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HIV-Specific IL-2^+ and/or IFN-γ^+ CD8^+ T Cell Reponses during Chronic HIV-1 Infection in Former Blood Donors

Biomedical and Environmental Sciences 2010年第5期23卷 391-401页

作者： YAN-MENG FENG YAN-MIN WAN LIAN-XIN LIU CHAO QIU PENG-FEI MA HONG PENG YU-HUA RUAN LI-FENG HAN KUN-XUE HONG HUI XING YI-MING SHAO State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071HubeiChina State Key Laboratory for Infectious Diseases Prevention and Control Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory for Infectious Diseases Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 100050China Graduate School of the Chinese Academy of Sciences Beijing 100049China

Objective Conflicting data have been generated from previous studies to determine which kind of relationship exists between HIV-1 specific CD8 Tcell responses and HIV-1 viral load or CD4 count over the course of *** this study,153 HIV-1 infected LTNPs were enrolled to investigate the role of HIV-1 specific CD8 T-cell responses in chronic HIV-1 infection among HIV-1 infected former blood *** The patients were stratified into three groups according to CD4 count：CD4≥500 cells/μL;350 cells/μL≤CD4〈500 cells/μL;CD4〈350 cells/μ*** were isolated from the patients＇ anticoagulated blood ***-2 and IFN-γ secretions of CD 8 T cells against 17 HIV-1 consensus B full peptide pools were analyzed by using ICS *** An overall inverse correlation were observed between CD4 count and plasma viral *** no significant difference was observed during the comparisons of frequency/breadth of HIV-1 specific CD8 T cell responses,CD4 count stratification analysis showed that different correlation pattern existed in three strata：as for patients whose CD4 counts were less than 350 cells/μL,no significant correlations were identified between frequency/breadth of HIV-1 specific CD8 T cell responses and CD4 count/viral load;as for patients whose CD4 counts ranged from 350 cells /μL to 500 cells/μL,significant correlation was only observed between the response breadth of IL-2＋IFN-γ＋ CD8 T cells and CD4 count;however,as for patients whose CD4 counts were more than 500 cells/μL,direct correlations were identified between IL-2＋IFN-γ＋/IL-2＋/IFN-γ＋ CD8 T cells and viral load or CD4 *** Universal consistent inverse correlation was only indentified between CD4 count and viral *** relationship between HIV-1 specific CD8 T cell responses and CD4 count/viral load varied in different CD4 strata,which showed that better preserved CD4 T cells were correlated with better CD8 T cell functions.

关键词： HIV-1 subtype B＇ CD8 T cell response IFN-γ IL-2 ICS

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control of HIV-1 in Carriers of the HLA-A*30/B*13/Cw*06 Haplotype in HIV-infected Former Plasma Donors from Anhui and Henan Provinces

Control of HIV-1 in Carriers of the HLA-A*30/B*13/Cw*06 Hapl...

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第八届中日国际病毒学研讨会

作者： Mingming Jia Bing SU Marcus Altfeld Bruce D.Walker Xu G.Yu Yiming Shao Kunxue Hong Jianping Chen Sha Liu Xiaoqing Zhang Hongjing Zhao Dan Li Yuhua Ruan Zhe Wang State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Anhui Center for Disease Control and Prevention Hefei 230061 China Ragon Institute of MGH MIT and Harvard Charlestown MA 02129 State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 10005 Henan Center for Disease Control and Prevention Zhengzhou 450016 China

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Comparison of the quantities and subset distributions of natural killer cells among different races

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Chinese Medical Journal 2010年第22期123卷 3272-3276页

作者： FENG Yan-meng ZHANG Rui-jun ZHU Hong PENG Hong ZHOU Xiao-ping HONG Kun-xue LIU Jian-li CHEN Jian-ping SHAO Yi-ming Wuhan Institute of Virology State Key Laboratory of Virology Chinese Academy of Sciences Wuhan Hubei 430071 China National Center for A1DS/STD Control and Prevention State Key Laboratory for Infectious Disease Prevention and Control Chinese Center for Disease Control and Prevention Beijing 102206 China Institute for Communicable Disease Control and Prevention State Key Laboratory for Infectious Disease Prevention and Control Chinese Center for Disease Control and Prevention Beijing 102206 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China HIV/AIDS Diagnosis and Confirmation Lab Beijing Entry-Exit Inspection and Quarantine Bureau Beijing 100013 China

Background Natural killer （NK） cells play critical roles in host immune defense, while the quantities and subset distributions may vary among different races. To address the difference, we compared these variables among Chinese Han, the Caucasians and the Blacks. The study may provide critical background information for both basic research and clinical investigation. Methods Blood samples collected from populations of different races were tested within 12 hours after collection and subsets of NK cells were characterized using flow cytometry. Results The absolute NK count in the Chinese Han was significantly higher than that in the Caucasian. The Han and Caucasian groups showed higher percentages of cytotoxic subset compared to that of the Black group. The percentage of cytokine-producing subset of Chinese Han group was lower than that of Caucasian and Black groups. Black group had a higher percentage of function-unknown NK subset than that of the Han and Caucasian groups. Conclusion Our data indicated that NK cell count and the distribution of different subsets varied among different races, which should be taken into consideration in related investigations.

关键词： natural killer cell different races comparison

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Dynamic Characteristic Analysis of HIV Mother to Child Transmission in China

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Biomedical and Environmental Sciences 2010年第5期23卷 402-408页

作者： JUN-JIE WANG KATHLEEN HEATHER REILLY HUA HAN ZHI-HANG PENG NING WANG National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Tulane University Health Sciences Center School of Public Health and Tropical MedicineNew OrleansLAUSA National ASIC Design Engineering Center Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Epidemiology and Biostatistics Nanjing Medical UniversityNanjing 210029China

Objective to explore dynamic characteristics of the HIV mother to child transmission （MTCT） epidemic in *** A deterministic dynamic transmission model was used to determine the effect of key parameters on the likely long-term trends of the HIV MTCT epidemic in *** 7.0 was used to develop the *** The number of the susceptibles （S）,the transmission rate （β）,and the screening proportion （α） of HIV positive pregnant women have the greatest impact on the HIV MTCT epidemic in *** growth of the MTCT epidemic in China could not be controlled only by decreasing the MTCT transmission *** prevalence of HIV positive women should be reduced and more pregnant women should be tested for *** prevention of MTCT （PMTCT） should focus not only on the reduction of HIV transmission rates and incidences of HIV among women but also on the increase of HIV testing for pregnant *** most cost-effective PMTCT means for China should be investigated in future studies.

关键词： mother to child transmission dynamic model HIV China

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Diagnosis of pulmonary tuberculosis among asymptomatic HIV＋ patients in Guangxi, China

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Chinese Medical Journal 2010年第23期123卷 3400-3405页

作者： ZHANG Yao YU Lan TANG Zhi-rong HUANG Shao-biao ZHENG Yuan-jia MENG Zhi-hao SUN Kai WANG Li-ming Ray Y.CHEN ZHANG Fu-jie Division of Treatment and Care National Center for AIDS/STD Control and Prevention Chinese Center for Diseases Control and Prevention Beijing 100050 China Beijing Ditan Hospital Beijing 100015 China Provincial Center of Diseases Control and Prevention NaningGuangxi 53000 China Nanning 4th People's Hospital Nanning Guangxi 530000 China Center for Diseases Control and Prevention of Liuzhou City Liuzhou Guangxi 545000 China Liuzhou Longtan Hospital Liuzhou Guangxi 545000 China University of North Carolina Chapel Hill USA Washington University in St. Louis School of Medicine St. LouisUSA Global AIDS Program U.S. Centers for Disease Control andPrevention Beijing 100600 China The Office of Global Research National Institute of Allergy andInfectious Diseases US National Institutes of Health Beijing100600 Chin

Background Pulmonary tuberculosis （PTB） among asymptomatic Chinese patients with HIV infection has not been investigated despite high tuberculosis burden in China. This study was aimed to evaluate the prevalence, risk factors and clinical outcomes of PTB among asymptomatic patients with HIV/aids in Guangxi to facilitate the development of diagnostic and treatment *** All asymptomatic adult HIV-infected patients with CD4 ＜350 cells/μl who attended four HIV clinics in Guangxi between August 2006 and March 2008 were evaluated for active PTB with physical examination, chest X-ray （CXR）,sputum smear and/or sputum liquid culture. Data were described using median （interquartile range, IQR） and *** and multivariate Logistic regression analyses were performed to identify risk factors associated with *** Among 340 asymptomatic subjects, 15 （4%） were diagnosed with PTB, with 4 （27%） sputum smear positive and 8 （53%） sputum culture positive. CXR has higher diagnostic sensitivity （87%） than sputum smear （25%） and sputum culture （67%）, but lower specificity （56%） compared with sputum smear （99%） and culture （100%）. In univariate analysis,injection drug user, body mass index （BMI）＜18 kg/m2, CD4 ＜50 cells/μl and presence of peripheral lymphadenopathy were associated with an increased risk of asymptomatic PTB, while in multivariate analysis only peripheral lymphadenopathy maintained statistical significance （OR=7.6, 95% CI 1.4-40）. Patients with negative smear and minor or no abnormalities on CXR had longer interval between screening and TB *** PTB was relatively common in this group of HIV＋ asymptomatic Chinese patients. Diagnosis is challenging especially where sputum culture is unavailable. These findings suggest that an enhanced evaluation for PTB needs to be integrated with HIV care in China and transmission prevention in China to control at both households and health care facilities, especially for patients with fact

关键词： tuberculosis human immunodeficiency virus diagnosis

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Corrigendum

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Journal of NeuroVirology 2010年第2期16卷 185-188页

作者： Robert K. Heaton Lucette A. Cysique Hua Jin Chuan Shi Xin Yu Scott Letendre Donald R. Franklin Christopher Ake Ofilio Vigil J. Hampton Atkinson Thomas D. Marcotte Igor Grant Zunyou Wu HIV Neurobehavioral Research Center (HNRC) Department of Psychiatry University of California at San Diego San Diego VA San Diego Health Care System San Diego Institute of Mental Health Peking University Beijing China National Center for AIDS/STD Control & Prevention (NCAIDS) China

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Potential protective role of HLA-A*03 in HIV-1 Infection and disease progression in a Chinese Former Blood Donor cohort

Potential protective role of HLA-A*03 in HIV-1 Infection and...

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21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Weilun Zhang Peng Zhang Li Wang Kunxue Hong Yanxin Liu Bing Su Cheng Xu Jianqin Xu Yuhua Ruan Yimin Shao Dexian Zheng Institute of Basic Medical Sciences Peking Union Medical College National Center for AIDS/STD Control and Prevention Anhui Center for Disease Control and Prevention Fuyang Center for Disease Control and Prevention

To assess the influence of human leukocyte antigen(HLA) on HIV-1 infection and the in vivo control of virus,294 HIV-positive and 59 HIV-negative former blood donors(FBDs) in Fuyang City of Anhui province were enrolled to perform HLA genotyping and the association of HIV-1 infection and the allele distribution were *** viral load and CD4/CD8 T cell counts were assessed in all *** observed that the frequency of HLA-A*03

关键词： HLA HIV Potential protective role of HLA-A in HIV-1 Infection and disease progression in a Chinese Former Blood Donor cohort

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A public health approach to rapid scale-up of free antiretroviral treatment in China： an ounce of prevention is worth a pound of cure

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Chinese Medical Journal 2009年第11期122卷 1352-1355页

作者： Marc Bulterys Sten H. Vermund Ray Y. Chen Chin-Yih Ou Global AIDS Program - China Office US Centers for Disease Control and Prevention Beijing 100600 China Division of Global AIDS National Center for HIV Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta Georgia USA Institute for Global Health and Department of Pediatrics Vanderbilt University School of Medicine Nashville Tennessee USA National Institute of Allergy and Infectious Diseases US Embassy Beijing/National Institutes of Health Beijing 100600 China

China＇s rapidly evolving HIV/aids epidemic calls for a dramatic expansion of both prevention and treatment services. Official state media recently reported that for the first time, in 2008, HIV/aids became China＇s leading cause of death among infectious diseases. Estimates from the Ministry of Health indicate that around 700 000 people were living with HIV and 85 000 people had aids in 2007. Initially, HIV-1 infection was confined primarily to certain high-risk populations such as injection drug users （IDU） along drug-trafficking routes, and former plasma donors （FPD） in rural communities in east-central China. Now, however, HIV prevalence is increasing among female sex workers （FSW） and men who have sex with men （MSM）.

关键词： antiretroviral therapy China human immunodeficiency virus drug resistance universal access

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P16-12. Relative dominance of Gag-specific cytotoxic T lymphocytes is associated with viral load inversely in HIV-1 clade B' infected Chinese

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Retrovirology 2009年第3期6卷 1-1页

作者： M Jia J Chen K Hong S Liu X Zhang H Zhao Y Shao M Altfeld B Walker X Yu Division of Virology and Immunology National Center for AIDS/STD Control and Prevention China CDC Beijing PR China Ragon Institute of MGH MIT and Harvard Boston MA USA

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P20-02. Characterization of phenotypic, genotypic and neutralization sensitivity of the HIV-1 CRF07_B'C Strains circulating in the Xinjiang Province of China

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Retrovirology 2009年第3期6卷 1-1页

作者： L Ma J Sun L Yuan Y Huang S Qu X Yu Z Meng X He Y Shao Y Guo S Jiang National Center for AIDS/STD Control and Prevention (NCAIDS) Chinese Center for Disease Control and Prevention (China-CDC) Beijing PR China the First Affiliated Hospital of Xinjiang Medical University Urumqi PR China Lindsley F. Kimball Research Institute New York Blood Center New York USA

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