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BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2023年第6期20卷 824-835页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species that is representative of the data obtained in many neuroscience laboratories interested in neuron tracing. Here, we report generated gold standard manual annotations for a subset of the available imaging datasets and quantified tracing quality for 35 automatic tracing algorithms. The goal of generating such a hand-curated diverse dataset is to advance the development of tracing algorithms and enable generalizable benchmarking. Together with image quality features, we pooled the data in an interactive web application that enables users and developers to perform principal component analysis, t-distributed stochastic neighbor embedding, correlation and clustering, visualization of imaging and tracing data, and benchmarking of automatic tracing algorithms in user-defined data subsets. The image quality metrics explain most of the variance in the data, followed by neuromorphological features related to neuron size. We observed that diverse algorithms can provide complementary information to obtain accurate results and developed a method to iteratively combine methods and generate consensus reconstructions. The consensus trees obtained provide estimates of the neuron structure ground truth that typically outperform single algorithms in noisy datasets. However, specific algorithms may outperform the consensus tree strategy in specific imaging conditions. Finally, to aid users in predicting the most accurate automatic tracing results without manual annotations for comparison, we used support vector machine regression to predict reconstruction quality given an image volume and a set of automatic tracings.

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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Characterising acute and chronic care needs: insights from the Global Burden of Disease study 2019

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Nature communications 2025年第1期16卷 4235-4235页

作者： Cecilia Anza-Ramirez J. Jaime Miranda Benedetta Armocida Jorge César Correia Harriette Gillian Christine Van Spall David Beran Amirali Aali Kalkidan Hassen Abate Semagn Mekonnen Abate Cristiana Abbafati Mohsen Abbasi-Kangevari Zeinab Abbasi-Kangevari Zahra Aryan Sina Azadnajafabad Mohammadreza Azangou-Khyavy Seyyed-Hadi Ghamari Mohammad Keykhaei Javad Khanali Sara Momtazmanesh Fateme Montazeri Shayan Rahmani Mohammad-Mahdi Rashidi Nazila Rezaei Negar Rezaei Sahar Saeedi Moghaddam Hossein Hassanian-Moghaddam Ali-Asghar Kolahi Ali Nikoobar Hedayat Abbastabar Ahmed M. Abdel-Azeem Michael Abdelmasseh Juan Sanabria Sherief Abd-Elsalam Ahmed Abdelwahab Gholamreza Abdoli Mohammad Abdollahi Meriem Abdoun Deldar Morad Abdulah Abu Yousuf Md Abdullah Ame Mehadi Abdurehman Getachew Abebe Aidin Abedi Chirag P. Doshi Vida Abedi Hassan Abidi Richard Gyan Aboagye Hassan Abolhassani Nima Rezaei Lucas Guimarães Abreu Michael R. M. Abrigo Yonas Derso Abtew Hiwa Abubaker Ali Eman Abu-Gharbieh Hiba Jawdat Barqawi Rabih Halwani Maha Mohamed Saber-Ayad Iman M. Talaat Ahmed Abu-Zaid Manfred Mario Kokou Accrombessi Juan Manuel Acuna Denberu Eshetie Adane Tigist Demssew Adane Isaac Yeboah Addo Giovanni Addolorato Oluwafemi Atanda Adeagbo Victor Adekanmbi Miracle Ayomikun Adesina Isaac Iyinoluwa Olufadewa Olatunji O. Adetokunboh Daniel Adedayo Adeyinka Qorinah Estiningtyas Sakilah Adnani Aanuoluwapo Adeyimika Afolabi Olayinka Stephen Ilesanmi Muhammad Sohail Afzal Saira Afzal Gina Agarwal Prerna Agarwal Pradyumna Agasthi Anurag Agrawal Marcela Agudelo-Botero Adolfo Martinez-Valle Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Sohail Ahmad Tauseef Ahmad Ali Ahmadi Siamak Sabour Keivan Ahmadi Sanjay Basu Sepideh Ahmadi Ali Ahmed Shaun Wen Huey Lee Ayman Ahmed Haroon Ahmed Jivan Qasim Ahmed Gahin Abdulraheem Tayib Yahya Yahya Luai A. Ahmed Iffat Elbarazi Syed Mahboob Shah Janardhana P. Aithala Marjan Ajami Budi Aji Hossein Akbarialiabad Yibeltal Akelew Meisam Akhlaghdoust Elham Jamshidi Addis Aklilu Azene Tesfaye Melat Woldemariam Maxwell Ak CRONICAS Center of Excellence in Chronic Diseases Universidad Peruana Cayetano Heredia Lima Peru School of Medicine Universidad Peruana Cayetano Heredia Lima Peru Sydney School of Public Health Faculty of Medicine and Health University of Sydney Sydney NSW Australia Faculty of Epidemiology and Population Health London School of Hygiene & Tropical Medicine London UK Division of Tropical and Humanitarian Medicine University of Geneva Geneva Switzerland Department of Cardiovascular Endocrine-metabolic Diseases and Aging Istituto Superiore di Sanità Rome Italy Division of Endocrinology Diabetology Nutrition and Therapeutic Patient Education Department of Medicine Geneva University Hospitals Geneva Switzerland Department of Medicine and Department of Health Research Evidence and Impact McMaster University Hamilton ON Canada Research Institute of St. Joe’s Hamilton ON Canada Population Health Research Institute Hamilton Canada Geneva University Hospitals Geneva Switzerland Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Nutrition and Dietetics Jimma University Jimma Ethiopia Anesthesiology Department Dilla University Addis Ababa Ethiopia Department of Juridical and Economic Studies La Sapienza University Rome Italy Non-Communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Brigham and Women’s Hospital Harvard University Boston MA USA Students’ Scientific Research Center (SSRC) Tehran University of Medical Sciences Tehran Iran School of Medicine Tehran University of Medical Sciences Tehran Iran School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Institute Tehran University of Medical Sciences Tehran Iran Chapter of Addiction Medicine University of Sydney Sydney NSW Australia Advanced Diagnostic and Intervent

Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic care, while 27% were due to acute care. Chronic care needs increased with age, representing 86% of YLDs and 71% of YLLs, and accounting for 93% of YLDs from sequelae. These findings highlight that chronic care needs far exceed acute care needs globally, necessitating health systems to adapt accordingly. © 2025. The Author(s).

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Iran in transition (vol 393, pg 1984, 2019)

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LANCET 2019年第10186期393卷 2124-2124页

作者： Danaei, G. Farzadfar, F. Kelishadi, R. [a]Department of Global Health and Population and Department of Epidemiology Harvard T H Chan School of Public Health Boston MA USA Department of Global Health and Population and Department of Epidemiology Harvard T H Chan School of Public Health Boston MA USA [b]Scientific Association for Public Health in Iran Boston MA USA Scientific Association for Public Health in Iran Boston MA USA [c]Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran [d]Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran [e]Diabetes Research Center Tehran University of Medical Sciences Tehran Iran Diabetes Research Center Tehran University of Medical Sciences Tehran Iran [f]Endocrinology and Metabolism Clinical Sciences Institute Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Clinical Sciences Institute Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran [g]Department of Global Health and Public Policy Tehran University of Medical Sciences Tehran Iran Department of Global Health and Public Policy Tehran University of Medical Sciences Tehran Iran [h]Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran [i]School of Public Health Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran [j]Faculty of Medicine Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Te

Summary Being the second-largest country in the Middle East, Iran has a long history of civilisation during which several dynasties have been overthrown and established and health-related structures have been reorganised. Iran has had the replacement of traditional practices with modern medical treatments, emergence of multiple pioneer scientists and physicians with great contributions to the advancement of science, environmental and ecological changes in addition to large-scale natural disasters, epidemics of multiple communicable diseases, and the shift towards non-communicable diseases in recent decades. Given the lessons learnt from political instabilities in the past centuries and the approaches undertaken to overcome health challenges at the time, Iran has emerged as it is today. Iran is now a country with a population exceeding 80 million, mainly inhabiting urban regions, and has an increasing burden of non-communicable diseases, including cardiovascular diseases, hypertension, diabetes, malignancies, mental disorders, substance abuse, and road injuries.

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DEA Model with Hesitant Fuzzy Polyhedral Set in Benchmarking

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Journal of Physics: Conference Series 2019年第1期1361卷

作者： Dahlan Abdullah H Hartono Cut Ita Erliana Defi Irwansyah Nurintan Asyiah Siregar Ayu Esteka Sari Abdurrozzaq Hasibuan Abdussakir Nuning Kurniasih Mas'ut Irma Yanti Rangkuti Nurmawati Erni Buston Apridar Abdurrahman Tita Septi Handayani Wiwien Hadikurniawati Edy Winarno Department of Informatics Universitas Malikussaleh Aceh Indonesia Department of Computer Science STMIK IBBI Medan Indonesia Department of Industrial Engineering Universitas Malikussaleh Aceh Indonesia Department of Management STIE Labuhanbatu Sumatera Utara Indonesia Department of Management STIE Sakti Alam Kerinci Jambi Indonesia Faculty of Engineering Universitas Islam Sumatera Utara Medan Indonesia Department of Mathematics Education State Islamic University of Malang MalangIndonesia Faculty of Communication Sciences Library and Information Science Program Universitas Padjadjaran Bandung Indonesia Faculty of Economic Universitas Islam Sumatera Utara Medan Indonesia Faculty of Medical Universitas Islam Sumatera Utara Medan Indonesia Faculty of Industry Technique University of 45 Surabaya Indonesia Departement of Nursing Politeknik Kesehatan Kementerian Bengkulu Indonesia Department of Management Universitas Malikussaleh Aceh Indonesia Departemen of Nursing Universitas Dehasen Bengkulu Indonesia Faculty of Information Technology Universitas Stikubank Semarang Indonesia

Data Envelopment Analysis (DEA) method is a linear programming approach that has been widely used as a framework for evaluating efficiency and measurement. DEA decision making is often faced with situations where the existing DMU has input and output that contains fuzzy and hesitant elements so that it is difficult to make efficiency measurements. This study will design a DEA model in the state of inputs and outputs that contain hesitant elements by using polyhedral uncertainty sets. The results of this study are expected to produce a benchmarking model with DEA that can overcome the hesitant element and have the advantage of using a polyhedral uncertainty set that can measure the linearity of the nominal problem.

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26th Annual Computational Neuroscience Meeting (CNS*2017) of the Organization for Computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Light, the universe, and everything-12 Herculean tasks for quantum cowboys and black diamond skiers

arXiv

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arXiv 2018年

作者： Agarwal, Girish Allen, Roland E. Bezdìková, Iva Boyd, Robert W. Chen, Goong Hanson, Ronald Hawthorne, Dean L. Hemmer, Philip Kim, Moochan B. Kocharovskaya, Olga Lee, David M. Lidström, Sebastian K. Lidström, Suzy Losert, Harald Maier, Helmut Neuberger, John W. Padgett, Miles J. Raizen, Mark Rajendran, Surjeet Rasel, Ernst Schleich, Wolfgang P. Scully, Marlan O. Shchedrin, Gavriil Shvets, Gennady Sokolov, Alexei Svidzinsky, Anatoly Walsworth, Ronald L. Weiss, Rainer Wilczek, Frank Willner, Alan E. Yablonovich, Eli Zheludev, Nikolay Department of Physics and Astronomy Texas A&M University College StationTX77843 United States Department of Physics Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague Brehova 7 Praha 1-Staré mìsto11519 Czech Republic Department of Physics Technical University of Ostrava 17 Listopadu 15 Ostrava-Poruba70833 Czech Republic Department of Physics School of Electrical Engineering and Computer Science University of Ottawa OttawaONK1N6N5 Canada Institute of Optics Department of Physics and Astronomy University of Rochester RochesterNY14627 United States School of Physics and Astronomy University of Glasgow GlasgowG128QQ United Kingdom Department of Mathematics Texas A&M University College StationTX77843 United States Science Program Texas A&M University at Qatar Education City Doha Qatar Texas A&M University College StationTX77843 United States QuTech and Kavli Institute of Nanoscience Delft University of Technology P.O. Box 5046 Delft2600 GA Netherlands Cornell Laboratory of Ornithology Cornell University IthacaNY14850 United States Laboratory of Atomic and Solid State Physics Cornell University IthacaNY14853 United States Department of Electrical & Computer Engineering Texas A&M Energy Institute Texas A&M University TX77843 United States Department of Physics Strathclyde University GlasgowG11XJ United Kingdom Physica Scripta Royal Swedish Academy of Sciences StockholmSE-10405 Sweden Universität Ulm Albert-Einstein-Allee 11 Ulm89081 Germany Institut für Zahlentheorie und Wahrscheinlichkeitstheorie Universität Ulm Albert-Einstein-Allee 11 Ulm89081 Germany Department of Mathematics University of North Texas DentonTX76203-5017 United States College of Natural Sciences University of Texas AustinTX78712 United States Department of Physics University of California BerkeleyCA94720-7300 United States Institut fuer Quantenoptik QUEST-LFS Welfengarten 1 Hannover30167 Germany Hagler Insti

The Winter Colloquium on the Physics of Quantum Electronics (PQE) has been a seminal force in quantum optics and related areas since 1971. It is rather mindboggling to recognize how the concepts presented at these conferences have transformed scientific understanding and human society. In January, 2017, the participants of PQE were asked to consider the equally important prospects for the future, and to formulate a set of questions representing some of the greatest aspirations in this broad field. The result is this multi-authored paper, in which many of the world's leading experts address the following fundamental questions: (1) What is the future of gravitational wave astronomy? (2) Are there new quantum phases of matter away from equilibrium that can be found and exploited-such as the time crystal? (3) Quantum theory in uncharted territory: What can we learn? (4) What are the ultimate limits for laser photon energies? (5) What are the ultimate limits to temporal, spatial, and optical resolution? (6) What novel roles will atoms play in technology? (7) What applications lie ahead for nitrogen-vacancy centers in diamond? (8) What is the future of quantum coherence, squeezing, and entanglement for enhanced superresolution and sensing? (9) How can we solve (some of) humanity's biggest problems through new quantum technologies? (10) What new understanding of materials and biological molecules will result from their dynamical characterization with free electron lasers? (11) What new technologies and fundamental discoveries might quantum optics achieve by the end of this century? (12) What novel topological structures can be created and employed in quantum optics? Copyright © 2018, The Authors. All rights reserved.

关键词： Quantum optics

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Commentaries on Viewpoint: Using V̇o2max as a marker of training status in athletes - can we do better?

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Journal of applied physiology (Bethesda, Md. : 1985) 2022年第1期133卷 148-164页

作者： Pedro L Valenzuela Manuel Mateo-March Xabier Muriel Mikel Zabala Alejandro Lucia David Barranco-Gil Grégoire P Millet Franck Brocherie Johannes Burtscher Martin Burtscher Benjamin J Ryan Rachel A Gioscia-Ryan Stephane Perrey Víctor Rodrigo-Carranza Fernando González-Mohíno José María González-Ravé Jordan Santos-Concejero Benedito S Denadai Camila C Greco Arturo Casado Carl Foster Raffaele Mazzolari Giulia Nicole Baldrighi Elisa Pastorio Davide Malatesta Aurélien Patoz Fabio Borrani Stephen J Ives Justin A DeBlauw Ricardo Dantas de Lucas Fernando Klitzke Borszcz Eduardo Marcel Fernandes Nascimento Luiz Guilherme Antonacci Guglielmo Tiago Turnes Richard T Jaspers Stephan van der Zwaard Romuald Lepers Julien Louis Anderson Meireles Hiago L. R. de Souza Géssyca T de Oliveira Marcelo P dos Santos Rhaí A Arriel Moacir Marocolo B Hunter S Meyler D Muniz-Pumares Renato M Ferreira Abigail S Sogard Stephen J Carter Timothy D Mickleborough Guilherme Pereira Saborosa Raphael Dinalli de Oliveira Freitas Paula Souza Alves dos Santos João Pedro de Souza Ferreira Francisco de Assis Manoel Sandro Fernandes da Silva Christoph Triska Bettina Karsten Dajo Sanders Elliot S Lipksi David J Spindler Matthijs K. C. Hesselink Rodrigo Zacca Márcio Fagundes Goethel David Bruce Pyne Brayden M Wood Peyton E Allen Jaden L Gabelhausen Alexandra M Keller Mast T Lige Alicia S Oumsang Greg L Smart Hunter L Paris Arthur H Dewolf Guillaume Toffoli Borja Martinez-Gonzalez Samuele M Marcora Daniela Terson de Paleville Ricardo J Fernandes Susana M Soares J. Arturo Abraldes Guilherme Matta Arthur Henrique Bossi D G McCarthy W Bostad J Gibala Mary Vagula Grupo de Investigación en Actividad física y Salud (PaHerg) Instituto de Investigación Hospital 12 de Octubre (imas12) Madrid Spain Faculty of Sport Sciences Universidad Europea de Madrid Madrid Spain Sport Science Department. Universidad Miguel Hernández Elche Spain Human Performance and Sports Science Laboratory Faculty of Sport Sciences University of Murcia Murcia Spain Department of Physical Education & Sport Faculty of Sport Sciences University of Granada Granada Spain Institute of Sport Sciences University of Lausanne Lausanne Switzerland Laboratory Sport Expertise and Performance (EA 7370) French Institute of Sport (INSEP) Paris France Department of Sport Science University of Innsbruck Innsbruck Austria Thermal and Mountain Medicine Division US Army Research Institute of Environmental Medicine Natick Massachusetts Department of Anesthesiology University of Michigan Ann Arbor Michigan EuroMov Digital Health in Motion University of Montpellier Montpellier France Sport Training Lab University of Castilla-La Mancha Toledo Spain Facultad de Ciencias de la Vida y de la Naturaleza Universidad Nebrija Madrid Spain Department of Physical Education and Sport University of the Basque Country UPV/EHU Vitoria-Gasteiz Spain Human Performance Laboratory São Paulo State University Rio Claro Brazil Center for Sport Studies Rey Juan Carlos University Madrid Spain University of Wisconsin-La Crosse La Crosse Wisconsin Department of Physical Education and Sport University of the Basque Country (UPV/EHU) Vitoria-Gasteiz Spain Department of Molecular Medicine University of Pavia Pavia Italy Department of Brain and Behavioural Sciences − Medical and Genomic Statistics Unit University of Pavia Pavia Italy Department of Biomedical Sciences for Health University of Milan Milan Italy Institute of Sport Sciences of University of Lausanne (ISSUL) University of Lausanne Lausanne Switzerland Health and Human Physiological Sciences Skidmore College Saratoga Springs New

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Erratum to: Search for production in the multilepton final state in proton–proton collisions at = 13 TeV with the ATLAS detector

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Journal of High Energy Physics 2025年第5期2025卷 1-22页

作者： Aad, G. Abbott, B. Abbott, D. C. Abeling, K. Abidi, S. H. Aboulhorma, A. Abramowicz, H. Abreu, H. Abulaiti, Y. Abusleme Hoffman, A. C. Acharya, B. S. Achkar, B. Adam, L. Adam Bourdarios, C. Adamczyk, L. Adamek, L. Addepalli, S. V. Adelman, J. Adiguzel, A. Adorni, S. Adye, T. Affolder, A. A. Afik, Y. Agaras, M. N. Agarwala, J. Aggarwal, A. Agheorghiesei, C. Aguilar-Saavedra, J. A. Ahmad, A. Ahmadov, F. Ahmed, W. S. Ai, X. Aielli, G. Aizenberg, I. Akbiyik, M. Åkesson, T. P. A. Akimov, A. V. Al Khoury, K. Alberghi, G. L. Albert, J. Albicocco, P. Alconada Verzini, M. J. Alderweireldt, S. Aleksa, M. Aleksandrov, I. N. Alexa, C. Alexopoulos, T. Alfonsi, A. Alfonsi, F. Alhroob, M. Ali, B. Ali, S. Aliev, M. Alimonti, G. Allaire, C. Allbrooke, B. M. M. Allport, P. P. Aloisio, A. Alonso, F. Alpigiani, C. Alunno Camelia, E. Alvarez Estevez, M. Alviggi, M. G. Amaral Coutinho, Y. Ambler, A. Amelung, C. Ames, C. G. Amidei, D. Amor Dos Santos, S. P. Amoroso, S. Amos, K. R. Amrouche, C. S. Ananiev, V. Anastopoulos, C. Andari, N. Andeen, T. Anders, J. K. Andrean, S. Y. Andreazza, A. Angelidakis, S. Angerami, A. Anisenkov, A. V. Annovi, A. Antel, C. Anthony, M. T. Antipov, E. Antonelli, M. Antrim, D. J. A. Anulli, F. Aoki, M. Aparisi Pozo, J. A. Aparo, M. A. Aperio Bella, L. Appelt, C. Aranzabal, N. Araujo Ferraz, V. Arcangeletti, C. Arce, A. T. H. Arena, E. Arguin, J-F. Argyropoulos, S. Arling, J.-H. Armbruster, A. J. Arnaez, O. Arnold, H. Arrubarrena Tame, Z. P. Artoni, G. Asada, H. Asai, K. Asai, S. Asbah, N. A. Asimakopoulou, E. M. Assahsah, J. Assamagan, K. Astalos, R. Atkin, R. J. Atkinson, M. Atlay, N. B. Atmani, H. Atmasiddha, P. A. Augsten, K. Auricchio, S. Auriol, A. D. Austrup, V. A. Avner, G. Avolio, G. Axiotis, K. Ayoub, M. K. Azuelos, G. Babal, D. Bachacou, H. Bachas, K. Bachiu, A. Backman, F. Badea, A. Bagnaia, P. Bahmani, M. Bailey, A. J. Bailey, V. R. Baines, J. T. Bakalis, C. Baker, O. K. Bakker, P. J. Bakos, E. Bakshi Gupta, D. Balaji, S. Balasubramanian, R. Baldin, E. M. Balek, P. Ballabene, E. Balli, F. Baltes CPPM Aix-Marseille Université CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman United States of America Department of Physics University of Massachusetts Amherst United States of America II. Physikalisches Institut Georg-August-Universität Göttingen Göttingen Germany Physics Department Brookhaven National Laboratory Upton United States of America Faculté des sciences Université Mohammed V Rabat Morocco Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion Israel Institute of Technology Haifa Israel Department of Physics New York University New York United States of America Departamento de Física Pontificia Universidad Católica de Chile Santiago Chile INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Department of Physics King’s College London London United Kingdom Institut für Physik Universität Mainz Mainz Germany LAPP Univ. Savoie Mont Blanc CNRS/IN2P3 Annecy France AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics University of Toronto Toronto Canada Department of Physics Brandeis University Waltham United States of America Department of Physics Northern Illinois University DeKalb United States of America Department of Physics Istanbul University Istanbul Türkiye Département de Physique Nucléaire et Corpusculaire Université de Genève Genève Switzerland Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz United States of America CERN Geneva Switzerland Institut de Física d’Altes Energies (IFAE) Barcelona Institute of Science and Technology Barcelona Spain INFN Sezione di Pavia Pavia Italy Dipartimento di Fisica Università di Pavia Pavia Italy Department of Physics Alexandru Ioan C

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