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Tree thorns-inspired hyaluronic acid-based dissolving microneedles loaded with salvianolic acid B for effective hypertrophic scar treatment with enhanced long-term stability

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Carbohydrate Polymers 2025年 364卷

作者： Mbituyimana, Bricard Luo, Longjun Qi, Fuyu Jiang, Yuchi Atta, Omar Mohammad Kishta, Mohamed S. Maboruk, Mostafa Wu, Min Ge, Wei Shi, Zhijun Yang, Guang Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan430074 China Hospital Huazhong University of Science and Technology Wuhan430074 China Department of Burns & Skin Wounds Repair Center The Third Hospital of Wuhan 216 Guanshan Avenue Hongshan District Wuhan430070 China Organ Transplantation Clinical Medical Research Center of Hubei Province Wuhan430030 China Department of Botany and Microbiology College of Science Al-Azhar University Assiut Branch Assiut71524 Egypt Hormones Department Medical Research and Clinical Studies Institute Stem Cell Lab. Center of Excellence for Advanced Sciences National Research Centre 33 El Bohouth St. Dokki Cairo12622 Egypt Refractories Ceramics and Building Materials Department Advanced Materials Technology and Mineral Resources Research Institute National Research Centre 33 El Bohouth St. Dokki Cairo12622 Egypt Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan430030 China

Hypertrophic scar (HS) represents a natural consequence of abnormal fibroproliferation occurring during wound healing, which not only leads to tissue dysfunction but also causes psychological issues for patients. Up to now, no completely effective therapy for HS has been found. Salvianolic acid B (Sal[sbnd]B), one of the natural plant-derived compounds, has the capacity to suppress the fibrosis process in scarring treatment. Nevertheless, due to its poor skin-penetration ability and unsatisfactory stability in existing formulations, its current clinical applicability is restricted. In this study, inspired by the separation behavior of the thorns on the trunks of the silk floss tree, we developed a hyaluronic acid (HA) dissolving microneedle (MN) platform loaded with Sal[sbnd]B. This platform can enhance the sustainable delivery of Sal-B directly into scar tissue in a minimally invasive manner, thereby enhancing the efficacy of HS therapy and improving the stability of Sal[sbnd]B. To evaluate the therapeutic efficacy of Sal-B MN, we established a rabbit ear HS model. After being administered five times, Sal-B MN significantly reduced the scar elevation index (SEI) and down-regulated the expressions of collagen I, transforming growth factor beta 1 (TGF-β1), Signal Transducer and Activator of Transcription 3 (STAT3), and alpha-smooth muscle actin (α-SMA). Notably, these effects were still evident even after six months of storage at room temperature. This indicates that tree-inspired Sal-B MN holds great potential as a highly effective tool for HS treatment with a long shelf-life. This makes the system suitable for clinical application and storage under various conditions. © 2025

关键词： Controlled drug delivery

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Mechanical characterization of soft silicone gels via spherical nanoindentation for applications in mechanobiology

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Acta Mechanica Sinica 2021年第4期37卷 554-561,I0001页

作者： Yajun Zhang Xiaoning Yang Chunyang Xiong Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China

As a biocompatible material,soft silicone gels like CY52-276 have been applied to many engineering fields associated with interactions between mammalian cells and extracellular matrices/substrates,due to its nontoxicity,ease of preparation,optical transparency and tunable mechanical *** quantification of mechanical properties of silicone gels is crucial for quantitatively investigating mechanical responses of cells to *** the material with high surface energy,we design a new strategy for the nanoindentation technique to reduce or even eliminate the effect of interfacial adhesions with the aid of some specified ***,we dissect the dependence of its Young’s modulus on the ratios of monomers and crosslinkers and curing conditions,and therefore identify a dose-response relationship between its moduli and the corresponding prepolymer *** the non-linear large deformation nanoindentation tests,we further showed that the two-parameter Mooney-Rivlin model may well characterize the hyperelastic deformations of the materials with different composition *** pave the way for more precise exploration of the interaction between cells and extracellular matrix and the underlying mechanotransduction pathways in mechanobiology.

关键词： Silicone gel Young's modulus Nanoindentation Mechanobiology

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Bandgap engineering to tune the optical properties of Be_xMg_(1-x)X(X=S, Se, Te) alloys

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Chinese Physics B 2018年第1期27卷 415-423页

作者： B Sabir N A Noor M Rashid Fasih Ud Din Shahid M Ramay Asif Mahmood Centre for Advanced Studies in Physics Government College University Department of Physics School of Science University of Management and TechnologyLahore Pakistan Department of Physics COMSATS Institute of Information Technology Physics and Astronomy Department College of Science King Saud University Chemical Engineering Department College of Engineering King Saud University

Structural, electronic, and optical properties of alloys BexMgl-xX （X = S, Se, Te） in the assortment 0 〈 x 〈 1 were theoretically reported for the first time in zinc-blende （ZB） phase. The calculations were carried out by using full-potential linearized augmented plane wave plus local orbitals （FP-LAPW＋lo） formalism contained by the framework of density functional theory （DFT）. Wu--Cohen （WC） generalized gradient approximation （GGA）, based on optimization energy, has been applied to calculate these theoretical results. In addition, we used Becke and Johnson （mBJ-GGA） potential, modified form of GGA functional, to calculate electronic structural properties up to a high precision degree. The alloys were composed with the concentrations x = 0.25, 0.5, and 0.75 in pursuance of ＇special quasi-random structures＇（SQS） approach of Zunger for the restoration of disorder around the observed site of alloys in the first few shells. The structural parameters have been predicted by minimizing the total energy in correspondence of unit cell volume. Our alloys established direct band gap at different concentrations that make their importance in optically active materials. Furthermore, density of states was discussed in terms of the contribution of Be and Mg s and chalcogen （S, Se, and Te） s and p states and observed charge density helped us to investigate the bonding nature. By taking into consideration of immense importance in optoelectronics of these materials, the complex dielectric function was calculated for incident photon energy in the range 0--15 eV.

关键词： BexMgl-xX （X = S Se Te） alloys zinc-blende （ZB） phase density functional theory （DFT）,electronic and optical properties

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Quantification of tolerance limits of engineering system using uncertainty modeling for sustainable energy

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International Journal of Intelligent Networks 2020年 1卷 1-8页

作者： Datta, Debabrata Mishra, Sangeeta Rajest, S. Suman Radiological Physics & Advisory Division Bhabha Atomic Research Centre Mumbai India Thakur College of Engineering and Technology Mumbai India Vels Institute of Science Technology & Advanced Studies ChennaiTamil Nadu India

Measurements always associate a certain degree of uncertainty. In order to achieve high precision measurement in presence of uncertainty an efficient computation is desired. Statistical definition of precision of any measurement is defined as one standard deviation divided by the square root of the sample size taken for measurements. Accordingly, tolerance limits are statistical in nature. Therefore, measurements are required to repeat large number of times to obtain better precision. Hence, the target is to establish the tolerance limits in presence of uncertainty in computer and communication systems. Nonparametric method is applied to establish the tolerance limits when uncertainty is present in measurements. The basic aim of the present paper is to explore order statistics based nonparametric method to estimate the appropriate number of samples required to generate the realizations of the uncertain random parameters which further will facilitate user to establish the tolerance limits. A case study of solute transport model is experimented where tolerance limits of solute concentration at any spatial location at any temporal moment is shown. Results obtained based on the nonparametric simulation are compared with the results obtained by executing traditional method of setting tolerance limits using Monte Carlo simulations using computer and communication systems. © 2020 The Author(s)

关键词： Uncertainty analysis

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Tunnel flexibility effect on the ground surface acceleration response

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Earthquake engineering and engineering Vibration 2016年第3期15卷 457-476页

作者： Mohammad Hassan Baziar asoud Rabeti Moghadam Yun Wook Choo Dong-Soo Kim Center of Excellence for Fundamental Studies in Structural Engineering School of Civil EngineeringIran University of Science and TechnologyTehranIran School of Civil Engineering Iran University of Science and TechnologyTehran1ran Department of Civil and Environmental Engineering College of EngineeringKongju National UniversityChungnam 330-717Republic of Korea Department of Civil and Environmental Engineering Korea Advanced Institute of Science&TechnologyDaejeon 305-701Republic of Korea

Flexibility of underground structures relative to the surrounding medium, referred to as the flexibility ratio, is an important factor that influences their dynamic interaction. This study investigates the flexibility effect of a box-shaped subway tunnel, resting directly on bedrock, on the ground surface acceleration response using a numerical model verified against dynamic centrifuge test results. A comparison of the ground surface acceleration response for tunnel models with different flexibility ratios revealed that the tunnels with different flexibility ratios influence the acceleration response at the ground surface in different ways. Tunnels with lower flexibility ratios have higher acceleration responses at short periods, whereas tunnels with higher flexibility ratios have higher acceleration responses at longer periods. The effect of the flexibility ratio on ground surface acceleration is more prominent in the high range of frequencies. Furthermore, as the flexibility ratio of the tunnel system increases, the acceleration response moves away from the free field response and shifts towards the longer periods. Therefore, the flexibility ratio of the underground tunnels influences the peak ground acceleration （PGA） at the ground surface, and may need to be considered in the seismic zonation of urban areas.

关键词： box-shaped tunnel flexibility ratio acceleration response ground surface centrifuge modeling numericalsimulation

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Improving Grid Stability and Power Quality in advanced Technologies-Based Bidirectional EV Charging Stations: A Review 4

Improving Grid Stability and Power Quality in Advanced Techn...

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4th International Conference on Sustainable Expert Systems, ICSES 2024

作者： Damodharan, Rajeshkumar Sivakumar, Pradeepkumar VISTAS-Vels Institute of Science Technology & Advanced Studies Department of Electrical and Electronics Engineering Pallavaram Chennai India

ISBN: (纸本)9798331540364

Integrating renewable energy into electric vehicle (EV) charging stations is crucial to improving sustainability, reducing carbon emissions and improving energy management. In addition to these benefits, addressing power quality concerns is essential for the infrastructure supporting EV charging to operate reliably. The issues about the quality of energy associated with bidirectional EV charging systems, particularly in Vehicle-to-Grid (V2G) and Grid-to-Vehicle (G2V) operations using advanced control methods and adaptive filtering to help address power quality issues by dynamically adjusting charging parameters and enhancing system stability. With EV sales rising quickly, significant obstacles such as voltage fluctuations, harmonic distortions, and grid instability have emerged, especially during peak charging periods. These issues with power quality do not just compromise grid reliability but also impact the infrastructure for EV charging's effectiveness and lifespan. The paper highlights important techniques for enhancing power quality, emphasizing advanced control schemes, including predictive and adaptive control, and innovative converter technologies. The objective of these methods is to maximize power flow, reduce energy losses, and strengthen grid stability. The focus will be on advanced power electronics, smart grid integration, and real-time monitoring systems to address the current challenges while supporting the widespread adoption of renewable energy sources in EV charging infrastructure. © 2024 IEEE.

关键词： Charging stations

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Investigation on mechanical characterization of Al/Mos2/WC hybrid composite

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Materials Today: Proceedings 2022年 69卷 995-999页

作者： Hemadri, Kadapa Ajith Arul Daniel, S. Kukanur, Vijayendra Vijayananth, S. Kumar, R. Department of Mechanical Engineering Sri Venkateswara Institute of Science and Technology Andhra Pradesh Kadapa 516003 India Department of Mechanical Engineering Vels Institute of Science Technology & Advanced Studies Tamil Nadu Chennai 600117 India Department of Mechanical Engineering S L N College of Engineering Karnataka Raichur 584135 India Department of Mechanical Engineering Eritrea Institute of Technology Eritrea

In the present research, Aluminium (Al6262) is chosen as matrix, Tungsten Carbide (WC) and Molybdenum Disulphide (MoS2) particulates as primary and secondary reinforcements in different weight fraction. The MMCs are fabricated by stir casting method with mechanical stirring arrangement. The Molybdenum Disulphide (MoS2) particulate was added in various proportions of 2%, 4 % and 6% on mass fraction and also added WC particulates at 4 %, 8 % and 12 % on mass percentage basis to the molten metal. For various created composites, experimental data such as Charpy Impact test, micro hardness,tensile and microstructural characterisation was analyzed. The distribution of WC particles and MoS2 in the base matrix was investigated microstructurally. The results revealed that increasing the weight fraction of WC and MoS2 increases the tensile, hardness and impact strength of the produced MMCs. © 2022

关键词： Tungsten carbide

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Artificial Neural Network-based Relay Selection in Underwater Wireless Sensor Network 2

Artificial Neural Network-based Relay Selection in Underwate...

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2nd International Conference on Smart Technologies for Smart Nation, SmartTechCon 2023

作者： Sreeraj, Anoop Vijayalakshmi, P. Rajendran, V. Department of Electronics & Communication Engineering Vels Institute of Science Technology & Advanced Studies Tamil Nadu Chennai India

ISBN: (纸本)9798350305418

As one of the most challenging and promising wireless communications, underwater communication has received much attention. According to the distance, there may be significant delay, limited bandwidth and attenuation, which reduce the system's overall performance. To solve these problems, Artificial Neural Network based Relay Selection (ANNRS) in Under Water Wireless Sensor Networks (UWSN) is introduced. This mechanism uses the Artificial Neural Network (ANN) algorithm to choose the relay nodes to pass the data from sender to receiver. The ANN algorithm picked out the relay using four input features: Energy, bandwidth, depth and packet received ratio (PRR). The UWSN may dynamically pick the optimum relay node depending on the current network circumstances by employing an ANN-based relay selection system, which improves network performance, lowers energy consumption, and increases data transmission reliability. The extensive simulation outcomes demonstrate that the ANNRS mechanism enhances the performance, such as PRR, and energy, and minimizes the delay and Assemble Propagation Distance in UWSN. © 2023 IEEE.

关键词： Artificial neural network Energy efficiency Relay selection Simulation analysis Underwater wireless sensor network

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The Effect of Drilling Parameters on the Hole Quality of Hybrid Fiber-Reinforced Epoxy Composite

The Effect of Drilling Parameters on the Hole Quality of Hyb...

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National Conference on Sustainable Machining Strategies for Better Performance, SMSBP 2020

作者： Santhanam, V. Sendhilkumar, S. Venkateshwaran, N. Chandrasekaran, M. Rajalakshmi Engineering College Chennai India Akshaya College of Engineering and Technology Coimbatore India Vels Institute of Science Technology and Advanced Studies Chennai India

ISBN: (纸本)9789811622779

In this work, hybrid fiber-reinforced epoxy composite had been developed by using woven banana fiber and woven glass fiber as reinforcements. Laminated composite sample was developed by using hand layup method. Glass fiber was kept as top layer, and banana fiber was kept as bottom layer with the arrangement of G-B-G-B. Drilling is one of the most common and critical machining operations during the assembly operation in manufacturing. In this work, the effect of drilling parameters on the quality of the hole and delamination was studied. Three different drill speeds and feed rates were used in this study. The machining was done by using a twist drill of diameter 8 mm, and the drilling was performed at the speeds of 700, 1400 and 2100 rpm. The feed rate was kept at 0.05, 0.12 and 0.20 mm/rev. The drilled holes were scanned in a high-resolution scanner, and digital image processing was further used to compute the hole dimensions. The details of the pixel values at the entry and exit were measured digitally, and subsequently, the pixel values were used to determine the extent of damage occurred due to the drilling operation. A two-dimensional array of hole dimension with respect to the feed rate and speed was obtained from the experimental results. Finally, ANOVA technique was used to determine the most influencing drilling parameter to get better hole quality. The experimental results indicated that the damage due to machining was greater at the exit than the damage at the entry. Also, ANOVA technique showed that the drilled hole quality depends on the drilling speed and feed rate, but the feed rate is the most significant parameter than the cutting speed. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： ANOVA technique Banana fiber Composite drilling Glass fiber Hybrid fiber-reinforced composite

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Harmonizing Healthcare Perspectives and In-Depth Strategy for Unifying Diverse Medical Big Data Sources 10

Harmonizing Healthcare Perspectives and In-Depth Strategy fo...

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10th International Conference on advanced Computing and Communication Systems, ICACCS 2024

作者： Manikandan, A. Thirumal, S. Kumar, N. Vels Institute of Science Technology &advanced Studies Department of Computer Science & Engineering Tamil Nadu Chennai India

ISBN: (数字)9798350384369

ISBN: (纸本)9798350384369

The healthcare sector has generated vast amounts of data, posing a significant challenge in terms of integration. Recently, deep learning frameworks have gained extensive utilization for forecasting relationships within healthcare systems. Specifically, the success of the Heterogeneous Multi-Layer Deep Learning Network (HMLDN) in seamlessly amalgamating diverse medical data for enhanced diagnostics and storage is explored in this paper. The initial discussion delves into capsule optimized networks and attention maps, laying the groundwork for their application in the formation of HMLDN to achieve efficient data integration. © 2024 IEEE.

关键词： Electronic health record

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