Addiction is a chronic and often relapsing brain disorder characterized by drug abuse and withdrawal symptoms and compulsive drug seeking(Koob and Volkow,2010)when access to the drug is *** leads to structural and fun...
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Addiction is a chronic and often relapsing brain disorder characterized by drug abuse and withdrawal symptoms and compulsive drug seeking(Koob and Volkow,2010)when access to the drug is *** leads to structural and functional brain changes implicated in reward,memory,motivation,and control(Volkow et al.,2019;Lüscher et al.,2020).
Isoforms refer to different mRNA molecules transcribed from the same gene, which can be translated into proteins with varying structures and functions. Predicting the functions of isoforms is an essential topic in bio...
Isoforms refer to different mRNA molecules transcribed from the same gene, which can be translated into proteins with varying structures and functions. Predicting the functions of isoforms is an essential topic in bioinformatics as it can provide valuable insights into the intricate mechanisms of gene regulation and biological processes. Conventionally, gene function labels are standardized in Gene Ontology (GO) terms. However, traditional methods for predicting isoform function are largely limited by the absence of isoform-specific labels, sparse annotations, and the vast number of GO terms. To address these issues, we propose HANIso, a deep learning-based method for isoform function prediction. HANIso leverages a pretrained protein language model to extract features from protein sequences. It also integrates heterogeneous information, such as isoform sequence features, GO annotations, and isoform interaction data, using a Heterogeneous Graph Attention Network (HAN). This allows the model to learn the importance of different sources of information and their semantic relationships through the attention mechanism. Our method can predict function labels at both the gene level and isoform level. We conduct experiments on two species datasets, and the results demonstrate that our method outperforms existing methods on both AUROC and AUPRC. HANIso has the potential to overcome the limitations of traditional methods and provide a more accurate and comprehensive understanding of isoform function.
This paper introduces the new qualitative and quantitative methods, which can diagnose breast tumors. Qualitative methods include blood vessel display inside and outside of pathological changes part of breast, display...
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This paper introduces the new qualitative and quantitative methods, which can diagnose breast tumors. Qualitative methods include blood vessel display inside and outside of pathological changes part of breast, display of equivalent pixel curves at the part of pathological changes and display of breast tumor image edge. Accordingly, three feature extraction operators are proposed, i.e. the combination operators of anisotropic gradient and smoothing operator, an improved Sobel operator and an edge sharpening operator. Furthermore, quantitative diagnostic approaches are discussed based on blood and oxygen contents according to abundant clinical data and pathological mechanism of breast tumors. The results of clinic show that the methods of combining qualitative and quantitative diagnose are effective for breast tumor images, especially for early and potential breast cancer
Short-term forecasting of travel time is essential for the success of intelligent transportation system. In this paper, we review the state-of-art of short-term traffic forecasting models and outline their basic ideas...
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Short-term forecasting of travel time is essential for the success of intelligent transportation system. In this paper, we review the state-of-art of short-term traffic forecasting models and outline their basic ideas, related works, advantages and disadvantages of each model. An improved adaptive exponential smoothing (IAES) model is also proposed to overcome the drawbacks of the previous adaptive exponential smoothing model. Then, comparing experiments are carried out under normal traffic condition and abnormal traffic condition to evaluate the performance of four main branches of forecasting models on direct travel time data obtained by license plate matching (LPM). The results of experiments show each model seems to have its own strength and weakness. The forecasting performance of IASE is superior to other models in shorter forecasting horizon (one and two step forecasting) and the IASE is capable of dealing with all kind of traffic conditions.
The random Fourier features (RFFs) method is a powerful and popular technique in kernel approximation for scalability of kernel methods. The theoretical foundation of RFFs is based on the Bochner theorem (Bochner, 200...
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An efficient image denoising algorithm is introduced. Firstly, image pixels are classified into noisy pixels and noise-free pixels by four directional operators. Then an adaptive weighted median filter is designed to ...
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An efficient image denoising algorithm is introduced. Firstly, image pixels are classified into noisy pixels and noise-free pixels by four directional operators. Then an adaptive weighted median filter is designed to remove and restore the detected noisy pixels and keep the noise-free ones unchanged. Experimental results indicate that the proposed algorithm preserves image details well while removing impulsive noise efficiently, and its filtering performance is significantly superior to the classical median filter and some other typical and recently developed improved median filters.
Nowadays, deep learning methods, especially the Graph Convolutional Network (GCN), have shown impressive performance in hyperspectral image (HSI) classification. However, the current GCN-based methods treat graph cons...
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Heterogeneity is a fundamental and challenging issue in federated learning, especially for the graph data due to the complex relationships among the graph nodes. To deal with the heterogeneity, lots of existing method...
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Estimating the Ratio of Edge-Users (REU) is an important issue in mobile networks, as it helps the subsequent adjustment of loads in different cells. However, existing approaches usually determine the REU manually, wh...
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Estimating the Ratio of Edge-Users (REU) is an important issue in mobile networks, as it helps the subsequent adjustment of loads in different cells. However, existing approaches usually determine the REU manually, which are experience-dependent and labor-intensive, and thus the estimated REU might be imprecise. Considering the inherited graph structure of mobile networks, in this paper, we utilize a graph-based deep learning method for automatic REU estimation, where the practical cells are deemed as nodes and the load switchings among them constitute edges. Concretely, Graph Attention Network (GAT) is employed as the backbone of our method due to its impressive generalizability in dealing with networked data. Nevertheless, conventional GAT cannot make full use of the information in mobile networks, since it only incorporates node features to infer the pairwise importance and conduct graph convolutions, while the edge features that are actually critical in our problem are disregarded. To accommodate this issue, we propose an Edge-Aware Graph Attention Network (EAGAT), which is able to fuse the node features and edge features for REU estimation. Extensive experimental results on two real-world mobile network datasets demonstrate the superiority of our EAGAT approach to several state-of-the-art methods.
In this paper, we consider the `q−regularized kernel regression with 0 q−penalty term over a linear span of features generated by a kernel function. We study the asymptotic behavior of the algorithm under the framewor...
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