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Voxel-based treatment prediction of glioblastoma multiform tumor using diffusion tensor imaging

Voxel-based treatment prediction of glioblastoma multiform t...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Hadi Sabahi Hamid Soltanian-Zadeh Lisa Scarpace Tom Mikkelsen Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran Image Analysis Laboratory Radiology Department Henry Ford Hospital Detroit MI USA Hermelin Brain Tumor Research Center Neurosurgery Department Henry Ford Health System Detroit MI USA

This paper proposes a method to predict the effect of Bevacizumab therapy on Glioblastoma Multiform (GBM) tumors. The prediction is critical for effective treatment planning. The proposed method is developed and evaluated using Diffusion Tensor Imaging (DTI) and post-contrast T1-weighted Magnetic Resonance images (pc-T1-MRI) of 14 patients with GBM tumors gathered before and after the treatment. First, the proposed method calculates diffusion anisotropy indices (DAI) of all voxels in the brain. These diffusion anisotropy indices are Fractional Anisotropy (FA), Mean Diffusivity (MD), Relative Anisotropy (RA), and Volume Ratio (VR). Then, it registers post-treatment pc-T1-MRI and pre-treatment DAI maps to pre-treatment pc-T1-MRI. Next, it uses a thresholding method to segment the tumor from pc-T1-MRI studies. Comparing Gd-enhanced voxels of the pre- and post-treatment pc-T1-MRI, the DAIs of the tumor are labeled based on their response to the treatment. The voxels of 7 patients are randomly selected to train 4 classifiers (ANN, SVM, KNN, and ANFIS) and then all voxels of the other 7 patients are used to test them. For each classifier, four performance measures (sensitivity, specificity, positive predictive value, and accuracy) are calculated. Experimental results show that the ANFIS is more accurate than the other classifiers in predicting the treatment response.

关键词： Support vector machines Noise Magnetic resonance imaging Sensitivity Tumors Biomedical imaging Artificial neural networks

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Automatic organs' detection in WCE

Automatic organs' detection in WCE

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International Symposium on Artificial Intelligence and Signal Processing (AISP)

作者： Omid Haji-Maghsoudi Alireza Talebpour Hamid Soltanian-Zadeh Navid Haji-maghsoodi Department of Radiation Medicine Shahid Beheshti University of Tehran Tehran Iran Radiology Image Analysis Laboratory Henry Ford Hospital Detroit MI USA Control and Intelligent Processing Center of Excellence (CIPCE) School of Electrical and Computer Engineering University of Tehran Tehran Iran Department of Mechatronics Sharif University of Tehran Tehran Iran

Wireless capsule endoscopy (WCE) views the entire gastrointestinal (GI) tract. A main problem associated with this novel device is that too many frames must be reviewed by physicians. Thus it is essential to find an automatic and intelligent method to help physicians. One of the problems in WCE is its difficulty to distinguish among different organ's tissues. So, we introduce two novel algorithms which are able to classify main organs (among esophagus, stomach, small bowel and colon) in WCE's frames. In order to obtain our aim, we use statistic features (Haralick features) and non-statistic features (different diagrams and Gabor filter banks), colored features and non-colored features. Our experimental studies indicate good results that are shown in conclusion.

关键词： Level set Medical services Gabor filters Active contours Wireless communication Optical wavelength conversion Esophagus

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Compressed sensing based intensity non-uniformity correction

Compressed sensing based intensity non-uniformity correction

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IEEE International Symposium on Biomedical Imaging

作者： Snehashis Roy Aaron Carass Jerry L. Prince Image Analysis and Communications Laboratory Electrical and Computer Engineering Johns Hopkins University USA

We present a compressed sensing based approach to remove gain field from magnetic resonance (MR) images of the human brain. During image acquisition, the inhomogeneity present in the radio-frequency (RF) coil appears as shading artifact in the intensity image. The inhomogeneity poses problem in any automatic algorithm that uses intensity as a feature. It has been shown that at low field strength, the shading can be assumed to be a smooth field that is composed of low frequency components. Thus most inhomogeneity correction algorithms assume some kind of explicit smoothness criteria on the field. This sometimes limits the performance of the algorithms if the actual inhomogeneity is not smooth, which is the case at higher field strength. We describe a model-free, nonparametric patch-based approach that uses compressed sensing for the correction. We show that these features enable our algorithm to perform comparably with a current state of the art method N3 on images acquired at low field, while outperforming N3 when the image has non-smooth inhomogeneity, such as 7T images.

关键词： Nonhomogeneous media image segmentation Compressed sensing Magnetic resonance imaging Radio frequency Minimization

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Effective supervised classification of fMRI activation maps between populations by spatial descriptors

Effective supervised classification of fMRI activation maps ...

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2011 7th Iranian Conference on Machine Vision and image Processing, MVIP 2011

作者： Eshaghian, Shaghayegh Hossein-Zadeh, Gholam-Ali Soltanian-Zadeh, Hamid Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran 14395-515 Iran Image Analysis Laboratory Radiology Department Henry Ford Hospital Detroit MI 48202 United States

ISBN: (纸本)9781457715358

The major obstacle in discrimination between different groups of subjects in a common cognitive state, by functional Magnetic Resonance Imaging (fMRI), has been the high intersubject functional and anatomical variability in the spatial patterns of brain activity. To overcome this, we have used two types of spatial descriptors that characterize the brain regions of interest (ROIs) involved in the cognitive tasks. They include, firstly three-dimensional invariant moment descriptors (3-DMIs), and secondly k-dimensional feature vectors based on concentric spheres. Both types of descriptors are applied to analyze the spatial patterns of cognitive activity of a challenging task and then to classify them across two different subject groups. SVM classifiers along with sequential floating forward feature selection technique are applied to the extracted descriptors of each ROI across the subjects. Our method is applied to experimental fMRI data with the aim of discriminating mental status of heroin IV (Intravenous) abusers and from of those in control subjects in a visual cue task which can induce drug craving. Our results demonstrate that 3-D texture of activation maps provide a good discrimination (with high accuracy) between healthy and addict group. © 2011 IEEE.

关键词： Brain

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Effect of different diffusion maps on registration results

Effect of different diffusion maps on registration results

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2011 7th Iranian Conference on Machine Vision and image Processing, MVIP 2011

作者： Afzali, Maryam Fatemizadeh, Emad Soltanian-Zadeh, Hamid Sharif University of Technology Tehran Iran School of Electrical and Computer Engineering University of Tehran Tehran 14399 Iran Image Analysis Laboratory Radiology Department Henry Ford Health System Detroit MI 48202 United States

ISBN: (纸本)9781457715358

In this paper, we compare registration results obtained using different diffusion maps extracted from diffusion tensor imaging (DTI). Fractional Anisotropy (FA) and Ellipsoidal Area Ratio (EAR) are two diffusion maps (indices) that may be used for image registration. First, we use FA maps to find deformation matrix and register diffusion weighted images. Then, we use EAR maps and finally we use both of FA and EAR maps to register diffusion weighted images. The difference between FA values before deformation and after registration using the FA alone or EAR alone has a median of 0.57 and using both of them has a median of 0.29. Therefore, the results of registration using both of the FA and EAR indices are superior to those obtained using only one of them alone. © 2011 IEEE.

关键词： Diffusion tensor imaging

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Universal image steganalysis against spatial-domain steganography based on energy distribution of singular values

Universal image steganalysis against spatial-domain steganog...

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7th International Conference on Information Technology and Application, ICITA 2011

作者： Shojaei-Hashemi, Anahita Soltanian-Zadeh, Hamid Ghaemmagham, Shahrokh Kamarei, Mahmoud School of Electrical and Computer Engineering College of Engineering University of Tehran Tehran Iran Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran Image Analysis Laboratory Department of Radiology Henry Ford Health System Detroit MI United States Electronics Research Institute Sharif University of Technology Tehran Iran

ISBN: (纸本)9780980326741

A passive image steganalysis method is proposed to universally detect spatial-domain steganography schemes. It is shown to have better performance than universal steganalyzers known to be powerful in spatial domain, including the WFLogSv and the WAM methods. This level of accuracy is the result of improving the WFLogSv steganalyzer by considering a more comprehensive relationship between the singular values of each image block and the linear correlation of the rows and the columns. That is, instead of the closeness of the lower singular values to zero, the energy distribution of the singular values is investigated. An innovative measure is proposed for this investigation, which is inspired from arithmetic mean-geometric mean inequality. Experimental results confirm the supremacy of the proposed steganalysis scheme over its counterparts.

关键词： Singular value decomposition

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Universal steganalysis based on local prediction error in wavelet domain

Universal steganalysis based on local prediction error in wa...

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7th International Conference on Intelligent Information Hiding and Multimedia Signal Processing, IIHMSP 2011

作者： Shojaei-Hashemi, Anahita Mehdipour-Ghazi, Mostafa Ghaemmaghami, Shahrokh Soltanian-Zadeh, Hamid School of Electrical and Computer Engineering College of Engineering University of Tehran Tehran Iran Electronics Research Institute Sharif University of Technology Tehran Iran Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran Image Analysis Laboratory Department of Radiology Henry Ford Health System Detroit MI United States

ISBN: (纸本)9780769545172

A passive universal image steganalysis method is proposed that is shown to be of higher detection accuracy than existing truly blind steganalysis methods including Farid's and the WAM. This is achieved by improving some weaknesses of Farid's steganalysis scheme in feature extraction, that is, instead of deriving an over-determined equation system for each sub band of the wavelet decomposition, the sub bands are divided into overlapping blocks and an over-determined equation system is constructed for each block. To guarantee the existence of finite answers, the over-determined equation systems are solved in a way different from Farid's by using Moore-Penrose pseudo-inverse concept. Further improvement to the performance is achieved by adding diagonal directions and increasing the number of moments. The comparative evaluations confirm the superiority of the proposed method over prevalent blind steganalysis schemes. © 2011 IEEE.

关键词： Wavelet decomposition

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Superiority of the 3rd order approximation model to the 2nd order in Diffusion Kurtosis Imaging

Superiority of the 3rd order approximation model to the 2nd ...

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作者： Iraji, Armin Davoodi-Bojd, Esmaeil Soltanian-Zadeh, Hamid Hossein-Zadeh, Gholam-Ali Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran 14395-515 Iran Image Analysis Laboratory Radiology Department Henry Ford Hospital Detroit MI 48202 United States

ISBN: (纸本)9789644634284

For estimating the kurtosis parameter in Diffusion Kurtosis Imaging (DKI), usually second order expansion of the diffusion signal is used in conventional acquisition data. However, in this work, we show that this is not sufficient and should be reconsidered. Instead of using the second order expansion, we propose to use the third order expansion. At first, we show that the third order term of the Taylor's expansion has considerable values compared to second and first terms for the conventional b-values used in DKI. Then, for proving our claim empirically, we use real data to compare the proposed model with the previous one. To this end, five regions of the brain are extracted and for each region the fitting errors of both models are computed. The results confirm that the fitting error of the third order model is always (for all regions) less than the second order model. Although the improvement of the fitting error seems to be small, but considering the sensitivity analysis, this improvement can enhance the estimation of kurtosis. The resulting maps of the kurtosis parameter show this enhancement. The white matter in the map of third order model is more distinguishable than in the other model. © 2011 AmirKabir Univ of Tech.

关键词： Diffusion

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Hippocampal shape analysis in epilepsy using Laplace-Beltrami spectrum

Hippocampal shape analysis in epilepsy using Laplace-Beltram...

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作者： Shishegar, Rosita Soltanian-Zadeh, Hamid Moghadasi, Seyed Reza Faculty of Engineering School of Electrical and Computer Engineering University of Tehran Tehran 14395-515 Iran Radiology Image Analysis Laboratory Henry Ford Health System Detroit MI 48202 United States Department of Mathematics Sharif University of Technology Tehran Iran

ISBN: (纸本)9789644634284

Shape analysis plays an important role in many medical imaging studies. One of the recent shape analysis methods uses the Laplace Beltrami eigenvalues which is also used in this paper for global shape comparison of hippocampus of normal subjects and epileptic patients. Popularity of the Laplace Beltrami operator in this field is due to its isometry-invariance which avoids pre-processing steps like mapping, registration, and alignment. In addition, it is capable of revealing fine details in shapes that makes this method a good choice for deformation detecting purposes like epilepsy diagnosis. To examine capability of the proposed method, statistical analysis and two ways of classification, support vector machine (SVM) and finding out of normal range (ONR) subjects, are used. Moreover, to evaluate our classification results, K-fold cross-validation is performed. The best achieved results were true positive rate of 91.9% and false positive rate of 33.3%, yielded by ONR classifiers using 3 selected eigenvalues. © 2011 AmirKabir Univ of Tech.

关键词： Statistical methods

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Assessing lung volumetric variation to detect and stage COPD

Assessing lung volumetric variation to detect and stage COPD

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2011 1st Middle East Conference on Biomedical engineering, MECBME 2011

作者： Hosseini, M. Parsa Soltanian-Zadeh, Hamid Akhlaghpoor, Shahram Department of Electrical Engineering Islamic Azad University Science and Research Branch of Tehran Tehran Iran Image Analysis Laboratory Department of Radiology Henry Ford Health System Detroit MI United States Department of Radiology Tehran University of Medical Sciences Sina Hospital Tehran Iran Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran

ISBN: (纸本)9781424470006

Chronic obstructive pulmonary disease (COPD) is a devastating disease. In this paper, we propose a novel method for scoring of air trapping in the lungs for detection and evaluation of COPD. The proposed method finds volumetric changes of the lungs from inspiration to expiration. To this end, trachea CT images at full inspiration and expiration are compared. For this comparison, the lungs parenchyma in the inspiration and expiration images are found and changes in the surface and volume of the lungs between inspiration and expiration are used to define quantitative measures (features). Using these features, the subjects are classified into two groups of normal class and COPD patients using a Bayesian classifier. In addition, t-tests are applied to evaluate discrimination powers of the features for this classification. The main advantage of the proposed method is its ability to estimate air trapping in the lungs from CT images without human intervention. The proposed method may assists radiologists in the detection of COPD as a computer aided diagnosis (CAD) system. It may also assist them with the scoring of the disease (severity of air trapping in the lungs). © 2011 IEEE.

关键词： computerized tomography

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