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SSRN 2024年

作者： Tolmacheva, Nelli Bhattacharyya, Amitava Kim, DaJeong Noh, Insup Convergence Institute of Biomedical Engineering and Biomaterials Seoul National University of Science and Technology Seoul01811 Korea Republic of Department of Chemical and Biomolecular Engineering Seoul National University of Science and Technology Seoul01811 Korea Republic of PSG Institute of Advanced Studies India

Alginate biogel with gelatin- coated octa-calcium phosphate (OCP) particles has great potential for improving 3D printability and biofunctionality for bone tissue engineering. In this study, micro/nano-OCP particles were co-precipitated with different concentrations of gelatin (1.5, 2.0, 2.5, and 3.0 wt.%) during the particle synthesis process to promote bioactivity, cell supportiveness, and osteogenic properties of the alginate biogel. The OCP particles loaded alginate biogels were investigated for their printability, mechanical and biological performances. The average particle diameter of the 1.5 wt.% gelatin-coated OCP was 35% smaller than that with gelatin untreated. The mechanical properties of the gelatin-OCP loaded biogels exhibited not only lower load resistance, approximately 40% decrease in hardness, but also lower printability, except for 1.5 wt.% gelatin-coated OCP, which made it difficult to print multi-layered structures. In vitro tests showed the biogel with gelatin-coated OCP demonstrated enhanced cell viability and growth rate ( © 2024, The Authors. All rights reserved.

关键词： Bone

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A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

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中国药理学报（英文版） 2022年第2期43卷 483-493页

作者： Peng-xuan Ren Wei-juan Shang Wan-chao Yin Huan Ge Lin Wang Xiang-lei Zhang Bing-qian Li Hong-lin Li Ye-chun Xu Eric H.Xu Hua-liang Jiang Li-li Zhu Lei-ke Zhang Fang Bai School of Life Science and Technology and Shanghai Institute for Advanced Immunochemical StudiesShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Life Science and Technology and Shanghai Institute for Advanced Immunochemical StudiesShanghaiTech UniversityShanghai 201210China Department of Chemistry Imperial College LondonLondonUnited Kingdom CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology and Shanghai Institute for Advanced Immunochemical StudiesShanghaiTech UniversityShanghai 201210China CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China

The COVID-19,caused by SARS-CoV-2,is threatening public health,and there is no effective *** this study,we have implemented a multi-targeted anti-viral drug design strategy to discover highly potent SARS-CoV-2 inhibitors,which simultaneously act on the host ribosome,viral RNA as well as RNA-dependent RNA polymerases,and nucleocapsid protein of the virus,to impair viral translation,frameshifting,replication,and *** by this strategy,three alkaloids,including lycorine,emetine,and cephaeline,were discovered to inhibit SARS-CoV-2 with EC50 values of low nanomolar levels *** findings in this work demonstrate the feasibility of this multi-targeting drug design strategy and provide a rationale for designing more potent anti-virus drugs.

关键词： SARS-CoV-2 inhibitors RdRp host ribosome Virus RNA

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Destabilizing effects of edge infernal components on resistive wall modes in advanced tokamak scenarios

Destabilizing effects of edge infernal components on resisti...

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作者： Han, Rui Zhu, Ping Zheng, Linjin Department of Plasma Physics and Fusion Engineering School of Nuclear Science and Technology University of Science and Technology of China Hefei230026 China International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and Technology Hubei Wuhan430074 China Department of Engineering Physics University of Wisconsin-Madison MadisonWI53706 United States Institute of Fusion Studies University of Texas at Austin AustinTX78712 United States

The stability of the n = 1 resistive wall modes (RWMs) dominated by the pressure-driven infernal components is investigated using the ideal magnetohydrodynamics (MHD) code AEGIS for the advanced tokamak scenarios. Here, n is the toroidal mode number. In the advanced tokamak scenarios, due to the large fraction of bootstrap current contribution, the profile of safety factor q is deeply reversed in magnetic shear in the central core region and locally flattened within the edge pedestal. Consequently, the pressure-driven infernal components develop in the corresponding flat-q regions of both core and edge. However, the edge infernal components dominate the n = 1 RWM structure and lead to lower βN limits for the advanced tokamak scenarios. In the framework of ideal MHD, the edge rotation is found the most critical to the stabilization due to the dominant influence of the edge infernal components, which should be maintained sufficiently large in magnitude and range in order for the rotation alone to fully suppress the n = 1 RWM in typical advanced tokamak scenarios. © 2023 Author(s).

关键词： Safety factor

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3D Bioprinting of Alginate Biogel with Gelatin-Coated Octa-Calcium Phosphate Micro/Nanoparticles for Bone Tissue engineering

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SSRN 2024年

关键词： Bone

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Local Excitation of Kagome Spin Ice Magnetism Seen by Scanning Tunneling Microscopy

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Physical Review Letters 2024年第4期133卷 046503-046503页

作者： Hanbin Deng Tianyu Yang Guowei Liu Lu Liu Lingxiao Zhao Wu Wang Tiantian Li Wei Song Titus Neupert Xiang-Rui Liu Jifeng Shao Y. Y. Zhao Nan Xu Hao Deng Li Huang Yue Zhao Liyuan Zhang Jia-Wei Mei Liusuo Wu Jiaqing He Qihang Liu Chang Liu Jia-Xin Yin Department of Physics Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area (Guangdong) Shenzhen China Shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices Shenzhen Institute for Quantum Science and Engineering Institute for Advanced Studies School of Physical Science and Technology Guangdong Provincial Key Laboratory of Computational Science and Material Design

The kagome spin ice can host frustrated magnetic excitations by flipping its local spin. Under an inelastic tunneling condition, the tip in a scanning tunneling microscope can flip the local spin, and we apply this technique to kagome metal HoAgGe with a long-range ordered spin ice ground state. Away from defects, we discover a pair of pronounced dips in the local tunneling spectrum at symmetrical bias voltages with negative intensity values, serving as a striking inelastic tunneling signal. This signal disappears above the spin ice formation temperature and has a dependence on the magnetic fields, demonstrating its intimate relation with the spin ice magnetism. We provide a two-level spin-flip model to explain the tunneling dips considering the spin ice magnetism under spin-orbit coupling. Our results uncover a local emergent excitation of spin ice magnetism in a kagome metal, suggesting that local electrical field induced spin flip climbs over a barrier caused by spin-orbital locking.

关键词： Electrical properties Magnetism Spin ice Scanning tunneling microscopy Scanning tunneling spectroscopy Two-level models

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Few-layer Ti_(3)CN MXene for ultrafast photonics applications in visible band

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Journal of Materiomics 2023年第1期9卷 44-55页

作者： Zixin Yang Qi Yang Yulin Tian Xianghe Ren Chun Li Yuqian Zu Syed Zaheer Ud Din Lingfeng Gao Jian Wu Hualong Chen Han Zhang Jie Liu Jingliang He Abdullah GAl-Sehemi International School for Optoelectronic Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Edu-cationHangzhou Normal UniversityHangzhou311121China College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha410073China Institute of Microscale Optoelectronics College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China Shandong Provincial Engineering and Technical Center of Light Manipulations and Shandong Provincial Key Laboratory of Optics and Photonic Device chool of Physics and ElectronicsShandong Normal UniversityJinan250358China State Key Laboratory of Crystal Materials Shandong UniversityJinan250100China Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityAbha61413Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha61413Saudi Arabia

Ti_(3)CN,as a typical hetero-MXene,has attracted tremendous attention for its unique ***,its ultrafast photonics applications are still ***,the few-layer Ti_(3)CN MXene was successfully prepared by selective etching and molecular delamination *** nonlinear optical response of few-layer Ti_(3)CN MXene at 640 nm was studied using the open-aperture Z-scan *** asprepared Ti_(3)CN MXene sample exhibited excellent nonlinear saturable absorption characteristics,resulting in the nonlinear absorption coefficient b of4.05×10^(-2)cm/GW,which was one order of magnitude larger than that of black phosphorus(BP)and molybdenum disulfide(MoS_(2)).For the optical modulation applications of few-layer Ti_(3)CN MXene,passively Q-switched(PQS)solid-state visible lasers based on Ti_(3)CN saturable absorber(SA)at 522 nm,607 nm,639 nm,and 721 nm were successfully ***,a Ti_(3)CN-based stable passively mode-locked Pr:YLF red laser was also successfully achieved with a pulse duration of 30 ps,and the corresponding repetition rate was 73.1 *** optical modulation device based on few-layer Ti_(3)CN MXene shows good *** work demonstrates that the tremendous prospects of the few-layer Ti_(3)CN MXene as a visible optical modulation device in ultrafast photonics applications.

关键词： Ti_(3)CN MXene Z-scan Saturable absorber Optical modulator Pulsed visible lasers

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Developing mapping and allotment in volunteer cloud systems using reliability profile algorithms in a virtual machine 2

Developing mapping and allotment in volunteer cloud systems ...

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2nd International Conference on Computation, Automation and Knowledge Management, ICCAKM 2021

作者： Jeyalaksshmi, S. Nidhya, M.S. Suseendran, G. Pal, Souvik Akila, D. Information Technology Vels Institute of Science Technology Advanced Studies Chennai India Periyar Maniammai Institute of Science Technology Dept of Software Engineering Vallam Thanjavur India Global Institute of Management and Technology Department of Computer Science and Engineering India

ISBN: (纸本)9781728194912

While the placement of the Virtual Computer was It remains an open challenge for Volunteer Cloud Computing, which reveals many divergent gaps in conventional cloud computing contexts, and has been thoroughly studied. Features, including sporadic usability of nodes and Infrastructure that's inefficient. In this article, we are modeling the Virtual In Volunteer Cloud Computing, computer positioning dilemma As a multi-dimensional, constrained 0-1 knapsack issue and Built algorithms to satisfy the basic aims and shortcomings of Volunteer Cloud Computing. The proof of a dedicated Cloud Computing Volunteer, The competitive success outcomes of these test beds are illustrated With algorithm. © 2021 IEEE.

关键词： Cloud computing

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A reappraisal of active faults in central-east Iran(Kerman province)

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Earthquake Science 2022年第2期35卷 122-137页

作者： Mohammad Talebi Abbas Sivandi-Pour Ghasem-Ali Ahmadi Ehsan Noroozinejad Farsangi Shamseddin Esmaeili Mohammad-Javad Banimahdi-Dehkordi Hamidreza Safizadeh Mahdieh Akbarpoor Ehsan Ebrahimi Rabe Sharifi Rad Manoochehr Fallah International Institute of Earthquake Engineering and Seismology(IIEES) Tehran ***Iran Faculty of Civil and Surveying Engineering Graduate University of Advanced TechnologyKerman ***Iran Geological and Geotechnical Department Padidab Sepahan Consulting EngineersEsfahan ***Iran Razi University Kermanshah ***Iran Institute for Advanced Studies in Basic Sciences(IASBS) Zanjan ***Iran Kerman Provincial Gas Corporation National Iranian Gas CompanyKerman ***Iran

Fault lineaments are the main input data in earthquake engineering and seismology *** study presents a digitally-based active fault map of the Kerman region in central-east Iran which experienced several devastating earthquakes on poorly exposed and/or not identified active *** Landsat 8 data,we have carried out the image-based procedures of fault mapping,which include applying the contrast stretching technique,the principal component analysis,the color composite technique,the spectral rationing,and creating the false-color composite ***,we have cross-checked the resulting map with the geological maps provided by the Geological Survey of Iran to decrease the associated *** resulting map includes 123 fault segments,still,a part of which has been expressed in the previously compiled active-fault maps of ***,the new one is mapping the poorly exposed active faults,so-called secondary faults,which are able to produce strong *** faults are primarily associated with poorly defined areas that accommodate low levels of seismicity;however,sporadic strong events are likely to *** has also been investigated that these kinds of faults are seismogenic and are able to produce destructive *** total,the outcome of this study can also be jointed with seismic studies for investigating parts of the earthquake activity in central-east Iran,in particular for the fault-based approaches in impending earthquake-resistant buildings.

关键词： central-east Iran Kerman active fault satellite image processing remote sensing

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High-Throughput Powder Diffraction Using White X-Ray Beam and a Simulated Energy-Dispersive Array Detector

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engineering 2022年第3期8卷 81-88页

作者： Xiaoping Wang Weiwei Dong Peng Zhang Haoqi Tang Lanting Zhang Tieying Yang Peng Liu Hong Wang X.-D.Xiang Materials Genome Initiative Center&School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering&Department of Physics Southern University of Science and TechnologyShenzhen 518055China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China Guangdong Provincial Key Laboratory of Energy Materials for Electric Power Southern University of Science and TechnologyShenzhen 518055China Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

High-throughput powder X-ray diffraction(XRD)with white X-ray beam and an energy-dispersive detector array is demonstrated in this work on a CeO;powder sample on a bending magnet synchrotron beamline at the Shanghai Synchrotron Radiation Facility(SSRF),using a simulated energy-dispersive array detector consisting of a spatially scanning silicon-drift detector(SDD).Careful analysis and corrections are applied to account for various experimental hardware-related and diffraction angle-related *** resulting diffraction patterns show that the relative strength between different diffraction peaks from energy-dispersive XRD(EDXRD)spectra is consistent with that from angle-resolved XRD(ARXRD),which is necessary for analyzing crystal structures for unknown *** X-ray fluorescence(XRF)signal is collected *** counts from all pixels are integrated directly by energy,while the diffraction spectra are integrated by d-spacing,resulting in a much improved peak strength and signal-to-noise(S/N)ratio for the array *** comparison with ARXRD,the diffraction signal generated by a white X-ray beam over monochromic light under the experimental conditions is about 104 times *** full width at half maximum(FWHM)of the peaks in q-space is found to be dependent on the energy resolution of the detector,the angle span of the detector,and the diffraction *** is possible for EDXRD to achieve the same or even smaller FWHM as ARXRD under the energy resolution of the current detector if the experimental parameters are properly chosen.

关键词： High-throughput experiment White beam X-ray diffraction Energy-dispersive array detector Energy-dispersive X-ray diffraction Angle-resolved X-ray diffraction

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ROS-based Hardware-in-the-Loop Simulation Framework for Fish-Inspired Robot for Safe Control Gain Tuning

ROS-based Hardware-in-the-Loop Simulation Framework for Fish...

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Conference on Information and Communication technology (CICT)

作者： Neelam Verma Pritam Ojha Anuj Kumar Sharma Atul Thakur Mechatronics Department Centre for Advanced Studies Lucknow Lucknow India Department of Mechanical Engineering Indian Institute of Technology Patna Patna India

Fish-inspired robots offer numerous advantages, including improved maneuverability, reduced power consumption, and quieter actuation than traditional propeller-based underwater robots. However, designing effective controllers for optimal performance is challenging due to the complex mechanisms and hydrodynamic forces involved. Traditional experimental methods for testing and tuning controllers can be costly and may even inflict physical damage to the robot during the development phase. In this paper, we propose a solution in the form of a ROS-based hardware-in-the-loop (HIL) simulation framework, which enables safe and efficient testing of control algorithms for fish-inspired robots. Our approach involves implementing the control algorithm on actual hardware while controlling a simulated robot equipped with virtual sensors to provide feedback. To demonstrate the effectiveness of our framework, we implement and tune a PID controller for path tracking on an anguilliform-inspired robot. Furthermore, we experimentally validate its feasibility and performance on a physical anguilliform-inspired fish robot. By leveraging our ROS-based HIL-simulation framework, this research contributes to advancing the development and control of fish-inspired robots, offering a cost-effective and reliable approach to controller tuning and testing.

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