检索结果-内蒙古大学图书馆

Collagen-chitosan scaffold - Lauric acid plasticizer for skin tissue engineering on burn cases

AIP Conference Proceedings 2017年第1期1817卷

作者： Prihartini Widiyanti Ewing Dian Setyadi Djony Izak Rudyardjo 1Biomedical Engineering Faculty of Science and Technology Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia 2Institute of Tropical Disease Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia 3Physics Study Program Faculty of Science and Technology Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia

The prevalence of burns in the world is more than 800 cases per one million people each year and this is the second highest cause of death due to trauma after traffic accident. Many studies are turning to skin substitute methods of tissue engineering. The purpose of this study is to determine the composition of the collagen, chitosan, and lauric acid scaffold, as well as knowing the results of the characterization of the scaffold. The synthesis of chitosan collagen lauric acid scaffold as a skin tissue was engineered using freeze dried method. Results from making of collagen chitosan lauric acid scaffold was characterized physically, biologically and mechanically by SEM, cytotoxicity, biodegradation, and tensile strength. From the morphology test, the result obtained is that pore diameter size ranges from 94.11 to 140.1 µm for samples A,B,C,D, which are in the range of normal pore size 63-150 µm, while sample E has value below the standard which is about 37.87 to 47.36 µm. From cytotoxicity assay, the result obtained is the percentage value of living cells between 20.11 to 21.51%. This value is below 50% the standard value of living cells. Incompatibility is made possible because of human error mainly the replication of washing process over the standard. Degradation testing obtained values of 19.44% - 40% by weight which are degraded during the 7 days of observation. Tensile test results obtained a range of values of 0.192 - 3.53 MPa. Only sample A (3.53 MPa) and B (1.935 MPa) meet the standard values of skin tissue scaffold that is 1-24 MPa. Based on the results of the characteristics of this study, composite chitosan collagen scaffold with lauric acid plasticizer has a potential candidate for skin tissue engineering for skin burns cases.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Search for new phenomena in events with an energetic jet and missing transverse momentum in pp collisions at s=13 TeV with the ATLAS detector

引用

Physical Review D 2021年第11期103卷 112006-112006页

作者： G. Aad B. Abbott D. C. Abbott A. Abed Abud K. Abeling D. K. Abhayasinghe S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya B. Achkar L. Adam C. Adam Bourdarios L. Adamczyk L. Adamek J. Adelman A. Adiguzel S. Adorni T. Adye A. A. Affolder Y. Afik C. Agapopoulou M. N. Agaras A. Aggarwal C. Agheorghiesei J. A. Aguilar-Saavedra A. Ahmad F. Ahmadov W. S. Ahmed X. Ai G. Aielli S. Akatsuka M. Akbiyik T. P. A. Åkesson E. Akilli A. V. Akimov K. Al Khoury G. L. Alberghi J. Albert M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa T. Alexopoulos A. Alfonsi F. Alfonsi M. Alhroob B. Ali S. Ali M. Aliev G. Alimonti C. Allaire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio F. Alonso C. Alpigiani E. Alunno Camelia M. Alvarez Estevez M. G. Alviggi Y. Amaral Coutinho A. Ambler L. Ambroz C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. S. Amrouche F. An C. Anastopoulos N. Andari T. Andeen J. K. Anders S. Y. Andrean A. Andreazza V. Andrei C. R. Anelli S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi C. Antel M. T. Anthony E. Antipov M. Antonelli D. J. A. Antrim F. Anulli M. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella N. Aranzabal V. Araujo Ferraz R. Araujo Pereira C. Arcangeletti A. T. H. Arce J-F. Arguin S. Argyropoulos J.-H. Arling A. J. Armbruster O. Arnaez H. Arnold Z. P. Arrubarrena Tame G. Artoni H. Asada K. Asai S. Asai T. Asawatavonvanich N. A. Asbah E. M. Asimakopoulou L. Asquith J. Assahsah K. Assamagan R. Astalos R. J. Atkin M. Atkinson N. B. Atlay H. Atmani P. A. Atmasiddha K. Augsten V. A. Austrup G. Avolio M. K. Ayoub G. Azuelos D. Babal H. Bachacou K. Bachas F. Backman P. Bagnaia H. Bahrasemani A. J. Bailey V. R. Bailey J. T. Baines C. Bakalis O. K. Baker P. J. Bakker E. Bakos D. Bakshi Gupta S. Balaji R. Balasubramanian E. M. Baldin P. Balek F. Balli W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay Sw. Banerjee L. Barak W. M. Barbe E. L. Barberio D. Barberis M. Barbero G. Barbour T. Barillari M-S. Barisits J CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Department of Physics University of Massachusetts Amherst Massachusetts USA CERN Geneva Switzerland II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Department of Physics Royal Holloway University of London Egham United Kingdom Department of Physics University of Toronto Toronto ON Canada Niels Bohr Institute University of Copenhagen Copenhagen Denmark Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel High Energy Physics Division Argonne National Laboratory Argonne Illinois USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Institut für Physik Universität Mainz Mainz Germany LAPP Univ. Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Department of Physics Bogazici University Istanbul Turkey Département de Physique Nucléaire et Corpusculaire Université de Genève Genève Switzerland Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA IJCLab Université Paris-Saclay CNRS/IN2P3 91405 Orsay France LPC Université Clermont Auvergne CNRS/IN2P3 Clermont-Ferrand France Institute for Mathematics Astrophysics and Particle Physics Radboud University/Nikhef Nijmegen Netherlands Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Departamento de Física Teórica y del Cosmos Universidad de Granada Granada (Spain)

Results of a search for new physics in final states with an energetic jet and large missing transverse momentum are reported. The search uses proton-proton collision data corresponding to an integrated luminosity of 139 fb−1 at a center-of-mass energy of 13 TeV collected in the period 2015–2018 with the ATLAS detector at the Large Hadron Collider. Compared to previous publications, in addition to an increase of almost a factor of four in the data size, the analysis implements a number of improvements in the signal selection and the background determination leading to enhanced sensitivity. Events are required to have at least one jet with transverse momentum above 150 GeV and no reconstructed leptons (e, μ or τ) or photons. Several signal regions are considered with increasing requirements on the missing transverse momentum starting at 200 GeV. Overall agreement is observed between the number of events in data and the Standard Model predictions. Model-independent 95% confidence-level limits on visible cross sections for new processes are obtained in the range between 736 fb and 0.3 fb. Results are also translated into improved exclusion limits in models with pair-produced weakly interacting dark-matter candidates, large extra spatial dimensions, supersymmetric particles in several compressed scenarios, axionlike particles, and new scalar particles in dark-energy-inspired models. In addition, the data are translated into bounds on the invisible branching ratio of the Higgs boson.

关键词： Cosmology Hypothetical particle physics models Invisible decays Particle dark matter Particle phenomena Supersymmetric models Axions Higgs bosons Hypothetical particles Weakly interacting massive particles Hadron colliders Particle accelerators

来源：评论

学校读者我要写书评

暂无评论

Exclusive dimuon production in ultraperipheral Pb+Pb collisions at sNN=5.02TeV with ATLAS

引用

Physical Review C 2021年第2期104卷 024906-024906页

作者： G. Aad B. Abbott D. C. Abbott A. Abed Abud K. Abeling D. K. Abhayasinghe S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya B. Achkar L. Adam C. Adam Bourdarios L. Adamczyk L. Adamek J. Adelman M. Adersberger A. Adiguzel S. Adorni T. Adye A. A. Affolder Y. Afik C. Agapopoulou M. N. Agaras A. Aggarwal C. Agheorghiesei J. A. Aguilar-Saavedra A. Ahmad F. Ahmadov W. S. Ahmed X. Ai G. Aielli S. Akatsuka M. Akbiyik T. P. A. Åkesson E. Akilli A. V. Akimov K. Al Khoury G. L. Alberghi J. Albert M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa T. Alexopoulos A. Alfonsi F. Alfonsi M. Alhroob B. Ali S. Ali M. Aliev G. Alimonti C. Allaire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio F. Alonso C. Alpigiani E. Alunno Camelia M. Alvarez Estevez M. G. Alviggi Y. Amaral Coutinho A. Ambler L. Ambroz C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. S. Amrouche F. An C. Anastopoulos N. Andari T. Andeen J. K. Anders S. Y. Andrean A. Andreazza V. Andrei C. R. Anelli S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi C. Antel M. T. Anthony E. Antipov M. Antonelli D. J. A. Antrim F. Anulli M. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella N. Aranzabal V. Araujo Ferraz R. Araujo Pereira C. Arcangeletti A. T. H. Arce F. A. Arduh J.-F. Arguin S. Argyropoulos J.-H. Arling A. J. Armbruster A. Armstrong O. Arnaez H. Arnold Z. P. Arrubarrena Tame G. Artoni H. Asada K. Asai S. Asai T. Asawatavonvanich N. A. Asbah E. M. Asimakopoulou L. Asquith J. Assahsah K. Assamagan R. Astalos R. J. Atkin M. Atkinson N. B. Atlay H. Atmani K. Augsten V. A. Austrup G. Avolio M. K. Ayoub G. Azuelos D. Babal H. Bachacou K. Bachas F. Backman P. Bagnaia H. Bahrasemani A. J. Bailey V. R. Bailey J. T. Baines C. Bakalis O. K. Baker P. J. Bakker E. Bakos D. Bakshi Gupta S. Balaji R. Balasubramanian E. M. Baldin P. Balek F. Balli W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay Sw. Banerjee L. Barak W. M. Barbe E. L. Barberio D. Barberis M. Barbero G. Barbour T. B CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Department of Physics University of Massachusetts Amherst Massachusetts USA CERN Geneva Switzerland II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Department of Physics Royal Holloway University of London Egham United Kingdom Department of Physics University of Toronto Toronto Ontario Canada Niels Bohr Institute University of Copenhagen Copenhagen Denmark Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel High Energy Physics Division Argonne National Laboratory Argonne Illinois USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Institut für Physik Universität Mainz Mainz Germany LAPP Université Savoie Mont Blanc CNRS/IN2P3 Annecy France Faculty of Physics and Applied Computer Science AGH University of Science and Technology Krakow Poland Department of Physics Northern Illinois University Dekalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Department of Physics Bogazici University Istanbul Turkey Département de Physique Nucléaire et Corpusculaire Université de Genève Genève Switzerland Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA IJCLab Université Paris-Saclay CNRS/IN2P3 91405 Orsay France LPC Université Clermont Auvergne CNRS/IN2P3 Clermont-Ferrand France Institute for Mathematics Astrophysics and Particle Physics Radboud University/Nikhef Nijmegen Netherlands Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romani

Exclusive dimuon production in ultraperipheral collisions (UPC), resulting from photon-photon interactions in the strong electromagnetic fields of colliding high-energy lead nuclei, PbPb(γγ)→μ+μ−(Pb(★)Pb(★)), is studied using Lint=0.48nb−1 of sNN=5.02TeV lead-lead collision data at the LHC with the ATLAS detector. Dimuon pairs are measured in the fiducial region pT,μ>4 GeV, |ημ|<2.4, invariant mass mμμ>10 GeV, and pT,μμ<2 GeV. The primary background from single-dissociative processes is extracted from the data using a template fitting technique. Differential cross sections are presented as a function of mμμ, absolute pair rapidity (|yμμ|), scattering angle in the dimuon rest frame (|cosϑμμ★|), and the colliding photon energies. The total cross section of the UPC γγ→μ+μ− process in the fiducial volume is measured to be σfidμμ=34.1±0.3(stat.)±0.7(syst.) μb. Generally good agreement is found with calculations from STARlight, which incorporate the leading-order Breit-Wheeler process with no final-state effects, albeit differences between the measurements and theoretical expectations are observed. In particular, the measured cross sections at larger |yμμ| are found to be about 10–20% larger in data than in the calculations, suggesting the presence of larger fluxes of photons in the initial state. Modification of the dimuon cross sections in the presence of forward and/or backward neutron production is also studied and is found to be associated with a harder incoming photon spectrum, consistent with expectations.

关键词： Photon, lepton & quark production Relativistic heavy-ion collisions

来源：评论

学校读者我要写书评

暂无评论

Search for trilepton resonances from chargino and neutralino pair production in s=13 TeV pp collisions with the ATLAS detector

引用

Physical Review D 2021年第11期103卷 112003-112003页

作者： G. Aad B. Abbott D. C. Abbott A. Abed Abud K. Abeling D. K. Abhayasinghe S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya B. Achkar L. Adam C. Adam Bourdarios L. Adamczyk L. Adamek J. Adelman M. Adersberger A. Adiguzel S. Adorni T. Adye A. A. Affolder Y. Afik C. Agapopoulou M. N. Agaras A. Aggarwal C. Agheorghiesei J. A. Aguilar-Saavedra A. Ahmad F. Ahmadov W. S. Ahmed X. Ai G. Aielli S. Akatsuka M. Akbiyik T. P. A. Åkesson E. Akilli A. V. Akimov K. Al Khoury G. L. Alberghi J. Albert M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa T. Alexopoulos A. Alfonsi F. Alfonsi M. Alhroob B. Ali S. Ali M. Aliev G. Alimonti C. Allaire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio F. Alonso C. Alpigiani E. Alunno Camelia M. Alvarez Estevez M. G. Alviggi Y. Amaral Coutinho A. Ambler L. Ambroz C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. S. Amrouche F. An C. Anastopoulos N. Andari T. Andeen J. K. Anders S. Y. Andrean A. Andreazza V. Andrei C. R. Anelli S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi C. Antel M. T. Anthony E. Antipov M. Antonelli D. J. A. Antrim F. Anulli M. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella N. Aranzabal V. Araujo Ferraz R. Araujo Pereira C. Arcangeletti A. T. H. Arce F. A. Arduh J-F. Arguin S. Argyropoulos J.-H. Arling A. J. Armbruster O. Arnaez H. Arnold Z. P. Arrubarrena Tame G. Artoni K. Asai S. Asai T. Asawatavonvanich N. A. Asbah E. M. Asimakopoulou L. Asquith J. Assahsah K. Assamagan R. Astalos R. J. Atkin M. Atkinson N. B. Atlay K. Augsten V. A. Austrup G. Avolio M. K. Ayoub G. Azuelos H. Bachacou K. Bachas M. Backes F. Backman P. Bagnaia H. Bahrasemani A. J. Bailey V. R. Bailey J. T. Baines C. Bakalis O. K. Baker P. J. Bakker E. Bakos D. Bakshi Gupta S. Balaji E. M. Baldin P. Balek F. Balli W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay Sw. Banerjee L. Barak W. M. Barbe E. L. Barberio D. Barberis M. Barbero G. Barbour T. Barillari M-S. Barisits J. Barkeloo T. Barklow R. Ba CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Department of Physics University of Massachusetts Amherst Massachusetts USA CERN Geneva Switzerland II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Department of Physics Royal Holloway University of London Egham United Kingdom Department of Physics University of Toronto Toronto ON Canada Niels Bohr Institute University of Copenhagen Copenhagen Denmark Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel High Energy Physics Division Argonne National Laboratory Argonne Illinois USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Institut für Physik Universität Mainz Mainz Germany LAPP Univ. Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Department of Physics Bogazici University Istanbul Turkey Département de Physique Nucléaire et Corpusculaire Université de Genève Genève Switzerland Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA IJCLab Université Paris-Saclay CNRS/IN2P3 91405 Orsay France LPC Université Clermont Auvergne CNRS/IN2P3 Clermont-Ferrand France Institute for Mathematics Astrophysics and Particle Physics Radboud University/Nikhef Nijmegen Netherlands Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Departam

A search is performed for the electroweak pair production of charginos and associated production of a chargino and neutralino, each of which decays through an R-parity-violating coupling into a lepton and a W, Z, or Higgs boson. The trilepton invariant-mass spectrum is constructed from events with three or more leptons, targeting chargino decays that include an electron or muon and a leptonically decaying Z boson. The analyzed dataset corresponds to an integrated luminosity of 139 fb−1 of proton-proton collision data produced by the Large Hadron Collider at a center-of-mass energy of s=13 TeV and collected by the ATLAS experiment between 2015 and 2018. The data are found to be consistent with predictions from the Standard Model. The results are interpreted as limits at 95% confidence level on model-independent cross sections for processes beyond the Standard Model. Limits are also set on the production of charginos and neutralinos for a minimal supersymmetric Standard Model with an approximate B−L symmetry. Charginos and neutralinos with masses between 100 and 1100 GeV are excluded depending on the assumed decay branching fractions into a lepton (electron, muon, or τ lepton) plus a boson (W, Z, or Higgs).

关键词： Supersymmetric models Hypothetical fermions Superpartners Baryon & lepton number symmetries

来源：评论

学校读者我要写书评

暂无评论

Search for bottom-squark pair production in pp collision events at s=13 TeV with hadronically decaying τ-leptons, b-jets, and missing transverse momentum using the ATLAS detector

引用

Physical Review D 2021年第3期104卷 032014-032014页

作者： G. Aad B. Abbott D. C. Abbott A. Abed Abud K. Abeling D. K. Abhayasinghe S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu Y. Abulaiti B. S. Acharya B. Achkar L. Adam C. Adam Bourdarios L. Adamczyk L. Adamek J. Adelman A. Adiguzel S. Adorni T. Adye A. A. Affolder Y. Afik C. Agapopoulou M. N. Agaras A. Aggarwal C. Agheorghiesei J. A. Aguilar-Saavedra A. Ahmad F. Ahmadov W. S. Ahmed X. Ai G. Aielli S. Akatsuka M. Akbiyik T. P. A. Åkesson E. Akilli A. V. Akimov K. Al Khoury G. L. Alberghi J. Albert M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa T. Alexopoulos A. Alfonsi F. Alfonsi M. Alhroob B. Ali S. Ali M. Aliev G. Alimonti C. Allaire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio F. Alonso C. Alpigiani E. Alunno Camelia M. Alvarez Estevez M. G. Alviggi Y. Amaral Coutinho A. Ambler L. Ambroz C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso C. S. Amrouche F. An C. Anastopoulos N. Andari T. Andeen J. K. Anders S. Y. Andrean A. Andreazza V. Andrei C. R. Anelli S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi C. Antel M. T. Anthony E. Antipov M. Antonelli D. J. A. Antrim F. Anulli M. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella N. Aranzabal V. Araujo Ferraz R. Araujo Pereira C. Arcangeletti A. T. H. Arce J-F. Arguin S. Argyropoulos J.-H. Arling A. J. Armbruster A. Armstrong O. Arnaez H. Arnold Z. P. Arrubarrena Tame G. Artoni H. Asada K. Asai S. Asai T. Asawatavonvanich N. Asbah E. M. Asimakopoulou L. Asquith J. Assahsah K. Assamagan R. Astalos R. J. Atkin M. Atkinson N. B. Atlay H. Atmani P. A. Atmasiddha K. Augsten V. A. Austrup G. Avolio M. K. Ayoub G. Azuelos D. Babal H. Bachacou K. Bachas F. Backman P. Bagnaia M. Bahmani H. Bahrasemani A. J. Bailey V. R. Bailey J. T. Baines C. Bakalis O. K. Baker P. J. Bakker E. Bakos D. Bakshi Gupta S. Balaji R. Balasubramanian E. M. Baldin P. Balek F. Balli W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay Sw. Banerjee L. Barak W. M. Barbe E. L. Barberio D. Barberis M. Barbero G. Barbour T. Bari CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Department of Physics University of Massachusetts Amherst Massachusetts USA CERN Geneva Switzerland II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Department of Physics Royal Holloway University of London Egham United Kingdom Department of Physics University of Toronto Toronto ON Canada Niels Bohr Institute University of Copenhagen Copenhagen Denmark Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel High Energy Physics Division Argonne National Laboratory Argonne Illinois USA INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Institut für Physik Universität Mainz Mainz Germany LAPP Univ. Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Department of Physics Bogazici University Istanbul Turkey Département de Physique Nucléaire et Corpusculaire Université de Genève Genève Switzerland Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA IJCLab Université Paris-Saclay CNRS/IN2P3 91405 Orsay France LPC Université Clermont Auvergne CNRS/IN2P3 Clermont-Ferrand France Institute for Mathematics Astrophysics and Particle Physics Radboud University/Nikhef Nijmegen Netherlands Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Departamento de Física Teórica y del Cosmos Universidad de Granada Granada (Spain)

A search for pair production of bottom squarks in events with hadronically decaying τ-leptons, b-tagged jets, and large missing transverse momentum is presented. The analyzed dataset is based on proton-proton collisions at s=13 TeV delivered by the Large Hadron Collider and recorded by the ATLAS detector from 2015 to 2018, and corresponds to an integrated luminosity of 139 fb−1. The observed data are compatible with the expected Standard Model background. Results are interpreted in a simplified model where each bottom squark is assumed to decay into the second-lightest neutralino χ˜20 and a bottom quark, with χ˜20 decaying into a Higgs boson and the lightest neutralino χ˜10. The search focuses on final states where at least one Higgs boson decays into a pair of hadronically decaying τ-leptons. This allows the acceptance and thus the sensitivity to be significantly improved relative to the previous results at low masses of the χ˜20, where bottom-squark masses up to 850 GeV are excluded at the 95% confidence level, assuming a mass difference of 130 GeV between χ˜20 and χ˜10. Model-independent upper limits are also set on the cross section of processes beyond the Standard Model.

关键词： Higgs bosons Tau leptons Supersymmetry

来源：评论

学校读者我要写书评

暂无评论

Observation of WWW Production in pp Collisions at s=13 TeV with the ATLAS Detector

引用

Physical Review Letters 2022年第6期129卷 061803-061803页

作者： G. Aad B. Abbott D. C. Abbott A. Abed Abud K. Abeling D. K. Abhayasinghe S. H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti A. C. Abusleme Hoffman B. S. Acharya B. Achkar L. Adam C. Adam Bourdarios L. Adamczyk L. Adamek S. V. Addepalli J. Adelman A. Adiguzel S. Adorni T. Adye A. A. Affolder Y. Afik C. Agapopoulou M. N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei J. A. Aguilar-Saavedra A. Ahmad F. Ahmadov W. S. Ahmed X. Ai G. Aielli I. Aizenberg M. Akbiyik T. P. A. Åkesson A. V. Akimov K. Al Khoury G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa T. Alexopoulos A. Alfonsi F. Alfonsi M. Alhroob B. Ali S. Ali M. Aliev G. Alimonti C. Allaire B. M. M. Allbrooke P. P. Allport A. Aloisio F. Alonso C. Alpigiani E. Alunno Camelia M. Alvarez Estevez M. G. Alviggi Y. Amaral Coutinho A. Ambler L. Ambroz C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso K. R. Amos C. S. Amrouche V. Ananiev C. Anastopoulos N. Andari T. Andeen J. K. Anders S. Y. Andrean A. Andreazza S. Angelidakis A. Angerami A. V. Anisenkov A. Annovi C. Antel M. T. Anthony E. Antipov M. Antonelli D. J. A. Antrim F. Anulli M. Aoki J. A. Aparisi Pozo M. A. Aparo L. Aperio Bella N. Aranzabal V. Araujo Ferraz C. Arcangeletti A. T. H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling A. J. Armbruster O. Arnaez H. Arnold Z. P. Arrubarrena Tame G. Artoni H. Asada K. Asai S. Asai N. A. Asbah E. M. Asimakopoulou J. Assahsah K. Assamagan R. Astalos R. J. Atkin M. Atkinson N. B. Atlay H. Atmani P. A. Atmasiddha K. Augsten S. Auricchio V. A. Austrup G. Avner G. Avolio M. K. Ayoub G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A. J. Bailey V. R. Bailey J. T. Baines C. Bakalis O. K. Baker P. J. Bakker E. Bakos D. Bakshi Gupta S. Balaji R. Balasubramanian E. M. Baldin P. Balek E. Ballabene F. Balli L. M. Baltes W. K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak E. L. Barberio D. Barberis M. Barbero G. Barbour CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Department of Physics University of Massachusetts Amherst Massachusetts USA CERN Geneva Switzerland II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Department of Physics Royal Holloway University of London Egham United Kingdom Physics Department Brookhaven National Laboratory Upton New York USA Faculté des sciences Université Mohammed V Rabat Morocco Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel Department of Physics New York University New York New York USA Departamento de Física Pontificia Universidad Católica de Chile Santiago Chile INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Institut für Physik Universität Mainz Mainz Germany LAPP Univ. Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics University of Toronto Toronto ON Canada Department of Physics Brandeis University Waltham Massachusetts USA Department of Physics Northern Illinois University DeKalb Illinois USA Department of Physics Bogazici University Istanbul Turkey Département de Physique Nucléaire et Corpusculaire Université de Genève Genève Switzerland Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA IJCLab Université Paris-Saclay CNRS/IN2P3 91405 Orsay France Institut de Física d’Altes Energies (IFAE) Barcelona Institute of Science and Technology Barcelona Spain INFN Sezione di Pavia Italy Dipartimento di Fisica Università di Pavia Pavia Italy Department of Physics Alexand

This Letter reports the observation of WWW production and a measurement of its cross section using 139 fb−1 of proton-proton collision data recorded at a center-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. Events with two same-sign leptons (electrons or muons) and at least two jets, as well as events with three charged leptons, are selected. A multivariate technique is then used to discriminate between signal and background events. Events from WWW production are observed with a significance of 8.0 standard deviations, where the expectation is 5.4 standard deviations. The inclusive WWW production cross section is measured to be 820±100 (stat)±80 (syst) fb, approximately 2.6 standard deviations from the predicted cross section of 511±18 fb calculated at next-to-leading-order QCD and leading-order electroweak accuracy.

关键词： Electroweak interaction Particle production W & Z bosons Hadron colliders

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

引用

Nature genetics 2023年第6期55卷 1080页

作者： Bernardo Rodriguez-Martin Eva G Alvarez Adrian Baez-Ortega Jorge Zamora Fran Supek Jonas Demeulemeester Martin Santamarina Young Seok Ju Javier Temes Daniel Garcia-Souto Harald Detering Yilong Li Jorge Rodriguez-Castro Ana Dueso-Barroso Alicia L Bruzos Stefan C Dentro Miguel G Blanco Gianmarco Contino Daniel Ardeljan Marta Tojo Nicola D Roberts Sonia Zumalave Paul A Edwards Joachim Weischenfeldt Montserrat Puiggròs Zechen Chong Ken Chen Eunjung Alice Lee Jeremiah A Wala Keiran M Raine Adam Butler Sebastian M Waszak Fabio C P Navarro Steven E Schumacher Jean Monlong Francesco Maura Niccolo Bolli Guillaume Bourque Mark Gerstein Peter J Park David C Wedge Rameen Beroukhim David Torrents Jan O Korbel Iñigo Martincorena Rebecca C Fitzgerald Peter Van Loo Haig H Kazazian Kathleen H Burns Peter J Campbell Jose M C Tubio Department of Zoology Genetics and Physical Anthropology Universidade de Santiago de Compostela Santiago de Compostela Spain. Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain. Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Transmissible Cancer Group Department of Veterinary Medicine University of Cambridge Cambridge UK. The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain. Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK. Genome Data Science Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology (BIST) Barcelona Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA) Barcelona Spain. The Francis Crick Institute London UK. Department of Human Genetics University of Leuven Leuven Belgium. Genomes and Disease Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology Daejeon South Korea. Cancer Ageing and Somatic Mutation Programme Wellcome Sanger Institute Cambridge UK. Department of Biochemistry Genetics and Immunology University of Vigo Vigo Spain. Galicia Sur Health Research Institute Vigo Spain. Faculty of Science and Technology University of Vic-Central University of Catalonia (UVic-UCC) Vic Spain. Barcelona Supercomputing Center (BSC) Barcelona Spain. Experimental Cancer Genetics Wellcome Sanger Institute Cambridge UK. Oxford Big Data Institute University of Oxford Oxford UK. DNA Repair and Genome Integrity Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Department of Biochemistry and Molecular Biology Universidade de Santiago de Compostela Santiago de Compostela Spain. Medical R

来源：评论

学校读者我要写书评

暂无评论

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

引用

Nature 2023年第7965期618卷 E19-E20页

作者： Sarah E Graham Shoa L Clarke Kuan-Han H Wu Stavroula Kanoni Greg J M Zajac Shweta Ramdas Ida Surakka Ioanna Ntalla Sailaja Vedantam Thomas W Winkler Adam E Locke Eirini Marouli Mi Yeong Hwang Sohee Han Akira Narita Ananyo Choudhury Amy R Bentley Kenneth Ekoru Anurag Verma Bhavi Trivedi Hilary C Martin Karen A Hunt Qin Hui Derek Klarin Xiang Zhu Gudmar Thorleifsson Anna Helgadottir Daniel F Gudbjartsson Hilma Holm Isleifur Olafsson Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M Brumpton Humaira Rasheed Sanni E Ruotsalainen Aki S Havulinna Yogasudha Veturi QiPing Feng Elisabeth A Rosenthal Todd Lingren Jennifer Allen Pacheco Sarah A Pendergrass Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E Miller Archie Campbell Kuang Lin Iona Y Millwood George Hindy Asif Rasheed Jessica D Faul Wei Zhao David R Weir Constance Turman Hongyan Huang Mariaelisa Graff Anubha Mahajan Michael R Brown Weihua Zhang Ketian Yu Ellen M Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian'an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood Yingji Ji Zishan Gao Simon Haworth Ruth E Mitchell Jin Fang Chai Mette Aadahl Jie Yao Ani Manichaikul Helen R Warren Julia Ramirez Jette Bork-Jensen Line L Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Carlo Sidore Edoardo Fiorillo Aaron F McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T Møllehave Betina H Thuesen Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E Galesloot Jonathan P Bradfield E Warwick Daw Joseph M Zmuda Jonathan S Mitchell Christian Fuchsberger Henry Christensen Jennifer A Brody Mary F Feitosa Mary K Wojczynski Michael Preuss Massimo Mangino Paraskevi Christofidou Niek Verweij Jan W Benjamins Jorgen Engmann Rachel L Kember Roderick C Slieker Ken Sin Lo Nuno R Zilhao Phuong Le Marcus E Kleber Graciela E Delgado Shaofeng Huo Dai Department of Internal Medicine Division of Cardiology University of Michigan Ann Arbor MI USA. VA Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Department of Biostatistics and Center for Statistics Genetics University of Michigan Ann Arbor MI USA. Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK. Endocrinology Boston Children's Hospital Boston MA USA. Medical and Population Genetics Broad Institute Cambridge MA USA. Department of Genetic Epidemiology University of Regensburg Regensburg Germany. McDonnell Genome Institute and Department of Medicine Washington University St Louis MO USA. Department of Precision Medicine Division of Genome Science National Institute of Health Cheongju-si South Korea. Tohoku Medical Megabank Organization Tohoku University Sendai Japan. Sydney Brenner Institute for Molecular Bioscience Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa. Center for Research on Genomics and Global Health National Human Genome Research Institute National Institutes of Health Bethesda MD USA. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Wellcome Sanger Institute Hinxton UK. Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA. Atlanta VA Health Care System Decatur GA USA. Malcolm Randall VA Medical Center Gainesville FL USA. Division of Vascular Sur

来源：评论

学校读者我要写书评

暂无评论

Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

引用

The Lancet Global Health 2023年第3期11卷 e385-e413页

作者： Micah, Angela E. Bhangdia, Kayleigh Cogswell, Ian E. Lasher, Dylan Lidral-Porter, Brendan Maddison, Emilie R. Nguyen, Trang Nhu Ngoc Patel, Nishali Pedroza, Paola Solorio, Juan Stutzman, Hayley Tsakalos, Golsum Wang, Yifeng Warriner, Wesley Zhao, Yingxi Zlavog, Bianca S. Abbafati, Cristiana Abbas, Jaffar Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abdelmasseh, Michael Abdulah, Deldar Morad Abedi, Aidin Abegaz, Kedir Hussein Abhilash, E.S. Aboagye, Richard Gyan Abolhassani, Hassan Abrigo, Michael R.M. Abubaker Ali, Hiwa Abu-Gharbieh, Eman Adem, Mohammed Hussien Afzal, Muhammad Sohail Ahmadi, Ali Ahmed, Haroon Ahmed Rashid, Tarik Aji, Budi Akbarialiabad, Hossein Akelew, Yibeltal Al Hamad, Hanadi Alam, Khurshid Alanezi, Fahad Mashhour Alanzi, Turki M. Al-Hanawi, Mohammed Khaled Alhassan, Robert Kaba Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Ameyaw, Edward Kwabena Amini-Rarani, Mostafa Amu, Hubert Ancuceanu, Robert Andrei, Tudorel Anwar, Sumadi Lukman Appiah, Francis Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Aravkin, Aleksandr Y. Aremu, Olatunde Aruleba, Raphael Taiwo Athari, Seyyed Shamsadin Avila-Burgos, Leticia Ayanore, Martin Amogre Azari, Samad Baig, Atif Amin Bantie, Abere Tilahun Barrow, Amadou Baskaran, Pritish Basu, Sanjay Batiha, Abdul-Monim Mohammad Baune, Bernhard T. Berezvai, Zombor Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Boachie, Micheal Kofi Bodolica, Virginia Botelho, João Silva Botelho Braithwaite, Dejana Breitborde, Nicholas J.K. Busse, Reinhard Cahuana-Hurtado, Lucero Catalá-López, Ferrán Chansa, Collins Charan, Jaykaran Chattu, Vijay Kumar Chen, Simiao Chukwu, Isaac Sunday Dadras, Omid Dandona, Lalit Dandona, Rakhi Dargahi, Abdollah Debela, Sisay Abebe Denova-Gutiérrez, Edgar Desye, Belay Dharmaratne, Samath Dhamminda Diao, Nancy Doan, Linh Phuong Dodangeh, Milad dos Santos, Wendel Mombaque Doshmangir, Leila Dube, John Eini, Ebrahim El Sayed Zaki, Maysaa El Tantawi, Maha Enyew, Daniel Berhanie Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Applied Mathematics University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Nuffield Department of Medicine University of Oxford Oxford United Kingdom Department of Juridical and Economic Studies La Sapienza University Rome Italy Antai College of Economics Shanghai Jiao Tong University Shanghai China Non-communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Tehran Heart Center Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Tehran University of Medical Sciences Tehran Iran National Institute for Health Research Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Department of Cardiology Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Department of Neurology Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic R

Background: The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic;characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic;and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods: In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global Health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. Health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings: In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95% uncertainty interval [UI] 9·1–9·3) was spent on health worldwide. We found great disparities in the amount of resources devoted to health, with high-income countries spending $7·3 trillion (95% UI 7·2–7·4) in 2019;293·7 times the $24·8 billion (95% UI 24·3–25·3) spent by low-income countries in 2019. That same year, $43·1 billion in development assistance was provided

关键词：

来源：评论

学校读者我要写书评

暂无评论

Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression

引用

European urology 2018年第3期73卷 322-339页

作者： Shancheng Ren Gong-Hong Wei Dongbing Liu Liguo Wang Yong Hou Shida Zhu Lihua Peng Qin Zhang Yanbing Cheng Hong Su Xiuqing Zhou Jibin Zhang Fuqiang Li Hancheng Zheng Zhikun Zhao Changjun Yin Zengquan He Xin Gao Haiyen E Zhau Chia-Yi Chu Jason Boyang Wu Colin Collins Stanislav V Volik Robert Bell Jiaoti Huang Kui Wu Danfeng Xu Dingwei Ye Yongwei Yu Lianhui Zhu Meng Qiao Hang-Mao Lee Yuehong Yang Yasheng Zhu Xiaolei Shi Rui Chen Yang Wang Weidong Xu Yanqiong Cheng Chuanliang Xu Xu Gao Tie Zhou Bo Yang Jianguo Hou Li Liu Zhensheng Zhang Yao Zhu Chao Qin Pengfei Shao Jun Pang Leland W K Chung Jianfeng Xu Chin-Lee Wu Weide Zhong Xun Xu Yingrui Li Xiuqing Zhang Jian Wang Huanming Yang Jun Wang Haojie Huang Yinghao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai China. Biocenter Oulu Faculty of Biochemistry and Molecular Medicine University of Oulu Oulu Finland. BGI-Shenzhen Shenzhen China China National GeneBank-Shenzhen BGI-Shenzhen Shenzhen China. Division of Biomedical Statistics and Informatics Mayo Clinic College of Medicine Rochester MN USA. China National GeneBank-Shenzhen BGI-Shenzhen Shenzhen China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Division of Genomics and Bioinformatics CUHK-BGI Innovation Institute of Trans-Omics The Chinese University of Hong Kong Hong Kong China. BGI Education Center University of Chinese Academy of Sciences Shenzhen China. BGI-Shenzhen Shenzhen China. School of Biological Science and Medical Engineering Southeast University Nanjing China State Key Laboratory of Bioelectronics Southeast University Nanjing China. Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing China. Department of Urology The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou China. Uro-Oncology Research Program Department of Medicine Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles CA USA. Vancouver Prostate Centre and Department of Urologic Sciences University of British Columbia Vancouver BC Canada. Department of Pathology and Laboratory Medicine David Geffen School of Medicine University of California Los Angeles CA USA. Department of Urology Changzheng Hospital Second Military Medical University Shanghai China. Department of Urology Fudan University Shanghai Cancer Center Shanghai China. Department of Pathology Shanghai Changhai Hospital Second Military Medical University Shanghai China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China Program for Personalized Cancer Care NorthShore University HealthS

BACKGROUND:Global disparities in prostate cancer (PCa) incidence highlight the urgent need to identify genomic abnormalities in prostate tumors in different ethnic populations including Asian men. OBJECTIVE:To systematically explore the genomic complexity and define disease-driven genetic alterations in PCa. DESIGN, SETTING, AND PARTICIPANTS:The study sequenced whole-genome and transcriptome of tumor-benign paired tissues from 65 treatment-naive Chinese PCa patients. Subsequent targeted deep sequencing of 293 PCa-relevant genes was performed in another cohort of 145 prostate tumors. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:The genomic alteration landscape in PCa was analyzed using an integrated computational pipeline. Relationships with PCa progression and survival were analyzed using nonparametric test, log-rank, and multivariable Cox regression analyses. RESULTS AND LIMITATIONS:We demonstrated an association of high frequency of CHD1 deletion with a low rate of TMPRSS2-ERG fusion and relatively high percentage of mutations in androgen receptor upstream activator genes in Chinese patients. We identified five putative clustered deleted tumor suppressor genes and provided experimental and clinical evidence that PCDH9, deleted/loss in approximately 23% of tumors, functions as a novel tumor suppressor gene with prognostic potential in PCa. Furthermore, axon guidance pathway genes were frequently deregulated, including gain/amplification of PLXNA1 gene in approximately 17% of tumors. Functional and clinical data analyses showed that increased expression of PLXNA1 promoted prostate tumor growth and independently predicted prostate tumor biochemical recurrence, metastasis, and poor survival in multi-institutional cohorts of patients with PCa. A limitation of this study is that other genetic alterations were not experimentally investigated. CONCLUSIONS:There are shared and salient genetic characteristics of PCa in Chinese and Caucasian men. Novel genetic alterations i

关键词： AR coactivator mutation Axon guidance pathway CHD1 deletion Chinese prostate cancer Clustered deleted tumor suppressor genes Personalized medicine Prognosis RNA-seq TMPRSS2-ERG fusion Whole genome sequencing

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：