The widespread availability of video recording through smartphones and digital devices has made video-based evidence more accessible than ever. Surveillance footage plays a crucial role in security, law enforcement, a...
详细信息
In this paper, some adaptive single-step methods like Trapezoid (TR), Implicit-mid point (IMP), Euler-backward (EB), and Radau IIA (Rad) methods are implemented in Maple to solve index-1 nonlinear Differential Algebra...
详细信息
1. Calibration is a crucial step for the validation of computational models and a challenging task to accomplish. 2. Dynamic Energy Budget (DEB) theory has experienced an exponential rise in the number of published pa...
详细信息
Brief communication 70 words: Generative models have been showing potential for producing data in mass. This study explores the enhancement of clinical natural language processing performance by utilizing synthetic da...
详细信息
Multivariate time series (MTS) data, when sampled irregularly and asynchronously, often present extensive missing values. Conventional methodologies for MTS analysis tend to rely on temporal embeddings based on timest...
详细信息
Relying on the anharmonic special displacement method, we introduce an ab initio quasistatic polymorphous framework to describe local disorder, anharmonicity, and electron-phonon coupling in superionic conductors. Usi...
详细信息
Severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) relies on the central molecular machine RNA-dependent RNA polymerase(Rd Rp) for the viral replication and transcription. Remdesivir at the template strand h...
详细信息
Severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) relies on the central molecular machine RNA-dependent RNA polymerase(Rd Rp) for the viral replication and transcription. Remdesivir at the template strand has been shown to effectively inhibit the RNA synthesis in SARS-Co V-2 Rd Rp by deactivating not only the complementary UTP incorporation but also the next nucleotide addition. However, the underlying molecular mechanism of the second inhibitory point remains unclear. In this work, we have performed molecular dynamics simulations and demonstrated that such inhibition has not directly acted on the nucleotide addition at the active site. Instead, the translocation of Remdesivir from +1 to-1 site is hindered thermodynamically as the posttranslocation state is less stable than the pre-translocation state due to the motif B residue G683. Moreover, another conserved residue S682 on motif B further hinders the dynamic translocation of Remdesivir due to the steric clash with the 1′-cyano substitution. Overall,our study has unveiled an alternative role of motif B in mediating the translocation when Remdesivir is present in the template strand and complemented our understanding about the inhibitory mechanisms exerted by Remdesivir on the RNA synthesis in SARS-Co V-2 Rd Rp.
Faradaic deionization (FDI) is a promising technology for energy-efficient water desalination using porous electrodes containing redox-active materials. Herein, we demonstrate for the first time the capability of a sy...
详细信息
Domestic cattle have spread across the globe and inhabit variable and unpredictable *** have been exposed to a plethora of selective pressures and have adapted to a variety of local ecological and management condition...
详细信息
Domestic cattle have spread across the globe and inhabit variable and unpredictable *** have been exposed to a plethora of selective pressures and have adapted to a variety of local ecological and management conditions,including UV exposure,diseases,and stall-feeding *** selective pressures have resulted in unique and important phenotypic and genetic differences among modern cattle breeds/*** efforts to sequence the genomes of local and commercial cattle breeds/populations,along with the growing availability of ancient bovid DNA data,have significantly advanced our understanding of the genomic architecture,recent evolution of complex traits,common diseases,and local adaptation in ***,we review the origin and spread of domestic cattle and illustrate the environmental adaptations of local cattle breeds/populations.
The rise of antibiotic resistance (AR) poses substantial threats to human and animal health, food security, and economic stability. Wastewater-based surveillance (WBS) has emerged as a powerful strategy for population...
详细信息
暂无评论