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The place-new relation in the context of experience and meaning: a bibliometric review (1992-2023)

JOURNAL OF ASIAN ARCHITECTURE AND BUILDING ENGINEERING 2025年第1期24卷 424-442页

作者： Hacioglu, Ebru Polatoglu, Cigdem Yildiz Tech Univ Fac Architecture Architectural Design PhD Program Istanbul Turkiye Yildiz Tech Univ Fac Architecture Head Architecture Dept Istanbul Turkiye Yildiz Tech Univ Fac Architecture Architectural Design PhD Program Yildiz Campus D Block TR-34349 Istanbul Turkiye

The research analyzes the literature by questioning the common denominator between "place and the new" through the concepts of experience and meaning to expand and deepen the existing knowledge on the meaning of place in the production of place. The paper discovers current approaches and notions in the place-new relationship and identifies leading keywords, authors, documents, sources, organizations, and references. It presents a systematic literature review based on bibliometric data in the context of place concept research. The analysis conducted on 27 May 202327 May 2023, with the concepts of place, new, experience, and meaning, covers the bibliometric data of 870 publications which included English articles and book chapters published since 1992 and chosen from specific research categories on the Web of Science. Documents published before 1992 without available content were excluded. Findings show an increasing tendency towards the concepts of sustainability, place-making, place attachment, urban regeneration, architectural design, and cultural heritage. While the number of investigations concentrating on landscape and COVID-19 has increased;concepts like everyday life, emotions, behavior, urban politics, phenomenology, design research, and displacement have been discovered as current research topics. This paper is potentially useful for future theoretical and practical work to create meaningful places and contributes to the further implementation of design and planning studies.

关键词： Bibliometrics analysis architecture place-new experience meaning

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Contributions of action potentials to scalp EEG: Theory and biophysical simulations

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PLOS COMPUTATIONAL BIOLOGY 2025年第2期21卷 e1012794页

作者： Brake, Niklas Khadra, Anmar McGill Univ Quantitat Life Sci PhD Program Montreal PQ Canada McGill Univ Dept Physiol Montreal PQ Canada

Differences in the apparent 1/f component of neural power spectra require correction depending on the underlying neural mechanisms, which remain incompletely understood. Past studies suggest that neuronal spiking produces broadband signals and shapes the spectral trend of invasive macroscopic recordings, but it is unclear to what extent action potentials (APs) influence scalp EEG. Here, we combined biophysical simulations with statistical modelling to examine the amplitude and spectral content of scalp potentials generated by the electric fields from spiking activity. In physiological parameter regimes, we found that APs contribute negligibly to the EEG spectral trend. Consistent with this, comparing our biophysical simulations with previously published data from pharmacologically paralyzed subjects suggested that the EEG spectral trend can be explained by a combination of synaptic timescales and electromyogram contamination. We also modelled rhythmic EEG generation, finding that APs can generate detectable narrowband power between approximately 60 and 1000 Hz, reaching frequencies much faster than would be possible from synaptic currents. Finally, we show that different spectral detrending strategies are required for AP generated oscillations compared to synaptically generated oscillations, suggesting that existing detrending methods for EEG spectra need to be modified for high frequency signals.

关键词： Electric fields

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How do you manage? An auto-ethnographic inquiry into contemporary maternal labor

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EQUALITY DIVERSITY AND INCLUSION 2024年第5期43卷 804-824页

作者： Balic, Ilkay Kadir Has Univ Womens Studies PhD Program Istanbul Turkiye

PurposeThis article tackles the intersection of mothering and labor through the author's own experience as a feminist mother/manager from Istanbul, Turkey. It aims to revisit the first years of motherhood, exploring the struggle to invent a peculiar maternal subjectivity in opposition and negotiation with the patriarchal institution of motherhood, the new definition of maternal labor in a highly digital, neoliberal context and the issue of marital fairness in a dual-income heterosexual ***/methodology/approachThe article presents an autoethnographic, retrospective and introspective inquiry into the first seven years of the author's mothering experience in order to offer an in-depth exploration of the various aspects of contemporary maternal *** article shows how maternal labor has shifted in nature and expanded in scope in a contemporary non-Western context. It investigates the dissolution of the spatial, temporal and sensorial boundaries between the managerial labor dedicated to the workplace, and to the family. Highlighting the similarities of the two forms of labor, the article manifests the materiality, tangibility and visibility of maternal *** limitations/implicationsFurther intersectional studies shall be beneficial to redefine maternal labor in different *** implicationsDeparting and diverting from the terms "invisible labor" and "mental load", the article suggests a shift in terminology to stress the multifaceted medley of managerial tasks mothers undertake ***/valueThe article provides an original take on maternal labor through the first-hand experience of a middle-class, professional mother from Istanbul, Turkey.

关键词： Gender Labor Motherhood Management Communication technologies

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Comparative Investigation of Process-Induced Transformations and Diffusional Mechanisms in Additively Manufactured AlCoCrFeNi High-Entropy Alloy

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METALLOGRAPHY MICROSTRUCTURE AND ANALYSIS 2024年第6期13卷 1179-1196页

作者： Oyerinde, Olujide Mastorakos, Ioannis Achuthan, Ajit Yuya, Philip Clarkson Univ Mech & Aerosp Engn Mat Sci & Engn PhD Program Potsdam NY 13699 USA

Additively manufactured high-entropy alloys are in a critical stage of development. More studies are required on how their compositions, processing routes, and microstructural evolutions intertwine to influence their (mechanical) properties for various fields of applications. In this study, equiatomic AlCoCrFeNi high-entropy alloys were fabricated via two additive manufacturing routes: binder jetting 3-D printing (BJ3DP) and directed energy deposition (DED). The response of the samples to isothermal heat treatment was investigated and compared with the as-printed samples. Their microstructural evolutions were studied with scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray diffractometer (XRD), and backscattered electron diffraction (EBSD). Nanoindentation was used to characterize their mechanical properties. The results show that the binder jetting and DED samples respond differently to isothermal heat treatments, as diffusion mechanisms like grain boundary precipitation, precipitate-free zones (PFZs), and Widmanstatten structures are observable in the binder jetting samples. The study provides significant insights into the differences in microstructural morphology, diffusion phenomena, and evolution of the alloy manufactured via the two additive manufacturing (AM) routes. The insights gained from this study will help to improve the properties and fabrication of AlCoCrFeNi HEA via the two additive manufacturing routes for applications.

关键词： High-entropy alloy Directed energy deposition Binder jetting Microstructure Nanoindentation Additive manufacturing

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Accounting for fascicle curvature affects muscle architecture characterization in dynamic conditions (isokinetic contractions)

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JOURNAL OF BIOMECHANICS 2025年 180卷 112520-112520页

作者： Bizet, Baptiste Trinchi, Michele Magris, Riccardo Monte, Andrea Zamparo, Paola Univ Verona Dept Neurosci Biomed & Movement Verona Italy Univ Verona Natl PhD Program Kinesiol & Sport Sci Verona Italy

Investigating muscle architecture in static and dynamic conditions is essential to understand muscle function and muscle adaptations. Muscle architecture analysis, primarily through extended field-of-view ultrasound imaging, offers high reliability at rest but faces limitations during dynamic conditions. Traditional methods often involve "best fitting" straight lines to track muscle fascicles, leading to possible errors, especially with longer fascicles or those with nonlinear paths. Moreover, muscle architecture varies along the same muscle, with potential differences in curvature. This study aimed to develop and test a new software for muscle architecture characterization considering fascicle curvature during dynamic conditions. Muscle architecture data from different muscle regions using various digitalization methods were compared. Ten healthy young adults (24.1 +/- 1.6 years;177.7 +/- 7.4 cm;72.7 +/- 7.7 kg;9M/1F) performed maximal knee extension at 75 degrees.s(-1) while B-mode ultrasound images of vastus lateralis muscle were captured in two muscle sites (at 50 % and 83 % of femur length). The analysis involved automated straight-line (ST) methods and custom manual linear extrapolation (MLE) software with segmented fascicle tracking using 2 (MLE2) and 4 (MLE4) segments inside the field of view. Results indicated significant overestimations of fascicle length, muscle belly length and thickness and underestimation of pennation angle using ST compared to MLE methods, especially in the distal region. Intra-rater repeatability for MLE4 was excellent (ICC = 0.93;0.90;0.93;0.88, respectively;P < 0.001), while inter-rater reliability varied. This study confirms the need to consider fascicle curvature for accurate resting muscle architecture characterization, even in the middle region of the muscle, and extends these considerations to dynamic conditions.

关键词： Fascile curvature Ultrasound data Muscle mechanics

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Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5′-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs

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BIOCHEMISTRY 2023年第11期62卷 1767-1775页

作者： Saha, Baishakhi Bhardwaj, Usha Goss, Dixie J. Hunter Coll Dept Chem New York NY 10065 USA CUNY Grad Ctr PhD Program Biochem New York NY 10016 USA CUNY PhD Program Chem Grad Ctr New York NY 10016 USA

During cellular stress conditions, particularly those seen in multiple cancers, canonical cap-dependent translation is suppressed and a subset of cellular mRNAs (e.g., those encoding FGF-9, HIF-1 alpha, and p53, among others) is known to translate in a cap-independent manner. Human eIF4GI specifically binds to the highly structured 5 '-untranslated regions (5 ' UTRs) of these mRNAs to promote cap independent translation. The thermodynamics of these protein-RNA interactions have not been explored, and such information will aid in understanding the basic interactions and in potential design of therapeutic drugs. Using fluorescence quenching-based assays and site-directed mutagenesis, we determined the thermodynamic properties of three eIF4GI constructs binding to the 5 ' UTRs of FGF-9, HIF-1 alpha, and p53 mRNA. These three constructs were designed to explore the importance of the eIF4E binding domain of eIF4GI, which has been shown to be important in binding and selectivity. eIF4GI557-1599, containing the eIF4E binding domain, had higher binding enthalpy (-21 to -14 kJ mol-1 higher), suggesting increased hydrogen bonding, whereas for eIF4GI682-1599 lacking the eIF4E binding domain, binding was entropically favored (T Delta S/Delta G of 46-85%), suggesting hydrophobic forces and/or less specific binding. A third construct where a cluster of positively charged amino acids was changed to neutral amino acids showed intermediate properties. Circular dichroism spectra confirmed the significant role of eIF4E binding domain in stable bond formation between eIF4GI and mRNAs via conformational changes. Together, these data contribute to a better understanding of the molecular forces involved in eIF4GI-mRNA recognition and elucidate properties important for the design of small molecules to mediate these interactions.

关键词： Amino acids

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An interpretable model of pre-mRNA splicing for animal and plant genes

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SCIENCE ADVANCES 2024年第19期10卷 eadn1547页

作者： Mccue, Kayla Burge, Christopher B. MIT Computat & Syst Biol PhD Program Cambridge MA 02139 USA MIT Dept Biol Cambridge MA 02139 USA

Pre-mRNA splicing is a fundamental step in gene expression, conserved across eukaryotes, in which the spliceosome recognizes motifs at the 3 ' and 5 ' splice sites (SSs), excises introns, and ligates exons. SS recognition and pairing is often influenced by protein splicing factors (SFs) that bind to splicing regulatory elements (SREs). Here, we describe SMsplice, a fully interpretable model of pre-mRNA splicing that combines models of core SS motifs, SREs, and exonic and intronic length preferences. We learn models that predict SS locations with 83 to 86% accuracy in fish, insects, and plants and about 70% in mammals. Learned SRE motifs include both known SF binding motifs and unfamiliar motifs, and both motif classes are supported by genetic analyses. Our comparisons across species highlight similarities between non-mammals, increased reliance on intronic SREs in plant splicing, and a greater reliance on SREs in mammalian splicing.

关键词： Mammals

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A new fast root-finder for black box polynomials

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THEORETICAL COMPUTER SCIENCE 2025年 1027卷

作者： Pan, Victor Y. Go, Soo Luan, Qi Zhao, Liang City Univ New York Lehman Coll Dept Comp Sci Bronx NY 10468 USA City Univ New York Grad Ctr PhD Program Math New York NY 10036 USA City Univ New York Grad Ctr PhD Program Comp Sci New York NY 10036 USA

Univariate polynomial root-finding has been studied for four millennia and very intensively in the last decades. Our black box root-finder involves no coefficients and works for a black box polynomial, defined by an oracle (that is, black box subroutine) for its evaluation. Such root-finders have various benefits, e.g., are particularly efficient where a polynomial can be evaluated fast, say, is the sum of a small number of shifted monomials (x - c)(a). With incorporation of a fast algorithm by the first author for compression of a disc on the complex plane without losing roots, our root-finder approximates all d complex zeros of a dth degree polynomial p(x) (aka roots of equation p(x) = 0) by using near-optimal Las Vegas expected number of bit-operations,(1) that is, the root-finder is expected to run almost as fast as one accesses the coefficients with a precision required for the solution within a prescribed error bound. The only other known near-optimal polynomial root-finder was presented by the first author at ACM STOC 1995. It is quite involved and has never been implemented, while already in its initial implementation our new root-finder competed with user's choice package of root-finding subroutines MPSolve, according to extensive numerical experiments with standard test polynomials. Furthermore we readily extend our black box root-finder to approximation of the eigenvalues of a matrix in record expected bit operation time, while the root-finder of STOC 1995, using the coefficients of p(x), does not support such extension.

关键词： Polynomial computations Symbolic-numeric computing Polynomial zeros Complexity Black box polynomials Matrix eigenvalues

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Attentional spatial cueing of the stop-signal affects the ability to suppress behavioural responses

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EXPERIMENTAL BRAIN RESEARCH 2024年第6期242卷 1429-1438页

作者： Haque, Md. Tanbeer Segreti, Mariella Giuffrida, Valentina Ferraina, Stefano Brunamonti, Emiliano Pani, Pierpaolo Sapienza Univ Dept Physiol & Pharmacol Rome Italy Sapienza Univ Behav Neurosci PhD Program Rome Italy

The ability to adapt to the environment is linked to the possibility of inhibiting inappropriate behaviours, and this ability can be enhanced by attention. Despite this premise, the scientific literature that assesses how attention can influence inhibition is still limited. This study contributes to this topic by evaluating whether spatial and moving attentional cueing can influence inhibitory control. We employed a task in which subjects viewed a vertical bar on the screen that, from a central position, moved either left or right where two circles were positioned. Subjects were asked to respond by pressing a key when the motion of the bar was interrupted close to the circle (go signal). In about 40% of the trials, following the go signal and after a variable delay, a visual target appeared in either one of the circles, requiring response inhibition (stop signal). In most of the trials the stop signal appeared on the same side as the go signal (valid condition), while in the others, it appeared on the opposite side (invalid condition). We found that spatial and moving cueing facilitates inhibitory control in the valid condition. This facilitation was observed especially for stop signals that appeared within 250ms of the presentation of the go signal, thus suggesting an involvement of exogenous attentional orienting. This work demonstrates that spatial and moving cueing can influence inhibitory control, providing a contribution to the investigation of the relationship between spatial attention and inhibitory control.

关键词： Stop signal task Attention Spatial attention Motor inhibition Cognitive control Executive functions

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Thinking in systems: Problems of organization at the Center for Advanced Study in the Behavioral Sciences and the Society for General Systems Research, 1950-7

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HISTORY OF THE HUMAN SCIENCES 2025年

作者： O'Neil, Libby Yale Univ PhD Candidate Program Hist Sci & Med 333 Cedar St New Haven CT 06510 USA

This article analyzes the approach to systems theory promoted by Ludwig von Bertalanffy and Kenneth Boulding during their time at the Ford Foundation's Center for Advanced Study in the Behavioral Sciences (CASBS) in 1954-5 and in the pages of the 1956 General Systems Yearbook. At the Ford Foundation's Center, social scientists engaged in interdisciplinary research on 'problems of organization' that encouraged them to develop theoretical tools that scaled between organisms, institutions, and social organizations. Bertalanffy and Boulding were able to gain financial support from the Center for their 'general system(s) theory' that promised to solve these 'problems of organization' while unifying the social sciences in the service of the Foundation's philanthropic mission. Systems thinkers at the Center founded the Society for General Systems Research, an important professional organization for systems theory in the coming decades. In the Society's General Systems Yearbook, Bertalanffy and Boulding debated the meaning and underlying politics of thinking in systems in language shaped by their time at CASBS. By attending to this instantiation of systems thinking in its institutional and social context, this article attempts to tell a history of system without accepting the universalizing aspirations of its historical subject.

关键词： behavioral science cybernetics interdisciplinarity organization systems theory

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