Protein-Protein Interaction (PPI) provides important insights into the metabolic mechanisms of different biological processes. Although PPIs in some organisms have been investigated systematically, PPIs in the ocean a...
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ISBN:
(纸本)9798400712203
Protein-Protein Interaction (PPI) provides important insights into the metabolic mechanisms of different biological processes. Although PPIs in some organisms have been investigated systematically, PPIs in the ocean archaea remain largely unexplored. But such species have special investigation value since their adaptation to extreme living conditions may generate unique PPIs. In this paper, we aim to characterize and predict PPIs in ocean archaea to advance understanding of their metabolic networks. First, we collect all ocean archaea PPIs with high confidence from STRING database and analyze the PPI network features, including centrality and enrichment analysis. The functional enrichment results of the largest connecting subgraph in the PPI network show most PPIs in our constructed dataset is related to the translation and transcription processes. Then, we generate an equal number of negative PPI pairs, whose members have either different subcellular locations or GO terms. We also use the generated dataset to test the performance of three pretraining methods and their ensemble methods in the binary PPI prediction task. Our results suggest the ensemble methods could be applied to further improve models’ performance. Fine-tuned models trained on the ocean archaea dataset are expected to predict the other ocean archaea PPIs that are not included in the STRING database and get more understanding about the ocean archaea PPI universe.
Producing traversability maps and understanding the surroundings are crucial prerequisites for autonomous navigation. In this paper, we address the problem of traversability assessment using point clouds. We propose a...
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Protein design has become a critical method in advancing significant potential for various applications such as drug development and enzyme engineering. However, protein design methods utilizing large language models ...
Deep convolutional neural networks have significantly advanced color image denoising. However, existing models often apply grayscale denoising techniques to color images without accounting for inter-channel correlatio...
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ISBN:
(数字)9798350368741
ISBN:
(纸本)9798350368758
Deep convolutional neural networks have significantly advanced color image denoising. However, existing models often apply grayscale denoising techniques to color images without accounting for inter-channel correlations, resulting in color distortion, detail loss, and visual artifacts. Moreover, these models frequently neglect salient features within convolutional maps. To address these issues, we propose a quaternion CNN model that captures channel correlations and extracts salient features, thereby enhancing color image denoising performance. Specifically, we convert color images into quaternion matrices to better capture these correlations and design a quaternion convolutional network to learn relevant features. Furthermore, an aggregated feature block is introduced to enhance the extraction of salient features and further refine the denoising process. Experimental results on multiple datasets demonstrate that the proposed model achieves superior performance compared to recent state-of-the-art methods.
Dental panoramic x-rays are commonly used in dental diagnosing. With the development of deep learning, auto detection of diseases from dental panoramic x-rays can help dentists to diagnose diseases more efficiently. T...
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Inferior Alveolar Nerve (IAN) canal detection in CBCT is an important step in many dental and maxillofacial surgery applications to prevent irreversible damage to the nerve during the procedure. The ToothFairy2023 Cha...
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Purpose: Accurate airway anatomical labeling is crucial for clinicians to identify and navigate complex bronchial structures during bronchoscopy. Automatic airway anatomical labeling is challenging due to significant ...
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This study investigates the reciprocal relationship between investor sentiment and capital market dynamics, leveraging advanced techniques in data extraction and analysis. By employing web crawling and natural languag...
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The seven-field classification plays a key role in ophthalmology, especially in the diagnosis and treatment of diabetic retinopathy. In this paper, we designed a framework that can classify 7 fields of each eye simult...
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The cultivation of expertise for large language models (LLMs) to solve tasks of specific areas often requires special-purpose tuning with calibrated behaviors on the expected stable outputs. To avoid huge cost brought...
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