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Cytocompatible magnetostrictive microstructures for nano- A nd microparticle manipulation on linear strain response piezoelectrics

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Multifunctional Materials 2018年第1期1卷

作者： Xiao, Zhuyun Khojah, Reem Chooljian, Marc Conte, Roberto Lo Schneider, Joseph D. Fitzell, Kevin Chopdekar, Rajesh V. Wang, Yilian Scholl, Andreas Chang, Jane Carman, Gregory P. Bokor, Jeffrey Carlo, Dino Di Candler, Rob N. Department of Electrical and Computer Engineering University of California Los Angeles United States Department of Bioengineering University of California Los Angeles United States University of California Berkeley UCSF Graduate Program in Bioengineering Berkeley United States Department of Electrical Engineering and Computer Sciences University of California Berkeley United States Department of Mechanical and Aerospace Engineering University of California Los Angeles United States Department of Chemical and Biomolecular Engineering University of California Los Angeles United States Advanced Light Source Lawrence Berkeley National Laboratory Berkeley United States California Nanosystems Institute Los Angeles United States

In this work, we investigate polycrystalline Ni and FeGamagnetostrictivemicrostructures on prepoled (011)-cut single crystal [Pb(Mg1/3Nb2/3)O3]1-x-[PbTiO3]x (PMN-PT, x ≈ 0.31) with linear strain profile versus applied electric field. Magnetostrictive microstructure arrays with various geometries are patterned on PMN-PT. Functionalizedmagnetic beads are trapped by localized stray fields originating fromthe microstructures. With an applied electric field, themagnetic domains are actuated, inducing the motion of the coupled particles with sub-micrometer precision. This work shows promise of using energy-efficient electric-field-controlled magnetostrictivemicro- A nd nanostructures formanipulatingmagnetic beads via a linear strain response. The work also demonstrates the viability of cells suspended in solution on these structures when subject to applied electric fields, proving the cytocompatibility of the platform for live cell sorting applications. © 2018 IOP Publishing Ltd.

关键词： Electric fields

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A new model for simulating heat, air and moisture transport in porous building materials

arXiv

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arXiv 2019年

作者： Berger, Julien Dutykh, Denys Mendes, Nathan Rysbaiuly, Bolatbek Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS LOCIE Chambéry73000 France LOCIE UMR 5271 CNRS Université Savoie Mont Blanc Campus Scientifique Le Bourget-du-Lac CedexF-73376 France Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS LAMA Chambéry73000 France LAMA UMR 5127 CNRS Université Savoie Mont Blanc Campus Scientifique Le Bourget-du-Lac CedexF-73376 France Thermal Systems Laboratory Mechanical Engineering Graduate Program Pontifical Catholic University of Paraná Rua Imaculada Conceição 1155 Curitiba - ParanáCEP: 80215-901 Brazil International Information Technology University Manas Str. 34/1 Almaty Kazakhstan

This work presents a detailed mathematical model combined with an innovative efficient numerical model to predict heat, air and moisture transfer through porous building materials. The model considers the transient effects of air transport and its impact on the heat and moisture transfer. The achievement of the mathematical model is detailed in the continuity of Luikov's work. A system composed of two advection-diffusion differential equations plus one exclusively diffusion equation is derived. The main issue to take into account the transient air transfer arises in the very small characteristic time of the transfer, implying very fine discretisation. To circumvent these difficulties, the numerical model is based on the Du Fort-Frankel explicit and unconditionally stable scheme for the exclusively diffusion equation. It is combined with a two-step Runge-Kutta scheme in time with the Scharfetter-Gummel numerical scheme in space for the coupled advection-diffusion equations. At the end, the numerical model enables to relax the stability condition, and, therefore, to save important computational efforts. A validation case is considered to evaluate the efficiency of the model for a nonlinear problem. Results highlight a very accurate solution computed about 16 times faster than standard approaches. After this numerical validation, the reliability of the mathematical model is evaluated by comparing the numerical predictions to experimental observations. The latter is measured within a multi-layered wall submitted to a sudden increase of vapor pressure on the inner side and driven climate boundary conditions on the outer side. A very satisfactory agreement is noted between the numerical predictions and experimental observations indicating an overall good reliability of the proposed model. Copyright © 2019, The Authors. All rights reserved.

关键词： Numerical models

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Author Correction: Effect of de novo transcriptome assembly on transcript quantification

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Scientific reports 2019年第1期9卷 18041页

作者： Ping-Han Hsieh Yen-Jen Oyang Chien-Yu Chen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei 10617 Taiwan. Department of Computer Science and Information Engineering National Taiwan University Taipei 10617 Taiwan. Department of Bio-Industrial Mechatronics Engineering National Taiwan University Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw. Genome and Systems Biology Program National Taiwan University and Academia sinica Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Evaluation of Interoperability between Automation systems using Multi-criteria Methods

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Procedia Manufacturing 2017年 11卷 1837-1845页

作者： Saturno, Maicon Ramos, Luiz Felipe Pierin Polato, Fabrício Deschamps, Fernando de Freitas Rocha Loures, Eduardo Graduate Program in Industrial and Systems Engineering (PPGEPS) Polytechnic School Pontifical Catholic University of Parana (PUCPR) Rua Imaculada Conceição Curitiba 1155 Paraná Brazil Dominus – Automação Sistemas e Acionamentos Avenida Manoel Ribas 8.120 Curitiba Paraná Brazil Department of Mechanical Engineering (DEMEC) Federal University of Paraná (UFPR) Rua Coronel Francisco Heráclito dos Santos Curitiba 230 Paraná Brazil Department of Electro-tecnology (DAEL) Federal University of Technology – Paraná (UTFPR) Avenida Sete de Setembro Curitiba 3033 Paraná Brazil

The diagnosis of automation systems in an existing production system through the analysis of the interoperability level between its components represents the first step in its evaluation for improving it towards alignment with Industry 4.0. The analysis of the level of interoperability finds in the multi-criteria decision making methods an auxiliary tool to evaluate and classify the solution. This work uses the AHP method for this evaluation, drawing criteria from the literature and expert experience. The application of the method is illustrated, showing that it can direct investment decisions. © 2017 The Authors

关键词： automation systems Automation technology (AT) diagnosis interoperability multi-criteria methods

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Lipid Bilayer Array: Rapid and Resilient Detection of Toxin Pore Formation Using a Lipid Bilayer Array (Small 49/2020)

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Small 2020年第49期16卷 2070268-2070268页

作者： Yoshihisa Ito Toshihisa Osaki Koki Kamiya Tetsuya Yamada Norihisa Miki Shoji Takeuchi Artificial Cell Membrane Systems Group Kanagawa Institute of Industrial Science and Technology 3‐2‐1 Sakado Takatsu‐ku Kawasaki Kanagawa 213‐0012 Japan Center for Multidisciplinary and Design Science School of Integrated Design Engineering Keio University 3‐14‐1 Hiyoshi Kohoku‐ku Yokohama Kanagawa 223‐8522 Japan Institute of Industrial Science The University of Tokyo 4‐6‐1 Komaba Meguro‐ku Tokyo 153‐8505 Japan Department of Mechanical Engineering Faculty of Science and Technology Keio University 3‐14‐1 Hiyoshi Kohoku‐ku Yokohama Kanagawa 223‐8522 Japan Department of Mechano‐Informatics Graduate School of Information Science and Technology The University of Tokyo 7‐3‐1 Hongo Bunkyo‐ku Tokyo 113–8656 Japan

In article number 2005550, Shoji Takeuchi and co‐workers present a parallel lipid bilayer array with integrating series resistors for sensitive and resilient detection of toxin pore formation, illustrated by electrical signatures. This array will help in understanding toxic activity and development of diagnosis, treatment, and control of bacterial infections in medicine.

关键词： electrophysiological analysis planar bilayer lipid membranes pore‐forming proteins stochastic process

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The effect of ZnO addition against crystallinity and water absorption capacity of biofoam based cassava starch reinforced bacterial cellulose

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AIP Conference Proceedings 2019年第1期2120卷

作者： Moh. Astono Basuki Heru Suryanto Aisyah Larasati Poppy Puspitasari Mujiono 1Master Program of Mechanical Engineering Graduate School Universitas Negeri Malang Jl. Semarang 5 Malang East Java Indonesia 2Centre of Advanced Materials for Renewable Energy Universitas Negeri Malang. Jl. Semarang 5 Malang East Java Indonesia 3Department of Mechanical Engineering Faculty of Engineering Universitas Negeri Malang. Jl. Semarang 5 Malang East Java Indonesia 4Department of Industrial Technology Universitas Negeri Malang. Jl. Semarang 5 Malang East Java Indonesia

Polystyrene is one type of plastic that is hard to be degraded, because of that, it requires an alternative to reduce polystyrene waste through biofoam. Biofoam which is made of starch is reinforced with bacterial cellulose that has high hydrophilic properties. This study aims to know the effect of ZnO addition to crystallinity and water absorption capacity of biofoam based cassava starch reinforced bacterial cellulose. The method used experimental design. Synthesis of biofoam was conducted using baking process method with varied the ZnO content in the biofoam were 0%, 3%, 6%, 9%. The resulted samples were analyzed by X-ray diffraction and water absorption test to determine the effect of ZnO concentration. The results showed that the addition of ZnO variation into biofoam caused the change in diffraction position and intensity. The control variation (0% ZnO) had the highest diffraction peak at the position of 20.88°2θ with an intensity of 68.65 counts, crystallite size of 20.795 nm. After adding ZnO variation of 3%, 6%, 9%, diffraction position and intensity change to be 36.31°2θ and 276.29 counts, 36.26°2θ and 558.81 counts, and 36.31°2θ and 725.78 counts, respectively. The addition of ZnO into biofoam composite decreased water absorption up to 33% compared than the control sample, and the lowest optimum absorption resulted in ZnO concentration of 9% with water absorption value of 0.164 (gH2O/g).

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Highly accurate model for prediction of lung nodule malignancy with ct scans

arXiv

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arXiv 2018年

作者： Causey, Jason Zhang, Junyu Ma, Shiqian Jiang, Bo Qualls, Jake Politte, David G. Prior, Fred Zhang, Shuzhong Huang, Xiuzhen Department of Computer Science Arkansas State University JonesboroAR72467 United States Department of Industrial and Systems Engineering University of Minnesota MinneapolisMN55455 United States Department of Systems Engineering and Engineering Management Chinese University of Hong Kong Shatin N.T. Hong Kong Research Center for Management Science and Data Analytics School of Information Management and Engineering Shanghai University of Finance and Economics Shanghai200433 China Mallinckrodt Institute of Radiology Washington University St. LouisMO63110 United States Department of Biomedical Informatics University of Arkansas for Medical Sciences Little RockAR72205 United States UALR/UAMS Joint Graduate Program in Bioinformatics Little RockAR72204 United States

Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve performance comparable to experienced radiologists. Here we present NoduleX, a systematic approach to predict lung nodule malignancy from CT data, based on deep learning convolutional neural networks (CNN). For training and validation, we analyze >1000 lung nodules in images from the LIDC/IDRI cohort. All nodules were identified and classified by four experienced thoracic radiologists who participated in the LIDC project. NoduleX achieves high accuracy for nodule malignancy classification, with an AUC of ~0.99. This is commensurate with the analysis of the dataset by experienced radiologists. Our approach, NoduleX, provides an effective framework for highly accurate nodule malignancy prediction with the model trained on a large patient population. Our results are replicable with software available at http://***/NoduleX. Copyright © 2018, The Authors. All rights reserved.

关键词： Forecasting

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Stable explicit schemes for simulation of nonlinear moisture transfer in porous materials

arXiv

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arXiv 2017年

作者： Gasparin, Suelen Berger, Julien Dutykh, Denys Mendes, Nathan Thermal Systems Laboratory Mechanical Engineering Graduate Program Pontifical Catholic University of Paraná Rua Imaculada Conceição 1155 Curitiba – ParanáCEP: 80215-901 Brazil Thermal Systems Laboratory Mechanical Engineering Graduate Program Pontifical Catholic University of Paraná Rua Imaculada Conceição 1155 Curitiba – ParanáCEP: 80215-901 Brazil LAMA UMR 5127 CNRS Université Savoie Mont Blanc Campus Scientifique Le Bourget-du-Lac Cedex73376 France Thermal Systems Laboratory Mechanical Engineering Graduate Program Pontifical Catholic University of Paraná Rua Imaculada Conceição 1155 Curitiba – ParanáCEP: 80215-901 Brazil

Implicit schemes have been extensively used in building physics to compute the solution of moisture diffusion problems in porous materials for improving stability conditions. Nevertheless, these schemes require important sub-iterations when treating nonlinear problems. To overcome this disadvantage, this paper explores the use of improved explicit schemes, such as Dufort–Frankel, Crank–Nicolson and hyperbolisation approaches. A first case study has been considered with the hypothesis of linear transfer. The Dufort–Frankel, Crank–Nicolson and hyperbolisation schemes were compared to the classical Euler explicit scheme and to a reference solution. Results have shown that the hyperbolisation scheme has a stability condition higher than the standard Courant-Friedrichs-Lewy (CFL) condition. The error of this schemes depends on the parameter τ representing the hyperbolicity magnitude added into the equation. The Dufort–Frankel scheme has the advantages of being unconditionally stable and is preferable for nonlinear transfer, which is the three others cases studies. Results have shown the error is proportional to O(∆t) . A modified Crank–Nicolson scheme has been also studied in order to avoid sub-iterations to treat the nonlinearities at each time step. The main advantages of the Dufort–Frankel scheme are (i) to be twice faster than the Crank–Nicolson approach;(ii) to compute explicitly the solution at each time step;(iii) to be unconditionally stable and (iv) easier to parallelise on high-performance computer systems. Although the approach is unconditionally stable, the choice of the time discretisation ∆t remains an important issue to accurately represent the physical phenomena. Copyright © 2017, The Authors. All rights reserved.

关键词： Numerical methods

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Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia

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Cell stem cell 2025年

作者： Maria Sirenko Soobeom Lee Zhengxi Sun Ronan Chaligne Sanam Loghavi Georgios Asimomitis Charlotte K Brierley Elsa Bernard Sheng F Cai Robert M Myers Bettina Nadorp Junya Sango Morgan Lallo Max F Levine Dylan Domenico Juan E Arango Ossa Juan S Medina-Martinez Kamal Menghrajani Audrey Lasry Alice S Mims Helee Desai Andrea Laganson Chris Famulare Minal Patel Gerard Lozanski Kelly L Bolton Aaron D Viny Mikhail Roshal Ross L Levine Eirini P Papapetrou Eytan M Stein Dan A Landau Ann-Kathrin Eisfeld Iannis Aifantis Elli Papaemmanuil Department of Pathology New York University Grossman School of Medicine New York NY USA Laura and Isaac Perlmutter Cancer Center New York University Grossman School of Medicine New York NY USA Louis V. Gerstner Jr. Graduate School of Biomedical Sciences Memorial Sloan Kettering Cancer Center New York NY USA Computational Oncology Service Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA. Department of Biology New York University New York NY USA. Laura and Isaac Perlmutter Cancer Center New York University Grossman School of Medicine New York NY USA. Program for Computational and Systems Biology Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY 10065 USA. Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA. Computational Oncology Service Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Biomedical Systems Laboratory Department of Mechanical Engineering National Technical University of Athens Athens Greece. Medical Research Council Weatherall Institute of Molecular Medicine University of Oxford Oxford UK NIHR Biomedical Research Centre University of Oxford Oxford UK. Leukemia Service Department of Medicine Center for Hematologic Malignancies Memorial Sloan Kettering Cancer Center New York NY USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY USA. Tri-Institutional MD-PhD Program Weill Cornell Medicine Rockefeller University Memorial Sloan Kettering Cancer Center New York NY USA. Division of Precision Medicine Department of Medicine New York University School of Medicine New York NY USA. Department of Oncological Sciences Tisch Cancer Institute Center for Advancement of Blood Cancer Therapies Icahn School of Medicine at Mount Sinai New York NY USA. Vilcek Institute of Graduate Biomedical Sciences NYU Grossman School of Medicine N

Isocitrate dehydrogenase 1/2 (IDH) mutations are early initiating events in acute myeloid leukemia (AML). The complex clonal architecture and cellular heterogeneity in IDH-mutant AML underlies the heterogeneous clinical presentation and outcomes. Integrating single-cell genotyping and transcriptomics, we demonstrate a stem-like and inflammatory phenotype of IDH-mutant AML and identify clone-specific programs associated with NPM1, NRAS, and SRSF2 co-mutations. Furthermore, these clones had distinct responses to treatment with combination IDH inhibitors and chemotherapy, including elimination, reconstitution of myeloid differentiation, or retention within progenitor populations. At relapse after IDH inhibitor monotherapy, we identify upregulated stemness, inflammation, mitochondrial metabolism, and anti-apoptotic factors, as well as downregulated major histocompatibility complex (MHC) class II antigen presentation. At the pre-leukemic stage, we observe upregulation of IDH2-associated pathways, including inflammation. We deliver a detailed phenotyping of IDH-mutant AML and a framework for dissecting contributions of recurrently mutated genes in AML at diagnosis and following therapy, with implications for precision medicine.

关键词： IDH inhibitors IDH1/2 mutations acute myeloid leukemia cellular hierarchy clonal architecture clonal evolution relapse single-cell transcriptomics targeted therapy treatment resistance

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A simple PID controller for a magnetic bearing with four poles and interconnected magnetic flux

A simple PID controller for a magnetic bearing with four pol...

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International Symposium on Advanced Control of industrial Processes (ADCONIP)

作者： Christian Tshizubu José Andrés Santisteban Graduate Program on Mechanical Engineering (PGMEC) Universidade Federal Fluminense Niterói BRAZIL Universidade Federal Fluminense Niteroi Rio de Janeiro BR

ISBN: (纸本)9781509043989

The conventional structures of active magnetic bearings to support rotors dispose of eight poles operating in such a way that two adjacent poles share the same magnetic flux. In this work, a different electromagnetic structure is presented which is based on the so named bearingless motor with split windings. While this device is originally supplied by alternate electrical currents, in this case, as the purpose is to generate only radial forces, the windings are supplied by continuous currents forming a magnetic flux with four equivalent poles. To test this approach, a conventional induction motor was used and its rotor was appropriately modified. It will be shown that although the magnetic fluxes are coupled, for low speed rotation, all the controlled plant can be modeled as an unstable second order system, so PID controllers can be appropriately designed. In order to test this approach, a workbench consisting of displacement sensors, signal conditioners and two microcontrollers development boards was implemented. For different radial loads and changes of displacement references, the experimental results were well succeeded.

关键词： Magnetic levitation Rotors Magnetic flux Windings Zirconium Stator windings

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