检索结果-内蒙古大学图书馆

Widely Tunable Berry Curvature in the Magnetic Semimetal Cr1+δTe2

Advanced Materials 2023年第12期35卷

作者： Fujisawa, Yuita Pardo-Almanza, Markel Hsu, Chia-Hsiu Mohamed, Atwa Yamagami, Kohei Krishnadas, Anjana Chang, Guoqing Chuang, Feng-Chuan Khoo, Khoong Hong Zang, Jiadong Soumyanarayanan, Anjan Okada, Yoshinori Okinawa904-0495 Japan Department of Physics National Sun Yat-sen University Kaohsiung80424 Taiwan Physics Division National Center for Theoretical Sciences Taipei10617 Taiwan Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore637371 Singapore Center for Theoretical and Computational Physics National Sun Yat-sen University Kaohsiung80424 Taiwan Institute of High Performance Computing Agency for Science Technology and Research Singapore138632 Singapore Department of Physics and Astronomy University of New Hampshire DurhamNH 03824 United States Materials Science Program University of New Hampshire DurhamNH 03824 United States Department of Physics National University of Singapore Singapore117551 Singapore Institute of Materials Research and Engineering Agency for Science Technology and Research Singapore138634 Singapore

Magnetic semimetals have increasingly emerged as lucrative platforms hosting spin-based topological phenomena in real and momentum spaces. Cr1+δTe2 is a self-intercalated magnetic transition metal dichalcogenide (TMD), which exhibits topological magnetism and tunable electron filling. While recent studies have explored real-space Berry curvature effects, similar considerations of momentum-space Berry curvature are lacking. Here, the electronic structure and transport properties of epitaxial Cr1+δTe2 thin films are systematically investigated over a range of doping, δ (0.33 – 0.71). Spectroscopic experiments reveal the presence of a characteristic semi-metallic band region, which shows a rigid like energy shift with δ. Transport experiments show that the intrinsic component of the anomalous Hall effect (AHE) is sizable and undergoes a sign flip across δ. Finally, density functional theory calculations establish a link between the doping evolution of the band structure and AHE: the AHE sign flip is shown to emerge from the sign change of the Berry curvature, as the semi-metallic band region crosses the Fermi energy. These findings underscore the increasing relevance of momentum-space Berry curvature in magnetic TMDs and provide a unique platform for intertwining topological physics in real and momentum spaces. © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.

关键词： Density functional theory

来源：评论

学校读者我要写书评

暂无评论

Isotope effects in molecular structures and electronic properties of liquid water via deep potential molecular dynamics based on the SCAN functional

引用

Physical Review B 2020年第21期102卷 214113-214113页

作者： Jianhang Xu Chunyi Zhang Linfeng Zhang Mohan Chen Biswajit Santra Xifan Wu Department of Physics Temple University Philadelphia Pennsylvania 19122 USA Program in Applied and Computational Mathematics Princeton University Princeton New Jersey 08544 USA CAPT HEDPS College of Engineering Peking University Beijing 100871 China Institute for Computational Molecular Science Temple University Philadelphia Pennsylvania 19122 USA

Feynman path-integral deep potential molecular dynamics (PI-DPMD) calculations have been employed to study both light (H2O) and heavy water (D2O) within the isothermalisobaric ensemble. In particular, the deep neural network is trained based on ab initio data obtained from the strongly constrained and appropriately normed (SCAN) exchange-correlation functional. Because of the lighter mass of hydrogen than deuteron, the properties of light water are more influenced by nuclear quantum effect than those of heavy water. Clear isotope effects are observed and analyzed in terms of hydrogen-bond structure and electronic properties of water that are closely associated with experimental observables. The molecular structures of both liquid H2O and D2O agree well with the data extracted from scattering experiments. The delicate isotope effects on radial distribution functions and angular distribution functions are well reproduced as well. Our approach demonstrates that deep neural network combined with SCAN functional based ab initio molecular dynamics provides an accurate theoretical tool for modeling water and its isotope effects.

关键词： Atomic & molecular structure Electronic structure Isotope effect Water Ab initio calculations Density functional theory Machine learning Molecular dynamics Path-integral methods

来源：评论

学校读者我要写书评

暂无评论

A route to hierarchical assembly of colloidal diamond

arXiv

引用

arXiv 2021年

作者： Zhou, Yuan Cersonsky, Rose K. Glotzer, Sharon C. Department of Chemical Engineering University of Michigan Ann ArborMI48109 United States Macromolecular Science and Engineering Program University of Michigan Ann ArborMI48109 United States Laboratory of Computational Science and Modelling STI Ècole Polytechnique Fèdèrale de Lausanne Lausanne1015 Switzerland Biointerfaces Institute University of Michigan Ann ArborMI48109 United States

Photonic crystals, appealing for their ability to control light, are constructed by periodic regions of different dielectric constants. Yet, the structural holy grail in photonic materials, diamond, remains challenging to synthesize at the colloidal length scale. Here we explore new ways to assemble diamond using modified gyrobifastigial (mGBF) nanoparticles, a shape that resembles two anti-aligned triangular prisms. We investigate the parameter space that leads to the self-assembly of diamond, and we compare the likelihood of defects in diamond self-assembled via mGBF vs. the nanoparticle shape that is the current focus for assembling diamond, the truncated tetrahedra. We introduce a potential route for realizing mGBF particles by dimerizing triangular prisms using attractive patches, and we report the impact of this superstructure on the photonic properties. Copyright © 2021, The Authors. All rights reserved.

关键词： Diamonds

来源：评论

学校读者我要写书评

暂无评论

Automating the Practice of science – Opportunities, Challenges, and Implications

arXiv

引用

arXiv 2024年

作者： Musslick, Sebastian Bartlett, Laura K. Chandramouli, Suyog H. Dubova, Marina Gobet, Fernand Griffiths, Thomas L. Hullman, Jessica King, Ross D. Nathan Kutz, J. Lucas, Christopher G. Mahesh, Suhas Pestilli, Franco Sloman, Sabina J. Holmes, William R. Institute of Cognitive Science Osnabrück University Osnabrück49090 Germany Department of Cognitive Linguistic & Psychological Sciences Brown University ProvidenceRI02912 United States Centre for Philosophy of Natural and Social Science London School of Economics Lakatos Building Houghton Street LondonWC2A 2AE United Kingdom AaltoFI-00076 Finland Department of Computing Science University of Alberta 8900 114 St NW EdmontonABT6G 2S4 Canada Cognitive Science Program Indiana University 1101 E 10th St BloomingtonIN47405 United States School of Psychology University of Roehampton LondonSW15 4JD United Kingdom Departments of Psychology and Computer Science Princeton University PrincetonNJ United States Department of Computer Science Northwestern University IL United States Department of Chemical Engineering and Biotechnology University of Cambridge CambridgeCB3 0AS United Kingdom Department of Computer Science and Engineering Chalmers University of Technology Gothenburg412 96 Sweden Department of Applied Mathematics and Electrical and Computer Engineering University of Washington Seattle98195 United States School of Informatics University of Edinburgh 10 Crichton St. EH8 9AB United Kingdom Department of Materials Science and Engineering University of Toronto Canada Department of Psychology Department of Neuroscience The University of Texas AustinTX United States Department of Computer Science University of Manchester M13 9PL United Kingdom

Automation transformed various aspects of our human civilization, revolutionizing industries and streamlining processes. In the domain of scientific inquiry, automated approaches emerged as powerful tools, holding promise for accelerating discovery, enhancing reproducibility, and overcoming the traditional impediments to scientific progress. This article evaluates the scope of automation within scientific practice and assesses recent approaches. Furthermore, it discusses different perspectives to the following questions: Where do the greatest opportunities lie for automation in scientific practice?;What are the current bottlenecks of automating scientific practice?;and What are significant ethical and practical consequences of automating scientific practice? By discussing the motivations behind automated science, analyzing the hurdles encountered, and examining its implications, this article invites researchers, policymakers, and stakeholders to navigate the rapidly evolving frontier of automated scientific practice. © 2024, CC BY.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Translation dysregulation in cancer as a source for targetable antigens

引用

Cancer Cell 2025年第5期43卷 823-840.e18,20页

作者： Weller, Chen Bartok, Osnat McGinnis, Christopher S. Palashati, Heyilimu Chang, Tian-Gen Malko, Dmitry Shmueli, Merav D. Nagao, Asuteka Hayoun, Deborah Murayama, Ayaka Sakaguchi, Yuriko Poulis, Panagiotis Khatib, Aseel Erlanger Avigdor, Bracha Gordon, Sagi Cohen Shvefel, Sapir Zemanek, Marie J. Nielsen, Morten M. Boura-Halfon, Sigalit Sagie, Shira Gumpert, Nofar Yang, Weiwen Alexeev, Dmitry Kyriakidou, Pelgia Yao, Winnie Zerbib, Mirie Greenberg, Polina Benedek, Gil Litchfield, Kevin Petrovich-Kopitman, Ekaterina Nagler, Adi Oren, Roni Ben-Dor, Shifra Levin, Yishai Pilpel, Yitzhak Rodnina, Marina Cox, Jürgen Merbl, Yifat Satpathy, Ansuman T. Carmi, Yaron Erhard, Florian Suzuki, Tsutomu Buskirk, Allen R. Olweus, Johanna Ruppin, Eytan Schlosser, Andreas Samuels, Yardena Department of Molecular Cell Biology Weizmann Institute of Science Rehovot 7610001 Israel Department of Pathology Stanford University Stanford 94305 CA United States Parker Institute for Cancer Immunotherapy San Francisco 94129 CA United States Department of Cancer Immunology Institute for Cancer Research Oslo University Hospital Oslo 0379 Norway Precision Immunotherapy Alliance University of Oslo Oslo Norway Cancer Data Science Laboratory Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda 20892 MD United States Department of Systems Immunology Weizmann Institute of Science Rehovot 7610001 Israel Department of Chemistry and Biotechnology of Engineering The University of Tokyo Tokyo 113-8656 Japan Department of Physical Biochemistry Max Planck Institute for Multidisciplinary Sciences Göttingen 37077 Germany Department of Pathology Sackler School of Medicine Tel Aviv University Tel Aviv 69978 Israel Department of Immunology and Regenerative Biology Weizmann Institute of Science Rehovot 7610001 Israel Computational Systems Biochemistry Research Group Max-Planck Institute of Biochemistry Martinsried 82152 Germany Department of Veterinary Resources Weizmann Institute of Science Rehovot 7610001 Israel Tissue Typing and Immunogenetics Unit Hadassah Hebrew University Hospital Jerusalem 9112102 Israel CRUK Lung Cancer Centre of Excellence University College London Cancer Institute London WC1E 6DD United Kingdom Tumour Immunogenomics and Immunosurveillance Laboratory University College London Cancer Institute London WC1E 6DD United Kingdom Department of Life Science Core Facilities Weizmann Institute of Science Rehovot 7610001 Israel Bioinformatics Unit Department of Life Sciences Core Facilities Weizmann Institute of Science Rehovot 7610001 Israel de Botton Institute for Protein Profiling the Nancy and Stephen Grand Israel National Center for Personalized Medicine Weizmann Institute of Science Rehovot

Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized as foreign by T cells. Protein synthesis in malignant cells is dysregulated, which may result in the generation and presentation of aberrant peptides that can be exploited for T cell-based therapies. To investigate the role of translational dysregulation in immunological tumor control, we disrupt translation fidelity by deleting tRNA wybutosine (yW)-synthesizing protein 2 (TYW2) in tumor cells and characterize the downstream impact on translation fidelity and immunogenicity using immunopeptidomics, genomics, and functional assays. These analyses reveal that TYW2 knockout (KO) cells generate immunogenic out-of-frame peptides. Furthermore, Tyw2 loss increases tumor immunogenicity and leads to anti-programmed cell death 1 (PD-1) checkpoint blockade sensitivity in vivo. Importantly, reduced TYW2 expression is associated with increased response to checkpoint blockade in patients. Together, we demonstrate that defects in translation fidelity drive tumor immunogenicity and may be leveraged for cancer immunotherapy. © 2025 The Author(s)

关键词： cancer immunopeptidome immune checkpoint blockade neoantigens non-canonical peptides translation fidelity

来源：评论

学校读者我要写书评

暂无评论

computational Design of Anisotropic Stealthy Hyperuniform Composites with Engineered Directional Scattering Properties

arXiv

引用

arXiv 2023年

作者： Shi, Wenlong Keeney, David Chen, Duyu Jiao, Yang Torquato, Salvatore Materials Science and Engineering Arizona State University TempeAZ85287 United States Materials Research Laboratory University of California Santa BarbaraCA93106 United States Department of Physics Arizona State University TempeAZ85287 United States Department of Chemistry Princeton University PrincetonNJ08544 United States Department of Physics Princeton University PrincetonNJ08544 United States Princeton Institute of Materials Princeton University PrincetonNJ08544 United States Program in Applied and Computational Mathematics Princeton University PrincetonNJ08544 United States

Disordered hyperuniform materials are an emerging class of exotic amorphous states of matter that endow them with singular physical properties, including large isotropic photonic band gaps, superior resistance to fracture, and nearly optimal electrical and thermal transport properties, to name but a few. Here, we generalize the Fourier-space based numerical construction procedure for designing and generating digital realizations of isotropic disordered hyperuniform two-phase heterogeneous materials (i.e., composites) developed by Chen and Torquato [Acta Mater. 142, 152 (2018)] to anisotropic microstructures with targeted spectral densities. Our generalized construction procedure explicitly incorporates the vector-dependent spectral density function χ˜V (k) of arbitrary form that is realizable. We demonstrate the utility of the procedure by generating a wide spectrum of anisotropic stealthy hyperuniform (SHU) microstructures with χ˜V (k) = 0 for k ∈ Ω, i.e., complete suppression of scattering in an "exclusion" region Ω around the origin in the Fourier space. We show how different exclusion-region shapes with various discrete symmetries, including circular-disk, elliptical-disk, square, rectangular, butterfly-shaped and lemniscate-shaped regions of varying size, affect the resulting statistically anisotropic microstructures as a function of the and phase volume fraction. The latter two cases of Ω lead to directionally hyperuniform composites, which are stealthy hyperuniform only along certain directions, and are non-hyperuniform along others. We find that, while the circular-disk exclusion regions give rise to isotropic hyperuniform composite microstructures, the directional hyperuniform behaviors imposed by the shape asymmetry (or anisotropy) of certain exclusion regions give rise to distinct anisotropic structures and degree of uniformity in the distribution of the phases on intermediate and large length scales along different directions. Moreover, while the anisotr

关键词： Volume fraction

来源：评论

学校读者我要写书评

暂无评论

Identifying topologically associating domains using differential kernels

arXiv

引用

arXiv 2023年

作者： Maisuradze, Luka King, Megan C. Surovtsev, Ivan V. Mochrie, Simon G.J. Shattuck, Mark D. O’Hern, Corey S. Department of Molecular Biophysics and Biochemistry Yale University New HavenCT United States Department of Cell Biology Yale School of Medicine New HavenCT United States Department of Physics Yale University New HavenCT United States Benjamin Levich Institute Physics Department The City College of New York New YorkNY United States Department of Mechanical Engineering and Materials Science Yale University New HavenCT United States Graduate Program in Computational Biology and Bioinformatics Yale University New HavenCT United States

Chromatin is a polymer complex of DNA and proteins that regulates gene expression. The three-dimensional (3D) structure and organization of chromatin controls DNA transcription and replication. High-throughput chromatin conformation capture techniques generate Hi-C maps that can provide insight into the 3D structure of chromatin. Hi-C maps can be represented as a symmetric matrix Aij, where each element represents the average contact probability or number of contacts between chromatin loci i and j. Previous studies have detected topologically associating domains (TADs), or self-interacting regions in Aij within which the contact probability is greater than that outside the region. Many algorithms have been developed to identify TADs within Hi-C maps. However, most TAD identification algorithms are unable to identify nested or overlapping TADs and for a given Hi-C map there is significant variation in the location and number of TADs identified by different methods. We develop a novel method to identify TADs, KerTAD, using a kernel-based technique from computer vision and image processing that is able to accurately identify nested and overlapping TADs. We benchmark this method against state-of-the-art TAD identification methods on both synthetic and experimental data sets. We find that the new method consistently has higher true positive rates (TPR) and lower false discovery rates (FDR) than all tested methods for both synthetic and manually annotated experimental Hi-C maps. The TPR for KerTAD is also largely insensitive to increasing noise and sparsity, in contrast to the other methods. We also find that KerTAD is consistent in the number and size of TADs identified across replicate experimental Hi-C maps for several organisms. Thus, KerTAD will improve automated TAD identification and enable researchers to better correlate changes in TADs to biological phenomena, such as enhancer-promoter interactions and disease states. © 2023, CC BY.

关键词： Topology

来源：评论

学校读者我要写书评

暂无评论

Nonuniform 3D finite difference elastic wave simulation on staggered grids

arXiv

引用

arXiv 2020年

作者： Gao, Longfei Ghattas, Omar Keyes, David Oden Institute for Computational Engineering and Sciences The University of Texas at Austin AustinTX78712 United States Oden Institute for Computational Engineering and Sciences Jackson School of Geosciences Department of Mechanical Engineering The University of Texas at Austin AustinTX78712 United States Applied Mathematics and Computational Science Program Extreme Computing Research Center King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia

We present an approach to simulate the 3D isotropic elastic wave propagation using nonuniform finite difference discretization on staggered grids. Specifically, we consider simulation domains composed of layers of uniform grids with different grid spacings, separated by nonconforming interfaces. We demonstrate that this layer-wise finite difference discretization has the potential to significantly reduce the simulation cost, compared to its fully uniform counterpart. Stability of such a discretization is achieved by using specially designed difference operators, which are variants of the standard difference operators with adaptations near boundaries or interfaces, and penalty terms, which are appended to the discretized wave system to weakly impose boundary or interface conditions. Combined with specially designed interpolation operators, the discretized wave system is shown to preserve the energy conserving property of the continuous elastic wave equation, and a fortiori ensure the stability of the simulation. Numerical examples are presented to demonstrate the efficacy of the proposed simulation approach. © 2020, CC BY.

关键词： Elastic waves

来源：评论

学校读者我要写书评

暂无评论

A sharp interface Lagrangian-Eulerian method for flexible-body fluid-structure interaction

arXiv

引用

arXiv 2022年

作者： Kolahdouz, Ebrahim M. Wells, David R. Rossi, Simone Aycock, Kenneth I. Craven, Brent A. Griffith, Boyce E. Center for Computational Biology Flatiron Institute Simons Foundation New YorkNY United States Department of Mathematics University of North Carolina Chapel HillNC United States Division of Applied Mechanics Office of Science and Engineering Laboratories Center for Devices and Radiological Health United States Food and Drug Administration Silver SpringMD United States Departments of Mathematics and Biomedical Engineering University of North Carolina Chapel HillNC United States Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel HillNC United States Computational Medicine Program University of North Carolina Chapel HillNC United States McAllister Heart Institute University of North Carolina Chapel HillNC United States

This paper introduces a sharp-interface approach to simulating fluid-structure interaction (FSI) involving flexible bodies described by general nonlinear material models and across a broad range of mass density ratios. This new flexible-body immersed Lagrangian-Eulerian (ILE) scheme extends our prior work on integrating partitioned and immersed approaches to rigid-body FSI. Our numerical approach incorporates the geometrical and domain solution flexibility of the immersed boundary (IB) method with an accuracy comparable to body-fitted approaches that sharply resolve flows and stresses up to the fluid-structure interface. Unlike many IB methods, our ILE formulation uses distinct momentum equations for the fluid and solid subregions with a Dirichlet-Neumann coupling strategy that connects fluid and solid subproblems through simple interface conditions. As in earlier work, we use approximate Lagrange multiplier forces to treat the kinematic interface conditions along the fluid-structure interface. This penalty approach simplifies the linear solvers needed by our formulation by introducing two representations of the fluid-structure interface, one that moves with the fluid and another that moves with the structure, that are connected by stiff springs. This approach also enables the use of multi-rate time stepping, which allows us to use different time step sizes for the fluid and structure subproblems. Our fluid solver relies on an immersed interface method (IIM) for discrete surfaces to impose stress jump conditions along complex interfaces while enabling the use of fast structured-grid solvers for the incompressible Navier-Stokes equations. The dynamics of the volumetric structural mesh are determined using a standard finite element approach to large-deformation nonlinear elasticity via a nearly incompressible solid mechanics formulation. This formulation also readily accommodates compressible structures with a constant total volume, and it can handle fully compressibl

关键词： Fluid structure interaction

来源：评论

学校读者我要写书评

暂无评论

Pre-clinical safety and efficacy of human induced pluripotent stem cell-derived products for autologous cell therapy in Parkinson's disease

引用

Cell Stem Cell 2025年第3期32卷 343-360.e7页

作者： Jeon, Jeha Cha, Young Hong, Yean Ju Lee, In-Hee Jang, Heejin Ko, Sanghyeok Naumenko, Serhiy Kim, Minseon Ryu, Hannah L. Shrestha, Zenith Lee, Nayeon Park, Tae-Yoon Park, HoeWon Kim, Seo-Hyun Yoon, Ki-Jun Song, Bin Schweitzer, Jeffrey Herrington, Todd M. Kong, Sek Won Carter, Bob Leblanc, Pierre Kim, Kwang-Soo Molecular Neurobiology Laboratory McLean Hospital and Department of Psychiatry Harvard Medical School Belmont 02478 MA United States Program in Neuroscience Harvard Medical School Belmont 02478 MA United States Department of Pediatrics Harvard Medical School Boston 02115 MA United States Computational Health Informatics Program Boston Children's Hospital Harvard Medical School Boston 02115 MA United States Department of Biostatistics Harvard Chan School of Public Health Boston 02215 MA United States Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Department of Neurosurgery Massachusetts General Hospital Harvard Medical School Boston 02114 MA United States Department of Neurology Massachusetts General Hospital Harvard Medical School Boston 02114 MA United States Harvard Stem Cell Institute Harvard Medical School Cambridge 02138 MA United States

Human induced pluripotent stem cell (hiPSC)-derived midbrain dopaminergic cells (mDACs) represent a promising source for autologous cell therapy in Parkinson's disease (PD), but standardized regulatory criteria are essential for clinical translation. In this pre-clinical study, we generated multiple clinical-grade hiPSC lines from freshly biopsied fibroblasts of four sporadic PD patients using episomal reprogramming and differentiated them into mDACs using a refined 21-day protocol. Rigorous evaluations included whole-genome/exome sequencing, RNA sequencing, and in vivo studies, including a 39-week Good Laboratory Practice-compliant mouse safety study. While mDACs from all lines met safety criteria, mDACs from one patient failed to improve rodent behavioral outcomes, underscoring inter-individual variability. Importantly, in vitro assessments did not reliably predict in vivo efficacy, identifying dopaminergic fiber density as a key efficacy criterion. These findings support comprehensive quality control guidelines for autologous cell therapy and pave the way for a clinical trial with eight sporadic PD patients, scheduled to commence in 2025. © 2025 Elsevier Inc.

关键词： autologous cell therapy dopaminergic fiber density genome integrity human induced pluripotent stem cells inter-individual variability midbrain dopaminergic cells Parkinson's disease phase 1 clinical trial pre-clinical study safety and efficacy

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：