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Evolutionary Algorithm Directed Synthesis of Mixed Anion Compounds LaF2X (X=Br, I) and LaFI2

Angewandte Chemie 2023年第30期135卷 e202301416-e202301416页

作者： Dr. Daichi Kato Dr. Peng Song Dr. Hiroki Ubukata Haruki Taguro Dr. Cédric Tassel Dr. Kohei Miyazaki Prof. Takeshi Abe Dr. Kousuke Nakano Prof. Kenta Hongo Prof. Ryo Maezono Prof. Hiroshi Kageyama Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering Kyoto University Nishikyo-ku Kyoto 615-8510 Japan PRESTO Japan Science and Technology Agency (JST) Kawaguchi Saitama 332-0012 Japan Contribution: Data curation (lead) Formal analysis (lead) Funding acquisition (lead) Investigation (lead) Methodology (lead) Project administration (lead) Resources (supporting) Supervision (lead) Validation (equal) Visualization (equal) Writing - original draft (lead) Writing - review & editing (lead) School of Information Science JAIST Asahidai 1-1 Nomi Ishikawa 923-1292 Japan Contribution: Data curation (supporting) Formal analysis (supporting) Funding acquisition (supporting) Methodology (supporting) Software (supporting) Validation (supporting) Writing - original draft (supporting) Contribution: Formal analysis (supporting) Writing - original draft (supporting) Contribution: Data curation (supporting) Contribution: Data curation (supporting) Formal analysis (supporting) Writing - original draft (supporting) Contribution: Funding acquisition (supporting) Resources (supporting) Writing - original draft (supporting) Center for Basic Research on Materials (CBRM) National Institute for Materials Science (NIMS) 1-2-1 Sengen Tsukuba Ibaraki 305-0047 Japan Contribution: Writing - original draft (supporting) Research Center for Advanced Computing Infrastructure JAIST Asahidai 1-1 Nomi Ishikawa 923-1292 Japan Contribution: Conceptualization (lead) Funding acquisition (lead) Project administration (lead) Resources (lead) Supervision (lead) Validation (lead) Writing - original draft (supporting)

Mixed-anion compounds have attracted growing attentions, but their synthesis is challenging, making a rational search desirable. Here, we explored LaF 3 -LaX 3 (X=Cl, Br, I) system using ab initio structure searches based on evolutionary algorithms, and predicted LaF 2 X and LaFX 2 (X=Br, I), which are respectively isostructural with LaHBr 2 and YH 2 I, consisting of layered La-F blocks with single and double ordered honeycomb lattices, separated by van der Waals gaps. We successfully synthesized these compounds: LaF 2 Br and LaFI 2 crystallize in the predicted structure, while LaF 2 I is similar to the predicted one but with different layer stacking. LaF 2 I exhibits fluoride ion conductivity comparable to that of non-doped LaF 3 , and has the potential to show better ionic conductivity upon appropriate doping, given the theoretically lower diffusion energy barrier and the presence of soft iodine anions. This study shows the structure prediction using evolutionary algorithms will accelerate the discovery of mixed-anion compounds in future, in particular those with an ordered anion arrangement.

关键词： Evolutionary Algorithm Fluoride Ion Conductor Mixed Anion

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Reducing EHR navigation time with an advanced hyperlipidemia management Tool: An evaluation of efficiency

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International journal of medical informatics 2025年 203卷

作者： Chin-Chen Chen Yu-Chen Liu Guan-Ling Lin Annisa Ristya Rahmant Der-Ming Liou Hsuan-Chia Yang Information Technology Department Cardinal Tien Hospital New Taipei City Taiwan Information Technology Department Yonghe Cardinal Tien Hospital New Taipei City Taiwan Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan School of Nursing College of Medicine National Taiwan University Taipei Taiwan. Department Health Policy and Management Faculty of Medicine Public Health and Nursing Universitas Gadjah Mada Yogyakarta Indonesia Department of Computer Science Faculty of Science and Technology Middlesex University London UK. Master Program in Medical Informatics National Tsing Hua University Hsinchu City Taiwan. International Center for Health Information Technology (ICHIT) Taipei Medical University Taipei Taiwan Clinical Big Data Research Center Taipei Medical University Hospital Taipei Taiwan Research Center of Big Data and Meta-analysis Wanfang Hospital Taipei Medical University Taipei Taiwan. Electronic address: lovejog@tmu.edu.tw.

BACKGROUND:Effective management of hyperlipidemia is crucial for preventing cardiovascular diseases. However, traditional monitoring systems often lack efficiency, particularly in navigating electronic health records (EHRs) to identify and track at-risk patients. OBJECTIVE:This study aims to evaluate the impact of a Hyperlipidemia Medication Reminder System (HLD-MRS) implemented in a district hospital to streamline EHR navigation and enhance patient management. METHODS:A pre-post prospective study was conducted at a district hospital. This study designed the HLD-MRS to integrate patient data, guideline recommendations, and risk factor assessments into a single interface, simplifying EHR navigation. This study compared EHR navigation times and patient tracking rates before and after HLD-MRS implementation across the Cardiology, Endocrinology, and Family Medicine departments. RESULTS:Among 750 patients with follow-up appointments, 334 were identified as having HLD or being at high-risk status. The HLD-MRS significantly reduced mean EHR navigation time from 83.9 s (SD = 8.6) to 53.8 s (SD = 6.6) across all departments (p < 0.001). The proportion of actively monitored HLD patients increased from 42.5 % to 56.6 %, while cases with unknown or withheld assessment status decreased from 57.5 % to 28.4 %. CONCLUSION:The HLD-MRS improved efficiency in EHR navigation and increased the frequency of active patient monitoring. This guideline-driven decision support system shows promise for enhancing hyperlipidemia care in high-volume outpatient settings.

关键词： Clinical decision support system EHR navigation Guideline-directed care Hyperlipidemia management Medication reminder system

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Publisher Correction: Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020

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Eye (London, England) 2024年第11期38卷 2229-2231页

作者： Konrad Pesudovs Hugh R. Taylor Tabassom Sedighi Rupert R. A. Bourne Shahina Pardhan Van Charles Lansingh John H. Kempen Ian Tapply Arthur G. Fernandes Maria Vittoria Cicinelli Alessandro Arrigo Nicolas Leveziel Serge Resnikoff Seth Flaxman Mukkharram M. Bikbov Tasanee Braithwaite Alain Bron Ching-Yu Cheng Monte A. Del Monte Joshua R. Ehrlich Leon B. Ellwein David Friedman João M. Furtado Gus Gazzard Ronnie George M. Elizabeth Hartnett Jost B. Jonas Rim Kahloun Moncef Khairallah Rohit C. Khanna Janet Leasher Julie-Anne Little Vinay Nangia Michal Nowak Tunde Peto Pradeep Ramulu Fotis Topouzis Mitiadis Tsilimbaris Ya Xing Wang Ningli Wang Paul Svitil Briant Theo Vos Katrin Burkart Kaleb Coberly Xiaochen Dai Stephen S. Lim Tomislav Mestrovic Ali H. Mokdad Christopher J. L. Murray Jaimie D. Steinmetz Awoke Misganaw Yohannes Habtegiorgis Abate Mohammad Abdollahi Mozhan Abdollahi Ayele Mamo Abebe Olumide Abiodun Richard Gyan Aboagye Woldu Aberhe Abrha Hasan Abualruz Hiwa Abubaker Ali Eman Abu-Gharbieh Salahdein Aburuz Tadele Girum Girum Adal Mesafint Molla Adane Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Muhammad Sohail Afzal Muhammad Umair Shahin Aghamiri Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Ali Ahmadi Siamak Sabour Ayman Ahmed Haroon Ahmed Ahmad Samir Alfaar Abid Ali Syed Shujait Shujait Ali Awais Altaf Hubert Amu Emmanuel Manu Sofia Androudi Rodrigo Anguita Abhishek Anil Rimple Jeet Kaur Muhammad Aaqib Shamim Saeid Anvari Anayochukwu Edward Anyasodor Francis Appiah Jalal Arabloo Haleh Ayatollahi Mosab Arafat Damelash Areda Reza Arefnezhad Brhane Berhe Aregawi Akeza Awealom Asgedom Tahira Ashraf Seyyed Shamsadin Athari Bantalem Tilaye Tilaye Atinafu Birhan Tsegaw Taye Maha Moh’d Wahbi Atout Alok Atreya Ahmed Y. Azzam Hassan Babamohamadi Sara Bagherieh Yogesh Bahurupi Atif Amin Baig Shumaila Nargus Biswajit Banik Mainak Bardhan Saurav Basu Kavita Batra Nebiyou Simegnew Bayileyegn Fatemeh Bazvand Addisu Shunu Beyene Awoke Masrie Asrat Derese Devidas S. Bhagat Akshaya Srikanth Bhagavathula Pankaj Bh Medicine & Health University of New South Wales Sydney NSW Australia School of Optometry and Vision Science University of New South Wales Sydney NSW Australia School of Population and Global Health University of Melbourne Carlton VIC Australia Vision and Eye Research Institute Anglia Ruskin University Cambridge UK HelpMeSee Instituto Mexicano de Oftalmologia Santiago de Querétaro Mexico University of Miami Gables FL USA University of Utah Salt Lake City UT USA Chief Medical Office HelpMeSee New York NY USA Mexican Institute of Ophthalmology Queretaro Mexico Department of Ophthalmology Massachusetts Eye and Ear/Shepens Eye Research Institute/Harvard Medical School Boston MA USA Eye Unit MyungSung Christian Medical Center (MCM) Comprehensive Specialized Hospital and MyungSun Medical College Addis Ababa Ethiopia Department of Ophthalmology Addis Ababa University Addis Ababa Ethiopia Sight for Souls Bellevue WA USA Department of Ophthalmology Harvard University Boston MA USA Eye Unit MyungSung Medical College Addis Ababa Ethiopia Addenbrooke’s Hospital Cambridge UK Department of Ophthalmology Cambridge University Hospitals Cambridge UK Federal University of Sao Paolo Sao Paolo SP Brazil University of Calgary Calgary AB Canada Department of Ophthalmology and Visual Sciences Federal University of São Paulo Sao Paulo Brazil School of Medicine Vita-Salute San Raffaele University Milan Italy Department of Ophthalmology IRCCS San Raffaele Scientific Institute Milan Italy Department of Ophthalmology San Raffaele Scientific Institute Milano Italy IRCCS San Raffaele Scientific Institute Vita-Salute University Milan Italy Scientific Institute San Raffaele Hospital Vita-Salute University Milan Italy University of Poitiers Poitiers France CHU de Poitiers Poitiers France Ophthalmology Department CHU de Poitiers (Poitiers University Hospital) Poitiers France Unité 1084 National Institute of Health and Medical Research (INSERM) Poitiers France

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Carbazole-Dendronized Luminescent Radicals

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Angewandte Chemie 2023年第28期135卷 e202302550-e202302550页

作者： Rui Xiaotian Wataru Ota Prof. Tohru Sato Minori Furukori Prof. Yasuo Nakayama Prof. Takuya Hosokai Eri Hisamura Kazuhiro Nakamura Kenshiro Matsuda Dr. Kohei Nakao Prof. Andrew P. Monkman Prof. Ken Albrecht Department of Applied Science for Electronics and Materials Interdisciplinary Graduate School of Engineering Sciences Kyushu University 6-1 Kasuga-Koen Kasuga-shi Fukuoka 816-8580 Japan Contribution: Conceptualization (supporting) Data curation (lead) Formal analysis (lead) Funding acquisition (supporting) Investigation (equal) Visualization (equal) Writing - original draft (lead) MOLFEX Inc. Takano Nishibiraki-cho 34–4 Sakyo-ku Kyoto 606-8103 Japan Contribution: Conceptualization (supporting) Data curation (equal) Formal analysis (equal) Investigation (equal) Methodology (equal) Resources (supporting) Software (supporting) Visualization (supporting) Writing - original draft (supporting) Fukui Institute for Fundamental Chemistry Kyoto University Takano Nishibiraki-cho 34–4 Sakyo-ku Kyoto 606-8103 Japan Department of Molecular Engineering Graduate School of Engineering Kyoto University Nishikyo-ku Kyoto 615-8510 Japan Elements Strategy Initiative for Catalysts & Batteries (ESICB) Kyoto University Kyotodaigaku Katsura Nishikyo-ku Kyoto 615-8245 Japan Contribution: Conceptualization (supporting) Software (supporting) Supervision (equal) Validation (supporting) Writing - review & editing (supporting) Department of Pure and Applied Chemistry Graduate School of Science and Technology Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 5 1-1-1 Higashi Tsukuba Ibaraki 305-8565 Japan Contribution: Data curation (supporting) Formal analysis (supporting) Investigation (supporting) Contribution: Supervision (supporting) Writing - review & editing (supporting) Contribution: Conceptualization (supporting) Data curation (supporting) Formal analysis (supporting) Funding acquisition (supporting) Supervision (equal) Writing - review & editing (equal) Institute for Materials Chemistry and Engineering Kyushu University 6-1 Kasuga-Koen Kasuga-shi Fukuoka 816-8580 J

A series of carbazole-dendronized tris(2,4,6-trichlorophenyl)methyl (TTM) radicals have been synthesized. The photophysical properties of dendronized radicals up to the fourth generation were compared systematically to understand how structure–property relationships evolve with generation. The photoluminescence quantum yield (PLQY) was found to increase with the increasing generation, and the fourth generation (G4TTM) in cyclohexane solution showed a PLQY as high as 63 % at a wavelength of 627 nm (in the deep-red region) from the doublet state. The dendron modification strategy also showed a blue-shift of the emission on increasing the generation number, and the photostability was also increased compared to the bare TTM radical.

关键词： Carbazoles Dendrimers Excited Doublet State Luminescencent Materials Stable Radicals

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Cations Determine the Mechanism and Selectivity of Alkaline Oxygen Reduction Reaction on Pt(111)**

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Angewandte Chemie 2023年第51期135卷 e202312841-e202312841页

作者： Dr. Tomoaki Kumeda Dr. Laura Laverdure Prof. Dr. Karoliina Honkala Dr. Marko M. Melander Prof. Dr. Ken Sakaushi Research Center for Energy and Environmental Materials National Institute for Materials Science 1-1 Namiki Tsukuba Ibaraki 305-0044 Japan Contribution: Data curation (lead) Investigation (lead) Validation (lead) Visualization (lead) Writing - original draft (equal) Department of Chemistry Nanoscience Center University of Jyväskylä P.O. Box 35 40014 Jyväskylä Finland Contribution: Formal analysis (supporting) Investigation (supporting) Validation (supporting) Writing - review & editing (supporting) Contribution: Funding acquisition (lead) Investigation (supporting) Supervision (supporting) Validation (supporting) Writing - review & editing (supporting) Contribution: Conceptualization (supporting) Data curation (equal) Formal analysis (equal) Funding acquisition (equal) Investigation (equal) Project administration (supporting) Resources (equal) Software (lead) Supervision (equal) Validation (lead) Writing - original draft (equal) Contribution: Conceptualization (lead) Data curation (equal) Formal analysis (equal) Funding acquisition (lead) Investigation (equal) Project administration (lead) Resources (lead) Supervision (lead) Validation (lead) Writing - original draft (equal) Writing - review & editing (lead)

The proton-coupled electron transfer (PCET) mechanism of the oxygen reduction reaction (ORR) is a long-standing enigma in electrocatalysis. Despite decades of research, the factors determining the microscopic mechanism of ORR-PCET as a function of pH, electrolyte, and electrode potential remain unresolved, even on the prototypical Pt(111) surface. Herein, we integrate advanced experiments, simulations, and theory to uncover the mechanism of the cation effects on alkaline ORR on well-defined Pt(111). We unveil a dual-cation effect where cations simultaneously determine i) the active electrode surface by controlling the formation of Pt−O and Pt−OH overlayers and ii) the competition between inner- and outer-sphere PCET steps. The cation-dependent transition from Pt−O to Pt−OH determines the ORR mechanism, activity, and selectivity. These findings provide direct evidence that the electrolyte affects the ORR mechanism and performance, with important consequences for the practical design of electrochemical systems and computational catalyst screening studies. Our work highlights the importance of complementary insight from experiments and simulations to understand how different components of the electrochemical interface contribute to electrocatalytic processes.

关键词： Constrained DFT Electrocatalysis Energy Conversion Kinetic Isotope Effects Marcus Theory

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CoSimLex: A resource for evaluating graded word similarity in context

arXiv

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arXiv 2019年

作者： Armendariz, Carlos Santos Purver, Matthew Ulčar, Matej Pollak, Senja Ljubešić, Nikola Robnik-Šikonja, Marko Granroth-Wilding, Mark Vaik, Kristiina Cognitive Science Research Group Queen Mary University of London London United Kingdom Department of Knowledge Technologies Jožef Stefan Institute Ljubljana Slovenia University of Ljubljana Faculty of Computer and Information Science Slovenia Department of Computer Science University of Helsinki Finland Department of Data Analysis Texta Estonia

State of the art natural language processing tools are built on context-dependent word embeddings, but no direct method for evaluating these representations currently exists. Standard tasks and datasets for intrinsic evaluation of embeddings are based on judgements of similarity, but ignore context;standard tasks for word sense disambiguation take account of context but do not provide continuous measures of meaning similarity. This paper describes an effort to build a new dataset, CoSimLex, intended to fill this gap. Building on the standard pairwise similarity task of SimLex-999, it provides context-dependent similarity measures;covers not only discrete differences in word sense but more subtle, graded changes in meaning;and covers not only a well-resourced language (English) but a number of less-resourced languages. We define the task and evaluation metrics, outline the dataset collection methodology, and describe the status of the dataset so far. Copyright © 2019, The Authors. All rights reserved.

关键词： Semantics

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A Green Paradigm for Internet of Things: Ambient Backscatter Communications

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China Communications 2019年第7期16卷 109-119页

作者： Wei Zhang Yao Qin Wenjing Zhao Minzheng Jia Qiang Liu Ruisi He Bo Ai Science and Technology on Information Systems Engineering Laboratory National University of Defense Technology and also with Institute of Telecommunication Satellites China Academy of Space Technology (CAST) Beijing Key Lab of Transportation Data Analysis and Mining Beijing Engineering Research Center of High-Speed Railway Broadband Mobile Communications School of Computer and Information Technology Beijing Jiaotong University Beijing 100044 China Department of Information Engineering Beijing Polytechnic College Beijing 100042 China State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong University Beijing 100044 China

Internet of Things (IoT) has attracted extensive interest from both academia and industries, and is recognized as an ultimate infrastructure to connect everything at anytime and anywhere. The implementation of IoT generally faces the challenges from energy constraint and implementation cost. In this paper, we will introduce a new green communication paradigm, the ambient backscatter (AmBC), that could utilize the environmental wireless signals for both powering a tiny-cost device and backscattering the information symbols. Specifically, we will present the basic principles of AmBC, analyze its features and advantages, suggest its open problems, and predict its potential applications for our future IoT.

关键词： ambient backscatter (AmBC) RF-powered device Internet of Things (IoT) battery-free tag wire-less sensor

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Palladium nanoparticles supported over Green tea extract-modified Zn(Al)O mixed metal oxide as a heterogeneous catalyst for cyanation of aryl halides

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Journal of Organometallic Chemistry 2025年

作者： Ali B.M. Ali Abdulla A. Al-dulaimi Shaxnoza Saydaxmetova Narinderjit Singh Sawaran Singh Elangovan Muniyandy S. Sunitha M.A. Diab Aseel Smerat Syed Waheedullah Ghori Saiful Islam Air Conditioning Engineering Department College of Engineering University of Warith Al-Anbiyaa Karbala Iraq College of Nursing University of Al Maarif Al Anbar 31001 Iraq Department of Chemistry and Its Teaching Methods Tashkent State Pedagogical University Tashkent Uzbekistan Faculty of Data Science and Information Technology INTI International University Persiaran Perdana BBN Putra Nilai Nilai 71800 Malaysia Department of Biosciences Saveetha School of Engineering. Saveetha Institute of Medical and Technical Sciences Chennai 602105 Tamil Nadu India Applied Science Research Center Applied Science Private University Amman Jordan Department of Chemistry Sathyabama Institute of Science and Technology Chennai Tamil Nadu India Department of Biotechnology Yeungnam University Gyeongsan Gyeongbuk 38541 Republic of Korea Water Analysis Department Central Public Health Laboratories Ministry of Health and Population Cairo 11613 Egypt Faculty of Educational Sciences Al-Ahliyya Amman University Amman 19328 Jordan. Computer Technologies Engineering Mazaya University College Nasiriyah Iraq Mechanical Engineering Department College of Engineering King Khalid University Abha Saudi Arabia Civil Engineering Department College of Engineering King Khalid University Abha 61421 Saudi Arabia

Recently, modified hydrotalcite-like materials featuring layers of metal oxides have gained significant attention as improved supports for nanoparticles (NPs) due to their well electronic effects that intrinsically stabilize the deposited NPs. This research presents a refined methodology for synthesizing palladium nanoparticles (Pd NPs) using green tea extract-modified zinc-aluminum mixed oxides (Zn(Al)O/GT extract/Pd NPs). Green tea extract serves as a platform and a green reducing agent, enabling the in situ formation of Pd NPs without the use of harsh chemicals. This innovative approach represents the first occasion of designing and bio-generating Pd NPs coordinated on Zn(Al)O mixed oxides, along with their catalytic effects for the cyanation of aryl halides. The physicochemical properties of the resulting materials were evaluated utilizing a range of techniques including FE-SEM, elemental mapping, EDX, TEM, and ICP-OES analysis. The Zn(Al)O/GT extract/Pd NPs nanocatalyst showed exceptional catalytic efficiency as a recyclable platform for the cyanation of iodo- and bromo-benzene derivatives, employing K 4 [Fe(CN) 6 ] as the cyanating sorce. The obtained benzonitriles were produced in good yields, and the catalyst demonstrated the capacity to be reused up to 7 runs with only a minimal reduction in its efficacy.

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Recent advances in T-cell receptor repertoire analysis: Bridging the gap with multimodal single-cell RNA sequencing

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ImmunoInformatics 2022年 5卷

作者： Sebastiaan Valkiers Nicky de Vrij Sofie Gielis Sara Verbandt Benson Ogunjimi Kris Laukens Pieter Meysman Adrem Data Lab Department of Computer Science University of Antwerp Antwerp Belgium Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS) University of Antwerp Antwerp Belgium Clinical Immunology Unit Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium Molecular Digestive Oncology Department of Oncology Katholieke Universiteit Leuven Leuven Belgium Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID) Vaccine & Infectious Disease Institute (VAXINFECTIO) University of Antwerp Antwerp Belgium Antwerp Center for Translational Immunology and Virology (ACTIV) Vaccine and Infectious Disease Institute (VAXINFECTIO) University of Antwerp Antwerp Belgium Department of Paediatrics Antwerp University Hospital Antwerp Belgium

T cells exercise a multitude of functions such as cytotoxicity, secretion of immunomodulating cytokines or regulation of tolerance, collectively resulting in an effective control of immune-related disease. Through the unique mechanism of V(D)J recombination, T cells express a highly specific receptor complex known as the T-cell receptor (TCR). Single-cell sequencing technologies have paved the road for interrogating the transcriptome and the paired αβ TCR repertoire of a single T cell in tandem. In contrast, conventional bulk methods are restricted to only one layer of information. This combination of transcriptomic- and repertoire information can provide novel insight into the functional character of T cell immunity. Recently, single-cell technologies have gained in popularity due to improvements in throughput, decrease in cost and the ability for multimodal experiments that integrate different information layers. Consequently, this prompts the need for the development of novel computational tools that integrate transcriptomic profiles and corresponding features of the TCR repertoire. Here we discuss the current progress in the field of single-cell T cell sequencing, with a focus on the multimodality of new approaches that allow the paired profiling of cellular phenotype and clonotype information. In addition, this review provides detailed descriptions of recent computational developments for analyzing single-cell TCR sequencing data in an integrative manner using novel computational approaches. Finally, we present an overview of the available software tools that can be used to perform integrative analysis of gene expression and TCR profiles.

关键词： Single-cell sequencing Single-cell immune profiling Single-cell gene expression T-cell receptor repertoire Multi-omics

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Spatiotemporally Targeted Polypeptide Nanoantidotes Improve Chemotherapy Tolerance of Cisplatin

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Angewandte Chemie 2022年第47期134卷 e202211136-e202211136页

作者： Dr. Jiazhen Yang Dr. Tianqi Su Dr. Haoyang Zou Prof. Guanqing Yang Prof. Jianxun Ding Prof. Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences 5625 Renmin Street Changchun 130022 P. R. China School of Applied Chemistry and Engineering University of Science and Technology of China 96 Jinzhai Road Hefei 230026 P. R. China Contribution: Conceptualization (equal) Formal analysis (lead) Investigation (lead) Methodology (lead) Resources (equal) Validation (equal) Visualization (equal) Writing - original draft (lead) Department of General Surgery The Second Hospital of Jilin University 218 Ziqiang Street Changchun 130041 P. R. China Contribution: Data curation (equal) Formal analysis (equal) Investigation (equal) Methodology (equal) Resources (equal) Software (equal) Validation (equal) Contribution: Data curation (lead) Formal analysis (equal) Funding acquisition (supporting) Investigation (supporting) Validation (equal) Visualization (equal) Writing - review & editing (equal) Contribution: Data curation (lead) Funding acquisition (supporting) Writing - review & editing (supporting) Contribution: Conceptualization (lead) Data curation (equal) Formal analysis (supporting) Funding acquisition (lead) Investigation (supporting) Project administration (lead) Supervision (lead) Writing - review & editing (lead) Contribution: Conceptualization (equal) Funding acquisition (lead) Project administration (lead) Supervision (lead) Writing - review & editing (lead)

The toxicity of drugs causes various adverse effects in patients. While antidotes that neutralize drug toxicity help reduce systemic damage during clinical therapy, these antidotes are generally accompanied by the loss of drug efficacy. Herein, the spatiotemporally targeted polycystine-based nanoantidotes were designed as a neutralizer of cisplatin (CDDP) to decrease its toxicity without affecting its anticancer efficacy. The nanoantidotes administered before CDDP selectively accumulated in the liver and kidney and then firmly bound to CDDP through the highly stable Pt−S bond during subsequent chemotherapy. This two-step administration strategy reduced the level of Pt in normal organs, shortened the half-life of CDDP in plasma, and increased the tolerance to CDDP. More importantly, the nanoantidotes maintained the anticancer efficacy of CDDP after reducing systemic toxicity, indicating its great potential in expanding the clinical application of CDDP.

关键词： polypeptides spatiotemporal targeting nanoantidotes drug tolerance chemotherapy

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