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Dysfunction and recovery of the cortical connectome gradient and its association with gene expression profiles in methamphetamine and heroin use disorders

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Progress in neuro-psychopharmacology & biological psychiatry 2025年 139卷 111391页

作者： Zhe Du Wenhan Yang Xinwen Wen Suping Cai Jun Liu Kai Yuan School of Life Science and Technology Xidian University Xi'an Shaanxi 710126 China. Department of Radiology Second Xiangya Hospital Central South University Changsha 410011 China. Electronic address: wenhany999@***. Department of Radiology Second Xiangya Hospital Central South University Changsha 410011 China. Electronic address: Junliu123@***. School of Life Science and Technology Xidian University Xi'an Shaanxi 710126 China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing School of Information Engineering Inner Mongolia University of Science and Technology Baotou Inner Mongolia 014010 China Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xi'an Shaanxi China Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information School of Life Science and Technology Xidian University Xi'an Shaanxi 710126 China. Electronic address: kyuan@***.

BACKGROUND:The hierarchy and segregation of community-based brain networks can be characterized by functional connectome gradient (FCG). Whether the cortical FCG was disrupted and could even be reversed after prolonged abstinence in substance use disorders (SUDs) remained unclear. Less is known about the underlying genetic basis. METHODS:We utilized three independent datasets (n = 247) to investigate cortical FCG dysfunction and recovery after prolonged abstinence in methamphetamine use disorder (MUD) (n = 131), and validated in heroin use disorder (HUD) (n = 36). Furthermore, magnetic resonance spectroscopy (MRS) was employed to test the relationship between the glutamate in the ventral tegmental area (VTA) and cortical FCG. Postmortem gene expression was utilized to assess the transcriptional profiles related to cortical FCG alterations. Support vector regression (SVR) model based on the baseline cortical FCG was built to predict craving changes after long-term abstinence. RESULTS:MUD and HUD individuals exhibited similar cortical FCG dysfunction and recovery at global and network levels, mainly in dorsal and ventral attentions network (DAN and VAN), frontoparietal network (FPN) and default mode network (DMN). The glutamate levels in VTA were correlated with the gradient distance between FPN and limbic network (LIM). The transcriptional profiles explained variance of the altered gradient pattern, with the most related genes enriched in synaptic signaling. Baseline cortical FCG significantly predicted craving changes after long-term abstinence. CONCLUSIONS:We provided novel insights into the understanding of SUD as treatable health conditions from cortical FCG changes, which could be considered as the potential biomarkers of craving changes after prolonged abstinence for SUDs.

关键词： Cortical functional connectome gradient Gene expression Glutamate Heroin use disorder Methamphetamine use disorder Support vector regression

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Face Forgery Detection Algorithm Based on Improved MobileViT Network

Face Forgery Detection Algorithm Based on Improved MobileViT...

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6th International Conference on intelligent Computing and Signal processing (ICSP)

作者： Tiantian Wang Xiaoqi Lu School of Information Engineering Inner Mongolia University of Science and Technology Baotou China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing Baotou China Institute of Information Engineering Inner Mongolia University of Technology Hohhot China

DeepFakes blur the boundaries between reality and forgery, resulting in the collapse of exiting credit system, causing immeasurable consequences for national security and social order. Through analysis of existing face forgery techniques, it is found that most generation techniques rely on random noise distribution, and global information will be lost after up sampling. Therefore, we propose a deepfake detection algorithm based on improved MobileViT, which uses CNN local space biasing and the global space representation of the Transformer network to learn the local features and global representation of forged faces, respectively. Coordinate attention is introduced to obtain directional perception and position sensitive information, making the model locate synthetic traces of fake faces better and fusion local and global representation more effectively. For the improved generalization of the model, with the GELU activation function to solve the problem of neuron death. Our model achieved 96.2% on FF++(C23) datasets, and 93.7%,94.1%,96.3%,87.9% on DF, F2F, FS, and NT datasets, respectively. Comparing with previous methods, our model has shown detection robustness and better generalization.

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Gait recognition Algorithm GCGait based on Skeleton

Gait Recognition Algorithm GCGait based on Skeleton

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Information Technology,Big Data and Artificial Intelligence (ICIBA), International Conference on IEEE International Conference on

作者： Ru Ma Jikai Zhang Mengyu Jia Xiaoqi Lv School of Information Engineering Inner Mongolia University of Science and Technology Baotou China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing Baotou China School of Information Engineering Inner Mongolia University of Technology Hohhot China

To solve the problem of low accuracy of gait recognition in complex scenes, a novel skeleton-based gait recognition algorithm, GCGait, is proposed. Taking human posture as the input of gait feature, the interference caused by wearing changes and other factors is reduced. To extract sufficient input features, multi-branch input is used in the early stage of the model. By introducing the multi-attention mechanism, the network can learn the semantic information of the non-directly connected joints, excavate the most discriminative features from complex videos, and further improve the recognition performance. In order to reduce the influence of cross view, the fusion loss function is used in the experiment. Experimental results show that the average recognition rate of the proposed algorithm on the CASIA-B dataset is improved by 5.2%, and the average recognition accuracy on the OU-MVLP dataset is increased by 66.3%, which proves the effectiveness of the proposed method.

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SiamCMN: Jointing cycle memory and correlation network for Siamese object tracking

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Optik 2023年第1期286卷

作者： Zhang, Baohua Zhang, Nianchao Li, Yongxiang Lu, Xiaoqi Gu, Yu Li, Jianjun School of Information Engineering Inner Mongolia University of Science and Technology Baotou Inner Mongolia014010 China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing Baotou Inner Mongolia014010 China School of Information Engineering Mongolia Industrial University Hohhot Inner Mongolia010051 China College of Energy and Transportation Engineering Inner Mongolia Agricultural University Hohhot Inner Mongolia010018 China

In heterogeneous scenes with latent non-deterministic states, template features determine the performance of the Siamese network-based trackers, however, background noise is easily introduced in the search area matching process, which causes the trackers lack sufficient discrimination. To solve this problem, this paper proposes an object tracking algorithm based on the cyclic memory module. Firstly, the extracted primary features are mapped to the cyclic spatial memory network, the spatial memory unit is used to store the interference components. On this basis, the cyclic structure is used to filter out the interference components and refine the template features. Then a channel correlation network is introduced into the proposed method, which can mine semantic complementary information and capture global contextual relevance by modeling the positive and the negative correlation between the channels. The experimental results on tracking benchmarks such as OTB50, OTB100, UAV123, VOT2018, GOT10k, and LaSOT have shown that the proposed method outperforms recent representative algorithms in tracking accuracy in challenging scenarios. © 2023 Elsevier GmbH

关键词： Semantics

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Implications of neuroimaging findings in addiction

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Psychoradiology 2023年第1期3卷 18-23页

作者： Xinwen Wen Lirong Yue Zhe Du Linling Li Yuanqiang Zhu Dahua Yu Kai Yuan School of Life Science and Technology Xidian UniversityXi’an 710126China School of Biomedical Engineering Medical SchoolShenzhen UniversityShenzhen 518060China Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging Shenzhen UniversityShenzhen 518060China Department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing School of Information EngineeringInner Mongolia University of Science and TechnologyBaotou 014010China Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xidian UniversityXi’an 710126China Xi’an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life Information School of Life Science and TechnologyXidian UniversityXi’an 710126China

Addiction is a chronic and often relapsing brain disorder characterized by drug abuse and withdrawal symptoms and compulsive drug seeking(Koob and Volkow,2010)when access to the drug is *** leads to structural and fun... 详细信息

关键词： motivation finding seeking

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Region-Based Simplification of Laser Scanned Meshes

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Journal of Graphics Tools 2003年第2期8卷 41-50页

作者： Ye Jianhui[a] [a]Image Processing & Intelligent Control Key Laboratory of China Institute of Pattern Recognition & Artificial Int elligence Huazhong University of Science and Technology Wuhan 430074 PR China E-mail:

To simplify the mesh acquired from at hree-dimensional laser scanner, it is more important to keep the boundary and quality of the region of interest than of other regions. The algorithm must not be sensitive to noise introduced in practical applications. In this paper, we present a novel vertex merging mesh simplification algorithm based on region segmentation. The algorithm can be divided into two stages: segmentation and simplification. After the segmentation of the 3D color mesh into different regions, vertices are classed into a region-boundary vertex, which can only be merged into a region-boundary vertex in order to guarantee the completeness of the regions' boundary, and region-inner vertex. The iterative vertex merging is applied with a region-weighted error metric, which implements controllable simplifications. We demonstrate our method with several examples of a 3D color human head mesh.

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Abnormal resting-state EEG power and impaired inhibition control in young smokers

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Neuroscience Letters 2021年第0期761卷 136120-136120页

作者： Dong, Fang Li, Xiaojian Zhang, Yunmiao Jia, Shaodi Zhang, Shidi Xue, Ting Ren, Yan Lv, Xiaoqi Yuan, Kai Yu, Dahua Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing School of Information Engineering Inner Mongolia University of Science and Technology Baotou 014010 Inner Mongolia China College of Information Engineering Inner Mongolia University of Technology Hohhot 010051 Inner Mongolia China School of Life Science and Technology Xidian University Xi'an 710071 Shaanxi China

Exposure to nicotine during adolescence may cause neurophysiological changes and increase the risks of developing nicotine dependence;it can even lead to lifelong smoking. The intake of nicotine may also lead to abnormal patterns of oscillatory brain activity and inhibition control deficits. However, little is known about the specific relationship between oscillatory brain activity during the resting state and inhibition control capacity in young smokers. In the present study, we acquired resting-state electroencephalography (EEG) data from thirty-four young smokers and 39 age-matched non-smoking controls. Inhibition control performance was measured by a Go/NoGo task. Compared with non-smoking controls, we detected reduced low-frequency delta band activity in the frontal, central and posterior cortices of young smokers. Furthermore, young smokers committed more errors in response to infrequent NoGo trials. Notably, we demonstrated that delta absolute power in the frontal region was negatively correlated with NoGo errors and that alpha power in the central region was positively correlated with NoGo errors in non-smoking controls but not in young smokers. These findings may suggest that these inhibitory control processes were associated with alterations in oscillatory brain activity during the resting state. Our findings suggest that alterations of power spectra in delta bands may act as a useful biomarker of inhibitory control performance and provide a scientific basis for the diagnosis and treatment of nicotine addiction in adolescents. © 2021 Elsevier B.V.

关键词： Brain oscillations Electroencephalography (EEG) Inhibition control Resting state Young smokers

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Medicine-engineering interdisciplinary researches for addiction: Opportunities and challenges

Meta-Radiology

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Meta-Radiology 2023年第2期1卷

作者： Wen, Xinwen Du, Zhe Wang, Zhen Xu, Yu Wang, Kunhua Yu, Dahua Liu, Jun Yuan, Kai School of Life Science and Technology Xidian University Shaanxi Xi'an 710126 China Yunnan University Yunnan Kunming 650500 China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing School of Information Engineering Inner Mongolia University of Science and Technology Inner Mongolia Baotou 014010 China Department of Radiology Second Xiangya Hospital Central South University Changsha 410011 China Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Shaanxi Xi'an 710126 China Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information School of Life Science and Technology Xidian University Shaanxi Xi'an 710126 China

Advances in neuroscience have suggested that addiction is not only an ongoing dynamic transaction between the person, their behavior, and the environment, but a disturbance of neurotransmitters in neurons involved in reward, memory, and cognitive control. Although the neural mechanism of addiction is complex and heterogeneous, previous addiction recovery and treatment studies have proven that addiction is amenable to treatment and recovery. At present, addiction treatment faces great challenges as well as many opportunities. The field of biomedical engineering is and will be at the forefront of these accelerating disciplines based on advances in imaging, genomics, systems medicine, molecular and cellular engineering, and other biomedical sciences. Thus, we propose several perspectives to accelerate the development of advanced and scientific approaches for addiction treatment: early prevention is better than cure and addiction treatment should focus on individualized regulation, whole-body interaction and the translation of effective animal models to human. © 2023 The Authors

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Correction to: Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway

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Brain imaging and behavior 2019年第4期13卷 1182页

作者： Ruonan Wang Min Li Meng Zhao Dahua Yu Yu Hu Corinde E Wiers Gene-Jack Wang Nora D Volkow Kai Yuan School of Life Science and Technology Xidian University Xi'an Shaanxi 710071 People's Republic of China. Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xi'an People's Republic of China. Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing School of Information Engineering Inner Mongolia University of Science and Technology Baotou Inner Mongolia 014010 People's Republic of China. National Institute on Alcoholism and Alcohol Abuse National Institutes of Health Bethesda MD 20892 USA. National Institute on Drug Abuse National Institutes of Health Bethesda MD 20892 USA. School of Life Science and Technology Xidian University Xi'an Shaanxi 710071 People's Republic of China. kyuan@***. Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xi'an People's Republic of China. kyuan@***. Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing School of Information Engineering Inner Mongolia University of Science and Technology Baotou Inner Mongolia 014010 People's Republic of China. kyuan@***. National Institute on Alcoholism and Alcohol Abuse National Institutes of Health Bethesda MD 20892 USA. kyuan@***. Guangxi Key Laboratory of Multi-Source Information Mining and Security Guangxi Normal University Guilin People's Republic of China. kyuan@***.

The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below.

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