Breast cancer is an occurrence of cancer that attacks breast tissue and is the most common cancer among women worldwide, affecting one in eight women. In this modern world, breast cancer image classification simplifie...
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Fetal mortality and newborn health issues require urgent attention because of high maternal and infant mortality rates during labor, highlighting the critical need for accurate fetal condition monitoring to reduce com...
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When I subjects answer questions regarding J variables K times, the data can be stored in a three-mode data set of size I× J× K. Among the various component analysis approaches to summarize such data, Three-...
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Currently, there are a lot of measurement data on different items collected over time. The GMANOVA model is appropriate for analyzing the trends in such data, in order to analyze some longitudinal data collected on di...
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The process of using ICT to provide services to the public is known as the Indonesian e-Government system, or Sistem Pemerintahan Berbasis Elektronik (SPBE). The e-Government initiative in Jakarta Provincial Health Of...
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Students 'attendance in class is one important success parameter in face-to-face learning processes. Conventional attendance systems, such as paper-based attendance sheets or identity card systems, require a long ...
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Defects in gastric progenitor cell differentiation are associated with various gastric disorders, including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the mechanisms underlying the multili...
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Defects in gastric progenitor cell differentiation are associated with various gastric disorders, including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the mechanisms underlying the multilineage differentiation of gastric progenitor cells during healthy homeostasis remain poorly understood. Here, using a single-cell RNA sequencing method, Quartz-Seq2, we analyzed the gene expression dynamics of progenitor cell differentiation toward pit cell, neck cell, and parietal cell lineages in healthy adult mouse corpus tissues. Enrichment analysis of pseudotime-dependent genes and a gastric organoid assay revealed that EGFR-ERK signaling promotes pit cell differentiation, whereas NF-κB signaling maintains gastric progenitor cells in an undifferentiated state. In addition, pharmacological inhibition of EGFR in vivo resulted in a decreased number of pit cells. Although activation of EGFR signaling in gastric progenitor cells has been suggested as one of the major inducers of gastric cancers, our findings unexpectedly identified that EGFR signaling exerts a differentiation-promoting function, not a mitogenic function, in normal gastric homeostasis.
Microsatellite instability (MSI) is a pivotal genetic marker influencing the efficacy of immunotherapy in colorectal cancer. Traditional MSI examination often requires additional genetic or immunohistochemical tests, ...
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In this work, we propose our top-ranking (2nd place) pipeline for the generation of discharge summary subsections as a part of the BioNLP 2024 Shared Task 2: "Discharge Me!". We evaluate both encoder-decoder...
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In 2022, Indonesia initiated a pilot project to transition from liquid petroleum gas (LPG) stoves to induction stoves, targeting 8.2 million households by 2025. While LPG is considered a clean cooking fuel by the Worl...
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