There are four non-isomorphic configurations of triples that can form a triangle in a 3-uniform hypergraph. Forbidding different combinations of these four configurations, fifteen extremal problems can be defined, sev...
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Taking into consideration the rise of Industry 5.0 (I5.0), more and more solutions are being developed, aiming towards increased environmental consciousness through advanced technologies, and human centricity. Digital...
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Network medicine has been actively pursued for drug repurposing, particularly lately for combating the Covid-19 pandemic. One such approach adopts structural controllability, a theory for controlling a network (the ce...
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Network medicine has been actively pursued for drug repurposing, particularly lately for combating the Covid-19 pandemic. One such approach adopts structural controllability, a theory for controlling a network (the cell). Motivated to protect, rather than control, the cell from viral infections, we extended this theory to total structural controllability and introduced the concept of control hubs. Perturbing any control hub may render the cell uncontrollable by exogenous stimuli like viral infections, so control hubs are ideal drug targets. We developed an efficient algorithm for finding all control hubs and applied it to the largest homogenous network of human protein-protein interactions and interactions between human and SARS-Cov-2 proteins. We identified 65 druggable control hubs enriched with antiviral functions and used them to prioritize drugs into four major categories: antiviral and anti-inflammatory agents, drugs on central nerve systems, dietary supplements, and hormones that help boost immunity. The functions of these druggable control hubs and their corresponding drugs validated our new method. One of the identified drugs is Fostamatinib, which was originally approved for chronic immune thrombocytopenia and is currently in a clinical trial for treating Covid-19. As shown in a preclinical trial, Fostamatinib can lower mortality, shorten the length of ICU stay, and reduce the disease severity of hospitalized Covid-19 patients. Fostamatinib targets 10 control hubs, 9 of which are kinases playing key roles in cell proliferation, differentiation, and programmed death. One of these kinases is RIPK1 which directly interacts with the RNA-dependent RNA polymerase of SARS-CoV-2. The functions and biological processes that the druggable control hubs were involved with have not only revealed the diverse cellular responses during SARS-CoV-2 infection but provided deep insight into the therapeutic mechanisms of the drugs for Covid-19 therapy, making the new approach
In 2020, Coregliano and Razborov introduced a general framework to study limits of combinatorial objects, using logic and model theory. They introduced the abstract chromatic number and proved/reproved multiple Erdős...
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The escalating frequency of geological disasters, local conflicts, and public health crises necessitates robust emergency communication systems within Internet of Things (IoT) frameworks to ensure public safety. Emplo...
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ISBN:
(数字)9798350368369
ISBN:
(纸本)9798350368376
The escalating frequency of geological disasters, local conflicts, and public health crises necessitates robust emergency communication systems within Internet of Things (IoT) frameworks to ensure public safety. Employing Power-Domain NOMA (PD-NOMA) and Successive Interference Cancellation (SIC) enables effective multi-device communication that is crucial for emergency responses. However, the practical implementation of NOMA technologies in emergency scenarios is hindered by existing resource constraints and the requirement of prioritizing critical emergency information. To address these limitations, we propose a multi-objective optimization-based NOMA framework to maximize network throughput while ensuring quality of service (QoS) and energy efficiency. This framework incorporates a novel communication grouping algorithm based on queue penalty optimization and an Actor-Critic-based dynamic updating algorithm for multiple resource allocation. Our study proposes a practical approach to enhance emergency communication in disaster areas, ensuring efficient and reliable network performance under various constraints.
The empirical distributions of various statistical indicators that influence the implementation of algorithms for information exchange between users of the social network •Vkontakte• are analyzed. The authors of the a...
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Applied physics serves as the bridge connecting theoretical principles with their practical implementations in everyday situations. informatics plays a crucial role in this subject because of its comprehensive and int...
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ISBN:
(数字)9798350371154
ISBN:
(纸本)9798350371161
Applied physics serves as the bridge connecting theoretical principles with their practical implementations in everyday situations. informatics plays a crucial role in this subject because of its comprehensive and intricate capacity to simulate and forecast physical phenomena. This research highlights the indispensability of computer-based algorithms for analyzing the Scanning Electron Images of the obtained materials, particularly materials synthesized by laboratory plasma. Herein, the conducted research highlights the advantages of image processing via Matlab and Python algorithms, in order to analyze the synthesized structures. This approach can offer perspectives on physical processes by employing image processing techniques. The approaches and future directions were identified.
In this study, we tackle the challenging fine-grained edge detection task, which refers to predicting specific edges caused by reflectance, illumination, normal, and depth changes, respectively. Prior methods exploit ...
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In this paper, we propose a novel voxel-based 3D single object tracking (3D SOT) method called Voxel Pseudo Image Tracking (VPIT). VPIT is the first method that uses voxel pseudo images for 3D SOT. The input point clo...
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Considering the uncertainty of the parameters affecting the conditions for the normal functioning of the territory of the state, it is proposed to create an effective information and analytical subsystem to manage the...
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