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33 PAN-cancer whole genome sequencing reveals patterns of subclonal mutations, signature changes and selection

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ESMO Open 2018年 3卷 A15-A15页

作者： K. Haase S. Dentro I. Leshchiner J. Wintersinger A. Deshwar M. Tarabichi Q. Morris D. Wedge P. Van Loo The Francis Crick Institute Cancer Genomics Group London UK Broad Institute of MIT and Harvard Cancer Genome Analysis group Cambridge USA University of Toronto Department of Computer Science Toronto Canada University of Toronto Banting and Best Department of Medical Research Toronto Canada University of Oxford Big Data Institute Oxford UK

Introduction During their development, tumour cells accumulate somatic mutations, structural variants and copy number alterations (CNAs). Driver events facilitate clonal expansions and lead to intra-tumour heterogeneity (ITH). While ITH is an important therapeutic challenge, its degree among different cancer types is largely unknown. Material and methods The pan-cancer analysis of whole genomes (PCAWG) enabled us to characterise ITH in an unprecedented set of 2778 tumour samples representing 36 histologically distinct cancer types. We applied six CNA callers and eleven subclonal reconstruction algorithms to integrate their solutions into robust consensus copy number profiles and subclonal reconstructions. Results and discussions Our analysis revealed pervasive ITH in all examined cancer types. We found at least one subclone in 96.7% of the 1801 samples for which we had statistical power to detect subclones. In addition, we find that the average proportions of subclonal point mutations, indels, SVs and CNAs are highly variable across cancer types. These observations suggest distinct evolutionary narratives of each histological cancer type. analysis of dN/dS ratios shows clear signs of positive selection within both clonal and subclonal mutations. We also identified subclonal mutations in driver genes that are recurrently hit and we found a significant enrichment of subclonal mutations in genes responsible for chromatin regulation. More than 5% of tumours contain driver mutations in genes for which specific treatment is available only in subclones, indicating the importance of assessing the clonality of targeted mutations for clinical decisions. Mutational signatures in the analysed samples show changes in activity over the course of tumour development. Characteristic carcinogen signatures, e.g. UV light exposure in melanomas, make less contributions to subclonal than clonal mutations, while APOBEC-induced mutagenesis has increased activity during the subclonal phase.

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Angular analysis of the B+ → K∗+µ+µ− decay

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arXiv 2020年

作者： Aaij, R. Beteta, C. Abellán Ackernley, T. Adeva, B. Adinolfi, M. Afsharnia, H. Aidala, C.A. Aiola, S. Ajaltouni, Z. Akar, S. Albrecht, J. Alessio, F. Alexander, M. Albero, A. Alfonso Aliouche, Z. Alkhazov, G. Cartelle, P. Alvarez Amato, S. Amhis, Y. An, L. Anderlini, L. Andreianov, A. Andreotti, M. Archilli, F. Artamonov, A. Artuso, M. Arzymatov, K. Aslanides, E. Atzeni, M. Audurier, B. Bachmann, S. Bachmayer, M. Back, J.J. Baker, S. Rodriguez, P. Baladron Balagura, V. Baldini, W. Leite, J. Baptista Barlow, R.J. Barsuk, S. Barter, W. Bartolini, M. Baryshnikov, F. Basels, J.M. Bassi, G. Batsukh, B. Battig, A. Bay, A. Becker, M. Bedeschi, F. Bediaga, I. Beiter, A. Belavin, V. Belin, S. Bellee, V. Belous, K. Belov, I. Belyaev, I. Bencivenni, G. Ben-Haim, E. Berezhnoy, A. Bernet, R. Berninghoff, D. Bernstein, H.C. Bertella, C. Bertolin, A. Betancourt, C. Betti, F. Bezshyiko, I. Bhasin, S. Bhom, J. Bian, L. Bieker, M.S. Bifani, S. Billoir, P. Birch, M. Bishop, F.C.R. Bizzeti, A. Bjørn, M. Blago, M.P. Blake, T. Blanc, F. Blusk, S. Bobulska, D. Boelhauve, J.A. Garcia, O. Boente Boettcher, T. Boldyrev, A. Bondar, A. Bondar, N. Borghi, S. Borisyak, M. Borsato, M. Borsuk, J.T. Bouchiba, S.A. Bowcock, T.J.V. Boyer, A. Bozzi, C. Bradley, M.J. Braun, S. Rodriguez, A. Brea Brodski, M. Brodzicka, J. Gonzalo, A. Brossa Brundu, D. Buonaura, A. Burr, C. Bursche, A. Butkevich, A. Butter, J.S. Buytaert, J. Byczynski, W. Cadeddu, S. Cai, H. Calabrese, R. Calefice, L. Diaz, L. Calero Cali, S. Calladine, R. Calvi, M. Gomez, M. Calvo Magalhaes, P. Camargo Camboni, A. Campana, P. Quezada, A.F. Campoverde Capelli, S. Capriotti, L. Carbone, A. Carboni, G. Cardinale, R. Cardini, A. Carli, I. Carniti, P. Akiba, K. Carvalho Vidal, A. Casais Casse, G. Cattaneo, M. Cavallero, G. Celani, S. Cerasoli, J. Chadwick, A.J. Chapman, M.G. Charles, M. Charpentier, P. Chatzikonstantinidis, G. Barajas, C.A. Chavez Chefdeville, M. Chen, C. Chen, S. Chernov, A. Chitic, S.-G. Chobanova, V. Cholak, S. Chrzaszcz, M. Rio de Janeiro Brazil Rio de Janeiro Brazil Center for High Energy Physics Tsinghua University Beijing China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China University of Chinese Academy of Sciences Beijing China Beijing China Institute of Particle Physics Central China Normal University Wuhan Hubei China Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS IN2P3-LAPP Annecy France Université Clermont Auvergne CNRS IN2P3 LPC Clermont-Ferrand France Aix Marseille Univ CNRS IN2P3 CPPM Marseille France Université Paris-Saclay CNRS IN2P3 IJCLab Orsay France Palaiseau France LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS IN2P3 Paris France I. Physikalisches Institut RWTH Aachen University Aachen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Heidelberg Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany School of Physics University College Dublin Dublin Ireland INFN Sezione di Bari Bari Italy INFN Sezione di Bologna Bologna Italy INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Firenze Firenze Italy INFN Laboratori Nazionali di Frascati Frascati Italy INFN Sezione di Genova Genova Italy INFN Sezione di Milano-Bicocca Milano Italy INFN Sezione di Milano Milano Italy INFN Sezione di Cagliari Monserrato Italy Universita degli Studi di Padova Universita e INFN Padova Italy INFN Sezione di Pisa Pisa Italy INFN Sezione di Roma Tor Vergata Roma Italy INFN Sezione di Roma La Sapienza Roma Italy Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Nikhef National Institute for Subatomic Physics VU University Amsterdam Amsterdam Netherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences Kraków Poland AGH - University of Science and Technology Faculty of Physics and Applied Computer Science Kraków Poland Warsaw Poland Horia Hulubei Nation

We present an angular analysis of the B+ → K∗+(→ KS0π+)µ+µ− decay using 9 fb−1 of pp collision data collected with the LHCb experiment. For the first time, the full set of CP-averaged angular observables is measured in intervals of the dimuon invariant mass squared. Local deviations from Standard Model predictions are observed, similar to those in previous LHCb analyses of the isospin-partner B0 → K∗0µ+µ− decay. The global tension is dependent on which effective couplings are considered and on the choice of theory nuisance parameters. © 2020, CC BY.

关键词： Hadrons

Hematologic and spirometric characteristics of Tajik and Kyrgyz highlanders in the Pamir Mountains

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American Journal of Human Biology 2020年第2期33卷

作者： Xierzhatijiang Sulaiman Wei-fang Xu Liu-Hong Cai Xiao-Yang Huang Lu-Feng Cheng Ya-Ping Zhang Department of Pharmacology School of Pharmacy Xinjiang Medical University Urumqi Xinjiang China Contribution: Data curation Formal analysis Investigation Visualization Writing - original draft Writing - review & editing Shenzhen Hospital of Guangzhou University of Chinese Medicine Shenzhen Guangdong China Contribution: Conceptualization Funding acquisition Investigation Chengdu Yumei Hospital Chengdu Sichuan China Contribution: Investigation The People's Hospital of Shawan County Shawan Xinjiang China Ya-Ping Zhang KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology Chinese Academy of Sciences 32 East Jiaochang Road Kunming Yunnan 650223 China. Contribution: Conceptualization Funding acquisition Methodology Supervision State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China State Key Laboratory for Conservation and Utilization of Bio-Resources Yunnan University Kunming Yunnan China Kunming College of Life Science University of Chinese Academy of Sciences Kunming Yunnan China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming Yunnan China Lu-Feng Cheng Department of Pharmacology School of Pharmacy Xinjiang Medical University 393 Xinyi Road Urumqi Xinjiang 830054 China.

Objectives In this study, we measured the hematologic and spirometric parameters of native Tajik and Kyrgyz highlanders in the Pamir Mountains to investigate adaptations to high altitude stressors. Methods Hematological parameters including arterial oxygen saturation (SaO 2 ), red blood cell (RBC) counts, and hemoglobin (Hb) concentration were measured on Sarikoli Tajik (n = 80; 3100 m), Wakhi Tajik (n = 48; 3500 m), and Kyrgyz (n = 64; 3250 m) in comparison to lowland Uyghurs (n = 50; 1300 m). Spirometric parameters including forced vital capacity (FVC), the first second of forced expiration (FEV1), and forced expiratory flow between 25% and 75% (FEF25-75) were measured. We also reported mountain sickness symptoms in these highlanders and conducted a multivariate regression analysis to analyze the association between these symptoms and the measured parameters. Results SaO 2 of Sarikoli Tajik, Wakhi Tajik, and Kyrgyz (91%-93.5%) are significantly lower than lowland Uyghurs, yet are comparable to other native highlanders at a similar altitude. RBC counts and Hb concentrations of all three highland populations are significantly increased compared to Uyghurs. FVC is lower in Sarikoli Tajik, Wakhi Tajik, and Kyrgyz (male: 3.48-3.86 L, female: 2.47-2.78 L) compared to Uyghurs. Combined with normal FEV1, elevated FEV1/FVC ratio, and FEF25-75, the spirometric patterns of these highlanders indicate restrictive lung disease. A high prevalence of mountain sickness symptoms such as headache and nausea was found in all three highland populations, and are attributed to low FVC and aging by regression analysis. Conclusion Tajik and Kyrgyz highlanders showed adaptation in SaO 2 , RBC, and Hb level, but poor performance in spirometry, which causes mountain sickness.

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Goodness-of-fit tests for the functional linear model based on randomly projected empirical processes

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arXiv 2017年

作者： Cuesta-Albertos, Juan A. García-Portugués, Eduardo Febrero-Bande, Manuel González-Manteiga, Wenceslao Department of Mathematics Statistics and Computer Science University of Cantabria Spain Department of Statistics Carlos III University of Madrid Spain UC3M-BS Institute of Financial Big Data Carlos III University of Madrid Spain Department of Statistics Mathematical Analysis and Optimization University of Santiago de Compostela Spain

MSC Codes 62G10, 62J05, 62G09We consider marked empirical processes indexed by a randomly projected functional covariate to construct goodness-of-fit tests for the functional linear model with scalar response. The test statistics are built from continuous functionals over the projected process, resulting in computationally efficient tests that exhibit root-n convergence rates and circumvent the curse of dimensionality. The weak convergence of the empirical process is obtained conditionally on a random direction, whilst the almost surely equivalence between the testing for significance expressed on the original and on the projected functional covariate is proved. The computation of the test in practice involves calibration by wild bootstrap resampling and the combination of several p-values, arising from different projections, by means of the false discovery rate method. The finite sample properties of the tests are illustrated in a simulation study for a variety of linear models, underlying processes, and alternatives. The software provided implements the tests and allows the replication of simulations and data applications. © 2017, CC BY-SA.

关键词： Statistical tests

Search for the rare decays Bs0 → e+e− and B0 → e+e−

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arXiv 2020年

作者： Aaij, R. Abellán Beteta, C. Ackernley, T. Adeva, B. Adinolfi, M. Afsharnia, H. Aidala, C.A. Aiola, S. Ajaltouni, Z. Akar, S. Albicocco, P. Albrecht, J. Alessio, F. Alexander, M. Alfonso Albero, A. Alkhazov, G. Alvarez Cartelle, P. Alves, A.A. Amato, S. Amhis, Y. An, L. Anderlini, L. Andreassi, G. Andreotti, M. Archilli, F. Artamonov, A. Artuso, M. Arzymatov, K. Aslanides, E. Atzeni, M. Audurier, B. Bachmann, S. Back, J.J. Baker, S. Balagura, V. Baldini, W. Baranov, A. Barlow, R.J. Barsuk, S. Barter, W. Bartolini, M. Baryshnikov, F. Basels, J.M. Bassi, G. Batozskaya, V. Batsukh, B. Battig, A. Bay, A. Becker, M. Bedeschi, F. Bediaga, I. Beiter, A. Belavin, V. Belin, S. Bellee, V. Belous, K. Belyaev, I. Bencivenni, G. Ben-Haim, E. Benson, S. Berezhnoy, A. Bernet, R. Berninghoff, D. Bernstein, H.C. Bertella, C. Bertholet, E. Bertolin, A. Betancourt, C. Betti, F. Bettler, M.O. Bezshyiko, Ia. Bhasin, S. Bhom, J. Bieker, M.S. Bifani, S. Billoir, P. Bizzeti, A. Bjørn, M. Blago, M.P. Blake, T. Blanc, F. Blusk, S. Bobulska, D. Bocci, V. Boente Garcia, O. Boettcher, T. Boldyrev, A. Bondar, A. Bondar, N. Borghi, S. Borisyak, M. Borsato, M. Borsuk, J.T. Bowcock, T.J.V. Bozzi, C. Bradley, M.J. Braun, S. Brea Rodriguez, A. Brodski, M. Brodzicka, J. Brossa Gonzalo, A. Brundu, D. Buchanan, E. Büchler-Germann, A. Buonaura, A. Burr, C. Bursche, A. Butkevich, A. Butter, J.S. Buytaert, J. Byczynski, W. Cadeddu, S. Cai, H. Calabrese, R. Calero Diaz, L. Cali, S. Calladine, R. Calvi, M. Calvo Gomez, M. Camargo Magalhaes, P. Camboni, A. Campana, P. Campora Perez, D.H. Campoverde Quezada, A.F. Capriotti, L. Carbone, A. Carboni, G. Cardinale, R. Cardini, A. Carli, I. Carniti, P. Carvalho Akiba, K. Casais Vidal, A. Casse, G. Cattaneo, M. Cavallero, G. Celani, S. Cenci, R. Cerasoli, J. Chapman, M.G. Charles, M. Charpentier, Ph. Chatzikonstantinidis, G. Chefdeville, M. Chekalina, V. Chen, C. Chen, S. Chernov, A. Chitic, S.-G. Chobanova, V. Cholak, S. Chrzaszcz, M. Chubykin, A. Rio de Janeiro Brazil Rio de Janeiro Brazil Center for High Energy Physics Tsinghua University Beijing China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China University of Chinese Academy of Sciences Beijing China Beijing China Institute of Particle Physics Central China Normal University Wuhan Hubei China Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS IN2P3 LAPP Annecy France Université Clermont Auvergne CNRS IN2P3 LPC Clermont-Ferrand France Aix Marseille Univ CNRS IN2P3 CPPM Marseille France Université Paris-Saclay CNRS IN2P3 IJCLab Orsay France LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS IN2P3 Paris France I. Physikalisches Institut RWTH Aachen University Aachen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Heidelberg Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany School of Physics University College Dublin Dublin Ireland INFN Sezione di Bari Bari Italy INFN Sezione di Bologna Bologna Italy INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Firenze Firenze Italy INFN Laboratori Nazionali di Frascati Frascati Italy INFN Sezione di Genova Genova Italy INFN Sezione di Milano-Bicocca Milano Italy INFN Sezione di Milano Milano Italy INFN Sezione di Cagliari Monserrato Italy INFN Sezione di Padova Padova Italy INFN Sezione di Pisa Pisa Italy INFN Sezione di Roma Tor Vergata Roma Italy INFN Sezione di Roma La Sapienza Roma Italy Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Nikhef National Institute for Subatomic Physics VU University Amsterdam Amsterdam Netherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences Kraków Poland AGH University of Science and Technology Faculty of Physics and Applied Computer Science Kraków Poland Warsaw Poland Horia Hulubei National Institute of Physics and Nuclear E

A search for the decays Bs0 → e+e− and B0 → e+e− is performed using data collected with the LHCb experiment in proton-proton collisions at center-of-mass energies of 7, 8 and 13 TeV, corresponding to integrated luminosities of 1, 2 and 2 fb−1, respectively. No signal is observed. Assuming no contribution from B0 → e+e− decays, an upper limit on the branching fraction B(Bs0 → e+e−) −9 is obtained at 90 (95) % confidence level. If no Bs0 → e+e− contribution is assumed, a limit of B(B0 → e+e−) −9 is determined at 90 (95) % confidence level. These upper limits are more than one order of magnitude lower than the previous values. Copyright © 2020, The Authors. All rights reserved.

关键词： High energy physics

Measurement of CP-averaged observables in the B0→ K∗0µ+µ− decay

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arXiv 2020年

作者： Aaij, R. Abellán Beteta, C. Ackernley, T. Adeva, B. Adinolfi, M. Afsharnia, H. Aidala, C.A. Aiola, S. Ajaltouni, Z. Akar, S. Albicocco, P. Albrecht, J. Alessio, F. Alexander, M. Alfonso Albero, A. Alkhazov, G. Alvarez Cartelle, P. Alves, A.A. Amato, S. Amhis, Y. An, L. Anderlini, L. Andreassi, G. Andreotti, M. Archilli, F. Artamonov, A. Artuso, M. Arzymatov, K. Aslanides, E. Atzeni, M. Audurier, B. Bachmann, S. Back, J.J. Baker, S. Balagura, V. Baldini, W. Baranov, A. Barlow, R.J. Barsuk, S. Barter, W. Bartolini, M. Baryshnikov, F. Basels, J.M. Bassi, G. Batozskaya, V. Batsukh, B. Battig, A. Bay, A. Becker, M. Bedeschi, F. Bediaga, I. Beiter, A. Belavin, V. Belin, S. Bellee, V. Belous, K. Belyaev, I. Bencivenni, G. Ben-Haim, E. Benson, S. Berezhnoy, A. Bernet, R. Berninghoff, D. Bernstein, H.C. Bertella, C. Bertholet, E. Bertolin, A. Betancourt, C. Betti, F. Bettler, M.O. Bezshyiko, Ia. Bhasin, S. Bhom, J. Bieker, M.S. Bifani, S. Billoir, P. Bizzeti, A. Bjørn, M. Blago, M.P. Blake, T. Blanc, F. Blusk, S. Bobulska, D. Bocci, V. Boente Garcia, O. Boettcher, T. Boldyrev, A. Bondar, A. Bondar, N. Borghi, S. Borisyak, M. Borsato, M. Borsuk, J.T. Bowcock, T.J.V. Bozzi, C. Bradley, M.J. Braun, S. Brea Rodriguez, A. Brodski, M. Brodzicka, J. Brossa Gonzalo, A. Brundu, D. Buchanan, E. Büchler-Germann, A. Buonaura, A. Burr, C. Bursche, A. Butkevich, A. Butter, J.S. Buytaert, J. Byczynski, W. Cadeddu, S. Cai, H. Calabrese, R. Calero Diaz, L. Cali, S. Calladine, R. Calvi, M. Calvo Gomez, M. Camargo Magalhaes, P. Camboni, A. Campana, P. Campora Perez, D.H. Campoverde Quezada, A.F. Capriotti, L. Carbone, A. Carboni, G. Cardinale, R. Cardini, A. Carli, I. Carniti, P. Carvalho Akiba, K. Casais Vidal, A. Casse, G. Cattaneo, M. Cavallero, G. Celani, S. Cenci, R. Cerasoli, J. Chapman, M.G. Charles, M. Charpentier, Ph. Chatzikonstantinidis, G. Chefdeville, M. Chekalina, V. Chen, C. Chen, S. Chernov, A. Chitic, S.-G. Chobanova, V. Cholak, S. Chrzaszcz, M. Chubykin, A. Rio de Janeiro Brazil Rio de Janeiro Brazil Center for High Energy Physics Tsinghua University Beijing China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China University of Chinese Academy of Sciences Beijing China Beijing China Institute of Particle Physics Central China Normal University Wuhan Hubei China Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS IN2P3 LAPP Annecy France Université Clermont Auvergne CNRS IN2P3 LPC Clermont-Ferrand France Aix Marseille Univ CNRS IN2P3 CPPM Marseille France Universit Paris-Saclay CNRS IN2P3 IJCLab Orsay France91405 France LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS IN2P3 Paris France I. Physikalisches Institut RWTH Aachen University Aachen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Heidelberg Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany School of Physics University College Dublin Dublin Ireland INFN Sezione di Bari Bari Italy INFN Sezione di Bologna Bologna Italy INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Firenze Firenze Italy INFN Laboratori Nazionali di Frascati Frascati Italy INFN Sezione di Genova Genova Italy INFN Sezione di Milano-Bicocca Milano Italy INFN Sezione di Milano Milano Italy INFN Sezione di Cagliari Monserrato Italy INFN Sezione di Padova Padova Italy INFN Sezione di Pisa Pisa Italy INFN Sezione di Roma Tor Vergata Roma Italy INFN Sezione di Roma La Sapienza Roma Italy Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Nikhef National Institute for Subatomic Physics VU University Amsterdam Amsterdam Netherlands Henryk Niewodniczanski Institute Nuclear Physics Polish Academy of Sciences Kraków Poland AGH - University of Science and Technology Faculty of Physics and Applied Computer Science Kraków Poland Warsaw Poland Horia Hulubei National Institute of Physics

An angular analysis of the B0 → K∗0(→ K+π−)µ+µ− decay is presented using a data set corresponding to an integrated luminosity of 4.7 fb−1 of pp collision data collected with the LHCb experiment. The full set of CP-averaged observables are determined in bins of the invariant mass squared of the dimuon system. Contamination from decays with the K+π− system in an S-wave configuration is taken into account. The tension seen between the previous LHCb results and the Standard Model predictions persists with the new data. The precise value of the significance of this tension depends on the choice of theory nuisance parameters. Copyright © 2020, The Authors. All rights reserved.

关键词： Shear waves

Search for the lepton flavour violating decay B+→ K+µ−τ+ using Bs∗20 decays

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arXiv 2020年

作者： Aaij, R. Abellán Beteta, C. Ackernley, T. Adeva, B. Adinolfi, M. Afsharnia, H. Aidala, C.A. Aiola, S. Ajaltouni, Z. Akar, S. Albicocco, P. Albrecht, J. Alessio, F. Alexander, M. Alfonso Albero, A. Alkhazov, G. Alvarez Cartelle, P. Alves, A.A. Amato, S. Amhis, Y. An, L. Anderlini, L. Andreassi, G. Andreotti, M. Archilli, F. Artamonov, A. Artuso, M. Arzymatov, K. Aslanides, E. Atzeni, M. Audurier, B. Bachmann, S. Back, J.J. Baker, S. Balagura, V. Baldini, W. Baranov, A. Barlow, R.J. Barsuk, S. Barter, W. Bartolini, M. Baryshnikov, F. Basels, J.M. Bassi, G. Batozskaya, V. Batsukh, B. Battig, A. Bay, A. Becker, M. Bedeschi, F. Bediaga, I. Beiter, A. Bel, L.J. Belavin, V. Belin, S. Bellee, V. Belous, K. Belyaev, I. Bencivenni, G. Ben-Haim, E. Benson, S. Beranek, S. Berezhnoy, A. Bernet, R. Berninghoff, D. Bernstein, H.C. Bertella, C. Bertholet, E. Bertolin, A. Betancourt, C. Betti, F. Bettler, M.O. Bezshyiko, Ia. Bhasin, S. Bhom, J. Bieker, M.S. Bifani, S. Billoir, P. Bizzeti, A. Bjørn, M. Blago, M.P. Blake, T. Blanc, F. Blusk, S. Bobulska, D. Bocci, V. Boente Garcia, O. Boettcher, T. Boldyrev, A. Bondar, A. Bondar, N. Borghi, S. Borisyak, M. Borsato, M. Borsuk, J.T. Bowcock, T.J.V. Bozzi, C. Bradley, M.J. Braun, S. Brea Rodriguez, A. Brodski, M. Brodzicka, J. Brossa Gonzalo, A. Brundu, D. Buchanan, E. Büchler-Germann, A. Buonaura, A. Burr, C. Bursche, A. Butkevich, A. Butter, J.S. Buytaert, J. Byczynski, W. Cadeddu, S. Cai, H. Calabrese, R. Calero Diaz, L. Cali, S. Calladine, R. Calvi, M. Calvo Gomez, M. Camargo Magalhaes, P. Camboni, A. Campana, P. Campora Perez, D.H. Campoverde Quezada, A.F. Capriotti, L. Carbone, A. Carboni, G. Cardinale, R. Cardini, A. Carli, I. Carniti, P. Carvalho Akiba, K. Casais Vidal, A. Casse, G. Cattaneo, M. Cavallero, G. Celani, S. Cenci, R. Cerasoli, J. Chapman, M.G. Charles, M. Charpentier, Ph. Chatzikonstantinidis, G. Chefdeville, M. Chekalina, V. Chen, C. Chen, S. Chernov, A. Chitic, S.-G. Chobanova, V. Cholak, S. Rio de Janeiro Brazil Rio de Janeiro Brazil Center for High Energy Physics Tsinghua University Beijing China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China University of Chinese Academy of Sciences Beijing China Beijing China Institute of Particle Physics Central China Normal University Wuhan Hubei China Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS IN2P3 LAPP Annecy France Université Clermont Auvergne CNRS IN2P3 LPC Clermont-Ferrand France Aix Marseille Univ CNRS IN2P3 CPPM Marseille France Universit Paris-Saclay CNRS IN2P3 IJCLab Orsay91405 France LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS IN2P3 Paris France I. Physikalisches Institut RWTH Aachen University Aachen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Heidelberg Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany School of Physics University College Dublin Dublin Ireland INFN Sezione di Bari Bari Italy INFN Sezione di Bologna Bologna Italy INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Firenze Firenze Italy INFN Laboratori Nazionali di Frascati Frascati Italy INFN Sezione di Genova Genova Italy INFN Sezione di Milano-Bicocca Milano Italy INFN Sezione di Milano Milano Italy INFN Sezione di Cagliari Monserrato Italy INFN Sezione di Padova Padova Italy INFN Sezione di Pisa Pisa Italy INFN Sezione di Roma Tor Vergata Roma Italy INFN Sezione di Roma La Sapienza Roma Italy Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Nikhef National Institute for Subatomic Physics VU University Amsterdam Amsterdam Netherlands Henryk Niewodniczanski Institute Nuclear Physics Polish Academy of Sciences Kraków Poland AGH University of Science and Technology Faculty of Physics and Applied Computer Science Kraków Poland Warsaw Poland Horia Hulubei National Institute of Physics and Nuclear

A search is presented for the lepton flavour violating decay (Equation Presented) using a sample of proton-proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to a total integrated luminosity of 9 fb−1. The τ leptons are selected inclusively, primarily via decays with a single charged particle. The four-momentum of the τ lepton is determined by using B+ mesons from (Equation Presented) decays. No significant excess is observed, and an upper limit is set on the branching fraction (Equation Presented) at 90% confidence level. The obtained limit is comparable to the world-best limit. Copyright © 2020, The Authors. All rights reserved.

关键词： Charged particles

Observation of new Ξc0 baryons decaying to Λ+c K−

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arXiv 2020年

作者： Aaij, R. Abellán Beteta, C. Ackernley, T. Adeva, B. Adinolfi, M. Afsharnia, H. Aidala, C.A. Aiola, S. Ajaltouni, Z. Akar, S. Albrecht, J. Alessio, F. Alexander, M. Alfonso Albero, A. Alkhazov, G. Alvarez Cartelle, P. Alves, A.A. Amato, S. Amhis, Y. An, L. Anderlini, L. Andreassi, G. Andreotti, M. Archilli, F. Artamonov, A. Artuso, M. Arzymatov, K. Aslanides, E. Atzeni, M. Audurier, B. Bachmann, S. Back, J.J. Baker, S. Balagura, V. Baldini, W. Baptista Leite, J. Barlow, R.J. Barsuk, S. Barter, W. Bartolini, M. Baryshnikov, F. Basels, J.M. Bassi, G. Batozskaya, V. Batsukh, B. Battig, A. Bay, A. Becker, M. Bedeschi, F. Bediaga, I. Beiter, A. Belavin, V. Belin, S. Bellee, V. Belous, K. Belyaev, I. Bencivenni, G. Ben-Haim, E. Benson, S. Berezhnoy, A. Bernet, R. Berninghoff, D. Bernstein, H.C. Bertella, C. Bertholet, E. Bertolin, A. Betancourt, C. Betti, F. Bettler, M.O. Bezshyiko, Ia. Bhasin, S. Bhom, J. Bieker, M.S. Bifani, S. Billoir, P. Bizzeti, A. Bjørn, M. Blago, M.P. Blake, T. Blanc, F. Blusk, S. Bobulska, D. Bocci, V. Boente Garcia, O. Boettcher, T. Boldyrev, A. Bondar, A. Bondar, N. Borghi, S. Borisyak, M. Borsato, M. Borsuk, J.T. Bowcock, T.J.V. Boyer, A. Bozzi, C. Bradley, M.J. Braun, S. Brea Rodriguez, A. Brodski, M. Brodzicka, J. Brossa Gonzalo, A. Brundu, D. Buchanan, E. Büchler-Germann, A. Buonaura, A. Burr, C. Bursche, A. Butkevich, A. Butter, J.S. Buytaert, J. Byczynski, W. Cadeddu, S. Cai, H. Calabrese, R. Calero Diaz, L. Cali, S. Calladine, R. Calvi, M. Calvo Gomez, M. Camargo Magalhaes, P. Camboni, A. Campana, P. Campora Perez, D.H. Campoverde Quezada, A.F. Capriotti, L. Carbone, A. Carboni, G. Cardinale, R. Cardini, A. Carli, I. Carniti, P. Carvalho Akiba, K. Casais Vidal, A. Casse, G. Cattaneo, M. Cavallero, G. Celani, S. Cenci, R. Cerasoli, J. Chapman, M.G. Charles, M. Charpentier, Ph. Chatzikonstantinidis, G. Chefdeville, M. Chekalina, V. Chen, C. Chen, S. Chernov, A. Chitic, S.-G. Chobanova, V. Cholak, S. Chrzaszcz, M. Rio de Janeiro Brazil Rio de Janeiro Brazil Center for High Energy Physics Tsinghua University Beijing China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China University of Chinese Academy of Sciences Beijing China Beijing China Institute of Particle Physics Central China Normal University Wuhan Hubei China Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS IN2P3 LAPP Annecy France Université Clermont Auvergne CNRS IN2P3 LPC Clermont-Ferrand France Aix Marseille Univ CNRS IN2P3 CPPM Marseille France Université Paris-Saclay CNRS IN2P3 IJCLab Orsay France LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS IN2P3 Paris France I. Physikalisches Institut RWTH Aachen University Aachen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Heidelberg Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany School of Physics University College Dublin Dublin Ireland INFN Sezione di Bari Bari Italy INFN Sezione di Bologna Bologna Italy INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Firenze Firenze Italy INFN Laboratori Nazionali di Frascati Frascati Italy INFN Sezione di Genova Genova Italy INFN Sezione di Milano-Bicocca Milano Italy INFN Sezione di Milano Milano Italy INFN Sezione di Cagliari Monserrato Italy INFN Sezione di Padova Padova Italy INFN Sezione di Pisa Pisa Italy INFN Sezione di Roma Tor Vergata Roma Italy INFN Sezione di Roma La Sapienza Roma Italy Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Nikhef National Institute for Subatomic Physics VU University Amsterdam Amsterdam Netherlands Henryk Niewodniczanski Institute Nuclear Physics Polish Academy of Sciences Kraków Poland AGH University of Science and Technology Faculty of Physics and Applied Computer Science Kraków Poland Warsaw Poland Horia Hulubei National Institute of Physics and Nuclear Engi

The Λ+c K− mass spectrum is studied with a data sample of pp collisions at a centreof-mass energy of 13 TeV corresponding to an integrated luminosity of 5.6 fb−1 collected by the LHCb experiment. Three Ξc0 states are observed with a large significance and their masses and natural widths are measured to be m(Ξc(2923)0) = 2923.04 ± 0.25 ± 0.20 ± 0.14 MeV, Γ(Ξc(2923)0) = 7.1 ± 0.8 ± 1.8 MeV, m(Ξc(2939)0) = 2938.55 ± 0.21 ± 0.17 ± 0.14 MeV, Γ(Ξc(2939)0) = 10.2 ± 0.8 ± 1.1 MeV, m(Ξc(2965)0) = 2964.88 ± 0.26 ± 0.14 ± 0.14 MeV, Γ(Ξc(2965)0) = 14.1 ± 0.9 ± 1.3 MeV, where the uncertainties are statistical, systematic, and due to the limited knowledge of the Λ+c mass. The Ξc(2923)0 and Ξc(2939)0 baryons are new states. The Ξc(2965)0 state is in the vicinity of the known Ξc(2970)0 baryon;however, their masses and natural widths differ significantly. Copyright © 2020, The Authors. All rights reserved.

关键词： Hadrons

Observation of structure in the J/ψ-pair mass spectrum

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arXiv 2020年

作者： Aaij, R. Beteta, C. Abellán Ackernley, T. Adeva, B. Adinolfi, M. Afsharnia, H. Aidala, C.A. Aiola, S. Ajaltouni, Z. Akar, S. Albrecht, J. Alessio, F. Alexander, M. Albero, A. Alfonso Aliouche, Z. Alkhazov, G. Cartelle, P. Alvarez Alves, A.A. Amato, S. Amhis, Y. An, L. Anderlini, L. Andreassi, G. Andreianov, A. Andreotti, M. Archilli, F. Artamonov, A. Artuso, M. Arzymatov, K. Aslanides, E. Atzeni, M. Audurier, B. Bachmann, S. Bachmayer, M. Back, J.J. Baker, S. Rodriguez, P. Baladron Balagura, V. Baldini, W. Leite, J. Baptista Barlow, R.J. Barsuk, S. Barter, W. Bartolini, M. Baryshnikov, F. Basels, J.M. Bassi, G. Batozskaya, V. Batsukh, B. Battig, A. Bay, A. Becker, M. Bedeschi, F. Bediaga, I. Beiter, A. Belavin, V. Belin, S. Bellee, V. Belous, K. Belyaev, I. Bencivenni, G. Ben-Haim, E. Berezhnoy, A. Bernet, R. Berninghoff, D. Bernstein, H.C. Bertella, C. Bertholet, E. Bertolin, A. Betancourt, C. Betti, F. Bettler, M.O. Bezshyiko, Ia. Bhasin, S. Bhom, J. Bian, L. Bieker, M.S. Bifani, S. Billoir, P. Birch, M. Bishop, F.C.R. Bizzeti, A. Bjørn, M. Blago, M.P. Blake, T. Blanc, F. Blusk, S. Bobulska, D. Bocci, V. Boelhauve, J.A. Garcia, O. Boente Boettcher, T. Boldyrev, A. Bondar, A. Bondar, N. Borghi, S. Borisyak, M. Borsato, M. Borsuk, J.T. Bouchiba, S.A. Bowcock, T.J.V. Boyer, A. Bozzi, C. Bradley, M.J. Braun, S. Rodriguez, A. Brea Brodski, M. Brodzicka, J. Gonzalo, A. Brossa Brundu, D. Buchanan, E. Buonaura, A. Burr, C. Bursche, A. Butkevich, A. Butter, J.S. Buytaert, J. Byczynski, W. Cadeddu, S. Cai, H. Calabrese, R. Diaz, L. Calero Cali, S. Calladine, R. Calvi, M. Gomez, M. Calvo Magalhaes, P. Camargo Camboni, A. Campana, P. Perez, D.H. Campora Quezada, A.F. Campoverde Capelli, S. Capriotti, L. Carbone, A. Carboni, G. Cardinale, R. Cardini, A. Carli, I. Carniti, P. Akiba, K. Carvalho Vidal, A. Casais Casse, G. Cattaneo, M. Cavallero, G. Celani, S. Cenci, R. Cerasoli, J. Chadwick, A.J. Chapman, M.G. Charles, M. Charpentier, Ph. Chatzikonstantinidis, G. Rio de Janeiro Brazil Rio de Janeiro Brazil Center for High Energy Physics Tsinghua University Beijing China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China University of Chinese Academy of Sciences Beijing China Beijing China Institute of Particle Physics Central China Normal University WuhanHubei China Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS IN2P3 LAPP Annecy France Université Clermont Auvergne CNRS IN2P3 LPC Clermont-Ferrand France Aix Marseille Univ CNRS IN2P3 CPPM Marseille France Université Paris-Saclay CNRS IN2P3 IJCLab Orsay France LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS IN2P3 Paris France I. Physikalisches Institut RWTH Aachen University Aachen Germany Fakultät Physik Technische Universität Dortmund Dortmund Germany Heidelberg Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany School of Physics University College Dublin Dublin Ireland INFN Sezione di Bari Bari Italy INFN Sezione di Bologna Bologna Italy INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Firenze Firenze Italy INFN Laboratori Nazionali di Frascati Frascati Italy INFN Sezione di Genova Genova Italy INFN Sezione di Milano-Bicocca Milano Italy INFN Sezione di Milano Milano Italy INFN Sezione di Cagliari Monserrato Italy Universita degli Studi di Padova Universita e INFN Padova Padova Italy INFN Sezione di Pisa Pisa Italy INFN Sezione di Roma Tor Vergata Roma Italy INFN Sezione di Roma La Sapienza Roma Italy Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Nikhef National Institute for Subatomic Physics VU University Amsterdam Amsterdam Netherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences Kraków Poland AGH - University of Science and Technology Faculty of Physics and Applied Computer Science Kraków Poland Warsaw Poland Horia Hulubei National Institut

Using proton-proton collision data at centre-of-mass energies of √s = 7, 8 and 13 TeV recorded by the LHCb experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 9 fb−1, the invariant mass spectrum of J/ψ pairs is studied. A narrow structure around 6.9 GeV/c2 matching the lineshape of a resonance and a broad structure just above twice the J/ψ mass are observed. The deviation of the data from nonresonant J/ψ-pair production is above five standard deviations in the mass region between 6.2 and 7.4 GeV/c2, covering predicted masses of states composed of four charm quarks. The mass and natural width of the narrow X(6900) structure are measured assuming a Breit–Wigner lineshape. Copyright © 2020, The Authors. All rights reserved.

关键词： Mass spectrometry