Understanding the reliability of engineering methods is crucial for its adoption and deployment. This research focuses on the reliability of the Power Spectral Density (PSD) method via the use of the F statistic for d...
Understanding the reliability of engineering methods is crucial for its adoption and deployment. This research focuses on the reliability of the Power Spectral Density (PSD) method via the use of the F statistic for damage detection. To the author best knowledge, the method is rather classic but its realibility has not been discussed in the context of a large data size. Priory, the research anticipates that the accuracy is a function of the damage level. In this study, we evaluate 3500 cases with five levels of structural integrity, namely, healthy condition and damaged conditions with 1%, 5%, 10%, and 20% damage levels. The dataset is established via a numerical analysis of a seven degree-of-freedom system loaded with a concentrated dynamic force with random magnitude. A spring on the system is reduced in its stiffness to simulate damages. Our significant findings are the following: it is challenging for the PSD-based method to differentiate the healthy condition from the damaged conditions when the damage level is small. However, the reliability is high at 95% probability when the structural integrity has dropped by five percent.
The development of technology has been very significant, not only in the fields of information, industry, education, but in agriculture. Therefore technological sophistication is also utilized by corn farmers to obtai...
The development of technology has been very significant, not only in the fields of information, industry, education, but in agriculture. Therefore technological sophistication is also utilized by corn farmers to obtain information about corn crops. Corn is included in plantation commodities in Indonesia. However, in corn cultivation there are various problems associated with the disease that is likely to attack the plant. Therefore, the authors designed the expert system of corn disease diagnosis using certainty method. This system will analyze based on symptoms - symptoms that are in the input by the user so that in obtaining a result of disease identification on corn in the name of the disease, the cause of the disease, the percentage value and how to handle it. This expert system is developed by using the visual basic application and Microsoft Access database with Certainty Factor method to measure the value of certainty of a hypothesis against a fact.
This study presents the outcomes of the shared task competition BioCreative VII (Task 3) focusing on the extraction of medication names from a Twitter user's publicly available tweets (the user's 'timeline...
This study presents the outcomes of the shared task competition BioCreative VII (Task 3) focusing on the extraction of medication names from a Twitter user's publicly available tweets (the user's 'timeline'). In general, detecting health-related tweets is notoriously challenging for natural language processing tools. The main challenge, aside from the informality of the language used, is that people tweet about any and all topics, and most of their tweets are not related to health. Thus, finding those tweets in a user's timeline that mention specific health-related concepts such as medications requires addressing extreme imbalance. Task 3 called for detecting tweets in a user's timeline that mentions a medication name and, for each detected mention, extracting its span. The organizers made available a corpus consisting of 182 049 tweets publicly posted by 212 Twitter users with all medication mentions manually annotated. The corpus exhibits the natural distribution of positive tweets, with only 442 tweets (0.2%) mentioning a medication. This task was an opportunity for participants to evaluate methods that are robust to class imbalance beyond the simple lexical match. A total of 65 teams registered, and 16 teams submitted a system run. This study summarizes the corpus created by the organizers and the approaches taken by the participating teams for this challenge. The corpus is freely available at https://***/tasks/biocreative-vii/track-3/. The methods and the results of the competing systems are analyzed with a focus on the approaches taken for learning from class-imbalanced data.
MOTIVATION:The synthesis of proteins with novel desired properties is challenging but sought after by the industry and academia. The dominating approach is based on trial-and-error inducing point mutations, assisted b...
详细信息
MOTIVATION:The synthesis of proteins with novel desired properties is challenging but sought after by the industry and academia. The dominating approach is based on trial-and-error inducing point mutations, assisted by structural information or predictive models built with paired data that are difficult to collect. This study proposes a sequence-based unpaired-sample of novel protein inventor (SUNI) to build ThermalProGAN for generating thermally stable proteins based on sequence information.
RESULTS:The ThermalProGAN can strongly mutate the input sequence with a median number of 32 residues. A known normal protein, 1RG0, was used to generate a thermally stable form by mutating 51 residues. After superimposing the two structures, high similarity is shown, indicating that the basic function would be conserved. Eighty four molecular dynamics simulation results of 1RG0 and the COVID-19 vaccine candidates with a total simulation time of 840[Formula: see text]ns indicate that the thermal stability increased.
CONCLUSION:This proof of concept demonstrated that transfer of a desired protein property from one set of proteins is feasible. The source code of ThermalProGAN can be freely accessed at https://***/markliou/ThermalProGAN/ with an MIT license. The website is https://***:433. Supplementary data are available on Github.
Corruption is an extraordinary crime and must be eradicated not only as fast as possible, but also as efficient and as effective as possible as it hinders the process of achieving sustainable economy. In current moder...
详细信息
Cumulative state loss over the years caused by corruption in Indonesia has reached a fantastic number of 15 Billion usn up until 2016 [1]. To imagine the severances of it, 10.000 KM of highway can be built with that m...
详细信息
The number of topological defects created in a system driven through a quantum phase transition exhibits a power-law scaling with the driving time. This universal scaling law is the key prediction of the Kibble-Zurek ...
详细信息
The number of topological defects created in a system driven through a quantum phase transition exhibits a power-law scaling with the driving time. This universal scaling law is the key prediction of the Kibble-Zurek mechanism (KZM), and testing it using a hardware-based quantum simulator is a coveted goal of quantum informationscience. Here we provide such a test using quantum annealing. Specifically, we report on extensive experimental tests of topological defect formation via the one-dimensional transverse-field Ising model on two different D-Wave quantum annealing devices. We find that the quantum simulator results can indeed be explained by the KZM for open-system quantum dynamics with phase-flip errors, with certain quantitative deviations from the theory likely caused by factors such as random control errors and transient effects. In addition, we probe physics beyond the KZM by identifying signatures of universality in the distribution and cumulants of the number of kinks and their decay, and again find agreement with the quantum simulator results. This implies that the theoretical predictions of the generalized KZM theory, which assumes isolation from the environment, applies beyond its original scope to an open system. We support this result by extensive numerical computations. To check whether an alternative, classical interpretation of these results is possible, we used the spin-vector Monte Carlo model, a candidate classical description of the D-Wave device. We find that the degree of agreement with the experimental data from the D-Wave annealing devices is better for the KZM, a quantum theory, than for the classical spin-vector Monte Carlo model, thus favoring a quantum description of the device. Our work provides an experimental test of quantum critical dynamics in an open quantum system, and paves the way to new directions in quantum simulation experiments.
Most tourists have limited time and schedule when they are visiting a particular tourism area. One of the main issues faced by those tourists is that they can not make simple queries to search engines about, for examp...
详细信息
Most tourists have limited time and schedule when they are visiting a particular tourism area. One of the main issues faced by those tourists is that they can not make simple queries to search engines about, for example, which sites or places to visit optimally if we only have one day or two-day visit? Search engines are better and better in replying users' queries with relevant answers. However, search engines are not always able to respond queries suited to users' characteristics such as their styles, personalities, knowledge backgrounds, etc. Also, search engines are not as flexible as chatbots in enabling dialogical-communication-queries. This case study aims to respond aformentioned issue by applying hierarchical cluster analysis on a set of tourism sites around Malang city, Malang regency, and Batu city based on AGNES (Agglomerative Nesting) algorithm. The result, then, is fed into chatbot's knowledge base. This chatbot will assist tourists to get information on which possible sites they have to visit optimally if they are under limited vacancy-time constraints.
Adolescents with obesity face numerous health risks and encounter barriers that lead to physical inactivity. We developed a virtual reality sports system, named REVERIE (Real-World Exercise and VR-Based Exercise Resea...
Adolescents with obesity face numerous health risks and encounter barriers that lead to physical inactivity. We developed a virtual reality sports system, named REVERIE (Real-World Exercise and VR-Based Exercise Research in Education), which used deep reinforcement learning to train transformer-based virtual coaching agents, offering immersive and effective sports guidance, with biomechanical performance comparable to real-world physical sports. We integrated REVERIE into a randomized controlled trial involving an 8-week intervention in adolescents with excess body weight (n = 227). Participants were randomized (1:1:1:1:1) to physical table tennis, physical soccer, REVERIE table tennis, REVERIE soccer or control. REVERIE sports intervention was effective in reducing primary outcome fat mass (mean -4.28 kg (95% confidence interval (CI) -6.35 to -2.22), relative to control), with no significant difference compared with physical sports (mean -5.06 kg (95% CI -7.13 to -2.98), relative to control). For secondary outcomes, decreases in liver enzymes and low-density lipoprotein cholesterol levels were found in physical and REVERIE sports groups compared to control. Physical and REVERIE sports showed improvements in physical fitness, psychological well-being and sports willingness after an 8-week intervention, which remained at the 6-month follow-up in the REVERIE sports group. REVERIE sports demonstrated superior cognitive enhancements compared to physical sports in exploratory analyses, as evidenced by olfactory tests (total score: mean 2.84 (95% CI 1.15 to 4.53)) and working memory paradigm (2-back accuracy: mean 10.88% (95% CI 1.19% to 20.56%)). Functional magnetic resonance imaging exhibited that REVERIE sports enhanced neural efficiency and neuroplasticity. Multi-omics analyses revealed distinct changes induced by REVERIE sports that were closely associated with cognitive improvement. Minimal injury rates were 7.69% for REVERIE and 13.48% for physical sports, with no
暂无评论