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Biological responses of fibroblasts and osteoblasts on modified bioactive titanium implant surfaces

Clinical Oral Implants Research 2018年第S17期29卷

作者： Beatriz Ferreira Mariana Cruz Gabriella Peñarrieta-Juanito Joana Marques Filipe Silva João Caramês Júlio Souza Ricardo Magini Mafalda Costa Georgina Miranda António Mata Faculty of Dental Medicine Universidade de Lisboa Portugal Center for Research on Dental Implants Post-graduate program in dentistry (PPGO) School of Dentistry Federal University of Santa Catarina (UFSC) Brazil Oral Biology and Biochemistry Research Group LIBPhys Faculty of Dental Medicine University of Lisbon Portugal Center for Microelectromechanical Systems (CMEMS) Dept. of Mechanical Engineering University of Minho Portugal Bone Physiology Research Group LIBPhys Faculty of Dental Medicine University of Lisbon Portugal Center for Research on Dental Implants Post-graduate program in dentistry (PPGO) School of Dentistry Federal University of Santa Catarina (UFSC) Portugal

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Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia

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Cell stem cell 2025年

作者： Maria Sirenko Soobeom Lee Zhengxi Sun Ronan Chaligne Sanam Loghavi Georgios Asimomitis Charlotte K Brierley Elsa Bernard Sheng F Cai Robert M Myers Bettina Nadorp Junya Sango Morgan Lallo Max F Levine Dylan Domenico Juan E Arango Ossa Juan S Medina-Martinez Kamal Menghrajani Audrey Lasry Alice S Mims Helee Desai Andrea Laganson Chris Famulare Minal Patel Gerard Lozanski Kelly L Bolton Aaron D Viny Mikhail Roshal Ross L Levine Eirini P Papapetrou Eytan M Stein Dan A Landau Ann-Kathrin Eisfeld Iannis Aifantis Elli Papaemmanuil Department of Pathology New York University Grossman School of Medicine New York NY USA Laura and Isaac Perlmutter Cancer Center New York University Grossman School of Medicine New York NY USA Louis V. Gerstner Jr. Graduate School of Biomedical Sciences Memorial Sloan Kettering Cancer Center New York NY USA Computational Oncology Service Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA. Department of Biology New York University New York NY USA. Laura and Isaac Perlmutter Cancer Center New York University Grossman School of Medicine New York NY USA. Program for Computational and Systems Biology Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY 10065 USA. Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA. Computational Oncology Service Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Biomedical Systems Laboratory Department of Mechanical Engineering National Technical University of Athens Athens Greece. Medical Research Council Weatherall Institute of Molecular Medicine University of Oxford Oxford UK NIHR Biomedical Research Centre University of Oxford Oxford UK. Leukemia Service Department of Medicine Center for Hematologic Malignancies Memorial Sloan Kettering Cancer Center New York NY USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY USA. Tri-Institutional MD-PhD Program Weill Cornell Medicine Rockefeller University Memorial Sloan Kettering Cancer Center New York NY USA. Division of Precision Medicine Department of Medicine New York University School of Medicine New York NY USA. Department of Oncological Sciences Tisch Cancer Institute Center for Advancement of Blood Cancer Therapies Icahn School of Medicine at Mount Sinai New York NY USA. Vilcek Institute of Graduate Biomedical Sciences NYU Grossman School of Medicine N

Isocitrate dehydrogenase 1/2 (IDH) mutations are early initiating events in acute myeloid leukemia (AML). The complex clonal architecture and cellular heterogeneity in IDH-mutant AML underlies the heterogeneous clinical presentation and outcomes. Integrating single-cell genotyping and transcriptomics, we demonstrate a stem-like and inflammatory phenotype of IDH-mutant AML and identify clone-specific programs associated with NPM1, NRAS, and SRSF2 co-mutations. Furthermore, these clones had distinct responses to treatment with combination IDH inhibitors and chemotherapy, including elimination, reconstitution of myeloid differentiation, or retention within progenitor populations. At relapse after IDH inhibitor monotherapy, we identify upregulated stemness, inflammation, mitochondrial metabolism, and anti-apoptotic factors, as well as downregulated major histocompatibility complex (MHC) class II antigen presentation. At the pre-leukemic stage, we observe upregulation of IDH2-associated pathways, including inflammation. We deliver a detailed phenotyping of IDH-mutant AML and a framework for dissecting contributions of recurrently mutated genes in AML at diagnosis and following therapy, with implications for precision medicine.

关键词： IDH inhibitors IDH1/2 mutations acute myeloid leukemia cellular hierarchy clonal architecture clonal evolution relapse single-cell transcriptomics targeted therapy treatment resistance

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Author Correction: Effect of de novo transcriptome assembly on transcript quantification

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Scientific reports 2019年第1期9卷 18041页

作者： Ping-Han Hsieh Yen-Jen Oyang Chien-Yu Chen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei 10617 Taiwan. Department of Computer Science and Information Engineering National Taiwan University Taipei 10617 Taiwan. Department of Bio-Industrial Mechatronics Engineering National Taiwan University Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw. Genome and Systems Biology Program National Taiwan University and Academia sinica Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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The effect of ZnO addition against crystallinity and water absorption capacity of biofoam based cassava starch reinforced bacterial cellulose

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AIP Conference Proceedings 2019年第1期2120卷

作者： Moh. Astono Basuki Heru Suryanto Aisyah Larasati Poppy Puspitasari Mujiono 1Master Program of Mechanical Engineering Graduate School Universitas Negeri Malang Jl. Semarang 5 Malang East Java Indonesia 2Centre of Advanced Materials for Renewable Energy Universitas Negeri Malang. Jl. Semarang 5 Malang East Java Indonesia 3Department of Mechanical Engineering Faculty of Engineering Universitas Negeri Malang. Jl. Semarang 5 Malang East Java Indonesia 4Department of Industrial Technology Universitas Negeri Malang. Jl. Semarang 5 Malang East Java Indonesia

Polystyrene is one type of plastic that is hard to be degraded, because of that, it requires an alternative to reduce polystyrene waste through biofoam. Biofoam which is made of starch is reinforced with bacterial cellulose that has high hydrophilic properties. This study aims to know the effect of ZnO addition to crystallinity and water absorption capacity of biofoam based cassava starch reinforced bacterial cellulose. The method used experimental design. Synthesis of biofoam was conducted using baking process method with varied the ZnO content in the biofoam were 0%, 3%, 6%, 9%. The resulted samples were analyzed by X-ray diffraction and water absorption test to determine the effect of ZnO concentration. The results showed that the addition of ZnO variation into biofoam caused the change in diffraction position and intensity. The control variation (0% ZnO) had the highest diffraction peak at the position of 20.88°2θ with an intensity of 68.65 counts, crystallite size of 20.795 nm. After adding ZnO variation of 3%, 6%, 9%, diffraction position and intensity change to be 36.31°2θ and 276.29 counts, 36.26°2θ and 558.81 counts, and 36.31°2θ and 725.78 counts, respectively. The addition of ZnO into biofoam composite decreased water absorption up to 33% compared than the control sample, and the lowest optimum absorption resulted in ZnO concentration of 9% with water absorption value of 0.164 (gH2O/g).

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Experimental investigation on the phenomena around the onset nucleate boiling during the impacting of a droplet on the hot surface

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AIP Conference Proceedings 2016年第1期1737卷

作者： Windy H. Mitrakusuma Deendarlianto Samsul Kamal Indarto M. Nuriyadi 1Graduate Program at Mechanical Engineering Engineering Faculty Gadjah Mada University Jl. Grafika No. 2 Yogyakarta 55281 Indonesia 3Refrigeration and Airconditioning Department Politeknik Negeri Bandung Jl. Gegerkalong Hilir Ds. Ciwaruga Kotak Pos 1234 Bandung Indonesia 2Mechanical and Industrial Department Engineering Faculty Gadjah Mada University Jl. Grafika No. 2 Yogyakarta 55281 Indonesia 4Centre for Energy Studies Gadjah Mada University Sekip K-1A Kampus UGM Yogyakarta 55281 Indonesia

Onset of nucleate boiling of a droplet when impacted onto hot surface was investigated. Three kinds of surfaces, normal stainless steel (NSS), stainless steel with TiO2 coating (UVN), and stainless steel with TiO2 coating and radiated by ultraviolet ray were employed to examine the effect of wettability. The droplet size was 2.4 mm diameter, and dropped under different We number. The image is generated by high speed camera with the frame speed of 1000 fps. The boiling conditions are identified as natural convection, nucleate boiling, critical heat flux, transition, and film boiling. In the present report, the discussion will be focused on the beginning of nucleate boiling on the droplet. Nucleate boiling occurs when bubbles are generated. These bubbles are probably caused by nucleation on the impurities within the liquid rather than at nucleation sites on the heated surface because the bubbles appear to be in the bulk of the liquid instead of at the liquid-solid interface. In addition, the smaller the contact angle, the fastest the boiling.

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High accuracy springback simulation by using material model considering the SD effect

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Journal of Physics: Conference Series 2018年第1期1063卷

作者： Nobuyasu Noma Koji Hashimoto Taiki Maeda Toshihiko Kuwabara Advanced Engineering Development Centre UNIPRES CORPOLATION 3-19-1 Shin-Yokohama Kohoku-ku Yokohama-shi Kanagawa 222-0033 Japan Department of Industrial Technology and Innovation Graduate School of Engineering Tokyo University of Agriculture and Technology 2-24-16 Naka-cho Koganei-shi Tokyo 184-8588 Japan Division of Advanced Mechanical Systems Engineering Institute of Engineering Tokyo University of Agriculture and Technology 2-24-16 Naka-cho Koganei-shi Tokyo 184-8588 Japan

In order to enhance the accuracy of springback simulation, the strength differential (SD) effect, i.e., the difference in flow stress between tension and compression, of a high strength cold-rolled steel sheet with a tensile strength of 980 MPa is measured by means of in-plane tension-compression test apparatus. Bi-axial stress tests are also performed to measure the contour of plastic work of the test material. From those experimental results, the material model which can consider the SD effect is determined. Furthermore, this material model is implemented into commercial FEM code by using user-subroutine function. To check the validity of this model and established FEM analysis system, curvature-hat crush forming experiment is performed. By comparing the experimental result and forming simulation result, the accuracy of the material model which can consider the SD effect is validated. Consequently it is concluded that the use of material model which is capable of reproducing the SD effect is a must to enhance the accuracy of springback simulation.

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A COMPUTER-MODEL FOR SHIPBOARD ENERGY ANALYSIS

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NAVAL ENGINEERS JOURNAL 1984年第5期96卷 33-45页

作者： DETOLLA, JP FLEMING, JR Joseph DeTolla:is a ship systems engineer in the Ship Systems Engineering Division SEA 56D5 at the Naval Sea Systems Command. His career with the Navy started in 1965 at the Philadelphia Naval Shipyard Design Division. In 1971 he transferred to the Naval Ship Engineering Center. He has held positions as a fluid systems design engineer and auxiliary systems design integration engineer. Mr. DeTolla has worked extensively in the synthesis and analysis of total energy systems notably the design development of the FFG-7 class waste heat recovery system. He is NA VSEA's machinery group computer supported design project coordinator and is managing the development of a machinery systems data base load forecasting algorithms and design analysis computer programs. Mr. DeTolla has a bachelor of science degree in mechanical engineering from Drexel University and a master of engineering administration degree from George Washington University. He is a registered professional engineer in the District of Columbia and has written several technical papers on waste heat recovery and energy conservation. Jeffrey Fleming:is a senior project engineer in the Energy R&D Office at the David Taylor Naval Ship R&D Center. In his current position as group leader for the future fleet energy conservation portion of the Navy's energy R&D program he is responsible for the identification and development of advanced components and subsystems which will lead to reductions in the fossil fuel consumption of future ships. Over the past several years he has also directed the development and application of total energy computer analysis techniques for the assessment of conventional and advanced shipboard machinery concepts. Mr. Fleming is a 1971 graduate electrical engineer of Virginia Polytechnic Institute and received his MS in electrical engineering from Johns Hopkins University in 1975. Mr. Fleming has authored various technical publications and was the recipient of the Severn Technical Society's “Best Technical Paper of the Year” award in 1

In support of the Navy's efforts to improve the energy usage of future ships and thereby to reduce fleet operating costs, a large scale computer model has been developed by the David Taylor Naval Ship Research and Development Center (DTNSRDC) to analyze the performance of shipboard energy systems for applications other than nuclear or oil-fired steam propulsion plants. This paper discusses the applications and utility of this computer program as a performance analysis tool for design of ship machinery systems. The program is a simulation model that performs a complete thermodynamic analysis of a user-specified energy system. It offers considerable flexibility in analyzing a variety of propulsion, electrical, and auxiliary plant configurations through a component building block structure. Component subroutines that model the performance of shipboard equipment such as engines, boilers, generators, and compressors are available from the program library. Component subroutines are selected and linked in the program to model the desired machinery plant functional configurations. The operation of the defined shipboard energy system may then be simulated over a user-specified scenario of temperature, time, and load profiles. The program output furnishes information on component operating characteristics and fuel demands, which allows evaluation of the total system performance.

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Performance of the prototype shaftless small scale horizontal wind turbine for electricity generating from industrial exhaust air system

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IOP Conference Series: Earth and Environmental Science 2020年第1期463卷

作者： Wachira Puttichaem Yuttanant Boonyongmaneerat Pakpachong Vadhanasindhu Sompong Putivisutisak Technopreneurship and Innovation Management Program Graduate School Chulalongkorn University Bangkok 10330 Thailand Metallurgy and Materials Science Research Institute (MMRI) Chulalongkorn University Bangkok 10330 Thailand Faculty of Commerce and Accountancy Chulalongkorn Business School Chulalongkorn University Bangkok 10330 Thailand Advanced Computational Fluid Dynamics Research Unit Department of Mechanical Engineering Faculty of Engineering Chulalongkorn University Bangkok 10330 Thailand

Man-made or unnatural wind from the industrial exhaust air system is an alternative wind resource for countries with natural low-speed or intermittent wind such as Thailand. It has strong and consistent wind speed when compared to the natural wind, with velocity about 5 to 10 m/s at a distance of 5 cm from the exhaust air outlet. However, some negative impacts to the exhaust air system performance was observed when a conventional wind turbine was employed. The objective of this research is to feasibility study the practicality of a prototype shaftless small scale horizontal axis wind turbine (SSHWT) to generate electricity from the exhaust air of the industrial exhaust air system. Aerodynamic, blade and generator designs were addressed in this study to maximize energy output and minimize negative impacts to the performance of the original exhaust air system. The performance of SSHWT was tested with a selected industrial fan that is widely used in industrial sections. The results showed that the SSHWT could generate electricity with less negative effect to exhaust air system performance. However, it still needs further improvements caused by the voltage output is too low. By the concept design, this innovative wind turbine is compact, thus needs only small space for installation. This SSHWT has high market potential for low wind speed countries to take advantage of unnatural wind resources which are better in terms of efficiency and economy for sustainable energy development.

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Implementation Method CUSUM To Determine The Accident Prone Areas in Web Based

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Journal of Physics: Conference Series 2018年第1期1114卷

作者： Rozzi Kesuma Dinata Dahlan Abdullah H Hartono Cut Ita Erliana Berliana Kusuma Riasti Akbar Iskandar Ifit Novita Sari Nurmawati Ricardo Freedom Nanuru Lusi Dwi Putri Rosida Tiurma Manurung S. Sriadhi A A Saleh T Astari Muammar Khaddafi Department of Informatics Universitas Malikussaleh Aceh Indonesia Department of Computer Science STMIK IBBI Medan Indonesia Department of Industrial Engineering Universitas Malikussaleh Aceh Indonesia Department of Informatics Universitas Sebelas Maret Surakarta. Indonesia Department of Informatics STMIK AKBA Makassar Indonesia Departement of: Social Science Education Program Post Graduate Program Universitas Kanjuruhan Malang Malang Indonesia Faculty of industry Technique University of 45 Surabaya Indonesia Universitas Kristen Indonesia Maluku Ambon Indonesia Department of Civil Engineering Universitas Lancang Kuning Pekanbaru Indonesia Graduate Program in Scientific Psychology Universitas Kristen Maranatha Indonesia Department of Electrical Engineering Universitas Negeri Medan Indonesia Statistics Financial & Social Sciences Research Group Indonesia Department of Elementary School Teacher Education STKIP Citra Bangsa Aceh Utara Aceh Indonesia Department of Accounting Universitas Malikussaleh Aceh Indonesia

At the Unit Laka Lantas Polres Lhokseumawe determining accident-prone areas on roads in Lhokseumawe still using manual systems. Determination of accident-prone areas are less effective because the police Unit Laka Lantas Polres Lhokseumawe just using the data of the last year and had to repeatedly calculate manually accident-prone areas based on the number of human casualties. In this study the system implementation CUSUM method (Cummulative Summary) to determine the accident-prone areas designed using the web-based programming language PHP. In this system there are three processes to determine areas prone to accidents, the accident rate calculations based on the weighted severity, blacksite calculations using the Z-Score method for determining areas prone to accident blackspots and calculations using the CUSUM method to determine the critical points of an accident. The data used are secondary data obtained from the Police Unit Laka Lantas Polres Lhokseumawe years 2009-2013.

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MERCHANT SHIPS FOR 70S

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NAVAL ENGINEERS JOURNAL 1970年第6期82卷 31-&页

作者： HIGGINS, JA GARVEY, JJ Higgins who is the Chief Office of Advanced Development MarAd is presently responsible for those areas of research and development that have to do with developing new ship design techniques improved shipbuilding methods and systems analysis programs leading to improved marine transportation systems. He has held responsible research positions with Maritime Administration since 1956. His previous experience includes six years at the David Taylor Model Basin sea duty with the Navy during World War II and six years shipyard experience. He is a graduate of the Newport News Shipbuildings and Dry Dock Company Apprentice School has mechanical and industrial engineering degrees from Virginia Polytechnic Institute and has done graduate work in naval architecture at M. I. T. and transportation economics at American University. Garvey a CMX Project Engineer for the Maritime Administration has been with the MarAd Office of Research and Development since 1968. Prior to that he was with the Office of Ship Construction Foster Wheeler Marine Department and the U. S. Navy. He graduated from the U. S. Merchant Marine Academy with a B. S. degree in 1956 and from Fairleigh Dickinson University in 1965 with an M. B. A.

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