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Informatica (Slovenia) 2025年第1期49卷 193-206页

作者： Ilham, Ahmad Nagara, Thahta Ardhika Prabu Kamaruddin, Mudyawati Khikmah, Laelatul Mantoro, Teddy Department of Informatics Universitas Muhammadiyah Semarang Semarang Indonesia Intelligent Data Science Research Group Universitas Muhammadiyah Semarang Semarang Indonesia Postgraduate Program of Medical Laboratory Science Universitas Muhammadiyah Semarang Semarang Indonesia Interdisciplinary Research Laboratory for Experimental Plasma Medicine Universitas Muhammadiyah Semarang Semarang Indonesia Department of Statistics Institut Teknologi Statistika dan Bisnis Muhammadiyah Semarang Semarang Indonesia School of Computer Science Nusa Putra University West Java Indonesia

Fetal mortality and newborn health issues require urgent attention because of high maternal and infant mortality rates during labor, highlighting the critical need for accurate fetal condition monitoring to reduce complications. This study proposes the development of a fetal health risk classification model based on Important Feature Selection (IFS) and a Classification and Regression Tree (CART) using cardiotocography (CTG) data from the UCI Machine Learning Repository. The IFS method was used to select the most relevant features, reduce model complexity, and increase generalization to prevent overfitting. The IFS-CART model was tested with 10-fold cross-validation and showed an accuracy of 94.50%, superior to the conventional CART, which only reached 93.83%. In addition, the average values of the True Positive Rate (TPR) and True Negative Rate (TNR) also increased, indicating that this model is effective in distinguishing normal, suspected, and pathological fetal conditions. Evaluation using the area under the curve receiver operating characteristic (AUC-ROC) showed that the model had high performance in detecting at-risk conditions, with an AUC of 0.981 for the"suspect" class. This finding confirmed that IFS-CART is not only accurate but also has high interpretability, making it easy for medical personnel to use for clinical decision support. The results of this study show that IFS-CART can serve as a reliable decision support system for real-time fetal health monitoring. Further implementation is expected to improve diagnostic accuracy and prevent complications during pregnancy and labor © 2025 Slovene Society Informatika. All rights reserved.

关键词： Fetal monitoring

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Psoriasis: Perspectives from Irwin M. Braverman, MD

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Clinics in Dermatology 2025年第2期43卷 166-169页

作者： Cohen, Jeffrey M. Bunick, Christopher G. Department of Dermatology Yale School of Medicine New Haven CT United States Department of Biomedical Informatics and Data Science Yale School of Medicine New Haven CT United States Program in Translational Biomedicine Yale University New Haven CT United States

Dr Irwin M. Braverman is recognized as an expert on many skin diseases, including psoriasis, an immune-mediated disorder that presents with scaly erythematous plaques. The most common clinical subtype is plaque psoriasis, with scalp, inverse, guttate, pustular, and nail psoriasis representing additional subtypes. Psoriasis has been associated with several comorbidities, particularly psoriatic arthritis, which affects up to 30% of those with psoriasis. Psoriasis can have an enormous impact on patients, and Dr Braverman reflects that “it is hard to think of another disease that can be so destructive or impactful.” Over the course of his career, Dr Braverman treated many patients with psoriasis and observed several significant therapeutic advances, including the widespread use of psoralens with UV-A phototherapy and the introduction of methotrexate. He also contributed to research on the pathophysiology of psoriasis, studying the hallmark dilated capillary loops. Dr Braverman ultimately believes that “taking care of a patient with psoriasis goes into the making of a dermatologist.” © 2024 Elsevier Inc.

关键词： Goeckerman regimen blood vessels electron microscopy methotrexate phototherapy psoriasis

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Drivers of the Sustainability Performance of Induction Stove Conversion program in Indonesia

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International Journal of Sustainable Energy Planning and Management 2025年 43卷 5-30页

作者： Damayanti, Retno Wulan Safira, Silvia Dhea Laksono, Pringgo Widyo Setiadi, Haryono Entifar, Nisa Aqilla Ellenahaya Industrial Engineering Study Program Sebelas Maret University Ir.Sutami 36A Surakarta57121 – 57162 Indonesia Center of Technology Development and Industrial Collaboration Institute for Research and Community Service Sebelas Maret University Ir.Sutami 36A Surakarta57121 – 57162 Indonesia Informatics and Science Data Study Program Sebelas Maret University Ir.Sutami 36A Surakarta57121 – 57162 Indonesia Smart Green Technology Engineering Department Pukyong National University 45 Yongso-ro Nam-Gu Busan Korea Republic of

In 2022, Indonesia initiated a pilot project to transition from liquid petroleum gas (LPG) stoves to induction stoves, targeting 8.2 million households by 2025. While LPG is considered a clean cooking fuel by the World Health Organization due to its low PM2.5 emissions, this program aims to further reduce CO2 emissions from cooking activities, aligning with Indonesia’s clean energy transition and 2060 Net Zero Emission goals. Throughout the program, doubts and criticisms arose among various sectors of society, particularly concerning the sustainability of this program. This research aims to determine and analyze the driving factors that support the sustainability of the induction stove transition program. Five sustainability aspects, namely, economic, social, environmental, technical, and institutional, were analyzed. A total of 315 Indonesian citizens participated as respondents in this research survey. The Partial Least Squares-Structural Equation Model (PLS–SEM) method was utilized as the analytical approach for the study. The results revealed that nine factors significantly influenced program sustainability, with the strongest impacts from technology costs (path coefficient = 0.859), contextual factors (0.803), electrical infrastructure (0.792), and community perception (0.773). Economic sustainability was driven by technology costs and business opportunities (0.643), while environmental sustainability was strongly influenced by electrical infrastructure. Post-installation support (0.307) and financial management (0.391) significantly impacted technical and institutional sustainability respectively. These empirical findings improve previous research on the sustainability of an energy transition program, which provides insights for researchers and stakeholders in the energy management field, especially in developing countries, for policy determination and decision-making. © 2025, Aalborg University Press. All rights reserved.

关键词： Clean energy

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Enhanced Performance and data Privacy in Lung Nodule Classification via Federated Deep Learning Approach 24

Enhanced Performance and Data Privacy in Lung Nodule Classif...

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2024 7th International Conference on Healthcare Service Management, ICHSM 2024

作者： Nguyen, Duc-Khanh Li, Ai-Hsien Adam Lai, Yen-Jun Chiu, Yen-Ling Phan, Dinh-Van Chien, Ting-Ying Chan, Chien-Lung Department of Information Management Yuan Ze University Taoyuan Taiwan Department of Statistics and Informatics University of Economics The University of Danang Danang Viet Nam Division of Cardiology Far Eastern Memorial Hospital New Taipei Taiwan Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan Taiwan Department of Radiology Far Eastern Memorial Hospital New Taipei Taiwan Graduate Institute of Medicine and Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan Taiwan Department of Medical Research Far Eastern Memorial Hospital New Taipei Taiwan Department of Computer Science and Engineering Yuan Ze University Taoyuan Taiwan ZDT Group- YZU Joint Research and Development Center for Big Data Taoyuan Taiwan Yuan Ze University Taoyuan Taiwan

ISBN: (纸本)9798400710162

This study explores the feasibility of deep learning for classifying nodule neoplasms, analyzing their performance on two openly available datasets, LUNGx SPIE, and LIDC-IDRI. These datasets offer valuable diversity in image quantity, quality, and malignancy annotation methodologies, posing a real-world challenge for effective model development. To handle the disparities in these diverse datasets, we aim to develop a robust classification model trained using federated learning. This decentralized approach allows model training across datasets without sharing patient data, preserving privacy and overcoming data fragmentation. Our experiments demonstrate that federated learning enables the development of a robust and superior deep learning model compared to individual models trained on limited data. This combination of deep learning, and federated learning holds immense promise for nodule neoplasm classification and can significantly improve patient care and outcomes. © 2024 Copyright held by the owner/author(s).

关键词： Federated learning

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Quantum variational autoencoder utilizing regularized mixed-state latent representations

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Physical Review A 2025年第4期111卷 042416-042416页

作者： Gaoyuan Wang Jonathan Warrell Prashant S. Emani Mark Gerstein Program in Computational Biology and Bioinformatics Yale University New Haven Connecticut 06520 USA Department of Molecular Biophysics and Biochemistry Yale University New Haven Connecticut 06520 USA NEC Laboratories America Princeton New Jersey 08540 USA Department of Computer Science Yale University New Haven Connecticut 06520 USA Department of Statistics & Data Science Yale University New Haven Connecticut 06520 USA Department of Biomedical Informatics & Data Science Yale University New Haven Connecticut 06520 USA

A major challenge in near-term quantum computing is its application to large real-world datasets due to scarce quantum hardware resources. One approach to enabling tractable quantum models for such datasets involves finding low-dimensional representations that preserve essential information for downstream analysis. In classical machine learning, variational autoencoders (VAEs) facilitate efficient data compression, representation learning for subsequent tasks, and novel data generation. However, no quantum model has been proposed that exactly captures all of these features for direct application to quantum data on quantum computers. Some existing quantum models for data compression lack regularization of latent representations, thus preventing direct use for generation and control of generalization. Others are hybrid models with only some internal quantum components, impeding direct training on quantum data. To address this, we present a fully quantum framework, ζ-QVAE, which encompasses all the capabilities of classical VAEs and can be directly applied to map both classical and quantum data to a lower-dimensional space, while effectively reconstructing much of the original state from it. Our model utilizes regularized mixed states to attain optimal latent representations. It accommodates various divergences for reconstruction and regularization. Furthermore, by accommodating mixed states at every stage, it can utilize the full data density matrix and allow for a training objective defined on probabilistic mixtures of input data. Doing so, in turn, makes efficient optimization possible and has potential implications for private and federated learning. In addition to exploring the theoretical properties of ζ-QVAE, we demonstrate its performance on representative genomics and synthetic data. Our results indicate that ζ-QVAE consistently learns representations that better utilize the capacity of the latent space and exhibits similar or better performance compared with

关键词： Quantum computers

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Time-dependent reduction of somatic variants in lichen striatus as evidence for the clearance of mutated skin cells

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Journal of the American Academy of Dermatology 2025年第6期92卷 1377-1379页

作者： Lee, Byunghyuk Lim, Dong Min Shin, Kihyuk Lee, Hyun Jung Lee, Jungsoo Kim, Hoon-Soo Kim, Byung-Soo Kim, Moon-Bum Kim, Kihun Kim, Won Kyu Kang, Junho Ko, Hyun-Chang Kim, Yun Hak Department of Dermatology College of Medicine Pusan National University Yangsan South Korea Interdisciplinary Program of Genomic Data Science Pusan National University Yangsan South Korea Department of Dermatology Pusan National University Yangsan Hospital Yangsan South Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan South Korea Department of Pathology School of Medicine Pusan National University Yangsan South Korea Department of Biomedical Informatics School of Medicine Pusan National University Yangsan South Korea Department of Anatomy School of Medicine Pusan National University Yangsan South Korea Natural Product Research Center Korea Institute of Science and Technology Gangneung South Korea Department of Research Keimyung University Dongsan Medical Center Daegu South Korea

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Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study

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The Lancet Infectious Diseases 2025年第6期25卷 625-633页

作者： Bajema, Kristina L Yan, Lei Li, Yuli Argraves, Stephanie Rajeevan, Nallakkandi Fox, Alexandra Vergun, Robert Berry, Kristin Bui, David Huang, Yuan Lin, Hung-Mo Hynes, Denise M Lucero-Obusan, Cynthia Schirmer, Patricia Cunningham, Francesca Huang, Grant D Aslan, Mihaela Ioannou, George N Veterans Affairs Portland Health Care System Portland OR United States Division of Infectious Diseases Department of Medicine Oregon Health & Science University Portland OR United States Veterans Affairs Cooperative Studies Program Clinical Epidemiology Research Center Veterans Affairs Connecticut Health Care System West Haven CT United States Department of Biostatistics Yale School of Public Health New Haven CT United States Biomedical Informatics & Data Science Yale School of Medicine New Haven CT United States Department of Internal Medicine Yale School of Medicine New Haven CT United States Seattle Epidemiologic Research and Information Center Veterans Affairs Puget Sound Health Care System Seattle WA United States Research and Development Veterans Affairs Puget Sound Health Care System Seattle WA United States Center of Innovation to Improve Veteran Involvement in Care Veterans Affairs Portland Health Care System Portland OR United States Health Management and Policy College of Health Oregon State University Corvallis OR United States Health Data and Informatics Program Center for Quantitative Life Sciences Oregon State University Corvallis OR United States Public Health National Program Office Veterans Health Administration Palo Alto CA United States Public Health National Program Office Veterans Health Administration Washington DC United States Veterans Affairs Center for Medication Safety—Pharmacy Benefit Management Services Hines IL United States Office of Research and Development Veterans Health Administration Washington DC United States Division of Gastroenterology Veterans Affairs Puget Sound Health Care System and University of Washington Seattle WA United States

Background: New respiratory syncytial virus (RSV) vaccines have been approved in the USA for the prevention of RSV-associated lower respiratory tract disease in adults aged 60 years and older. Information on the real-world effectiveness of these vaccines is needed. Methods: We used electronic health records in the Veterans Health Administration to emulate a target trial comparing a single dose of a recombinant stabilised prefusion F protein RSV vaccine versus no vaccination among veterans aged 60 years and older. We matched eligible vaccine recipients with up to four unvaccinated individuals in four monthly nested sequential trials from Sept 1 to Dec 31, 2023. Outcomes were ascertained up to March 31, 2024. The primary outcome was any positive RSV test from day 14 following the matched index date. Secondary outcomes included hospitalisation and emergency department or urgent care encounter occurring within 1 day before or after a positive RSV test. We estimated vaccine effectiveness as 100 × (1 – risk ratio). Findings: We included 146 852 vaccinated individuals matched to 582 936 unique control individuals, weighted equally to represent 146 852 individuals. Across the two groups, 276 039 (94·0%) of 293 704 veterans were male, 17 665 (6·0%) were female, and median age was 75·9 years (IQR 71·7–79·7). Over a median follow-up of 124 days (IQR 102–150), the incidence rate of documented RSV infection was 1·7 (95% CI 1·4–2·1) events per 1000 person-years (88 total events) in the vaccinated group and 7·3 (6·6–8·1) per 1000 person-years in the unvaccinated group (372 total events), and vaccine effectiveness was estimated as 78·1% (72·6–83·5). Among the secondary outcomes, vaccine effectiveness was estimated at 78·7% (72·2–84·8) against RSV-associated emergency department or urgent care encounters, and 80·3% (65·8–90·1) against RSV-associated hospitalisation. Interpretation: RSV vaccination was effective in preventing RSV-related illness, including associated health-care use,

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ProHap Explorer: Visualizing Haplotypes in Proteogenomic datasets

arXiv

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arXiv 2025年

作者： Vašíček, Jakub Skiadopoulou, Dafni Kuznetsova, Ksenia G. Käll, Lukas Vaudel, Marc Bruckner, Stefan Mohn Center for Diabetes Precision Medicine Department of Clinical Science University of Bergen Bergen Norway Computational Biology Unit Department of Informatics University of Bergen Bergen Norway Metabolism Program Broad Institute of MIT and Harvard CambridgeMA United States Science for Life Laboratory Department of Gene Technology KTH - Royal Institute of Technology Stockholm Sweden Department of Genetics and Bioinformatics Health Data and Digitalization Norwegian Institute of Public Health Oslo Norway Institute for Visual and Analytic Computing University of Rostock Rostock Germany

In mass spectrometry-based proteomics, experts usually project data onto a single set of reference sequences, overlooking the influence of common haplotypes (combinations of genetic variants inherited together from a parent). We recently introduced ProHap, a tool for generating customized protein haplotype databases. Here, we present ProHap Explorer, a visualization interface designed to investigate the influence of common haplotypes on the human proteome. It enables users to explore haplotypes, their effects on protein sequences, and the identification of non-canonical peptides in public mass spectrometry datasets. The design builds on well-established representations in biological sequence analysis, ensuring familiarity for domain experts while integrating novel interactive elements tailored to proteogenomic data exploration. User interviews with proteomics experts confirmed the tool's utility, highlighting its ability to reveal whether haplotypes affect proteins of interest. By facilitating the intuitive exploration of proteogenomic variation, ProHap Explorer supports research in personalized medicine and the development of targeted therapies. © 2025, CC BY.

关键词： Proteomics

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Improved LSTM hyperparameters alongside sentiment walk-forward validation for time series prediction

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Journal of Open Innovation: Technology, Market, and Complexity 2025年第1期11卷

作者： Wahyuddin, Eko Putra Caraka, Rezzy Eko Kurniawan, Robert Caesarendra, Wahyu Gio, Prana Ugiana Pardamean, Bens Department of Statistical Computing Politeknik Statistika STIS Jakarta 13330 Indonesia Statistics Indonesia (BPS) Jl. Dr Sutomo 6-8 Jakarta Indonesia School of Economics and Business Telkom University Bandung 40257 Indonesia Research Center for Data and Information Sciences Research Organization for Electronics and Informatics National Research and Innovation Agency (BRIN) Bandung 40135 Indonesia Faculty of Integrated Technologies Universiti Brunei Darussalam Gadong BE1410 Brunei Darussalam Department of Mathematics Universitas Sumatera Utara Medan 20155 Indonesia Bioinformatics and Data Science Research Centre Bina Nusantara University DKI Jakarta 11480 Indonesia Computer Science Department BINUS Graduate Program Master of Computer Science Program Bina Nusantara University DKI Jakarta 11480 Indonesia

This study aims to address the common issue of biased estimation errors in time series modeling by analyzing the error in locating ideal hyperparameters and defining appropriate validation methods. Specifically, it focuses on predicting the stock price of Bank Rakyat Indonesia using a combination of historical stock prices, technical indicators, exchange rates, and news sentiment data, while determining the optimal variables for deep learning models. Employing a deep learning-based Long-Short Term Memory (LSTM) model, the study optimizes hyperparameters alongside walk-forward validation for time series prediction. It explores different combinations of variables and adapts the sliding window approach to the context of the data. The results highlight the importance of optimizing hyperparameters and utilizing walk-forward validation for accurate time series prediction. The model incorporating historical stock prices and sentiment scores outperforms others, achieving an RMSE of 96.61 and MAE of 86.97. Incorporating sentiment scores reduces RMSE by 39.55 % compared to models using only historical stock prices, while adding technical indicators does not yield improvement. This study contributes to the field by addressing the issue of biased estimation errors in time series modeling, offering insights into the optimization of hyperparameters and validation methods for accurate predictions. It also underscores the significance of incorporating sentiment analysis alongside historical stock prices for improved forecasting accuracy. © 2024 The Authors

关键词： LSTM Sentiment analysis Stock price prediction Time series modeling Validation methods

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Herb compounds screening as meningitis inhibitor candidates using neural network and random forest methods

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AIP Conference Proceedings 2025年第1期3250卷

作者： Riska Aprilia Mohammad Hamim Zajuli Al Faroby Muhammad Adib Kamali Muhammad Dzulfikar Fauzi Information Technology Study Program Faculty of Information Technology and Business Institut Teknologi Telkom Surabaya Surabaya Indonesia Data Science Study Program Faculty of Information Technology and Business Institut Teknologi Telkom Surabaya Surabaya Indonesia Informatics Study Program Faculty of Information Technology and Business Institut Teknologi Telkom Surabaya Surabaya Indonesia

Meningitis is an inflammation of the meninges that occurs in the protective lining of the brain and spinal cord caused by bacterial, viral, or fungal infections. This disease is difficult to recognize because it has initial symptoms like the flu where the patient has a fever and headache. Current efforts to prevent the disease by strengthening antibodies. Meanwhile, drug candidates for the treatment of this disease still have not found optimal results in reducing mortality due to meningitis. This study aims to find and analyses herbal compound candidates that might be inhibitors of meningitis. Compound data was acquired from a validated open database. The data acquired are smiles of the chemical bond structure of the compounds. In the data processing process, compound feature extraction is required by applying the concept of molecular fingerprint. The results of feature extraction are used as datasets to build classification models by applying the Multilayer Perceptron (MLP) and Random Forest algorithms. The two models are compared, and a more robust model is selected to be used as a prediction model for herbal compound search. The MLP model has a better accuracy of 0.97 compared to the Random Forest model. The results of screening using the MLP learning model obtained Symphytine, cis-Linalool oxide, and 3-O-Methylcalopocarpin compounds have the highest probability compared to thousands of other herbal compounds. This candidate compound can be used as a recommendation for drug discovery to treat patients who contract Meningitis.

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