The award is given by the company to the best employees always to provide the best performance for companies that carry out duties and obligations in the company. How to give rewards to employees not only for how long...
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Nowadays, making games is more complicated than typical applications. Based on the survey, most of the architecture applied by the development industry still does not have a pattern. Therefore the game becomes difficu...
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Nowadays, making games is more complicated than typical applications. Based on the survey, most of the architecture applied by the development industry still does not have a pattern. Therefore the game becomes difficult to develop. This study aims to create a sandbox by applying a microservice and design patterns in the game. The development of this research also involves the gaming industry to increase credibility. The results show that the platform developed has run smoothly and received good feedback from users. Therefore, the output of this research can be useful for developers in making games easy and efficient.
Modern healthcare operating rooms are cumbersome, especially in the current pandemic of Coronavirus (COVID-19) to manage the safety and security of the patients and the staff. Conditions in a modern operating room are...
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The discovery and identification of molecules in biological and environmental samples is crucial for advancing biomedical and chemical sciences. Tandem mass spectrometry (MS/MS) is the leading technique for high-throu...
ISBN:
(纸本)9798331314385
The discovery and identification of molecules in biological and environmental samples is crucial for advancing biomedical and chemical sciences. Tandem mass spectrometry (MS/MS) is the leading technique for high-throughput elucidation of molecular structures. However, decoding a molecular structure from its mass spectrum is exceptionally challenging, even when performed by human experts. As a result, the vast majority of acquired MS/MS spectra remain uninterpreted, thereby limiting our understanding of the underlying (bio)chemical processes. Despite decades of progress in machine learning applications for predicting molecular structures from MS/MS spectra, the development of new methods is severely hindered by the lack of standard datasets and evaluation protocols. To address this problem, we propose MassSpecGym - the first comprehensive benchmark for the discovery and identification of molecules from MS/MS data. Our benchmark comprises the largest publicly available collection of high-quality labeled MS/MS spectra and defines three MS/MS annotation challenges: de novo molecular structure generation, molecule retrieval, and spectrum simulation. It includes new evaluation metrics and a generalization-demanding data split, therefore standardizing the MS/MS annotation tasks and rendering the problem accessible to the broad machine learning community. MassSpecGym is publicly available at https://***/pluskal-lab/MassSpecGym.
The digitisation of the smart electrical grid provides several advantages and valuable services, such as self-monitoring, pervasive control and smart healing. However, despite the benefits of this progression, critica...
The digitisation of the smart electrical grid provides several advantages and valuable services, such as self-monitoring, pervasive control and smart healing. However, despite the benefits of this progression, critical cybersecurity and privacy issues are raised due to the vulnerabilities of legacy Electrical Power and Energy Systems (EPES) and the evolution of stealthy cyberthreats and malware. In this paper, we give emphasis to False Data Injection Attacks (FDIAs) that can affect the EPES State Estimation (SE). In particular, we investigate two FDIA categories, namely: (a) Global Positioning System (GPS) Spoofing Attacks and (b) IEEE C37.118 FDIAs against an actual testbed emulating a high-voltage IEEE 9-Bus transmission grid. Finally, we provide a relevant Intrusion Detection System (IDS) capable of detecting the aforementioned FDIAs. The evaluation analysis demonstrates the impact of the above FDIAs and the efficiency of the proposed IDS.
As continuous-flow microfluidic biochips technology rapidly advances, its automated synthesis methods require adapting to increasingly complex and stringent biochemical applications. In particular, with the introducti...
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ISBN:
(数字)9798350309270
ISBN:
(纸本)9798350309287
As continuous-flow microfluidic biochips technology rapidly advances, its automated synthesis methods require adapting to increasingly complex and stringent biochemical applications. In particular, with the introduction of time-sensitive bioassays, in this work, we present a timing-driven high-level synthesis method to optimize the resource efficiency of bioassays considering the time constraints. Specifically, we investigate the existing forms of time constraints and propose a corresponding flexible modeling approach based on reaction-control which can achieve downward compatibility for physical design. Additionally, we also analyze the impact of storage and wash on time constraints. The experimental results show that our method achieves efficient execution and low devices cost while satisfying time constraints.
This study proposes a Boolean network model to identify optimal drug targets and select the most effective FDA-approved drug combinations for Non-Small Cell Lung Cancer (NSCLC). The Boolean network models the signalin...
This study proposes a Boolean network model to identify optimal drug targets and select the most effective FDA-approved drug combinations for Non-Small Cell Lung Cancer (NSCLC). The Boolean network models the signaling pathways in NSCLC to capture the intricate molecular interactions driving tumor progression. We evaluate the model by employing the size difference (SD) score, which reflects the degree of cell dysregulation due to gene mutations and allows us to identify optimal drug targets in NSCLC cells to address this dysregulation. Specifically, leveraging the FDA-approved drug database, we identified the robust drug or drug combination for 1, 2, and 3 mutations that maximize tumor cell death and minimize cell proliferation for NSCLC-associated gene mutations. Our findings provide a strong foundation for personalized therapeutic strategies and hold promise for advancing precision oncology to effectively combat NSCLC.
Molecular hydrogen and its isotopologues are key systems to test quantum electrodynamics (QED) at molecular length scales, as their energy levels can be calculated with high accuracy[1]. Comparison of the theoretical ...
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We study the problem of efficiently charging a set of rechargeable nodes using a set of wireless chargers, under safety constraints on the electromagnetic radiation incurred. In particular, we define a new charging mo...
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An acoustic keylogger is a form of side-channel attack where an attacker can extract and log what a victim typed on a keyboard by capturing the keystroke emanations and audio signals. Using a compromised smartphone mi...
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