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CLEO: Applications and Technology in CLEO 2024, CLEO: A and T 2024 - Part of Conference on Lasers and Electro-Optics

作者： Hao, Senyue Adkins, Aaron J. Zhang, Yitian Zhou, Chao Department of Electrical & Systems Engineering Washington University Saint Louis United States Imaging Science PhD Program Washington University Saint Louis United States Department of Biomedical Engineering Washington University Saint Louis United States

To implement optical coherence tomography on photonic chips, we developed optimized and experimentally validated silicon nitride-based components for photonic integrated circuits in order to achieve high sensitivity a... 详细信息

关键词： Photonic integrated circuits

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Optimized photonic integrated circuit components for optical coherence tomography at 1060 nm

Optimized photonic integrated circuit components for optical...

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2024 Conference on Lasers and Electro-Optics, CLEO 2024

ISBN: (纸本)9781957171395

关键词： Photonic integrated circuits

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Space Division Multiplexing Optical Coherence Tomography for Wide-field Angiographic imaging of the Human Retina

Space Division Multiplexing Optical Coherence Tomography for...

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2024 Frontiers in Optics, FiO 2024

作者： Adkins, Aaron J. Hao, Senyue Ren, Chao Song, Andrew Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO United States Department of Electrical and Systems Engineering Washington University in St. Louis St. LouisMO United States

We have constructed a parallelized 4-channel multi-beam optical coherence tomography system capable of achieving high speed and wide field of view angiographic imaging of the retina. © Optica Publishing Group 202... 详细信息

关键词： Optical coherence tomography

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Optimized Silicon Nitride-Based Passive Components for 850 nm OCT on Photonic Chips

Optimized Silicon Nitride-Based Passive Components for 850 n...

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2024 Laser science, LS 2024

作者： Meng, Jiawei Hao, Senyue Adkins, Aaron J. Zhou, Weiyan Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Electrical & Systems Engineering Washington University in St. Louis St. LouisMO63130 United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO63130 United States

For optical coherence tomography (OCT) on photonic chips, we designed and validated optimized silicon nitride-based passive components for photonic integrated circuits. Centered at 850 nm, these components offer high ... 详细信息

关键词： Silicon nitride

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Optimized Photonic Integrated Circuit Components for Optical Coherence Tomography at 1060 nm

Optimized Photonic Integrated Circuit Components for Optical...

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Conference on Lasers and Electro-Optics (CLEO)

作者： Senyue Hao Aaron J Adkins Yitian Zhang Chao Zhou Department of Electrical & Systems Engineering Washington University in Saint Louis USA Imaging Science PhD Program Washington University in Saint Louis USA Department of Biomedical Engineering Washington University in Saint Louis USA

ISBN: (纸本)9798350369311

关键词： Sensitivity Optical coherence tomography Photonic integrated circuits Silicon Electro-optical waveguides Photonics

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Understanding age-related middle ear properties and basilar membrane damage in hearing loss: A finite element analysis and retrospective cohort study

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Computers in Biology and Medicine 2025年 184卷 109376-109376页

作者： Shih, Tzu-Ching Yu, You-Cheng Wang, Tang-Chuan Department of Biomedical Imaging and Radiological Science College of Medicine China Medical University Taichung404328 Taiwan The PhD Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University Taichung404328 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404328 Taiwan Department of Otolaryngology-Head and Neck Surgery China Medical University Hsinchu Hospital Zhubei City Hsinchu302056 Taiwan

Age-related hearing loss (ARHL) is primarily attributed to inner-ear factors, yet the role of age-related middle ear characteristics remains elusive. Employing a finite element (FE) model, we conducted a comparative analysis with clinical data extracted from a retrospective cohort study involving 90 younger adults (mean age = 38.1 ± 7.7) and 111 older adults (mean age = 63.8 ± 8.4). The clinical dataset encompassed air-bone gap (ABG) measurements obtained through pure-tone audiometry (PTA) at frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. FE results quantified the normalized stapes displacement value of the simulated form of air-bone gap (ABGSim) between the two age groups. The Mann-Whitney U test, with a significance threshold set at P © 2024

关键词： Bone

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A Prototype Coded Sensing SPECT designed for Ultra-high Sensitivity imaging

A Prototype Coded Sensing SPECT designed for Ultra-high Sens...

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IEEE Symposium on Nuclear science (NSS/MIC)

作者： L. Cai S. Aggarwal K. Enninful Y. Chen S. Komarov D. Thorek A. K. Jha Y.-C. Tai Imaging Science Phd Program Washington University in St. Louis Saint Louis Missouri United States of America Department of Biomedical Engineering Washington University in St. Louis Saint Louis Missouri United States of America Mallinckrodt Institute of Radiology Washington University in St. Louis Saint Louis Missouri United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In this work, we discuss the design and development of an ultra-high sensitivity imaging system, Coded Sensing SPECT (CS-SPECT), dedicated to guide and optimize application of alpha particle-emitting radiopharmaceutical therapy ($\alpha$RPT). Alpha particles are highly potent and unlike conventional external beam therapy, they can be used in metastatic settings. Currently, the lack of information of radionuclide distribution hinders estimated internal absorbed dose from $\alpha$RPT, which calls for ultrasensitive SPECT technologies that can report reliable activity distribution under ultra-low count rate imaging conditions. The proposed CS-SPECT is based on an innovative design that incorporates the geometry of both conventional pinhole collimator and coded aperture. Aimed to decouple the dependence of resolution and sensitivity, the heavy metal collimator is replaced by scintillator crystals to serve dual purposes of increasing detected events and providing spatial information. The proposed detector module consists of a 9×9 array of crystal elements. Each crystal presents an alternating pattern of GAGG scintillator and acrylic. The depth of interaction (DOI) information is obtained through dual-ended readout system. Our experimental results are based on a working prototype CS module that has 8x8 detector columns and is fully functional under a broad range of energy (70 keV – more than 511 keV), which is well-suited for alpha particle emitter imaging applications. Furthermore, we performed a preliminary imaging study of Tc99m point source. The number of detected events by the whole detector module is 11-fold higher than that from the bottom detectors resembling a conventional pinhole camera alone, demonstrating a tremendous improvement in system sensitivity.

关键词： Temperature sensors Collimators Sensitivity Scintillators Prototypes Medical treatment Crystals

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Functional Connectome-Based Predictive Modeling in Autism

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BIOLOGICAL PSYCHIATRY 2022年第8期92卷 626-642页

作者： Horien, Corey Floris, Dorothea L. Greene, Abigail S. Noble, Stephanie Rolison, Max Tejavibulya, Link O'Connor, David McPartland, James C. Scheinost, Dustin Chawarska, Katarzyna Lake, Evelyn M. R. Constable, R. Todd [a]Interdepartmental Neuroscience Program Yale School of Medicine New Haven Connecticut [b]MD-PhD Program Yale School of Medicine New Haven Connecticut [c]Department of Pediatrics Yale School of Medicine New Haven Connecticut [d]Department of Neurosurgery Yale School of Medicine New Haven Connecticut [e]Department of Radiology and Biomedical Imaging Yale School of Medicine New Haven Connecticut [f]Department of Biomedical Engineering Yale University New Haven Connecticut [g]Department of Psychology Yale University New Haven Connecticut [h]Department of Statistics and Data Science Yale University New Haven Connecticut [i]Yale Child Study Center New Haven Connecticut [j]Methods of Plasticity Research Department of Psychology University of Zürich Zurich Switzerland [k]Donders Center for Brain Cognition and Behavior Radboud University Nijmegen Nijmegen The Netherlands

Autism is a heterogeneous neurodevelopmental condition, and functional magnetic resonance imaging-based studies have helped advance our understanding of its effects on brain network activity. We review how predictive modeling, using measures of functional connectivity and symptoms, has helped reveal key insights into this condition. We discuss how different prediction frameworks can further our understanding of the brain-based features that underlie complex autism symptomatology and consider how predictive models may be used in clinical settings. Throughout, we highlight aspects of study interpretation, such as data decay and sampling biases, that require consideration within the context of this condition. We close by suggesting exciting future directions for predictive modeling in autism.

关键词： Clinical translation Development Fingerprinting Individual differences Machine learning Resting-state fMRI

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Cryo-EM structure of the plant 26S proteasome

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Plant Communications 2022年第3期3卷 116-126页

作者： Susanne Kandolf Irina Grishkovskaya Katarina Belacic Derek L.Bolhuis Sascha Amann Brent Foster Richard Imre Karl Mechtler Alexander Schleiffer Hemant D.Tagare Ellen D.Zhong Anton Meinhart Nicholas G.Brown David Haselbach Research Institute of Molecular Pathology(IMP) Vienna BioCenter(VBC)Campus-Vienna-BioCenter 11030 ViennaAustria Department of Radiology and Biomedical Imaging Yale UniversityNew HavenCT 06510USA Department of Pharmacology and Lineberger Comprehensive Cancer Center University of North Carolina School of MedicineChapel HillNC 27599USA Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of TechnologyCambridgeMA 02139USA Vienna BioCenter PhD Program Doctoral School of the University at Vienna and Medical University of ViennaVienna BioCenter(VBC)ViennaAustria Institute of Physical Chemistry University of FreiburgAlbertstraße 21Freiburg 79104Germany CIBSS Centre for Integrative Biological Signalling Studies University of FreiburgFreiburgGermany

Targeted proteolysis is a hallmark of *** is especially important in long-lived cells that can be found in higher eukaryotes,like *** task is mainly fulfilled by the ubiquitin–proteasome ***,proteolysis by the 26S proteasome is vital to development,immunity,and cell *** the yeast and animal proteasomes are well characterized,there is only limited information on the plant *** determined the first plant 26S proteasome structure from Spinacia oleracea by single-particle electron cryogenic microscopy at an overall resolution of 3.3 A°.We found an almost identical overall architecture of the spinach proteasome compared with the known structures from mammals and ***,we noticed a structural difference in the proteolytic active b1 ***,we uncovered an unseen compression state by characterizing the proteasome’s conformational *** suspect that this new conformation of the 20S core protease,in correlation with a partial opening of the unoccupied gate,may contribute to peptide release after *** data provide a structural basis for the plant proteasome,which is crucial for further studies.

关键词： 26S proteasome spinach UPS cryo-EM conformational landscape

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Initial human study of an AWSM-PET Device for Augmented Whole-body PET imaging

Initial human study of an AWSM-PET Device for Augmented Whol...

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IEEE Symposium on Nuclear science (NSS/MIC)

作者： Y. Chen M. Hamdi S. Komarov A. Thomas R. A. Mintzer S. Cho D. Pocci J. Corbeil J. Breuer M. S. Judenhofer N. Wu L. Cai J. Frye F. Dehdashti J. A. O’Sullivan R. Laforest S. B. Siegel Y.-C. Tai Washington University in St.Louis Imaging Science PhD program St. Louis Missouri United States of America Washington University in St.Louis Radiology St. Louis Missouri United States of America Washington University in St.Louis Chemistry St. Louis Missouri United States of America Siemens Medical Solutions USA Inc. Molecular Imaging Knoxville Tennessee United States of America Washington University in St.Louis Public Health Sciences St. Louis Missouri United States of America Washington University in St.Louis Electrical & Systems Engineering St. Louis Missouri United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

The Augmented Whole-body Scanning via Magnifying PET (AWSM-PET) device is a novel technology designed to improve the detectability of lesions in whole-body PET/CT imaging. We have developed a prototype AWSM-PET device that consists of two panels of high-resolution time-of-flight (TOF) PET detectors, integrated with the standard readout electronics and event processing architecture of the Biograph Vision (Siemens Healthineers). The system exhibits excellent spatial, energy and timing resolution, with an average coincidence resolving time of $\sim 217$ ps FWHM and an average energy resolution of $\sim 11 \%$ FWHM at 511 keV. Custom firmware and software have been developed to encode the large number of detector elements and to form coincidences between the AWSM-PET detectors and the Biograph Vision scanner. We have pioneered a specialized image reconstruction approach utilizing a GPU-based list-mode framework, which incorporates the system’s point-spread function (PSF) to optimize image quality and spatial resolution. Continuous-bed motion (CBM) whole-body imaging protocols have been implemented for the AWSM-PET operation to improve the uniformity of sensitivity across the patient’s body. Sensitivity enhancement was evaluated using a point source. The first human subject study was a head-andneck cancer patient scheduled for a standard-of-care (SOC) FDG PET/CT scan following treatment. Both the SOC-PET/CT images and the AWSM-PET images were acquired simultaneously for a total of 17 minutes using the CBM mode. Results show high-resolution and high-quality AWSM-PET images. We anticipate to image more patients in the summer, refine AWSM-PET image reconstruction parameters and correction techniques. Comparison between the AWSM-PET and the SOC-PET/CT will be presented at the 2024 IEEE MIC conference.

关键词： Microwave integrated circuits Sensitivity Biographies Energy resolution Whole-body PET Software Timing

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