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17th International Conference on Photonics and imaging in Biology and Medicine, PIBM 2024

作者： Chen, Yichu Chen, Xiao College of Biomedical Engineering and Medical Imaging Hubei University of Science and Technology Xianning China

ISBN: (数字)9781510688070

ISBN: (纸本)9781510688063

Elasticity is one of the fundamental properties of materials. It is an important diagnostic parameter to investigate physiological dysfunctions in biological tissues. This paper presents a novel method to accurately measure the elastic by Rayleigh wave tracing on the surface of phantoms using laser profilometer with airpuff excitation. We developed a laser profilometer elastography system, including the optical system, timing sequence, and control software. The elastics of agarose phantoms with 0.6%, 0.8%, 1.2% and 1.5% concentration were measured. The method was validated by comparing it with the results obtained by using a laser speckle elastography. To the best of our knowledge, this is the first elastic modality based on a laser profilometer. This method can be used for online elasticity measurement of biological. © 2025 SPIE.

关键词： Tissue

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Polymer-based smart fibers and textiles for wearable electronics

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science China(Technological sciences) 2025年第1期68卷 81-116页

作者： Sanming HU Li WANG Zaixian YUAN Kun CHEN Wei PENG Hai YIN Zhijun SHI Guang YANG School of Biomedical Engineering and Imaging Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China College of Life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Wuhan Branch of the National Science Library Chinese Academy of SciencesWuhan 430071China

Smart fibers and textiles have attracted considerable interest for application in wearable devices because of their advantages of being human-friendly,lightweight,flexible,and *** addition,they are considered to have potential applications in health monitoring,energy management,and human-machine interaction *** and polymer fibers,with excellent mechanical strength,wrinkle resistance,and heat resistance,are widely used to fabricate smart fibers and ***,a comprehensive overview of polymer-based fibers and textiles is ***,we review the design principles of various polymer-based smart textiles,including textile-based sensors,energy capture and storage textiles,and computation and display ***,materials used for preparing polymer-based smart fibers,such as metals,carbon-based materials,and natural and synthetic polymers,particularly conductive polymers,are *** addition,this review summarizes key technologies used for preparing smart fibers and the conventional structures of smart ***,the applications of smart textiles in personal health monitoring,thermal management,energy capture and storage,and computation and displays are ***,the current challenges,limitations,and future trends of smart fibers and textiles are discussed.

关键词： polymers smart fibers smart textiles wearable electronics health management

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Parallel processing model for low-dose computed tomography image denoising

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Visual Computing for Industry,Biomedicine,and Art 2024年第1期7卷 237-256页

作者： Libing Yao Jiping Wang Zhongyi Wu Qiang Du Xiaodong Yang Ming Li Jian Zheng School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Medical Imaging Department Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China

Low-dose computed tomography(LDCT)has gained increasing attention owing to its crucial role in reducing radiation exposure in ***,LDCT-reconstructed images often suffer from significant noise and artifacts,negatively impacting the radiologists’ability to accurately *** address this issue,many studies have focused on denoising LDCT images using deep learning(DL)***,these DL-based denoising methods have been hindered by the highly variable feature distribution of LDCT data from different imaging sources,which adversely affects the performance of current denoising *** this study,we propose a parallel processing model,the multi-encoder deep feature transformation network(MDFTN),which is designed to enhance the performance of LDCT imaging for multisource *** traditional network structures,which rely on continual learning to process multitask data,the approach can simultaneously handle LDCT images within a unified framework from various imaging *** proposed MDFTN consists of multiple encoders and decoders along with a deep feature transformation module(DFTM).During forward propagation in network training,each encoder extracts diverse features from its respective data source in parallel and the DFTM compresses these features into a shared feature ***,each decoder performs an inverse operation for multisource loss *** collaborative training,the proposed MDFTN leverages the complementary advantages of multisource data distribution to enhance its adaptability and *** experiments were conducted on two public datasets and one local dataset,which demonstrated that the proposed network model can simultaneously process multisource data while effectively suppressing noise and preserving fine *** source code is available at https://***/123456789ey/MDFTN.

关键词： Deep learning Low-dose computed tomography Multi-encoder deep feature transformation Multisource denoising

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Vortex clusters and their active control in a cold Rydberg atomic system with PT-symmetric Bessel potential

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Chinese Physics B 2024年第12期33卷 180-186页

作者： Zhuo Fan Yi Shi Hang Wang Yuan Zhao Wei Peng Siliu Xu Key Laboratory of Optoelectronic Sensing and Intelligent Control Hubei University of Science and TechnologyXianning 437100China School of Biomedical Engineering and Imaging Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China School of Electronic and Information Engineering Hubei University of Science and TechnologyXianning 437100China

We propose an approach for generating robust two-dimensional(2D)vortex clusters(VCs)in a Rydberg atomic system by utilizing parity-time(PT)symmetric optical Bessel *** show that the system supports novel multicore VCs with four and eight cores,corresponding to topological charges 2 and 4,*** stability of these VCs can be dynamically adjusted through the manipulation of the gain-loss component,Kerr nonlinearities,and the degree of nonlocality inherent in the Rydberg *** VCs are confined within the first lattice well of the Bessel potential,and both the power and width of lights undergo a quasi-periodic breathing phenomenon,which is attributed to the power exchange between the light fields and Bessel *** self-attractive and self-repulsive Kerr interactions can sustain robust VCs within this *** insights presented here not only facilitate the creation and manipulation of 2D VCs through PT-symmetric potentials but also pave the way for potential applications in optical information processing and transmission.

关键词： vortex clusters PT symmetry Bessel potential Rydberg-Rydberg interaction

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Parameter-Efficient Fine-Tuning Medical Multimodal Large Language Models for Medical Visual Grounding 22

Parameter-Efficient Fine-Tuning Medical Multimodal Large Lan...

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22nd IEEE International Symposium on biomedical imaging, ISBI 2025

作者： He, Jinlong Li, Pengfei Liu, Gang Zhong, Shenjun College of Computer Science and Technology Harbin Engineering University China Monash University Monash Biomedical Imaging Australia

ISBN: (纸本)9798331520526

Multimodal Large Language Models (MLLMs) inherit the superior text understanding capabilities of LLMs and extend these capabilities to multimodal scenarios. These models achieve excellent results in the general domain of multimodal tasks. However, in the medical domain, the substantial training costs and the requirement for extensive medical data pose challenges to the development of medical MLLMs. Furthermore, due to the free-text form of answers, tasks such as visual grounding that need to produce output in a prescribed form become difficult for MLLMs. So far, there have been no medical MLLMs works in medical visual grounding area. For the medical vision grounding task, which involves identifying locations in medical images based on short text descriptions, we propose Parameter-efficient Fine-tuning medical multi-modal large language models for Medcial Visual Grounding (PFMVG). To validate the performance of the model, we evaluate it on a public benchmark dataset for medical visual grounding, where it achieves competitive results, and significantly outperforming GPT-4v. © 2025 IEEE.

关键词： Medical Multimodal Large Language Model Medical Visual Grounding Parameter-Efficient Fine-Tuning

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Epsilon-caprolactone-modified polyethylenimine as a genetic vehicle for stem cell-based bispecific antibody and exosome synergistic therapy

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Regenerative Biomaterials 2023年第1期10卷 97-106页

作者： Yan Tan Jiali Cai Zhiyong Wang Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhen 518060China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Materials Science and EngineeringCenter for Functional BiomaterialsSun Yat-Sen UniversityGuangzhou 510275China

Bispecific antibodies(BsAb)have gained significant momentum in clinical ***,the rapid enzymolysis and metabolism of protein drugs usually induce short circulation in vivo,and developing an efficient protein delivery system still is a *** stem cells(MSCs)have become an attractive therapeutic carrier for *** modification enables MSCs to express and secrete specific proteins,which is essential for therapeutic ***,efficient gene transfer into MSCs is still a *** this study,we applied epsilon-caprolactone-modified polyethylenimine(PEI-CL)as an efficacy carrier for plasmid transfection into MSC that served as in situ‘cell factory’for anti-CD3/CD20 BsAb ***,the PEI-CL encapsulates the minicircle plasmid and mediates cell transfection ***,the anti-CD3/CD20 BsAb is secreted from MSC and recruited T cell,resulting in highly sensitive cytotoxicity in the human B-cell ***,these stem cells produce exosomes bearing MiR-15a/MiR-16,which could negatively regulate cancer’s oncogenes BCL-2 for adjuvant ***,high immunologic factors like tumor necrosis factor-αand interferon-γare generated and enhance immunotherapy *** engineered MSCs are demonstrated as an efficient route for BsAb production,and these bioactive components contribute to synergistic therapy,which would be an innovative treatment.

关键词： polyethylenimine stem cell bispecific antibody exosome

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Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzhu Xu Wenyi Wang Liang Qiao Yunzhe Fu Xichuan Ge Kun Zhao Karl Zhanghao Meiling Guan Xin Chen Meiqi Li Dayong Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution

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Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing

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National science Review 2023年第5期10卷 262-271页

作者： Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai Zhaokui Jin Shucun Qin Wenjiang Ding Qianjun He Taishan Institute for Hydrogen Biomedical Research School of Basic Medical SciencesThe Second Affiliated Hospital of Shandong First Medical University&Shandong Academy of Medical Sciences Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringMedical SchoolShenzhen University Shanghai Key Laboratory of Hydrogen Science&Center of Hydrogen Science School of Materials Science and EngineeringShanghai Jiao Tong University

It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H2is an emerging energy-regulating molecule possessing both high biosafety and high tissue *** this work,we propose a concept of sonocatalytic hydrogen/hole-combined 'inside/outside-cooperation'anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric ***-of-concept experiments using C3N4nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H2and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound *** proposed strategy of sonocatalytic hole/hydrogen-combined 'inside/outside-cooperation' will make a highway for treatment of deep-seated biofilm infection.

关键词： nanocatalytic medicine hydrogen therapy biofilm diabetic foot piezoelectric catalysis

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PD-L1 targeted iron oxide SERS bioprobe for accurately detecting circulating tumor cells and delineating tumor boundary

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Chinese Chemical Letters 2025年第1期36卷 408-414页

作者： Ting Pan Dinghu Zhang Guomei You Xiaoxia Wu Chenguang Zhang Xinyu Miao Wenzhi Ren Yiwei He Lulu He Yuanchuan Gong Jie Lin Aiguo Wu Guoliang Shao Department of Interventional Radiology Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Cixi Institute of Biomedical EngineeringInternational Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Early diagnosis and accurate boundary delineation are the key steps of tumor precision *** tumor cells(CTCs)detection of liquid biopsy can provide abundant information for early diagnosis of *** detection specificity and good enrichment features are two key factors for CTCs accurate identification in peripheral blood *** this purpose,iron oxide(IO)-based surface-enhanced Raman scattering(SERS)bioprobes with good biocompatibility,high detection sensitivity,remarkable detection specificity,and good enrichment efficiency,were developed for detecting different types of *** SERS bioprobes combined with programmed death ligand-1(PD-L1)antibody are regarded as an effective way to boost the targeting ability and detection specificity,benefiting for accurately capturing and identifying rare *** types of CTCs with different PD-L1 expression were accurately distinguished among white blood cells via high-resolution SERS mapping images and stable Raman ***,CTCs blood samples obtained from the triple negative breast cancer patients were also successfully recognized compared to that of health people,indicating IO@AR@PDA-a PD-L1 SERS bioprobe possessed great potential for CTCs detection in liquid ***,IO-based bioprobe exhibited excellent dual-modal imaging abilities of high-resolution SERS imaging mode and microimaging magnetic resonance imaging *** two highly complementary imaging modes endowed IO-based bioprobes unrivalled capacity in tumor boundary differentiation,supporting tumor accurate resection and precise *** our best knowledge,this is the first time that biocompatible IO-based SERS bioprobes without noble metal element were reported not only for CTCs accurate detection,but also for precise tumor boundary delineation,showing great advantages in tumor diagnosis and treatment.

关键词： Circulating tumor cells Surface-enhanced Raman scattering PD-L1 Iron oxide bioprobe Dual-modal imaging Tumor boundaries delineation

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Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing

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Bio-Design and Manufacturing 2023年第3期6卷 268-283页

作者： Lixing Zhang Xin Miao Meijia Wang Aihua Shi Jingwen Wang Zhonglin Ma Yunhai Zhang Jingzhong Zhang Shuang Yu Suzhou Institute of Biomedical Engineering and Technology(SIBET) Chinese Academy of SciencesSuzhou 215163China Department of Biomedical Engineering School of Medical ImagingXuzhou Medical UniversityXuzhou 221004China Zhengzhou Zhongke Institute of Biomedical Engineering and Technology Affiliated with SIBET Zhengzhou 450001China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China School of Radiation Medicine and Protection Soochow UniversitySuzhou 215123China

The process of wound healing is routinely evaluated by histological evaluation in the clinic,which may cause scarring and secondary *** confocal microscopy(RCM)represents a noninvasive,real-time imaging technique that allows in vivo evaluation of the *** RCM was wide-probe-based,which limited its application on uneven and covered *** this study,we report the development of a portable reflectance confocal microscope(PRCM)in which all components were assembled in a handheld *** the size and weight of the PRCM were reduced based on the use of a microelectromechanical system,the resolution was kept at 0.91μm,and the field of view of the system was 343μm×532μ*** used in vivo,the PRCM was able to visualize cellular and nuclear morphology for both mouse and human *** evaluations were then performed on wounds after topically applied mesenchymal stem cells(MSCs)or saline *** PRCM allowed visualization of the formation of collagen bundles,re-epithelization from the wound edge to the wound bed,and hair follicle regeneration,which were consistent with histological ***,we offer new insights into monitoring the effects of topically applied MSCs on the process of wound healing by using *** study illustrates that the newly developed PRCM represents a promising device for real-time,noninvasive monitoring of the dynamic process of wound healing,which demonstrates its potential to diagnose,monitor,or predict disease in clinical wound therapy.

关键词： Portable reflectance confocal microscope Wound healing Noninvasive optical imaging Real-time in vivo visualization

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