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FANTOM5 CAGE profiles of human and mouse samples

Scientific Data 2017年第1期4卷 1-10页

作者： Noguchi, Shuhei Arakawa, Takahiro Fukuda, Shiro Furuno, Masaaki Hasegawa, Akira Hori, Fumi Ishikawa-Kato, Sachi Kaida, Kaoru Kaiho, Ai Kanamori-Katayama, Mutsumi Kawashima, Tsugumi Kojima, Miki Kubosaki, Atsutaka Manabe, Ri-Ichiroh Murata, Mitsuyoshi Nagao-Sato, Sayaka Nakazato, Kenichi Ninomiya, Noriko Nishiyori-Sueki, Hiromi Noma, Shohei Saijyo, Eri Saka, Akiko Sakai, Mizuho Simon, Christophe Suzuki, Naoko Tagami, Michihira Watanabe, Shoko Yoshida, Shigehiro Arner, Peter Axton, Richard A. Babina, Magda Kenneth Baillie, J. Barnett, Timothy C. Beckhouse, Anthony G. Blumenthal, Antje Bodega, Beatrice Bonetti, Alessandro Briggs, James Brombacher, Frank Carlisle, Ailsa J. Clevers, Hans C. Davis, Carrie A. Detmar, Michael Dohi, Taeko Edge, B. Albert S. Edinger, Matthias Ehrlund, Anna Ekwall, Karl Endoh, Mitsuhiro Enomoto, Hideki Eslami, Afsaneh Fagiolini, Michela Fairbairn, Lynsey Farach-Carson, Mary C. Faulkner, Geoffrey J. Ferrai, Carmelo Fisher, Malcolm E. Forrester, Lesley M. Fujita, Rie Furusawa, Jun-Ichi Geijtenbeek, Teunis B. Gingeras, Thomas Goldowitz, Daniel Guhl, Sven Guler, Reto Gustincich, Stefano Ha, Thomas J. Hamaguchi, Masahide Hara, Mitsuko Hasegawa, Yuki Herlyn, Meenhard Heutink, Peter Hitchens, Kelly J. Hume, David A. Ikawa, Tomokatsu Ishizu, Yuri Kai, Chieko Kawamoto, Hiroshi Kawamura, Yuki I. Kempfle, Judith S. Kenna, Tony J. Kere, Juha Khachigian, Levon M. Kitamura, Toshio Klein, Sarah Peter Klinken, S. Knox, Alan J. Kojima, Soichi Koseki, Haruhiko Koyasu, Shigeo Lee, Weonju Lennartsson, Andreas MacKay-Sim, Alan Mejhert, Niklas Mizuno, Yosuke Morikawa, Hiromasa Morimoto, Mitsuru Moro, Kazuyo Morris, Kelly J. Motohashi, Hozumi Mummery, Christine L. Nakachi, Yutaka Nakahara, Fumio Nakamura, Toshiyuki Nakamura, Yukio Nozaki, Tadasuke Ogishima, Soichi Ohkura, Naganari Ohno, Hiroshi Ohshima, Mitsuhiro Okada-Hatakeyama, Mariko Okazaki, Yasushi Orlando, Valerio Ovchinnikov, Dmitry A. Passier, Robert Patrikakis, Margaret Pombo, Ana Pradhan-Bhatt, Swati Qin, Xian-Yang Rehli, Michael Rizzu, Patrizia Roy, S Division of Genomic Technologies RIKEN Center for Life Science Technologies Yokohama Kanagawa 230-0045 Japan RIKEN Omics Science Center Yokohama Kanagawa 230-0045 Japan Department of Medicine Karolinska Institutet Stockholm 14186 Sweden Karolinska University Hospital Center for Metabolism and Endocrinology Stockholm 14186 Sweden Scottish Centre for Regenerative Medicine University of Edinburgh 5 Little France Drive Edinburgh EH164UU United Kingdom Department of Dermatology and Allergy Charite University Medicine Berlin Charitéplatz 1 Berlin 10117 Germany Roslin Institute and Royal School of Veterinary Studies University of Edinburgh Edinburgh EH259RG United Kingdom Australian Infectious Diseases Research Centre University of Queensland St Lucia 4072 QLD Australia School of Chemistry and Molecular Biosciences University of Queensland St Lucia 4072 QLD Australia Bio-Rad Laboratories Pty Ltd Hercules 94547 CA United States University of Queensland Diamantina Institute University of Queensland Woolloongabba 4102 QLD Australia IRCCS Fondazione Santa Lucia Via del Fosso di Fiorano 64 Rome 00143 Italy Australian Institute for Bioengineering and Nanotechnology University of Queensland Brisbane St Lucia 4072 QLD Australia Division of Immunology Institute of Infectious Diseases and Molecular Medicine University of Cape Town Anzio Road Observatory 7925 South Africa Immunology of Infectious Diseases Faculty of Health Sciences South African Medical Research Council University of Cape Town Anzio Road 7925 South Africa International Centre for Genetic Engineering and Biotechnology Cape Town Component Anzio Road 7925 South Africa Hubrecht Institute Royal Netherlands Academy of Arts and Sciences Uppsalalaan 8 3584 Netherlands University Medical Centre Utrecht Postbus 85500 Utrecht 3508 Netherlands Genomics Cold Spring Harbor Laboratory Cold Spring Harbor New York 11797 NY United States Institute of Pharmaceutical Sciences ETH Zurich Vladi

In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.

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A comparative study of various microstrip bandpass filters topologies for UWB applications

A comparative study of various microstrip bandpass filters t...

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International Design and Test Workshop

作者： A. A. Saadi M. C. E. Yagoub R. Touhami Faculty of Electronics and Informatics U.S.T.H.B Algiers Algeria Centre de Développement des Technologies Avancées Algiers Algeria School of Electrical Engineering and Computer Science University of Ottawa Ottawa ON Canada

Because of their large spectrum, Ultra-Wide Band (UWB) systems are requested to maintain a very low power spectral density, making them vulnerable to higher power narrowband signals. To mitigate any in-band narrowband interference (NBI), which may degrade the overall UWB system performance, filtering is an inescapable solution. The aim of this paper is to compare the performance of various microstrip planar filters which are designed based on a specific electric model in order to provide UWB filter designers with key design tools to efficiently select the most suitable filter based on their particular needs.

关键词： Band-pass filters Matched filters Microstrip filters Chebyshev approximation Bandwidth Topology Tuning

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Permutation polynomials with low differential uniformity over finite fields of odd characteristic

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science China Mathematics 2013年第7期56卷 1429-1440页

作者： JIA WenJie ZENG XiangYong LI ChunLei HELLESETH Tor HU Lei Faculty of Mathematics and Computer Science Hubei University State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of Sciences Department of Informatics University of Bergen

In this paper, we propose a construction of functions with low differential uniformity based on known perfect nonlinear functions over finite fields of odd characteristic. For an odd prime power q, it is proved that t... 详细信息

关键词： permutation perfect nonlinear function almost perfect nonlinear function differential uniformity

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A model-based approach in VEP-based brain-computer interface

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ICIC Express Letters 2013年第4期7卷 1393-1400页

作者： Mizoguchi, Takashi Irie, Jun Inoue, Katsuhiro Department of Systems Design and Informatics Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology 680-4 Kawazu Iizuka-shi Fukuoka 820-8502 Japan

Recently a lot of researchers have studied brain-computer interface (BCI) systems and several applications have already been put into practical use. For instance, P300-based systems have been actively used. However, the electroencephalogram (EEG) signal is often very noisy, which makes the P300 detection difficult in a single trial. Therefore, it is necessary to introduce some information from the EEG signal. In this contribution, we propose a model-based analysis using a model of visual evoked potentials (VEPs), which is estimated by the maximum a posteriori probability (MAP) algorithm. Simulation shows that this method is a promising approach to extract information related to the presence or absence of a visual stimulus. © 2013 ICIC International.

关键词： Brain computer interface

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A Novel Method for Extrinsic Parameters Estimation between a Single-Line Scan LiDAR and a Camera

A Novel Method for Extrinsic Parameters Estimation between a...

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IEEE Intelligent Vehicles Symposium

作者： Pakapoj Tulsuk Panu Srestasathiern Miti Ruchanurucks Teera Phatrapornnant Hiroshi Nagahashi Faculty of Electrical Engineering Kasetsart University Thailand Geo-Informatics and Space Technology Development Agency Thailand National Electronics and Computer Technology Center National Science and Technology Development Agency Thailand Department of Information Processing Tokyo Institute of Technology Japan

ISBN: (纸本)9781479936397

This paper presents a novel method for extrinsic parameters estimation of a single line scan LiDAR and a camera. Using a checkerboard, the calibration setup is simple and practical. Particularly, the proposed calibration method is based on resolving geometry of the checkerboard that visible to the camera and the LiDAR. The calibration setup geometry is described by planes, lines and points. Our novelty is a new hypothesis of the geometry which is the orthogonal distances between LiDAR points and the line from the intersection between the checkerboard and LiDAR scan plane. To evaluate the performance of the proposed method, we compared our proposed method with the state of the art method i.e. Zhang and Pless [1]. The experimental results showed that the proposed method yielded better results.

关键词： planes lines points

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Educational cooperation across countries by shared course materials: More than 10 years of experience

Educational cooperation across countries by shared course ma...

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International Conference on Interactive Collaborative Learning (ICL)

作者： Klaus Bothe Zoran Budimac Zoran Putnik Mirjana Ivanovic Stanimir Stoyanov Asya Stoyanova-Doyceva Katerina Zdravkova Boro Jakimovski Ioan Jurca Novica Nosovic Damir Kalpic Betim Cico Elinda Kajo Sanja Čandrlić Institute of Computer Science Humboldt University Berlin Berlin Germany Institute of Mathematics and Informatics University of Novi Sad Novi Sad Serbia Institute of Informatics University “Paisii Hilendarski” Plovdiv Bulgaria Institute of Informatics University “Paisii Hilendarski” Bulgaria Institute of Informatics University “Sts. Cyril and Methodius” Skopje FYR Macedonia Institute of Informatics Technical University Timisoara Timisoara Romania University of Sarajevo Sarajevo Bosnia Herzegovina Faculty of Electrical Engineering and Computing University of Zagreb Zagreb Croatia Faculty of Contemporary Sciences and Technologies South East European University Tetovo Macedonia Faculty of Electrical Engineering Polytechnic University Tirana Tirana Albania University of Rijeka Rijeka Croatia

At the beginning of the new century, we started with an educational project aimed at the joint development and shared use of teaching materials for software engineering education. The aim was to transfer knowledge, as well as to save expenses. Over the years, our cooperation did not only cover the development of the course, but also its delivery, e.g. by guest lecturing. This paper reports on the experience gained in a multi-country project. Both success factors and problems are outlined.

关键词： Materials Educational institutions Project management Web sites Collaborative work informatics

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11th German Conference on Chemoinformatics (GCC 2015) Abstracts

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JOURNAL OF CHEMinformatics 2016年第SUPPL 1期8卷 1-27页

作者： [Anonymous] GDCh-CIC Division Associated Board Member Beilstein-Institut zur Förderung der Chemischen Wissenschaften Trakehner Str. 7-9 60487 Frankfurt Germany. ufechner@beilstein-institut.de. Division Medicinal Chemistry Amsterdam Institute for Molecules Medicines and Systems (AIMMS) VU University Amsterdam The Netherlands. Centre for Bioinformatics Uni Hamburg Bundesstr. 43 20146 Hamburg Germany. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. stefan.guessregen@***. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. GlaxoSmithKline Stevenage SG1 2NY UK. nicola.j.richmond@***. Discngine Paris 75011 France. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. marwin.segler@wwu.de. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. Bundeskriminalamt Wiesbaden Central Analytics II 65173 Wiesbaden Germany. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. shea@chem.ucsb.edu. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. Chemistry Department Ludwig-Maximilians-Universität München Butenandtstr. 7 81377 Munich Germany. Inorganic Chemistry and Center for Nanointegration University of Duisburg-Essen Essen Germany. CAM-D Technologies Essen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. achim.zielesny@w-hs.de. Leiden University Leiden Netherlands. j.fraaije@chem.leidenuniv.nl. Culgi BV Berlin Germany. Physikalische Chemie III TU Dortmund 44227 Dortmund Germany. stefan.kast@tu-dortmund.de. Centre for Molecular Informatics Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW United Kingdom. kcb27@cam.ac.uk. Centre for Molecular Informatics Department of Chemistry

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ZZ→ℓ+ℓ−ℓ′+ℓ′− cross-section measurements and search for anomalous triple gauge couplings in 13 TeV pp collisions with the ATLAS detector

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Physical Review D 2018年第3期97卷 032005-032005页

作者： M. Aaboud G. Aad B. Abbott O. Abdinov B. Abeloos S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu R. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder Y. Afik T. Agatonovic-Jovin C. Agheorghiesei J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli S. Akatsuka H. Akerstedt T. P. A. Åkesson E. Akilli A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. C. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. I. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso G. Amundsen C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov N. Anjos A. Annovi C. Antel M. Antonelli A. Antonov D. J. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos M. Arik A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi L. Asquith K. Assamagan R. Astalos M. Atkinson N. B. Atlay K. Augsten G. Avolio B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes P. Bagnaia M. Bahmani H. Bahrasemani J. T. Baines M. Bajic O. K. Baker E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas A. Bandyopadhyay Sw. Banerjee A. A. E. Bannoura L. Barak E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits J. T. Barkeloo T. Barklow N. Barlow S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Barton P. Bartos A. Basalaev A. B Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel Center for High Energy Physics University of Oregon Eugene Oregon USA Department of Physics Stockholm University Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Institute of Physics University of Belgrade Belgrade Serbia Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Laboratório de Instrumentação e Física Experimental de Partículas - LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos Universidad de Granada Granada Portugal Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Italy Dipartimento di Fisica Un

Measurements of ZZ production in the ℓ+ℓ−ℓ′+ℓ′− channel in proton–proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 fb−1 of collisions collected by the ATLAS experiment in 2015 and 2016. Here ℓ and ℓ′ stand for electrons or muons. Integrated and differential ZZ→ℓ+ℓ−ℓ′+ℓ′− cross sections with Z→ℓ+ℓ− candidate masses in the range of 66 GeV to 116 GeV are measured in a fiducial phase space corresponding to the detector acceptance and corrected for detector effects. The differential cross sections are presented in bins of twenty observables, including several that describe the jet activity. The integrated cross section is also extrapolated to a total phase space and to all standard model decays of Z bosons with mass between 66 GeV and 116 GeV, resulting in a value of 17.3±0.9[±0.6(stat)±0.5(syst)±0.6(lumi)] pb. The measurements are found to be in good agreement with the standard model. A search for neutral triple gauge couplings is performed using the transverse momentum distribution of the leading Z boson candidate. No evidence for such couplings is found and exclusion limits are set on their parameters.

关键词： Electroweak interaction W & Z bosons Particle data analysis

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A user-centric approach for developing mobile applications

A user-centric approach for developing mobile applications

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7th International Conference on Knowledge Management in Organizations, KMO 2012

作者： Černezel, Aleš Heričko, Marjan University of Maribor Faculty of Electrical Engineering Computer and Information Science Institute of Informatics Smetanova 17 Maribor Slovenia

ISBN: (纸本)9783642308666

Creating mobile applications that are accepted by users is critical for a successful business. This article presents a user-centric approach for developing applications. In the theoretical part, we will present some background information about the three analytic tools that were used with this approach. In the practical part, these analytic tools will be practically applied on a case study for a mobile application. First, the three analytic tools are practically applied and after identifying use cases, the application will be implemented. The application consists of two parts: server and client. The server is based on Java EE technology and the client is based on the Android platform. © 2013 Springer-Verlag.

关键词： Mobile computing

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What Do Doctors Need for Effective Adoption and Integration of Clinical Guidelines into Daily Practice?

What Do Doctors Need for Effective Adoption and Integration ...

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IEEE International Conference on Healthcare informatics (ICHI)

作者： Manuel Campos Beatriz García José M. Juárez Juan M. Guillamón Francisco Palacios Dep. Informatics and Systems. Faculty of Computer Science. University of Murcia Murcia Spain Dep. Information and Communication Engineering. University of Murcia Murcia Spain Intensive Care Unit. University Hospital of Getafe. Madrid Spain

Catheter-related bloodstream infection (CRBSI) is one of the major existing problems in Intensive Care Units (ICU). CRBSI has a high prevalence and its treatment is quite costly in time and medication. One of the essential efforts in the diagnosis and treatment of CRBSI is the use of existing Clinical Guidelines (CG). Nevertheless, its adoption and integration into daily practice is quite complex due to the lack of software tools that cover all the needs. Considering this problem, in this work we identify some of the needs detected in daily work, and we present two tools for ICUs that makes the introduction of CGs and patient's data visualization simple. As a first goal we propose to obtain a computerized model of the clinical guideline. Gewel is an application that allows the mapping of a textual CG into a workflow model. In this tool we propose a process that (1) organizes the parts of the textual document according to GEM, (2) maps concepts to the Electronic Health Record (EHR) system, called CH4, so that it can automatically retrieve data and send HL7 messages, (3) supports the design of a workflow model that assists the following up of the steps and the measure of adherence to the CG, and (4) according to Evidence Based Medicine principles, allows the doctors to trace from the task or decision point of the workflow to the exact part of the document where it was originated. Once the CG is computerized and integrated in the EHR, the next goal is to identify key clinical problems, such as CRBSI, and retrieve the relevant information from the EHR. Due to the big amount of the EHR data registered in an ICU, physician's attention should be drawn to the clinical information related to the problem to be solved. We propose a mobile application, called mProblem View, that permits to establish and visualize relations between the elements of the EHR in a Problem-Oriented EHR approach.

关键词： Medical services Medical diagnostic imaging Guidelines Standards Computational modeling XML Mobile communication

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