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LIVE FIRE TEST AND EVALUATION FOR SHIPS

NAVAL ENGINEERS JOURNAL 1994年第3期106卷 228-245页

作者： BLOOM, JB REESE, RM HOPKINS, TM Joel B. Bloom:is a staff specialist in the Office of the Deputy Director Land and Maritime Programs Test and Evaluation Directorate of the Office of the Secretary of Defense (OSD). He is the OSD action officer for developmental testing including live fire testing for ships submarines underwater weapons and Army direct fire weapons. He is responsible for day-to-day OSD oversight of Navy ship vulnerability and is a member of the crew casualty working group of the Joint Technical Coordinating Group for Munitions Effectiveness. Previously he worked at the Philadelphia Naval Shipyard the Marine Division of the Army Corps of Engineers the David Taylor Model Basin and the Office of Naval Intelligence and on the staff of the Navy's Ship Characteristics and Improvement Board. Mr. Bloom graduated from Virginia Polytechnic Institute with a BS in mechanical engineering (naval architecture and marine engineering). His graduate work was in oceanography and in engineering administration. He is a member of ASNE SNAME the International Test and Evaluation Association the U.S. Naval Institute and the Naval Submarine League and is listed inWho's Who in the East.He is a recent recipient of the Secretary of Defense Meritorious Civilian Service Medal. Dr. Ronald M. Reese:has headed the live fire test and evaluation sea systems team in the operational evaluation division of the Institute for Defense Analyses (IDA) for the past three years. From 1980–1990 he worked at NKF Engineering Inc. in various areas of ship survivability and ship design specializing in ship signature reduction. From 1960–1980 he served in the U.S. Navy as a surface line officer and in various capacities as an Engineering Duty Officer including Naval Ship Engineering Center Ship Design Manager for PHM and Continuing CV Conceptual Design NavSea PMS 378 Program Manager/SUPSHIP Newport News Project Officer forVirginia(CGN-38) class construction and Force Maintenance Officer Commander Naval Surface Force U.S. Atlantic Fleet. He retired from t

Live Fire Test and Evaluation (LFT&E) is a relatively recent addition to the requirements for ship acquisition programs. Ship LFT&E requires a combination of testing and analysis in order to evaluate the vulnerability of a new acquisition ship class to the threat weapons it is likely to encounter in combat. LFT&E supports the ship acquisition process by identifying vulnerability weaknesses early in a development program and enabling timely, well informed decisions regarding ship vulnerability reduction features. This paper discusses the various aspects of ship LFT&E and how they relate to make a positive impact on a ship acquisition program in a timely fashion. It describes a four-element approach to ship LFT&E consisting of (1) component, system, and full-scale ship tests, (2) surrogate tests, (3) damage scenario-based engineering analyses, and (4) a Total Ship Survivability Trial demonstrating the ability of the full-up ship to combat damage and ''fight hurt.''

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Transdermal nanolipoplex simultaneously inhibits subcutaneous melanoma growth and suppresses systemically metastatic melanoma by activating host immunity

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Nanomedicine: Nanotechnology, Biology, and Medicine 2023年 47卷 102628-102628页

作者： Chen, Chia-Hung Weng, Tzu-Han Chuang, Cheng-Hsun Huang, Kai-Yao Huang, Sih-Cheng Chen, Pin-Rong Huang, Hsiao-Hsuan Huang, Ling-Ya Shen, Pei-Chun Chuang, Po-Ya Huang, Hsiao-Yen Wu, Yi-Syuan Chang, Hao-Chiun Weng, Shun-Long Liao, Kuang-Wen Department of Medical Research Hsinchu MacKay Memorial Hospital Hsinchu City30071 Taiwan Dependent of Medical Education MacKay Memorial Hospital Taipei10449 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Industrial Development Graduate Program of College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Medicine MacKay Medical College New Taipei City25245 Taiwan Department of Obstetrics and Gynecology Hsinchu MacKay Memorial Hospital Hsinchu City30071 Taiwan MacKay Junior College of Medicine Nursing and Management Taipei City11260 Taiwan Drug Development and Value Creation Research Center College of Dental Medicine Kaohsiung Medical University School of Dentistry Graduate Institute of Medicine College of Medicine Center for Cancer Research Kaohsiung Medical University Kaohsiung City80708 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Biotechnology and Bioindustry Sciences National Cheng Kung University Tainan City70101 Taiwan Ph.D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan

Benefit for clinical melanoma treatments, the transdermal neoadjuvant therapy could reduce surgery region and increase immunotherapy efficacy. Using lipoplex (Lipo-PEG-PEI-complex, LPPC) encapsulated doxorubicin (DOX) and carrying CpG oligodeoxynucleotide;the transdermally administered nano-liposomal drug complex (LPPC-DOX-CpG) would have high cytotoxicity and immunostimulatory activity to suppress systemic metastasis of melanoma. LPPC-DOX-CpG dramatically suppressed subcutaneous melanoma growth by inducing tumor cell apoptosis and recruiting immune cells into the tumor area. Animal studies further showed that the colonization and growth of spontaneously metastatic melanoma cells in the liver and lung were suppressed by transdermal LPPC-DOX-CpG. Furthermore, NGS analysis revealed IFN-γ and NF-κB pathways were triggered to recruit and activate the antigen-presenting-cells and effecter cells, which could activate the anti-tumor responses as the major mechanism responsible for the therapeutic effect of LPPC-DOX-CpG. Finally, we have successfully proved transdermal LPPC-DOX-CpG as a promising penetrative carrier to activate systemic anti-tumor immunity against subcutaneous and metastatic tumor. © 2022

关键词： Tumors

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U. S. NAVAL ACADEMY'S NEW YARD PATROL CRAFT: FROM CONCEPT TO DELIVERY.

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Naval Engineers Journal 1987年第1期99卷 37-58页

作者： Compton, Roger H. Chatterton, Howard A. Hatchell, Gordon McGrath, Frank K. Roger H:. Compton is a Webb graduate who since 1966 has been a part of the naval architecture faculty at the U.S. Naval Academy. Since accepting the appointment to the Academy he has been instrumental in establishing the ABET accredited major program in naval architecture in the conceptual design and operation of the Naval Academy Hydromechanics Laboratory and in the conceptual design of the 108-ft yard patrol craft. Besides his Naval Academy involvement he serves as an adjunct professor with Virginia Polytechnic Institute in its NAVSEA Institute graduate program at Crystal City. He is an active member of both ASNE and SNAME and has published technical papers with both societies. Howard A. Chatterton:began his career as a Navy coop student at the Boston Naval Shipyard in 1960. He received his bachelor's degree in naval architecture and marine engineering from Massachusetts Institute of Technology in 1966 and his master's degree in 1968. He was employed by the Preliminary Design Division of BuShips in the submarine design and hydrofoil design groups until 1972 when he joined the Coast Guard's Naval Engineering Division. He remained with the Design Branch until 1981 when he accepted a faculty position at the U.S. Naval Academy as the research director for the Academy's hydromechanics laboratory. He has recently returned to Coast Guard Headquarters as the assistant chief Naval Architecture Branch Office of Merchant Marine Safety. Gordon Hatchell:is a naval architect at the Naval Sea Combat Systems Engineering Station Norfolk Virginia in the Combatant Craft Engineering Department. He served as lead-ship YP project engineer from its inception to delivery and continues to serve as project coordinator on follow-up ship procurements. He has worked on other boat procurements as well as serving as weight and stability coordinator. Mr. Hatchell began his engineering career in the Design Division at the Norfolk Naval Shipyard in Portsmouth Virginia after receiving a BS in civil engineering from Virginia Polytec

The design of the new 108-ft yard patrol craft (YPs) for the U. S. Naval Academy is described from its beginnings as a senior midshipman design project, through its preliminary and contract design development at the U. S. Navy's small craft design team headquarters, Naval Sea Combat systems engineering Station, Norfolk, Virginia (NAVSEACOMBAT-SYSENGSTA-Norfolk). During preliminary and contract design the Naval Academy Hydromechanics Laboratory (NAHL) provided experimental data to support NAVSEA-COMBATSYSENGSTA-Norfolk's design analyses in powering, seakeeping, and maneuvering. Several tradeoff studies of interest to patrol craft designers are presented. Major events in the detail design and construction of the first boat are described from both the designer's and the shipbuilder's points of view. The launching, builder's and sea trials of the first boat are described.

关键词： NAVAL VESSELS

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Changing the public perception of human embryology ( vol 25, pg 1717, 2023)

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NATURE CELL BIOLOGY 2023年第12期25卷 1884-1884页

作者： Rivron, Nicolas C. Martinez-Arias, Alfonso Sermon, Karen Mummery, Christine Scholer, Hans R. Wells, James Nichols, Jenny Hadjantonakis, Anna-Katerina Lancaster, Madeline A. Moris, Naomi Fu, Jianping Sturmey, Roger G. Niakan, Kathy Rossant, Janet Kato, Kazuto Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) Vienna BioCenter (VBC) Vienna Austria Systems Bioengineering MELIS Universidad Pompeu Fabra and Catalan Institution for Research and Advanced Studies (ICREA) Barcelona Spain Research Group Reproduction and Genetics Vrije Universiteit Brussel Brussels Belgium European Society for Human Reproduction and Embryology (ESHRE) Strombeek-Bever Belgium Leiden University Medical Center Leiden the Netherlands Max Planck Institute for Molecular Biomedicine Münster Germany Center for Stem Cell and Organoid Medicine Cincinnati Children’s Hospital Medical Center Cincinnati OH USA Division of Developmental Biology Cincinnati Children’s Hospital Medical Center Cincinnati OH USA MRC Human Genetics Unit Institute of Genetics and Cancer The University of Edinburgh Crewe Road Edinburgh UK Developmental Biology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA MRC Laboratory of Molecular Biology Cambridge UK The Francis Crick Institute London UK Department of Mechanical Engineering University of Michigan Ann Arbor MI USA Department of Biomedical Engineering University of Michigan Ann Arbor MI USA Department of Cell & Developmental Biology University of Michigan Medical School Ann Arbor MI USA Biomedical Institute for Multimorbidity Hull York Medical School University of Hull Hull UK Cambridge Reproduction University of Cambridge Cambridge UK The Centre for Trophoblast Research Department of Physiology Development and Neuroscience University of Cambridge Cambridge UK Human Embryo and Stem Cell Laboratory The Francis Crick Institute London UK Wellcome Trust–Medical Research Council Stem Cell Institute University of Cambridge Jeffrey Cheah Biomedical Centre Cambridge UK Epigenetics Programme Babraham Institute Cambridge UK The Hospital for Sick Children Toronto ON Canada Department of Biomedical Ethics and Public Policy Graduate School of Medicin

Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific advances require meticulous experimental work and a refined ethical framework, but also sensible ... 详细信息

关键词： Embryology Embryonic stem cells

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Study of cultivation and growth rate kinetic for mixed cultures of local microalgae as third generation (G-3) bioethanol feedstock in thin layer photobioreactor

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Journal of Physics: Conference Series 2018年第1期1022卷

作者： Wahyu Prihastuti Yuarrina Yano Surya Pradana Arief Budiman Akmal Irfan Majid Indarto Eko Agus Suyono Master Program of Systems Engineering Universitas Gadjah Mada Jalan Teknika Utara 3 Yogyakarta Indonesia Chemical Engineering Department Universitas Gadjah Mada Jalan Grafika No. 2 Yogyakarta Indonesia Center for Energy Studies Universitas Gadjah Mada Sekip K1a Yogyakarta Indonesia Mechanical and Industrial Engineering Department Universitas Gadjah Mada Jalan Grafika No. 2 Yogyakarta Indonesia Faculty of Biology Universitas Gadjah Mada Jalan Teknika Selatan Yogyakarta Indonesia

The increasing use of fossil fuels causes the depletion in supply and contributes to climate change by GHG emissions into the atmosphere. Microalgae indicate as renewable and sustainable energy sources as they have a high potential for producing large amounts of biomass for third-generation biofuels (bioethanol and biodiesel) feedstock. However, there are several parameters which should be considered for microalgae cultivation, such as environmental conditions, medium composition and microalgae species. The aim of this research was to study cultivation of mixed microalgae cultures (Glagah consortium and Arthrospira maxima) in a thin layer photobioreactor. Farmpion medium, Bold's Basal Medium (BBM) and Thoriq Eko Arief (TEA) medium were investigated as cultivation medium for bioethanol feedstock for 7 days. The results showed that the highest dry weight concentration of microalgae was in Farmpion medium (0.35 mg/ml) and the highest carbohydrate concentration of microalgae was in BBM (0.14 mg/ml). Thus, the optimum medium of microalgae cultivation for bioethanol feedstock was BBM because of the highest carbohydrate-dry weight ratio (0.88). In addition, mathematical approach by using Contois model was used to find out the growth rate of microalgae cultivation in each medium.

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SHIP ENERGY-CONSERVATION ASSIST TEAM (SECAT)

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NAVAL ENGINEERS JOURNAL 1984年第2期96卷 47-58页

作者： DANGEL, R BRICE, AE The Authors A. Edward Brice was born and educated in Scotland where he graduated from the James Watt Memorial College and Paisley Technical College. His earliest marine engineering experience was obtained at Scotts's Shipbuilding and Engineering Company Limited from 1952 to 1959 where he was involved in the production and design of steam and diesel machinery plants for both Naval and commercial ships. During a five year stay in Canada Mr. Brice gained diversified experience in industries other than marine such as petrochemical plants and steel mills. He moved to the U.S. in 1964 where he was the design supervisor in charge of marine engineering at NASSCO covering new construction for American President Lines AFS type ships for the U.S. Navy Project Mohole Car Ferries for the State of Washington and 17 LST's for the U.S. Navy. During the contract definition phase of the DD-963 Mr. Brice authored several portions of the technical proposal while employed by Litton industries. He was also responsible for the system and detail design including the technical management of sub-contracts for the steam propulsion plant for the LHA 1 Class ships. Mr. Brice has been active in the Washington area for the last ten years performing marine engineering projects for the U.S. Navy. His principal interest since 1974 has been in shipboard energy conservation. He assisted in the development of the NavySTMSYS program and later in the operational verification aboard FF-1074. Mr. Brice has conducted four SECA T visits aboard ships with 1200 PSI steam plants and has recently completed an at-sea visit aboard on AOR with a 600 PSI steam plant. Richard Dangel was bom in New York City. He received his Bachelor's degree from the Sloan School of Industrial Management of the Massachusetts Institute of Technology in 1955. He has also completed graduate work for a Masters in Engineering Administration at George Washington University. Since graduation he has spent 11 years in private industry with companies in the DOD engineering research

The Ship Energy Conservation Assist Team (SECAT) program was initiated in Fiscal Year (FY) 82 by the Naval Sea systems Command (NAVSEA) to demonstrate and introduce individual Ship Commands to known energy conserving techniques without adding equipment complexity or additional maintenance burden. The principal objective is to provide each ship with an energy consumption, coupled with recommended energy conservation strategies. The technique involves both in-port and underway monitoring and introduction of energy efficient machinery plant alignments, fuel consumption curve generation, and most efficient speed curves. The program has completed visits on six combatants and enjoys the support of both the Commander, Naval Surface Forces, U.S. Atlantic Fleet (COMNAVSURFLANT) and the Commander-in-Chief, U.S. Atlantic Fleet (CINCLANT). Plans are to perform SECAT on additional DDG 2 and FF 1052/1078 Class ships and initiate SECAT on additional ship types in FY 83.

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Windows computer laboratory as a tutorial for undergraduate electromagnetics

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Computer Applications in engineering Education 1995年第3期3卷 183-183页

作者： McCulloch, J. Keddy, W.A. Stuchly, M.A. University of Victoria Department of Electrical and Computer Engineering University of Victoria Victoria British Columbia Canada Janet McCulloch:is a native of Toronto Canada where she briefly attended both York University and the University of Toronto before she set off on a year-long adventure through the Middle East and North Africa. When she returned to Canada she relocated to California. She spent a number of years living both in Los Angeles and coastal Northern California interspersed with several extended trips through the United States Mexico and Central America. Ms. McCulloch moved to Victoria British Columbia in 1989 and a year later registered in the cooperative education program in Electrical Engineering at the University of Victoria. She is presently in the fifth and final year of the program and has her sights set on graduate school. Besides the work described in this article she has been very much involved in the use of technology to assist in the delivery of curriculum at the senior secondary level. She lives on a country property a half-hour from the University with her husband her horse and three cats. W. Alfred Keddy:is an applications programmer/analyst for the Department of Electrical and Computer Engineering at the University of Victoria. He received a BEng (1988) in Electrical Engineering and an MASc (1994) from the University of Victoria. His research interests include distributed systems image processing local area networks VLSI and DSP system design for computation and communication and human–computer interface design. Maria A. Stuchly:received an MSc in Electrical Engineering in 1962 from Warsaw Technical University and a PhD in Electrical Engineering from the Polish Academy of Sciences in 1970. Between the years of 1962 and 1970 she was with the Warsaw Technical University an Institute of the Polish Academy of Sciences. After immigrating to Canada during 1970 her first position was with the University of Manitoba. In 1976 she became employed by the Bureau of Radi

Contents and implementation of a computer laboratory for undergraduate electromagnetics are described. The laboratory consists of four 3-hour sessions covering vector calculus, Maxwell's equations (integral and differential forms), wave propagation in materials, and wave behavior at planar interfaces. Each session contains theory (in the Help file), animations (where relevant) and a quiz. The program runs on IBM compatible 486-based PCs in a Windows environment and uses the Borland C ++ 4.0 compiler.

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A SUBMARINE CONTROL-SYSTEM TEST VEHICLE

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NAVAL ENGINEERS JOURNAL 1980年第2期92卷 148-155页

作者： SEJD, JJ WATKINSON, KW HILL, WF Mr. James J. Sejd received his B.S. degree in Civil Engineering from Case Western Reserve University and has since undergone considerable graduate study at both The George Washington and American Universities. He served almost four years in the U.S. Navy as a Naval Aviator and enjoys the unique distinction of being qualified in both Heavier- and Lighter-than-Air aircraft. Early in his career he was employed at the Navy's Bureau of Ships in the capacity of a Structural Designer and Structural Research Monitor. In 1966 he joined the Staff of the Center for Naval Analyses where he was involved in the mathematical modeling of ships and aircraft and in economic “trade-off‘ analysis. In 1970. he went to the Naval Ship Engineering Center as an Operations Research Analyst in the Ship Design and Development Division. At the present time he is employed as a Program Manager for the Naval Sea Systems Command Ship Design Research and Development Office. A member of ASNE since 1973 he also is a member of the Association of Scientists and Engineers at NAVSEA the Operations Research Society of America and the Lighter-Than-Air Society. Mr. Kenneth W. Watkinson received both is B.S. and M.S. degrees in Engineering Science from Florida State University in 1970 and 1971 respectively. Since graduation he has been employed at the Naval Coastal Systems Center (NCSC). Panama City. Fla. where he is primarily involved in the investigation of the stability and control of underwater vehicles. For the past four years he has been the Task Leader and Principal Investigator for the NCSC portion of the Advanced Submarine Control Program involved in developing control design methods and the instrumentation system for the Submarine Control System Test Vehicle. Mr. William F. Hill is currently the ASCOP Program Manager at Lockheed Missiles & Space Company (LMSC) Inc. where he has the overall responsibility for design and construction of the Control System Test Vehicle (CSTV). He entered the aircraft industry in England as an Apprentice w

As part of the Advanced Submarine Control program (ASCOP), the Naval Sea systems Command has developed an open water Submarine Control System Test Vehicle (CSTV). This vehicle is a 1/12 scale model of an SSN 688 Class Submarine, with provisions for easy geometric changes. Such changes include alternate Sail size and location, the addition of parallel middle-bodies, alternative tail sections, and alternative control configurations. A self-contained instrumentation and control system provides the capability for “on-board” recording of all relevant Submarine-state variables, over the entire speed and depth range, to a degree of data accuracy exceeding any known system. With the means thus available to correlate measured vehicle hydrodynamics with selected maneuvers, conditions, and changes in hull geometry and control surface configuration, modern mathematical techniques for improving submarine equations of motion can be employed to permit dramatic design enhancements in both safety and performance. This paper provides the rationale and history of the development of this vehicle, a description of the instrumentation and control package, and a description of the vehicle itself.

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Modeling of the Plasma Electrode Bias in the Negative Ion Sources with 1D PIC Method

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AIP Conference Proceedings 2009年第1期1097卷

作者： D. Matsushita S. Kuppel A. Hatayama A. Fukano M. Bacal Graduate School of Science and Technology Keio University 3‐14‐1 Hiyoshi Kouhoku‐ku Yokohama 223‐8522 Japan Mechanical Systems Engineering Cource Monozukuri Department Tokyo Metropolitan College of Industrial Technology Higashioi Shinagawa Tokyo 140‐0011 Japan Laboratoire de Physique et Technologie des Plasmas UMR 7648 du CNRS Ecole Polytechnique 91128 Palaiseau France

The effect of the plasma electrode bias voltage in the negative ion sources is modeled and investigated with one‐dimensional plasma simulation. A particle‐in‐cell (PIC) method is applied to simulate the motion of charged particles in their self‐consistent electric field. In the simulation, the electron current density is fixed to produce the bias voltage. The tendency of current‐voltage characteristics obtained in the simulation show agreement with the one obtained from a simple probe theory. In addition, the H− ion density peak appears at the bias voltage close to the plasma potential as observed in the experiment. The physical mechanism of this peak H− ion density is discussed.

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Numerical simulation of coalescence and break-up of drops in shear flow based on the meshless localized radial basis function method

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Journal of Physics: Conference Series 2021年第1期1825卷

作者： Pranowo Agung Tri Wijayanta Yoshinori Itaya Informatics Department Faculty of Industrial Technology Universitas Atma Jaya Yogyakarta Jl. Babarsari 43 Yogyakarta 55281 Indonesia Research Group of Sustainable Thermofluids Engineering Faculty Universitas Sebelas Maret Jl. Ir. Sutami 36A Kentingan Surakarta 57126 Indonesia Mechanical Engineering Department Faculty of Engineering Universitas Sebelas Maret Jl. Ir. Sutami 36A Kentingan Surakarta 57126 Indonesia Environmental and Renewable Energy Systems Division Graduate School of Engineering Gifu University 1-1 Yanagido Gifu-shi Gifu 501-1193 Japan

In the present paper, the meshless localized radial basis function (RBF) is proposed for simulating of two-phase incompressible viscous flow. Due to the velocity of the shear flow is very low, the fluid can modeled by Stokes equations. For more convenience the primitive variables, i.e., pressure and velocity components of the Stokes equations are transformed into stream function formulation. The interface of the fluid system is modeled by using Cahn-Hilliard equation. The spatial terms of the governing equations are discretized numerically by using the RBF method. The temporal term is integrated by using fully implicit Euler method. The nonlinear terms of Cahn-Hilliard equation is linearized using the Picard iteration. The proposed method is applied to simulate coalescence and break-up of drops in shear flow. The numerical results show that the deformation of the interface can be modeled without any difficulties.

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