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Search for a vector-like quark T′ → tH via the diphoton decay mode of the Higgs boson in proton-proton collisions at √s = 13 TeV

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Journal of High Energy Physics 2023年第9期2023卷 1-40页

作者： Tumasyan, A. Adam, W. Andrejkovic, J.W. Bergauer, T. Chatterjee, S. Damanakis, K. Dragicevic, M. Escalante Del Valle, A. Hussain, P.S. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I. Paulitsch, P. Pitters, F.M. Schieck, J. Schöfbeck, R. Schwarz, D. Sonawane, M. Templ, S. Waltenberger, W. Wulz, C.-E. Darwish, M.R. Janssen, T. Kello, T. Rejeb Sfar, H. Van Mechelen, P. Bols, E.S. D’Hondt, J. De Moor, A. Delcourt, M. El Faham, H. Lowette, S. Moortgat, S. Morton, A. Müller, D. Sahasransu, A.R. Tavernier, S. Van Doninck, W. Vannerom, D. Clerbaux, B. De Lentdecker, G. Favart, L. Hohov, D. Jaramillo, J. Lee, K. Mahdavikhorrami, M. Makarenko, I. Malara, A. Paredes, S. Pétré, L. Postiau, N. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. Dobur, D. Knolle, J. Lambrecht, L. Mestdach, G. Rendón, C. Samalan, A. Skovpen, K. Tytgat, M. Van Den Bossche, N. Vermassen, B. Wezenbeek, L. Benecke, A. Bruno, G. Bury, F. Caputo, C. David, P. Delaere, C. Donertas, I.S. Giammanco, A. Jaffel, K. Jain, Sa. Lemaitre, V. Mondal, K. Taliercio, A. Tran, T.T. Vischia, P. Wertz, S. Alves, G.A. Coelho, E. Hensel, C. Moraes, A. Rebello Teles, P. Aldá Júnior, W.L. Alves Gallo Pereira, M. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E.M. Da Silveira, G.G. De Jesus Damiao, D. Dos Santos Sousa, V. Fonseca De Souza, S. Martins, J. Mora Herrera, C. Mota Amarilo, K. Mundim, L. Nogima, H. Santoro, A. Silva Do Amaral, S.M. Sznajder, A. Thiel, M. Vilela Pereira, A. Bernardes, C.A. Calligaris, L. Fernandez Perez Tomei, T.R. Gregores, E.M. Mercadante, P.G. Novaes, S.F. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Shumka, E. Thakur, S. Cheng, T. Javaid, T. Mittal, M. Yuan, L. Ahmad, M. Bauer, G. Hu, Z. Lezki, S. Yi, K. Chen, G.M. Chen, H.S. Chen, M. Iemmi, F. Jiang, C.H. Kapoor, A. Liao, H. Liu, Z.-A. Milosevic, V. Monti, F. Sharma, R. Tao, J. Thomas-Wilsker Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Casilla 7 D Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) — Fudan University Shanghai China Zhejiang University Zhejiang Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High Energy Physics (CHEP-FU) Fayoum University El-Fayoum Egypt National Institute of Chemical Physics and Biophysics Tallinn Estonia Department of Physics

A search for the electroweak production of a vector-like quark T′, decaying to a top quark and a Higgs boson is presented. The search is based on a sample of proton-proton collision events recorded at the LHC at s = 13 TeV, corresponding to an integrated luminosity of 138 fb¹. This is the first T′ search that exploits the Higgs boson decay to a pair of photons. For narrow isospin singlet T′ states with masses up to 1.1 TeV, the excellent diphoton invariant mass resolution of 1–2% results in an increased sensitivity compared to previous searches based on the same production mechanism. The electroweak production of a T′ quark with mass up to 960 GeV is excluded at 95% confidence level, assuming a coupling strength κ_T = 0.25 and a relative decay width Γ/M_T′ < 5%. [Figure not available: see fulltext.]. © 2023, The Author(s).

关键词： Beyond Standard Model Hadron-Hadron Scattering Top Physics

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Measurements of inclusive and differential cross sections for the Higgs boson production and decay to four-leptons in proton-proton collisions at s = 13 TeV

引用

Journal of High Energy Physics 2023年第8期2023卷 40页

作者： Hayrapetyan, A. Tumasyan, A. Adam, W. Andrejkovic, J.W. Bergauer, T. Chatterjee, S. Damanakis, K. Dragicevic, M. Escalante Del Valle, A. Hussain, P.S. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I. Schieck, J. Schöfbeck, R. Schwarz, D. Sonawane, M. Templ, S. Waltenberger, W. Wulz, C.-E. Darwish, M.R. Janssen, T. Kello, T. Van Mechelen, P. Bols, E.S. D’Hondt, J. De Moor, A. Delcourt, M. El Faham, H. Lowette, S. Makarenko, I. Morton, A. Müller, D. Sahasransu, A.R. Tavernier, S. Van Putte, S. Vannerom, D. Clerbaux, B. Dansana, S. De Lentdecker, G. Favart, L. Hohov, D. Jaramillo, J. Lee, K. Mahdavikhorrami, M. Malara, A. Paredes, S. Pétré, L. Postiau, N. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. De Coen, M. Dobur, D. Knolle, J. Lambrecht, L. Mestdach, G. Rendón, C. Samalan, A. Skovpen, K. Tytgat, M. Van Den Bossche, N. Vermassen, B. Wezenbeek, L. Benecke, A. Bruno, G. Bury, F. Caputo, C. Delaere, C. Donertas, I.S. Giammanco, A. Jaffel, K. Jain, Sa. Lemaitre, V. Lidrych, J. Mastrapasqua, P. Mondal, K. Tran, T.T. Wertz, S. Alves, G.A. Coelho, E. Hensel, C. Moraes, A. Rebello Teles, P. Aldá Júnior, W.L. Alves Gallo Pereira, M. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E.M. Da Silveira, G.G. De Jesus Damiao, D. Dos Santos Sousa, V. Fonseca De Souza, S. Martins, J. Mora Herrera, C. Mota Amarilo, K. Mundim, L. Nogima, H. Santoro, A. Silva Do Amaral, S.M. Sznajder, A. Thiel, M. Vilela Pereira, A. Bernardes, C.A. Calligaris, L. Fernandez Perez Tomei, T.R. Gregores, E.M. Mercadante, P.G. Novaes, S.F. Orzari, B. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Shopova, M. Sultanov, G. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Shumka, E. Keshri, S. Thakur, S. Cheng, T. Guo, Q. Javaid, T. Mittal, M. Yuan, L. Bauer, G. Hu, Z. Yi, K. Chen, G.M. Chen, H.S. Chen, M. Iemmi, F. Jiang, C.H. Kapoor, A. Liao, H. Liu, Z.-A. Monti, F. Sharma, R. Song, J.N. Tao, J. Wang, J. Zhang, C. Zhang, H. Agapitos, A. Ba Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Casilla 7 D Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) — Fudan University Shanghai China Zhejiang University Zhejiang Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High Energy Physics (CHEP-FU) Fayoum University El-Fayoum Egypt National Institute of Chemical Physics and Biophysics Tallinn Estonia Department of Physics

Measurements of the inclusive and differential fiducial cross sections for the Higgs boson production in the H → ZZ → 4ℓ (ℓ = e, μ) decay channel are presented. The results are obtained from the analysis of proton-proton collision data recorded by the CMS experiment at the CERN LHC at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb⁻¹. The measured inclusive fiducial cross section is 2.73 ± 0.26 fb, in agreement with the standard model expectation of 2.86 ± 0.1 fb. Differential cross sections are measured as a function of several kinematic observables sensitive to the Higgs boson production and decay to four leptons. A set of double-differential measurements is also performed, yielding a comprehensive characterization of the four leptons final state. Constraints on the Higgs boson trilinear coupling and on the bottom and charm quark coupling modifiers are derived from its transverse momentum distribution. All results are consistent with theoretical predictions from the standard model. © The Author(s) 2023.

关键词： Hadron-Hadron Scattering Higgs Physics

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Transfer learning versus multi-agent learning regarding distributed decision-making in highway traffic 10

Transfer learning versus multi-agent learning regarding dist...

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10th International Workshop on Agents in Traffic and Transportation, ATT 2018

作者： Schutera, Mark Goby, Niklas Neumann, Dirk Reischl, Markus Institute for Automation and Applied Informatics Karlsruhe Institute of Technology Germany Chair for Information Systems Research University of Freiburg Germany IT Innovation Chapter Data Science ZF Friedrichshafen AG Germany Research and Development ZF Friedrichshafen AG Germany

Transportation and traffic are currently undergoing a rapid increase in terms of both scale and complexity. At the same time, an increasing share of traffic participants are being transformed into agents driven or supported by artificial intelligence resulting in mixed-intelligence traffic. This work explores the implications of distributed decision-making in mixed-intelligence traffic. The investigations are carried out on the basis of an online-simulated highway scenario, namely the MIT DeepTraffic simulation. In the first step traffic agents are trained by means of a deep reinforcement learning approach, being deployed inside an elitist evolutionary algorithm for hyperparameter search. The resulting architectures and training parameters are then utilized in order to either train a single autonomous traffic agent and transfer the learned weights onto a multi-agent scenario or else to conduct multi-agent learning directly. Both learning strategies are evaluated on different ratios of mixed-intelligence traffic. The strategies are assessed according to the average speed of all agents driven by artificial intelligence. Traffic patterns that provoke a reduction in traffic flow are analyzed with respect to the different strategies. © 2018 CEUR-WS. All rights reserved.

关键词： Reinforcement learning

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Quantum Games and Interactive Tools for Quantum Technologies Outreach and Education

arXiv

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arXiv 2022年

作者： Seskir, Zeki C. Migdal, Piotr Weidner, Carrie Anupam, Aditya Case, Nicky Davis, Noah Decaroli, Chiara Ercan, İlke Foti, Caterina Gora, Pawel Jankiewicz, Klementyna La Cour, Brian R. Malo, Jorge Yago Maniscalco, Sabrina Naeemi, Azad Nita, Laurentiu Parvin, Nassim Scafirimuto, Fabio Sherson, Jacob F. Surer, Elif Wootton, James Yeh, Lia Zabello, Olga Chiofalo, Marilù Karlsruhe Institute of Technology ITAS Karlstraße 11 Karlsruhe76133 Germany Quantum Flytrap ul. Ceglowska 29 Warsaw01-809 Poland Quantum Engineering Technology Laboratories H.H. Wills Physics Laboratory Department of Electrical and Electronic Engineering University of Bristol BristolBS8 1FD United Kingdom Georgia Institute of Technology School of Literature Media and Communication 686 Cherry St NW AtlantaGA30313 United States The University of Texas at Austin Center for Quantum Research Applied Research Laboratories 10000 Burnet Rd AustinTX78758 United States National Quantum Computing Center Oxfordshire DidcotOX11 0GD United Kingdom TU Delft Department of Microelectronics Mekelweg 4 Delft2628 CD Netherlands QPlayLearn Aalto University InstituteQ - The Finnish Quantum Institute Department of Applied Physics AaltoFI-00076 11000 Finland Quantum AI Foundation Sanocka 9/103 Warsaw02-110 Poland University of Pisa Department of Physics Largo Bruno Pontecorvo 3 PisaI-56126 Italy University of Helsinki InstituteQ - The Finnish Quantum Institute Department of Physics Helsinki Finland Georgia Institute of Technology School of Electrical and Computer Engineering 777 Atlantic Drive NW AtlantaGA30332 United States Quarks Interactive Strada Bailor 93a Miercurea-Ciuc Harghita4500 Romania IBM Quantum IBM Research - Zurich Säumerstrasse 4 Rüschlikon8803 Switzerland ScienceAtHome Fuglesangs Allé 4 Aarhus8210 Denmark Aarhus University Institute for Physics and Astronomy Ny Munkegade 120 Aarhus8000 Denmark Middle East Technical University Graduate School of Informatics Department of Modeling and Simulation Üniversiteler Mah. Dumlupınar Blv. No:1 Ankara06800 Turkey University of Oxford Department of Computer Science Wolfson Building Parks Road OxfordOX1 3QD United Kingdom IBM Quantum IBM T. J. Watson Research Center Yorktown HeightsNY10598 United States Offenburg University of Applied Sciences Department of Business and Industrial Eng

In this article, we provide an extensive overview of a wide range of quantum games and interactive tools that have been employed by the community in recent years. The paper presents selected tools, as described by their developers. The list includes Hello Quantum, Hello Qiskit, Particle in a Box, Psi and Delta, QPlayLearn, Virtual Lab by Quantum Flytrap, Quantum Odyssey, ScienceAtHome, and The Virtual Quantum Optics Laboratory. Additionally, we present events for quantum game development: hackathons, game jams, and semester projects. Furthermore, we discuss the Quantum Technologies Education for Everyone (QUTE4E) pilot project, which illustrates an effective integration of these interactive tools with quantum outreach and education activities. Finally, we aim at providing guidelines for incorporating quantum games and interactive tools in pedagogic materials to make quantum technologies more accessible for a wider population. Copyright © 2022, The Authors. All rights reserved.

关键词： Quantum optics

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Modeling and synthesis of control the process of casting 17

Modeling and synthesis of control the process of casting

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17th Conference on applied Mathematics, APLIMAT 2018

作者： Palenčár, Jakub Kubis, Milan Institute of automation measurement and applied informatics Slovak University of Technology in Nám. slobody 17 Bratislava812 31 Slovakia

ISBN: (纸本)9788022747653

This article is focused on modeling and design of thermal control of distributed parameter systems. Partial differential equations describe the dynamics of these systems. Currently, to solve these equations using numerical methods, concrete the finite elements method. The numerical model was created based on the finite elements method using software COMSOL Multiphysics, which is adequate for modeling the process of casting. This software was linked with MATLAB & Simulink environment, where control of temperature fields in casting mold was simulated. Linked software provides for foundry practice to include the possibility of controlling the process at the very beginning of the design and by the can reduce the cost of casting production. © 2018 Slovak University of technology in Bratislava. All Rights Reserved.

关键词： Simulink

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BME-has system for CoNLL–SIGMORPHON 2018 shared task: Universal morphological reinflection

BME-has system for CoNLL–SIGMORPHON 2018 shared task: Unive...

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2018 CoNLL-SIGMORPHON Shared Task: Universal Morphological Reinflection, CoNLL 2018

作者： Ács, Judit Department of Automation and Applied Informatics Budapest University of Technology and Economics Hungary Institute for Computer Science and Control Hungarian Academy of Sciences Hungary

This paper presents an encoder-decoder neural network based solution for both subtasks of the CoNLL–SIGMORPHON 2018 Shared Task: Universal Morphological Reinflection. All of our models are sequence-to-sequence neural... 详细信息

ISBN: (纸本)9781948087834

关键词： Decoding

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Analysis of the German Continuous Intraday Market and the Revenue Potential for Flexibility Options

Analysis of the German Continuous Intraday Market and the Re...

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International Conference on European Electricity Market, EEM

作者： Julian Rominger Manuel Losch Sebastian Steuer Katrin Köper Hartmut Schmeck FZI Research Center for Information Technology Haid-und-Neu-Str. 10-14 Karlsruhe Germany E.ON Inhouse Consulting GmbH Briisseler Platz 1 Essen Germany Karlsruhe Institute of Technology Institute of Applied Informatics and Formal Description Methods Kaiserstr. 89 Karlsruhe Germany

As the share of energy from fluctuating renewable energy resources traded on the German power spot markets has risen over the past years, energy prices on these markets have become more volatile. Therefore, the opportunities for utilizing the flexibility of energy demand or supply to gain monetary benefits have increased significantly. Especially the EPEX Intraday Continuous power market appears to be a favorable market place for demand- and supply-side flexibility options as continuously changing prices for power products offer the possibility to profit from consecutive rescheduling up to only five minutes before delivery. The contribution of this paper is twofold. Firstly, we provide an analysis of the development of the German Intraday Continuous power market over the years 2015 to 2017, and secondly, we quantify the revenue potential for different flexibility options participating in this market. The results of this work show an increasing revenue potential over the course of the three years. The revenues equal up to 3.4 times the wholesale energy costs for solely consuming and up to 12.4 times for consuming and generating flexibility options.

关键词： Data models Power markets Optimization Mathematical model Renewable energy sources Power generation

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Photonic Wire Bonding and 3D Nanoprinting in Photonic Integration – from Lab Demonstrations to Production

Photonic Wire Bonding and 3D Nanoprinting in Photonic Integr...

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European Conference on Optical Communication (ECOC)

作者： C. Koos W. Freude S. Randel M. R. Billah M. Blaicher P.-I. Dietrich T. Hoose Y. Xu J. N. Kemal A. Nesic A. Hofmann Institute of Photonics and Quantum Electronics (IPQ) Karlsruhe Institute of Technology (KIT) Karlsruhe Germany Institute for Automation and Applied Informatics (IAI) Karlsruhe Institute of Technology (KIT) Eggenstein-Leopoldshafen Germany

We give an overview of our research towards exploiting direct-write 3D laser lithography as a tool for advanced photonic integration. The technique offers new perspectives for a wide variety of applications, ranging from photonic wire bonding and multi-chip integration of high-speed communication engines to facet-attached beam-shaping elements and highly efficient coupling in astrophotonic systems. We are currently working on transferring the concept from laboratory demonstrations to industrial manufacturing.

关键词： Photonics Optical fibers Wires Couplings Bonding Three-dimensional displays Silicon

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Characterization of Alternative Sinter Materials for Power Electronics

Characterization of Alternative Sinter Materials for Power E...

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European Microelectronics and Packaging Conference, EMPC

作者： David Stenzel Christian Schwarzer Michael Schnepf Ly May Chew Thomas Blank Jörg Franke Michael Kaloudis Karlsruhe Institute of Technology Karlsruhe Germany Aschaffenburg University of Applied Sciences Aschaffenburg Germany Heraeus Deutschland GmbH & Co. KG Hanau Germany Institute for Factory Automation and Production Systems (FAPS) Friedrich-Alexander-University Erlangen-Nuremberg Nuremberg Germany

Silver Sintering for die attach has gained increasing interest in past years. Compared to known interconnect materials such as Adhesives and Solder, the unique superior thermal and electrical properties of sintered silver joints enable power electronics to operate at greater reliability and at higher temperature. Copper, touted as the alternative, possess similar properties to silver and being the same material as metalized substrate can reduce CTE mis-match. Up till now copper sintering attracts great interest as an alternative optionfor die attach material. This study investigates the influence of using copper as the non-silver additives for formation of silver sintered layers as well as the effects on material properties of the sintered joints for die attach applications. The different sinter materials are evaluated by tensile strength, Young's modulus, die shear strength and electrical conductivity. Process-oriented test specimen were used to replicate the die attach layer formed during pressure sintering. This contribution demonstrates that the mechanical and electrical properties of the sintered layer are affected by non-silver particles. It was found that the used filler materials can lead to a decrease of mechanical and electrical properties in comparison to the pure silver interconnection. It was also found, that the copper paste obtained a relatively strong bonding and confirms thefeasibility as an alternative die attach material.

关键词： Silver Copper Microassembly Conductivity Powders Reliability Mechanical factors

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CoNIC Challenge: Pushing the Frontiers of Nuclear Detection, Segmentation, Classification and Counting

arXiv

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arXiv 2023年

作者： Graham, Simon Vu, Quoc Dang Jahanifar, Mostafa Weigert, Martin Schmidt, Uwe Zhang, Wenhua Zhang, Jun Yang, Sen Xiang, Jinxi Wang, Xiyue Rumberger, Josef Lorenz Baumann, Elias Hirsch, Peter Liu, Lihao Hong, Chenyang Aviles-Rivero, Angelica I. Jain, Ayushi Ahn, Heeyoung Hong, Yiyu Azzuni, Hussam Xu, Min Yaqub, Mohammad Blache, Marie-Claire Piégu, Benoît Vernay, Bertrand Scherr, Tim Böhland, Moritz Löffler, Katharina Li, Jiachen Ying, Weiqin Wang, Chixin Snead, David Raza, Shan E. Ahmed Minhas, Fayyaz Rajpoot, Nasir M. Tissue Image Analytics Centre University of Warwick Coventry United Kingdom Histofy Ltd Birmingham United Kingdom Institute of Bioengineering School of Life Sciences Epfl Lausanne Switzerland Dresden Germany The Department of Computer Science The University of Hong Kong Hong Kong Tencent Ai Lab Shenzhen China College of Biomedical Engineering Sichuan University Chengdu China Department of Precision Instruments Tsinghua University Beijing China College of Computer Science Sichuan University Chengdu China Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association Berlin Germany Humboldt University of Berlin Faculty of Mathematics and Natural Sciences Berlin Germany Charité University Medicine Berlin Germany University of Bern Bern Switzerland Department of Applied Mathematics and Theoretical Physics University of Cambridge United Kingdom Department of Computer Science and Engineering Chinese University of Hong Kong Hong Kong Softsensor.ai BridgewaterNJ United States PRR.ai TX United States Department of R&d Center Arontier Co. Ltd Seoul Korea Republic of Computer Vision Department Mohamed Bin Zayed University of Artificial Intelligence Abu Dhabi United Arab Emirates Cnrs Ifce Inrae Université de Tours Prc Nouzilly3780 France Institut de Génétique et de Biologie Moléculaire et Cellulaire Illkirch France Centre National de la Recherche Scientifique UMR7104 Illkirch France Institut National de la Santé et de la Recherche Médicale Inserm U1258 Illkirch France Université de Strasbourg Strasbourg France Institute for Automation and Applied Informatics Karlsruhe Institute of Technology Eggenstein-Leopoldshafen Germany School of Software Engineering South China University of Technology Guangzhou China Department of Pathology University Hospitals Coventry Warwickshire Nhs Trust Coventry United Kingdom Division of Biomedical Sciences Warwick Medical School University of Warwick Coventry United Kingdom

Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using the largest available dataset of its kind to assess nuclear segmentation and cellular composition. Our challenge, named CoNIC, stimulated the development of reproducible algorithms for cellular recognition with real-time result inspection on public leaderboards. We conducted an extensive post-challenge analysis based on the top-performing models using 1,658 whole-slide images of colon tissue. With around 700 million detected nuclei per model, associated features were used for dysplasia grading and survival analysis, where we demonstrated that the challenge's improvement over the previous state-of-the-art led to significant boosts in downstream performance. Our findings also suggest that eosinophils and neutrophils play an important role in the tumour microevironment. We release challenge models and WSI-level results to foster the development of further methods for biomarker discovery. © 2023, CC BY-NC-SA.

关键词： Grading

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