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A novel method for identification of COPD in inspiratory and expiratory states of CT images

A novel method for identification of COPD in inspiratory and...

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2011 1st Middle East Conference on Biomedical engineering, MECBME 2011

作者： Hosseini, M. Parsa Soltanian-Zadeh, Hamid Akhlaghpoor, Shahram Department of Electrical Engineering Islamic Azad University Science and Research Branch of Tehran Tehran Iran Image Analysis Laboratory Department of Radiology Henry Ford Health System Detroit MI United States Department of Radiology Tehran University of Medical Sciences Sina Hospital Tehran Iran Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran

ISBN: (纸本)9781424470006

Chronic obstructive pulmonary disease (COPD) refers to a group of lung diseases that block airflow and cause a huge degree of human suffering. While there is no cure for COPD and the lung damage that results in this disease cannot be reversed, it is very important to diagnose it as early as possible. Additional to diagnosis, using a mathematical model to estimate severity of disease would be helpful for evaluation of treatment effects. This paper presents a new method for identifying COPD from three-dimensional (3-D) pulmonary X-ray CT images. The method has five main steps. First, corresponding positions of lungs in inspiration and expiration are found based on anatomical structures. Then, lung regions are segmented from the CT images by active contours. Next, the left and right lungs are separated using a sequence of morphological operations. Then, parenchyma variations in each lung are found as a relationship between inspiratory and expiratory states. Finally, a classifier is used to decide about the disease and its severity. A t-test is done to evaluate the results. Twelve patients with variable severity of COPD and twelve normal adults were included in this study. The proposed method may assist radiologists in the detection of COPD as a computer aided diagnosis (CAD) system. © 2011 IEEE.

关键词： Pulmonary diseases

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Development of a variational Bayesian expectation maximization (VBEM) method for model inversion of multi-area E/MEG model

Development of a variational Bayesian expectation maximizati...

引用

IEEE International Symposium on Biomedical Imaging

作者： Abbas Babajani-Feremi Kourosh Jafari-Khouzani Hamid Soltanian-Zadeh Image Analysis Laboratory Radiology Department Henry Ford Health System Detroit MI USA CIPCE Electrical and Computer Engineering Department University of Tehran Tehran Iran

ISBN: (纸本)9781424441273

We develop and evaluate a variational Bayesian expectation maximization (VBEM) method for model inversion of our multi-area extended neural mass model (MEN) using EEG/MEG data. Parameters of MEN have suitable prior distributions that enable us to use properties of a conjugate-exponential model in implementing VBEM. Consequently, VBEM leads to analytically tractable forms that starts with initialization and consists of repeated iterations of a variational Bayesian expectation step (VB E-step) and a variational Bayesian maximization step (VB M-step). Posterior distributions of model parameters are updated in the VB M-step. Distribution of the hidden state is updated in the VB E-step using variational extended Kalman smoother. We evaluate and validate performance of VBEM method for model inversion of MEN using simulation studies in various signal-to-noise ratios. The proposed approach provides a useful technique for analyzing effective connectivity using non-invasive EEG and MEG methods.

关键词： Brain modeling Signal to noise ratio Data models Bayesian methods Computational modeling Mathematical model Analytical models

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Voxel based treatment prediction using diffusion anisotropy indices and spatial information in Glioblastoma Multiform tumor

Voxel based treatment prediction using diffusion anisotropy ...

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2011 18th Iranian Conference of Biomedical engineering, ICBME 2011

作者： Sabahi, Hadi Soltanian-Zadeh, Hamid Scarpace, Lisa Mikkelsen, Tom Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran 14395-515 Iran Image Analysis Laboratory Radiology Department Henry Ford Hospital Detroit MI 48202 United States Hermelin Brain Tumor Research Center Neurosurgery Department Henry Ford Health System Detroit MI 48202 United States

ISBN: (纸本)9781467310055

In this paper, we propose a method to predict the outcome of Bevacizumab therapy on Glioblastoma Multiform (GBM) tumors. The method uses diffusion anisotropy indices (DAI) and spatial information to predict the treatment response of each tumor voxel. These DAIs are Fractional Anisotropy, Mean Diffusivity, Relative Anisotropy, and Volume Ratio, extracted from Diffusion Tensor Imaging (DTI) data before treatment. The spatial information is considered as the distance of each tumor voxel from the tumor center, extracted from pre-treatment post-contrast T1-weighted Magnetic Resonance images (pc-T1-MRI). DAIs and spatial information of each tumor voxel are considered as feature vector. DTI and pc-T1-MRI are gathered before and after the treatment of seven GBM patients. First, DAIs of all brain voxels and the distance of each tumor voxel from the tumor center are calculated. Second, the method registers pre-treatment DAI maps and post-treatment pc-T1-MRI to pre-treatment pc-T1-MRI. Next, the tumor is segmented using thresholding technique from pc-T1-MRI. Then, Gd-enhanced voxels of the pre- and post-treatment pc-T1-MRI are compared to label the feature vectors. Three classifiers were evaluated, including Support Vector Machine, K-Nearest Neighbor, and Artificial Neural Network. Classification results show a preference for K-Nearest Neighbor based on well-established performance measures. © 2011 IEEE.

关键词： Tumors

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Effect of Different Diffusion Maps on Registration Results

Effect of Different Diffusion Maps on Registration Results

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Iranian Machine Vision and image Processing (MVIP)

作者： Maryam Afzali Emad Fatemizadeh Hamid Soltanian-Zadeh Department of Electrical Engineering Biomedical Signal and Image Processing Laboratory (BiSIPL) Sharif University of Technology Tehran Iran Image Analysis Laboratory Radiology Department Henry Ford Health System Detroit MI USA Control and Intelligent Processing Center of Excellence (CIPCE) School of Electrical and Computer Engineering University of Tehran Tehran Iran

In this paper, we compare registration results obtained using different diffusion maps extracted from diffusion tensor imaging (DTI). Fractional Anisotropy (FA) and Ellipsoidal Area Ratio (EAR) are two diffusion maps (indices) that may be used for image registration. First, we use FA maps to find deformation matrix and register diffusion weighted images. Then, we use EAR maps and finally we use both of FA and EAR maps to register diffusion weighted images. The difference between FA values before deformation and after registration using the FA alone or EAR alone has a median of 0.57 and using both of them has a median of 0.29. Therefore, the results of registration using both of the FA and EAR indices are superior to those obtained using only one of them alone.

关键词： Ear Diffusion tensor imaging Tensile stress Registers Eigenvalues and eigenfunctions Anisotropic magnetoresistance image registration

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A new semi-supervised algorithm for hyperspectral image classification based on spectral unmixing concepts

A new semi-supervised algorithm for hyperspectral image clas...

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3rd Workshop on Hyperspectral image and Signal Processing: Evolution in Remote Sensing, WHISPERS 2011

作者： Villa, Alberto Li, Jun Plaza, Antonio Bioucas-Dias, Jose M. GIPSA-lab Signal and Image Dept. Grenoble Institute of Technology - INPG France Faculty of Electrical and Computer Engineering Iceland University of Iceland Iceland Instituto de Telecomunicações Instituto Superior Técnico TULisbon 1900-118 Lisboa Portugal Hyperspectral Computing Laboratory Department of Technology of Computers and Communications University of Extremadura E-10071 Caceres Spain

Spectral unmixing is a fast growing area in hyperspectral image analysis. Many algorithms have been recently developed to retrieve pure spectral components (endmembers) and determine their abundance fractions in mixed pixels, which dominate hyperspectral images. However, possible connections between spectral unmixing concepts and classification algorithms have been rarely investigated. In this work, we propose a new method to perform semi-supervised hyperspectral image classification exploiting the information retrieved with spectral unmixing. The proposed method integrates a well-established discriminative classifier (multinomial logistic regression) with linear spectral unmixing. Furthermore, the proposed method uses a new active sampling approach which takes into account spatial context when generating new samples. The proposed method is experimentally validated using both simulated and real hyperspectral data sets. © 2011 IEEE.

关键词： Classification (of information)

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Evaluation of functional connectivity in control and ADHD subjects by generalized Canonical Correlation and Probabilistic Independent Component analysis

Evaluation of functional connectivity in control and ADHD su...

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Iranian Conference of Biomedical engineering (ICBME)

作者： AmirEhsan Lashkari Hamid Soltanian-Zadeh GholamAli Hosseinzadeh Control and Intelligent Processing Center of Excellence Electrical and Computer Engineering Department Faculty of Engineering University of Tehran Tehran Iran Radiology Image Analysis Laboratory Henry Ford Health System Detroit MI USA

Functional connectivity can be evaluated by temporal correlation between spatial neurophysiologic events or correlation between neural activities of brain regions. Unlike anatomical connectivity which represents physical connections between two brain regions, functional connectivity investigates interactions between brain regions. In this study, we implemented and evaluated Probabilistic Independent Component analysis (PICA) and generalized Canonical Correlation analysis (gCCA) on resting state data of healthy subjects and subjects with ADHD disorders from NITRC database. This was done to detect brain functional connectivity and compare the results in normal and diseased subjects. In addition, speed of the methods was compared. Our study shows that relative to PICA, gCCA has higher precision and accuracy and lower computational complexity and run time in addition to capability of extracting more reproducible statistical maps in both control and ADHD subjects.

关键词： Correlation Magnetic resonance imaging Independent component analysis Educational institutions Biomedical engineering Probabilistic logic Basal ganglia

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Effective Supervised Classification of fMRI Activation Maps between Populations by Spatial Descriptors

Effective Supervised Classification of fMRI Activation Maps ...

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Iranian Machine Vision and image Processing (MVIP)

作者： Shaghayegh Eshaghian Gholam-Ali Hossein-Zadeh Hamid Soltanian-Zadeh Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran Image Analysis Laboratory Radiology Department Henry Ford Hospital Detroit MI USA

The major obstacle in discrimination between different groups of subjects in a common cognitive state, by functional Magnetic Resonance Imaging (fMRI), has been the high inter- subject functional and anatomical variability in the spatial patterns of brain activity. To overcome this, we have used two types of spatial descriptors that characterize the brain regions of interest (ROIs) involved in the cognitive tasks. They include, firstly three-dimensional invariant moment descriptors (3-DMIs), and secondly k-dimensional feature vectors based on concentric spheres. Both types of descriptors are applied to analyze the spatial patterns of cognitive activity of a challenging task and then to classify them across two different subject groups. SVM classifiers along with sequential floating forward feature selection technique are applied to the extracted descriptors of each ROI across the subjects. Our method is applied to experimental fMRI data with the aim of discriminating mental status of heroin IV (Intravenous) abusers and from of those in control subjects in a visual cue task which can induce drug craving. Our results demonstrate that 3-D texture of activation maps provide a good discrimination (with high accuracy) between healthy and addict group.

关键词： Feature extraction Accuracy Drugs Brain Support vector machine classification Visualization Humans

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Improved particle swarm optimization and applications to Hidden Markov Model and Ackley function

Improved particle swarm optimization and applications to Hid...

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IEEE International Conference on Computational Intelligence for Measurement Systems and Applications (CIMSA)

作者： Saeed Motiian Hamid Soltanian-Zadeh Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran Image Analysis Laboratory Radiology Department Henry Ford Hospital Detroit MI USA

Particle Swarm Optimization (PSO) is an algorithm based on social intelligence, utilized in many fields of optimization. In applications like speech recognition, due to existence of high dimensional matrices, the speed of standard PSO is very low. In addition, PSO may be trapped in a local optimum. In this paper, we introduce a novel algorithm that is faster and generates superior results than the standard PSO. Also, the probability of being trapped in a local optimum is decreased. To illustrate advantages of the proposed algorithm, we use it to train a Hidden Markov Model (HMM) and find the minimum of the Ackley function.

关键词： Hidden Markov models Training Particle swarm optimization Speech processing Educational institutions Algorithm design and analysis Optimization

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A novel method for identification of COPD in inspiratory and expiratory states of CT images

A novel method for identification of COPD in inspiratory and...

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Middle East Conference on Biomedical engineering (MECBME)

作者： M. Parsa Hosseini Hamid Soltanian-Zadeh Shahram Akhlaghpoor Department of Electrical Engineering Islamic Azad University Tehran Iran Department of Radiology Henry Ford Health System Image Analysis and Communications Laboratory Detroit MI USA Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran Department of Radiology Tehran University of Medical Sciences Sina Hospital Tehran Iran

关键词： Lungs Computed tomography Diseases image segmentation Biomedical imaging Gaussian distribution

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Assessing lung volumetric variation to detect and stage COPD

Assessing lung volumetric variation to detect and stage COPD

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Middle East Conference on Biomedical engineering (MECBME)

Chronic obstructive pulmonary disease (COPD) is a devastating disease. In this paper, we propose a novel method for scoring of air trapping in the lungs for detection and evaluation of COPD. The proposed method finds volumetric changes of the lungs from inspiration to expiration. To this end, trachea CT images at full inspiration and expiration are compared. For this comparison, the lungs parenchyma in the inspiration and expiration images are found and changes in the surface and volume of the lungs between inspiration and expiration are used to define quantitative measures (features). Using these features, the subjects are classified into two groups of normal class and COPD patients using a Bayesian classifier. In addition, t-tests are applied to evaluate discrimination powers of the features for this classification. The main advantage of the proposed method is its ability to estimate air trapping in the lungs from CT images without human intervention. The proposed method may assists radiologists in the detection of COPD as a computer aided diagnosis (CAD) system. It may also assist them with the scoring of the disease (severity of air trapping in the lungs).

关键词： Lungs Computed tomography Diseases Active contours image segmentation Charge carrier processes

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