctr Struct Biol Program 1275 York Ave New York NY 10021 USA

Here, the authors provide mechanistic evidence for the piRNA pathway connection to the heterochromatin machinery in Drosophila. Nuclear Argonaute proteins, guided by small RNAs, mediate sequence-specific heterochromatin formation. The molecular principles that link Argonaute-small RNA complexes to cellular heterochromatin effectors on binding to nascent target RNAs are poorly understood. Here, we explain the mechanism by which the PIWI-interacting RNA (piRNA) pathway connects to the heterochromatin machinery in Drosophila. We find that Panoramix, a corepressor required for piRNA-guided heterochromatin formation, is SUMOylated on chromatin in a Piwi-dependent manner. SUMOylation, together with an amphipathic LxxLL motif in Panoramix's intrinsically disordered repressor domain, are necessary and sufficient to recruit Small ovary (Sov), a multi-zinc-finger protein essential for general heterochromatin formation and viability. Structure-guided mutations that eliminate the Panoramix-Sov interaction or that prevent SUMOylation of Panoramix uncouple Sov from the piRNA pathway, resulting in viable but sterile flies in which Piwi-targeted transposons are derepressed. Thus, Piwi engages the heterochromatin machinery specifically at transposon loci by coupling recruitment of a corepressor to nascent transcripts with its SUMOylation.

关键词： Gene silencing Non-coding RNAs Piwi RNAs Sumoylation Life Sciences general Biochemistry Protein Structure Membrane Biology Biological Microscopy

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Selfish conflict underlies RNA-mediated parent-of-origin effects

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NATURE 2024年第8006期628卷 122-129页

作者： Pliota, Pinelopi Marvanova, Hana Koreshova, Alevtina Kaufman, Yotam Tikanova, Polina Krogull, Daniel Hagmueller, Andreas Widen, Sonya A. Handler, Dominik Gokcezade, Joseph Duchek, Peter Brennecke, Julius Ben-David, Eyal Burga, Alejandro Inst Mol Biotechnol Austrian Acad Sci IMBA Vienna Bioctr VBC Vienna Austria Univ Vienna Doctoral Sch Vienna Bioctr PhD Program Vienna Austria Med Univ Vienna Vienna Austria Hebrew Univ Jerusalem Inst Med Res Israel Canada Dept Biochem & Mol Biol Jerusalem Israel Illumina Illumina Artificial Intelligence Lab San Diego CA USA

Genomic imprinting-the non-equivalence of maternal and paternal genomes-is a critical process that has evolved independently in many plant and mammalian species1,2. According to kinship theory, imprinting is the inevitable consequence of conflictive selective forces acting on differentially expressed parental alleles3,4. Yet, how these epigenetic differences evolve in the first place is poorly understood3,5,6. Here we report the identification and molecular dissection of a parent-of-origin effect on gene expression that might help to clarify this fundamental question. Toxin-antidote elements (TAs) are selfish elements that spread in populations by poisoning non-carrier individuals7-9. In reciprocal crosses between two Caenorhabditis tropicalis wild isolates, we found that the slow-1/grow-1 TA is specifically inactive when paternally inherited. This parent-of-origin effect stems from transcriptional repression of the slow-1 toxin by the PIWI-interacting RNA (piRNA) host defence pathway. The repression requires PIWI Argonaute and SET-32 histone methyltransferase activities and is transgenerationally inherited via small RNAs. Remarkably, when slow-1/grow-1 is maternally inherited, slow-1 repression is halted by a translation-independent role of its maternal mRNA. That is, slow-1 transcripts loaded into eggs-but not SLOW-1 protein-are necessary and sufficient to counteract piRNA-mediated repression. Our findings show that parent-of-origin effects can evolve by co-option of the piRNA pathway and hinder the spread of selfish genes that require sex for their propagation. In Caenorhabditis tropicalis, selective expression of genetic alleles from one parent but not the other can arise from maternally inherited small transcripts acting via the PIWI-interacting RNA host defence pathway.

关键词： Development Gene regulation Imprinting Molecular evolution Piwi RNAs

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Challenging the Astral mass analyzer to quantify up to 5,300 proteins per single cell at unseen accuracy to uncover cellular heterogeneity

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NATURE METHODS 2025年第3期22卷 1-10页

作者： Bubis, Julia A. Arrey, Tabiwang N. Damoc, Eugen Delanghe, Bernard Slovakova, Jana Sommer, Theresa M. Kagawa, Harunobu Pichler, Peter Rivron, Nicolas Mechtler, Karl Matzinger, Manuel Vienna Bioctr Res Inst Mol Pathol IMP Vienna Austria Thermo Fisher Sci Bremen Germany Austrian Acad Sci Vienna BioCtr Inst Mol Biotechnol IMBA Vienna Austria Univ Vienna Vienna BioCtr PhD Program Doctoral Sch Vienna Austria Med Univ Vienna Vienna Austria Austrian Acad Sci Vienna Bioctr Gregor Mendel Inst Mol Plant Biol GMI Vienna Austria

Despite significant advancements in sample preparation, instrumentation and data analysis, single-cell proteomics is currently limited by proteomic depth and quantitative performance. Here we demonstrate highly improved depth of proteome coverage as well as accuracy and precision for quantification of ultra-low input amounts. Using a tailored library, we identify up to 7,400 protein groups from as little as 250 pg of HeLa cell peptides at a throughput of 50 samples per day. Using a two-proteome mix, we check for optimal parameters of quantification and show that fold change differences of 2 can still be successfully determined at single-cell-level inputs. Eventually, we apply our workflow to A549 cells, yielding a proteome coverage ranging from 1,801 to a maximum of >5,300 protein groups from a single cell depending on cell size and search strategy used, which allows for the study of dependencies between cell size and cell cycle phase. Additionally, our workflow enables us to distinguish between in vitro analogs of two human blastocyst lineages: naive human pluripotent stem cells (epiblast) and trophectoderm-like cells. Our data harmoniously align with transcriptomic data, indicating that single-cell proteomics possesses the capability to identify biologically relevant differences within the blastocyst.

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