检索结果-内蒙古大学图书馆

Understanding age-related middle ear properties and basilar membrane damage in hearing loss: A finite element analysis and retrospective cohort study

引用

Computers in Biology and Medicine 2025年 184卷 109376-109376页

作者： Shih, Tzu-Ching Yu, You-Cheng Wang, Tang-Chuan Department of Biomedical Imaging and Radiological Science College of Medicine China Medical University Taichung404328 Taiwan The PhD Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University Taichung404328 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404328 Taiwan Department of Otolaryngology-Head and Neck Surgery China Medical University Hsinchu Hospital Zhubei City Hsinchu302056 Taiwan

Age-related hearing loss (ARHL) is primarily attributed to inner-ear factors, yet the role of age-related middle ear characteristics remains elusive. Employing a finite element (FE) model, we conducted a comparative analysis with clinical data extracted from a retrospective cohort study involving 90 younger adults (mean age = 38.1 ± 7.7) and 111 older adults (mean age = 63.8 ± 8.4). The clinical dataset encompassed air-bone gap (ABG) measurements obtained through pure-tone audiometry (PTA) at frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. FE results quantified the normalized stapes displacement value of the simulated form of air-bone gap (ABGSim) between the two age groups. The Mann-Whitney U test, with a significance threshold set at P © 2024

关键词： Bone

来源：评论

学校读者我要写书评

暂无评论

Optimized photonic integrated circuit components for optical coherence tomography at 1060 nm

Optimized photonic integrated circuit components for optical...

引用

CLEO: Applications and Technology in CLEO 2024, CLEO: A and T 2024 - Part of Conference on Lasers and Electro-Optics

作者： Hao, Senyue Adkins, Aaron J. Zhang, Yitian Zhou, Chao Department of Electrical & Systems Engineering Washington University Saint Louis United States Imaging Science PhD Program Washington University Saint Louis United States Department of Biomedical Engineering Washington University Saint Louis United States

To implement optical coherence tomography on photonic chips, we developed optimized and experimentally validated silicon nitride-based components for photonic integrated circuits in order to achieve high sensitivity a... 详细信息

关键词： Photonic integrated circuits

来源：评论

学校读者我要写书评

暂无评论

Optimized photonic integrated circuit components for optical coherence tomography at 1060 nm

Optimized photonic integrated circuit components for optical...

引用

2024 Conference on Lasers and Electro-Optics, CLEO 2024

ISBN: (纸本)9781957171395

关键词： Photonic integrated circuits

来源：评论

学校读者我要写书评

暂无评论

Space Division Multiplexing Optical Coherence Tomography for Wide-field Angiographic imaging of the Human Retina

Space Division Multiplexing Optical Coherence Tomography for...

引用

2024 Frontiers in Optics, FiO 2024

作者： Adkins, Aaron J. Hao, Senyue Ren, Chao Song, Andrew Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO United States Department of Electrical and Systems Engineering Washington University in St. Louis St. LouisMO United States

We have constructed a parallelized 4-channel multi-beam optical coherence tomography system capable of achieving high speed and wide field of view angiographic imaging of the retina. © Optica Publishing Group 202... 详细信息

关键词： Optical coherence tomography

来源：评论

学校读者我要写书评

暂无评论

Optimized Silicon Nitride-Based Passive Components for 850 nm OCT on Photonic Chips

Optimized Silicon Nitride-Based Passive Components for 850 n...

引用

2024 Laser science, LS 2024

作者： Meng, Jiawei Hao, Senyue Adkins, Aaron J. Zhou, Weiyan Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Electrical & Systems Engineering Washington University in St. Louis St. LouisMO63130 United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO63130 United States

For optical coherence tomography (OCT) on photonic chips, we designed and validated optimized silicon nitride-based passive components for photonic integrated circuits. Centered at 850 nm, these components offer high ... 详细信息

关键词： Silicon nitride

来源：评论

学校读者我要写书评

暂无评论

Optimized Photonic Integrated Circuit Components for Optical Coherence Tomography at 1060 nm

Optimized Photonic Integrated Circuit Components for Optical...

引用

Conference on Lasers and Electro-Optics (CLEO)

作者： Senyue Hao Aaron J Adkins Yitian Zhang Chao Zhou Department of Electrical & Systems Engineering Washington University in Saint Louis USA Imaging Science PhD Program Washington University in Saint Louis USA Department of Biomedical Engineering Washington University in Saint Louis USA

ISBN: (纸本)9798350369311

关键词： Sensitivity Optical coherence tomography Photonic integrated circuits Silicon Electro-optical waveguides Photonics

来源：评论

学校读者我要写书评

暂无评论

Functional Connectome-Based Predictive Modeling in Autism

引用

BIOLOGICAL PSYCHIATRY 2022年第8期92卷 626-642页

作者： Horien, Corey Floris, Dorothea L. Greene, Abigail S. Noble, Stephanie Rolison, Max Tejavibulya, Link O'Connor, David McPartland, James C. Scheinost, Dustin Chawarska, Katarzyna Lake, Evelyn M. R. Constable, R. Todd [a]Interdepartmental Neuroscience Program Yale School of Medicine New Haven Connecticut [b]MD-PhD Program Yale School of Medicine New Haven Connecticut [c]Department of Pediatrics Yale School of Medicine New Haven Connecticut [d]Department of Neurosurgery Yale School of Medicine New Haven Connecticut [e]Department of Radiology and Biomedical Imaging Yale School of Medicine New Haven Connecticut [f]Department of Biomedical Engineering Yale University New Haven Connecticut [g]Department of Psychology Yale University New Haven Connecticut [h]Department of Statistics and Data Science Yale University New Haven Connecticut [i]Yale Child Study Center New Haven Connecticut [j]Methods of Plasticity Research Department of Psychology University of Zürich Zurich Switzerland [k]Donders Center for Brain Cognition and Behavior Radboud University Nijmegen Nijmegen The Netherlands

Autism is a heterogeneous neurodevelopmental condition, and functional magnetic resonance imaging-based studies have helped advance our understanding of its effects on brain network activity. We review how predictive modeling, using measures of functional connectivity and symptoms, has helped reveal key insights into this condition. We discuss how different prediction frameworks can further our understanding of the brain-based features that underlie complex autism symptomatology and consider how predictive models may be used in clinical settings. Throughout, we highlight aspects of study interpretation, such as data decay and sampling biases, that require consideration within the context of this condition. We close by suggesting exciting future directions for predictive modeling in autism.

关键词： Clinical translation Development Fingerprinting Individual differences Machine learning Resting-state fMRI

来源：评论

学校读者我要写书评

暂无评论

Cryo-EM structure of the plant 26S proteasome

引用

Plant Communications 2022年第3期3卷 116-126页

作者： Susanne Kandolf Irina Grishkovskaya Katarina Belacic Derek L.Bolhuis Sascha Amann Brent Foster Richard Imre Karl Mechtler Alexander Schleiffer Hemant D.Tagare Ellen D.Zhong Anton Meinhart Nicholas G.Brown David Haselbach Research Institute of Molecular Pathology(IMP) Vienna BioCenter(VBC)Campus-Vienna-BioCenter 11030 ViennaAustria Department of Radiology and Biomedical Imaging Yale UniversityNew HavenCT 06510USA Department of Pharmacology and Lineberger Comprehensive Cancer Center University of North Carolina School of MedicineChapel HillNC 27599USA Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of TechnologyCambridgeMA 02139USA Vienna BioCenter PhD Program Doctoral School of the University at Vienna and Medical University of ViennaVienna BioCenter(VBC)ViennaAustria Institute of Physical Chemistry University of FreiburgAlbertstraße 21Freiburg 79104Germany CIBSS Centre for Integrative Biological Signalling Studies University of FreiburgFreiburgGermany

Targeted proteolysis is a hallmark of *** is especially important in long-lived cells that can be found in higher eukaryotes,like *** task is mainly fulfilled by the ubiquitin–proteasome ***,proteolysis by the 26S proteasome is vital to development,immunity,and cell *** the yeast and animal proteasomes are well characterized,there is only limited information on the plant *** determined the first plant 26S proteasome structure from Spinacia oleracea by single-particle electron cryogenic microscopy at an overall resolution of 3.3 A°.We found an almost identical overall architecture of the spinach proteasome compared with the known structures from mammals and ***,we noticed a structural difference in the proteolytic active b1 ***,we uncovered an unseen compression state by characterizing the proteasome’s conformational *** suspect that this new conformation of the 20S core protease,in correlation with a partial opening of the unoccupied gate,may contribute to peptide release after *** data provide a structural basis for the plant proteasome,which is crucial for further studies.

关键词： 26S proteasome spinach UPS cryo-EM conformational landscape

来源：评论

学校读者我要写书评

暂无评论

Tract Integrity Predicts Neurological Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy

引用

Pediatrics & Neonatology 2025年

作者： Pei-Ling Tsai Yu-Chun Lo Yi-Shan Tsai Yea-Shwu Hwang Ting-Chun Lin Yao-Wen Liang Chen-En Huang Fu-Chun Hsu Yi-Fang Tu You-Yin Chen Institute of Allied Health Sciences College of Medicine National Cheng Kung University Tainan Taiwan PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Medical Imaging National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Department of Occupational Therapy College of Medicine National Cheng Kung University Tainan Taiwan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei Taiwan College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Department of Pediatrics National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan Medical Device Innovation and Translation Center National Yang Ming Chiao Tung University Taipei Taiwan

Objective Early prognostication in infants with neonatal hypoxic-ischemic encephalopathy (HIE) is crucial for follow-up management. Alternations of microstructural integrity of neural fiber tracts in large-scale neural networks might predict neurological outcomes. Methods All consecutively-admitted patients with neonatal HIE from 2016 to 2020 were enrolled. Diffusion tensor imaging (DTI) tractography was performed at 4–7 days of age. Neurodevelopmental outcomes at 24 months of age were assessed with Bayley Scales of Infant Development, 3rd edition. Results A total of 62 HIE infants were enrolled, and 53 of these underwent DTI. Fractional anisotropy (FA) and mean diffusivity (MD) were measured to indicate the microstructural integrity of tracts, including the arcuate fasciculus, uncinate fasciculus, inferior fronto-occipital fasciculus, corticospinal tract (CST), and optic radiations (OR). Lower FA values of target tracts were associated with lower developmental scores at 24 months of age, particularly in the CST and OR (all P ≤ 0.003). The prognostic accuracy of FA values in CST surpassed that in the region of thalamus/basal ganglia (area under curves 0.839, 95% CI: 0.728–0.950 vs. 0.755, 95% CI: 0.583–0.928). Furthermore, the correlation between FA values in target tracts and developmental scores was most significant in infants with HIE stage III and this was not affected by therapeutic hypothermia. Conclusion Tract integrity in the CST and OR detected by DTI provides valuable insights for early prognostication in infants with HIE, regardless of therapeutic hypothermia.

关键词： neonatal hypoxic-ischemic encephalopathy diffusion tensor imaging tractography corticospinal tract optic radiations neurodevelopmental outcome

来源：评论

学校读者我要写书评

暂无评论

A Prototype Coded Sensing SPECT designed for Ultra-high Sensitivity imaging

A Prototype Coded Sensing SPECT designed for Ultra-high Sens...

引用

IEEE Symposium on Nuclear science (NSS/MIC)

作者： L. Cai S. Aggarwal K. Enninful Y. Chen S. Komarov D. Thorek A. K. Jha Y.-C. Tai Imaging Science Phd Program Washington University in St. Louis Saint Louis Missouri United States of America Department of Biomedical Engineering Washington University in St. Louis Saint Louis Missouri United States of America Mallinckrodt Institute of Radiology Washington University in St. Louis Saint Louis Missouri United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In this work, we discuss the design and development of an ultra-high sensitivity imaging system, Coded Sensing SPECT (CS-SPECT), dedicated to guide and optimize application of alpha particle-emitting radiopharmaceutical therapy ($\alpha$RPT). Alpha particles are highly potent and unlike conventional external beam therapy, they can be used in metastatic settings. Currently, the lack of information of radionuclide distribution hinders estimated internal absorbed dose from $\alpha$RPT, which calls for ultrasensitive SPECT technologies that can report reliable activity distribution under ultra-low count rate imaging conditions. The proposed CS-SPECT is based on an innovative design that incorporates the geometry of both conventional pinhole collimator and coded aperture. Aimed to decouple the dependence of resolution and sensitivity, the heavy metal collimator is replaced by scintillator crystals to serve dual purposes of increasing detected events and providing spatial information. The proposed detector module consists of a 9×9 array of crystal elements. Each crystal presents an alternating pattern of GAGG scintillator and acrylic. The depth of interaction (DOI) information is obtained through dual-ended readout system. Our experimental results are based on a working prototype CS module that has 8x8 detector columns and is fully functional under a broad range of energy (70 keV – more than 511 keV), which is well-suited for alpha particle emitter imaging applications. Furthermore, we performed a preliminary imaging study of Tc99m point source. The number of detected events by the whole detector module is 11-fold higher than that from the bottom detectors resembling a conventional pinhole camera alone, demonstrating a tremendous improvement in system sensitivity.

关键词： Temperature sensors Collimators Sensitivity Scintillators Prototypes Medical treatment Crystals

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：