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Simulation of arrow-shaped micromixer with obstacles in blood plasma mixing

AIP Conference Proceedings 2024年第1期3080卷

作者： Ziyan Muhammad Aqsha Basari Mohammad Akita Indianto Ridho Irwansyah Muhammad Satrio Utomo Siti Fauziyah Rahman Biomedical Engineering Study Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia Energy Systems Engineering Graduate Program Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia Department of Mechanical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia Research Center for Metallurgy National Research and Innovation Agency Komplek PUSPIPTEK Setu Tangerang Selatan Banten 15314 Indonesia

In recent years, several applications of micromixers have been reported to have a number of advantages, including the use of small amounts of plasma, short reaction times, and good reaction efficiency. The samples analyzed in this study were blood plasma and distilled water. The process is carried out by passive mixing which is based on a microchannel structure to enhance the diffusion of molecules for efficient mixing. The arrow shape was chosen as the micromixer design because it has a better blending performance than the T and Y shapes. The types of obstacles also used to improve the mixing process. The simulation was carried out on COMSOL Multiphysics software version 5.6. The results showed better mixing results for the micromixer design with triangle right facing obstacles with the highest Reynolds number was 9.4326. Then followed by ellips obstacles with a value of 9.4322, then without obstacles that is 9.4309, after that the triangle left facing with a value of 9.4006, and finally the lowest Reynolds number is a design with a diamond obstacles of 9.2514.

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Development of a Bioactive, Piezoelectric PVDF-TrFE Scaffold to Modulate Wound Response in the Peripheral Nervous System

SSRN

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SSRN 2024年

作者： Bryan, Andrew E. Krutko, Maksym Rebholz, Sandra Marquez, Lindsey E. Busch, Emma Dong, Kevin Pixley, Sarah K. Cushion, Melanie T. Esfandiari, Leyla Harris, Greg M. Department of Chemical and Environmental Engineering University of Cincinnati CincinnatiOH45221 United States Department of Biomedical Engineering University of Cincinnati CincinnatiOH45221 United States Department of Internal Medicine University of Cincinnati College of Medicine CincinnatiOH45267 United States Medical Research Service Cincinnati Veterans Affairs Medical Center CincinnatiOH45220 United States Department of Pharmacology and Systems Physiology University of Cincinnati College of Medicine CincinnatiOH45267 United States Department of Electrical Engineering University of Cincinnati CincinnatiOH45221 United States Department of Environmental & Public Health Sciences University of Cincinnati College of Medicine CincinnatiOH45267 United States Neuroscience Graduate Program University of Cincinnati College of Medicine CincinnatiOH45267 United States

To address current limitations in biomaterials for peripheral nerve repair regarding a lack of physiologically relevant signaling and immune response following implantation, this study evaluated the development and feasibility of a multi-cue biomaterial with physiologically relevant chemical, electrical, and physical signaling. To accomplish this, a bulk-functionalized poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) scaffold was fabricated using blend electrospinning to incorporate decellularized extracellular matrix (dECM) to mediate the foreign body response in vivo and promote enhanced wound healing. Decellularized ECM was secreted and assembled by fibroblast cells and incorporated into the electrospinning solution with concentration values ranging from 0% to 0.4% (m/v). Physical, chemical, and electrical properties of the scaffold were analyzed by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), mechanical tensile testing, and voltage readings for piezoelectricity. Blended scaffolds were evaluated in vitro for analysis of cell-material interactions in the context of peripheral nerve injury (PNI) repair and in vivo for immune response. In vitro work demonstrated increased cell metabolism and elongated, repair-like morphologies in Schwann cells on scaffolds with higher dECM concentrations. Subcutaneous implantation of blended scaffolds in rats at 7 days revealed limited multi-nucleated giant cell formation. Following 28 days in vivo, regenerative characteristics of the proliferative phase of wound healing were present with enhanced nerve growth and vasculature to scaffold. Overall, blend-electrospun scaffolds with native dECM showed promise in mitigating pro-inflammatory responses and promote advanced regenerative behaviors, thereby providing an implantable biomaterial with the necessary physical, chemical, and electrical characteristics desired for c

关键词： Fourier transform infrared spectroscopy

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STRUCTURAL-ANALYSIS METHODS FOR LIGHTWEIGHT METALLIC CORRUGATED CORE SANDWICH PANELS SUBJECTED TO BLAST LOADS

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NAVAL ENGINEERS JOURNAL 1991年第4期103卷 134-136页

作者： WIERNICKI, CJ LIEM, F WOODS, GD FURIO, A WHIDDON, WD SMITH, MA PACKARD, WT Christopher J. Wiernickiis the director of the Structures and Materials Division of Designers and Planners Inc. He has over 10 years of experience in marine structural design and advanced material product development. He received a B.S. degree in civil engineering from Vanderbilt University and M.S. degrees from both George Washington University and Massachusetts Institute of Technology. He is a registered professional engineer and is a member of ASNE SNAME and SAMPE. Franz Liemis a senior structural engineer of ASTECH. He has over 18 years of experience in structural engineering. He received M.S. degrees in civil/structural engineering from Carollo Wilhelmina University in West Germany. He is a registered professional engineer. Gregory D. Woodsis the Naval Sea Systems Command's lightweight metallic structures program manager. Until recently a naval architect in the Structural Integrity Application Division he currently works in the Amphibious Auxiliary and Support Ship Branch. He received a B.S. degree in mechanical engineering from Tennessee State University with additional graduate level course work at the NavSea Institute. Anthony J. Furiois the program manager for lightweight metallic structures in the Ship Structure Division of the David Taylor Research Center. He has over 19 years of experience in ship structure research and light weight metallic development for U.S. Navy fleet applications. He received a B.S. in civil engineering from Long Island University and a M.S. in ocean engineering from Stevens Institute of Technology.

Since the early 1980s, the U.S. Navy, in conjunction with industry, has continued to develop and test innovative lightweight structural concepts with the purpose of seeking alternative replacements for conventional plate beam metallic structures. One commercially available concept currently under investigation is lightweight metallic corrugated core sandwich panels. This paper presents both elastic and plastic design methods for lightweight metallic corrugated core sandwich panels subjected to air blast loading. The equations presented in this paper, while not a complete solution to the complicated dynamic, elastic plastic phenomena of blast wave-rigid body interaction, are offered as a set of relatively simple analytical expressions that can be used in preliminary design. Because of the closed form nature of the equations the designer has the capability to quickly identify the most important parameters effecting the response of lightweight metallic corrugated core sandwich panels to air blast loads.

关键词： Shipbuilding Materials

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A Radial Basis Function Spike Model for Indirect Learning via Integrate-and-Fire Sampling and Reconstruction Techniques

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Advances in Artificial Neural systems 2012年第1期2012卷

作者： X. Zhang G. Foderaro C. Henriquez A. M. J. VanDongen S. Ferrari Laboratory for Intelligent Systems and Control (LISC) Department of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USAduke.edu Department of Biomedical Engineering and Department of Computer Science Duke University Durham NC 27708 USAduke.edu Program in Neuroscience & Behavioral Disorders Duke-NUS Graduate Medical School Singapore Singapore

This paper presents a deterministic and adaptive spike model derived from radial basis functions and a leaky integrate-and-fire sampler developed for training spiking neural networks without direct weight manipulation. Several algorithms have been proposed for training spiking neural networks through biologically-plausible learning mechanisms, such as spike-timing-dependent synaptic plasticity and Hebbian plasticity. These algorithms typically rely on the ability to update the synaptic strengths, or weights, directly, through a weight update rule in which the weight increment can be decided and implemented based on the training equations. However, in several potential applications of adaptive spiking neural networks, including neuroprosthetic devices and CMOS/memristor nanoscale neuromorphic chips, the weights cannot be manipulated directly and, instead, tend to change over time by virtue of the pre- and postsynaptic neural activity. This paper presents an indirect learning method that induces changes in the synaptic weights by modulating spike-timing-dependent plasticity by means of controlled input spike trains. In place of the weights, the algorithm manipulates the input spike trains used to stimulate the input neurons by determining a sequence of spike timings that minimize a desired objective function and, indirectly, induce the desired synaptic plasticity in the network.

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Incomplete Balancing Domain Decomposition for Large scale 3-D non-stationary incompressible flow problems

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IOP Conference Series: Materials Science and engineering 2010年第1期10卷

作者： Q H Yao H Kanayama M Ognio H Notsu Department of Intelligent Machinery and Systems Graduate School of Engineering Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan School of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510640 China Department of Mechanical Engineering Faculty of Engineering Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan Research Center for Hydrogen Industrial Use and Storage (HYDROGENIUS) National Institute of Advanced Industrial Science and Technology (AIST) Japan

To solve large scale 3-D non-stationary incompressible flow problems, an algorithm to perform an Incomplete Balancing Domain Decomposition (IBDD) is constructed in this work; as an improvement of the Balancing Domain Decomposition (BDD) method, it reduce the computation cost of the coarse problem by replacing the exact balancing procedure with an inexact balancing procedure; the nonlinear convection term of the Navier-Stokes equation is approximated by a characteristic-curve method, which is advantageous as it renders the matrix for linear equations symmetric, thus enabling the Conjugate Gradient (CG) method to be used together with the Schur complement system of Domain Decomposition Method (DDM); the algorithms are all implemented in parallel by the Hierarchical Domain Decomposition Method (HDDM) system, and the program provides solvability for models of over 10 million degrees of freedom (DOF).

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NUCLEAR VS NONNUCLEAR ATTACK SUBMARINE POWERPLANTS

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NAVAL ENGINEERS JOURNAL 1993年第3期105卷 224-231页

作者： RAINS, DA MITCHELL, KA Dr. Dean A. Rains:is president of Decision Engineering Pascagoula Miss. He has been an active member of ASNE since 1970 a frequent contributor to the Naval Engineers Journal and a participant at ASNE Day as an author and a discusser. He was either chairman or paper chairman for several Cruiser Destroyer and Frigate Technology Symposiums held in Biloxi Miss. He is past chairman of the Pascagoula Section of ASNE. He is currently the program chairman for the Pascagoula Section. He has forty-two years engineering experience and is a graduate of the California Institute of Technology from which he received his B.S. M.S. and Ph.D. all in mechanical engineering. Kenneth A. Mitchell Jr.:is an engineer with U.S. Marine New Orleans La. He was formerly an engineer at Decision Engineering Pascagoula Miss. and has three years of engineering experience. He is an active member of ASNE. Mr. Mitchell received his B.S. in naval architecture and marine engineering from the University of New Orleans.

The budget cuts of the 1990s have placed the Navy in a difficult position when trying to maintain neet levels capable of meeting a more dispersed and less defined threat. The cancellation of Seawolf initiated a large effort to define a suhmarine that is capable and affordable with today's shrinking budget. Manv European countries have turned to air independent (AIP), non-nuclear propulsion systems as a way of increasing the effectiveness of their fleets when compared to their current diesel/electric bouts. Bv evaluating and comparing two AIP and one hybrid propulsion systems to current nuclear capabilities, we can help define options for the next generation submarine. This paper attempts to provide design and cost information which can be used in conjunction with mission profiles to determine the best system for the desired job. Tomorrow's submarine will perform a variety of missions. Most all can be handled well bv nuclear submarines, but at what cost? These performance/cost tradeoffs are the subject of this paper.

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MEDIUM-SPEED DIESEL PROPULSION REDUCTION GEARING

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NAVAL ENGINEERS JOURNAL 1994年第3期106卷 29-40页

作者： PHINNEY, JM The Author:is the senior application specialist for the enclosed drive group of the Philadelphia Gear Corporation where his responsibilities include conceptual design and quotation of sophisticated equipment in the marine propulsion special products industrial gear products and high speed products areas. Prior to joining Philadelphia Gear Mr. Phinney's career included positions as Engineering Supervisor at Newport News Shipbuilding Director of Product Engineering for SKF Industries Manager of Engineering for Propulsion Systems Inc and Chief of Design Engineering for High Speed and Marine Drives at the Falk Corporation. The scope of his marine experience includes management design of propulsion equipment and logistic support for military and commercial vessels ranging from fishing vessels to aircraft carriers. Mr. Phinney is a graduate of Antioch College earning his BSME in 1963. A member of ASNE since 1985 Mr. Phinney is a past member of the National Council representing the mid-Atlantic region. He is active in the Delaware Valley Section where he heads the Awards Committee and previously served as the section Chairman Vice Chairman and Program Committee head. He has also been active in other engineering societies with several papers to his credit.

Current interest in medium speed diesel propulsion for maritime vessels is driving a third generation of reduction gear designs. The first generation nourished in the 1930s and looked remarkably like those proposed today. However, by comparison, they were designed with low power density;used lightly loaded gear teeth and bearings;had to cope with poorly filtered and blended lubricants;used relatively inaccurate manufacturing techniques, and were based on inaccurate analysis of operating conditions. The second generation, starting in the late 1960s and continuing through 1980, had the benefit of the rational AGMA gear design method, Raimondi and Boyd's work on bearing design, and sophisticated techniques for alignment and vibratory analysis. Power and loading levels increased and many variations of equipment were tried: reversing engines, reversing gears, and reversing propellers. Individually, each was successful and we now have the benefit of two decades of operating experience for this design generation. This paper will explore the design principles of the gear/engine/propeller/auxiliary equipment package to define the guiding parameters for the third generation based upon the lessons provided by the experience gained in the two previous generations.

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Modeling crystallographic anisotropy in interfacial sliding phenomenon in nanoindentation of nanoscale Cu/Nb accumulated rolling bonding (ARB) multilayered materials

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AIP Conference Proceedings 2023年第1期2594卷

作者： A. S. Budiman R. Sahay F. E. Gunawan C. Harito H. Gunawan I. Radchenko E. Navarro S. Escoubas T. Cornelius O. Thomas N. Raghavan Industrial Engineering Department BINUS Graduate Program – Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia Xtreme Materials Lab Engineering Product Development Singapore University of Technology and Design (SUTD) Singapore Industrial Engineering Department Faculty of Engineering Bina Nusantara University Jakarta Indonesia 11480 Center for Advancing Materials Performance from the Nanoscale (CAMP-nano) State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University (XJTU) Xi'an China Aix-Marseille Université CNRS IM2NP UMR 7334 Marseille France

Nanoindentation is widely used to investigate mechanical properties of materials at small scales. In this work, owing to the presence of contrasting interfaces along rolling (RD) and transverse direction (TD), a 16 nm accumulative roll bonding (ARB) Cu/Nb nanolaminate as a test material due to its crystallographic anisotropy was used. Nanoindentation was performed and then Scanning Probe Microscopy (SPM) data was conducted to measure the pile-up height along RD and TD in the nanoscale Cu/Nb multilayered materials. It was found that the 16 nm Cu/Nb ARB nanolayered material along RD showed higher surface pile-up than TD attributed the observation to the variation in the Cu/Nb interface plasticity along RD and TD. Further, a comparation and validation of experimental indentation data by performing 2D axisymmetric Finite Element Analysis (FEA) indicated that the simulation compares well with the experimentally generated load-displacement curves, while qualitative agreement was obtained with the pileup data. It is believed that the characterization of surface pile-up is very important for enabling the nanoscale Cu/Nb ARB nanolaminates as the novel stretchable/flexible metallic conductor materials (with emerging applications such as e-skins, human-computer interaction, and soft robotics) that may prove crucial for the global green and sustainability efforts (soft robots for collecting plastic trashes in ocean).

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Back Cover, Volume 2, Number 3, July 2023

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Droplet 2023年第3期2卷

作者： Izumi Hashimoto Toshihisa Osaki Hirotaka Sugiura Hisatoshi Mimura Sho Takamori Norihisa Miki Shoji Takeuchi Artificial Cell Membrane Systems Group Kanagawa Institute of Industrial Science and Technology Kanagawa Japan Department of Mechanical Engineering Keio University Kanagawa Japan Institute of Industrial Science The University of Tokyo Tokyo Japan Graduate School of Information Science and Technology The University of Tokyo Tokyo Japan

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Correction: A review of Gum Metal: Developments over the years and new perspectives

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Journal of Materials Research 2023年第1期38卷 265-265页

作者： da Silva, Murillo Romero Plaine, Athos Henrique Pinotti, Vitor Eduardo Mazzer, Eric Marchezini Bolfarini, Claudemiro School of Metallurgical Industrial Engineering of Volta Redonda Federal Fluminense University Volta Redonda Brazil Department of Mechanical Engineering State University of Santa Catarina - UDESC Joinville Brazil Graduate Program in Materials Science and Engineering Federal University of São Carlos São Carlos Brazil Department of Metallurgical and Materials Engineering Federal University of Minas Gerais Belo Horizonte Brazil Department of Materials Engineering Federal University of São Carlos São Carlos Brazil

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