The application of mixed-linker strategies in the synthesis of metal-organic frameworks (MOFs) has garnered considerable interest owing to their potential as fluorescent sensors, attributed to their facile synthesis a...
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The realization of 100%polarized topologicalWeyl fermions in half-metallic ferromagnets is of particular importance for fundamental research and spintronic ***,we theoretically investigate the electronic and topologic...
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The realization of 100%polarized topologicalWeyl fermions in half-metallic ferromagnets is of particular importance for fundamental research and spintronic ***,we theoretically investigate the electronic and topological properties of the zinc-blende compound VAs,which was deemed as a half-metallic ferromagnet related to dynamic *** on the combination of density functional theory and dynamical mean field theory,we uncover that the half-metallic ferromagnet VAs exhibits attractive Weyl semimetallic behaviors which are very close to the Fermi level in the DFT+U regime with effect U values ranging from 1.5 eV to 2.5 ***,we also investigate the magnetization-dependent topological properties;the results show that the change of magnetization directions only slightly affects the positions of Weyl points,which is attributed to the weak spin–orbital coupling *** topological surface states of VAs projected on semi-infinite(001)and(111)surfaces are *** Fermi arcs of all Weyl points are clearly visible on the projected Fermi *** findings suggest that VAs is a fully spin-polarized Weyl semimetal with many-body correlated effects in the effective U values range from 1.5 eV to 2.5 eV.
The polycomb repressive complex 2 (PRC2) catalyzes the methylation of histone H3 on lysine 27 (H3K27) to generate trimethyl-H3K27 (H3K27me3) marks,thereby leading to a repressive chromatin state that inhibits gene exp...
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The polycomb repressive complex 2 (PRC2) catalyzes the methylation of histone H3 on lysine 27 (H3K27) to generate trimethyl-H3K27 (H3K27me3) marks,thereby leading to a repressive chromatin state that inhibits gene expression.C10ORF12 was recently identified as a novel PRC2 ***,we show that C10ORF12 specifically interacts with PRC2 through its middle region (positions 619-718).C10ORF12 significantly enhances the histone methyltransferase activity of PRC2 in vitro and dramatically increases the total H3K27me3 levels in HeLa cells.C10ORF12 also antagonizes Jarid2,which is an auxiliary factor of the PRC2.2 subcomplex,to promote increased H3K27me3 levels in HeLa ***,C10ORF12 alters the substrate preference of *** results indicate that C10ORF12 functions as a positive regulator of PRC2 and facilitates PRC2-mediated H3K27me3 modification of *** findings provide new insight into the roles of C10ORF12 in regulating the activity of the PRC2 complex.
Phase change materials(PCMs)have great potential in thermal energy management,but their low ther-mal conductivity,easy leakage,and poor thermal stability limit their wide *** constructing the biomimetic leaf-vein-like...
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Phase change materials(PCMs)have great potential in thermal energy management,but their low ther-mal conductivity,easy leakage,and poor thermal stability limit their wide *** constructing the biomimetic leaf-vein-like three-dimensional(3D)structure of boron nitride(BN)and impregnated with polyethylene glycol(PEG),the comprehensive properties of phase change composites were effec-tively enhanced under low filler *** PEG is stored in the 3D structure of BN,which can prevent leakage at high temperatures and enhance the composites’thermal stability and storage *** a fast channel of transmission of phonons,the BN skeleton can effectively reduce thermal *** the amount of filler is 10 vol%,the highest thermal conductivity of the composite PCMs is 2.62 W m-1 K-1,which is 10.1 times than that of pure *** the infrared camera,the composite PCMs yielded excellent battery thermal management performance,indicating that the material has great potential in thermal management.
Two new tetrazole 1-acetato complexes, [Ag（1-tza）（phen）]∞ （1） and [Cd（1- tza）2（2,2＇-bipy）]∞ （2） （1-Htza = tetrazole 1-acetato, phen = 1,10-phenanthroline, 2,2＇-bipy = 2,2＇-bipyridine）, have been syn...
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Two new tetrazole 1-acetato complexes, [Ag（1-tza）（phen）]∞ （1） and [Cd（1- tza）2（2,2＇-bipy）]∞ （2） （1-Htza = tetrazole 1-acetato, phen = 1,10-phenanthroline, 2,2＇-bipy = 2,2＇-bipyridine）, have been synthesized by solvothermal synthesis and structurally characterized by elemental analyses, IR spectra and single-crystal X-ray diffraction. Complex 1 shows a 1-D chained structure, while the structure of 2 contains two 1-D chains, which is the first 1-tza-based complex containing three different coordination modes of the 1-tza ligand. The aromatic stacking effects play an important role in the formation of supramolecular frameworks of these two complexes. Photoluminescent studies show that the two complexes exhibit efficient luminescence. In addition, optical diffuse reflectance spectra and thermogravimetric analyses of 1 and 2 have also been investigated.
作者：
Carlson, JHHill, SADepartment of Health and Human Services
National Institutes of Health National Institute of Allergy and Infectious Diseases Laboratory of Microbial Structure and Function Rocky Mountain Laboratories Hamilton MT 59840 USA
Thymidylate synthase converts deoxyuridylate to deoxythymidylate. The thyA gene has been cloned and sequenced from Neisseria gonorrhoeae MS11. This gene has an open reading frame of 795-801 bp and encodes a product wh...
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Thymidylate synthase converts deoxyuridylate to deoxythymidylate. The thyA gene has been cloned and sequenced from Neisseria gonorrhoeae MS11. This gene has an open reading frame of 795-801 bp and encodes a product which shares 71% identity with its Escherichia coli homolog. Unlike its E. coli counterpart, gonococcal thyA has a large, upstream transcribed region (300+ bp) that lacks a translatable reading frame. Gonococcal thyA is capable of complementing an E. coli thyA null mutant and shares similar levels of sensitivity with trimethoprim.
作者：
SALEMME, AFURANO, AVSection on Genomic Structure and Function
Laboratory of Biochemical Pharmacology National Institute of Arthritis Diabetes and Digestive and Kidney Diseases National Institutes of HealthBuilding 4 Room 116 Bethesda MD 20205 USA
In investigating sequence variants in a family of highly repeated rat DNA, we needed to search the consensus sequence of the repeat unit of this family for short sequences which would become, with one base change, rec...
In investigating sequence variants in a family of highly repeated rat DNA, we needed to search the consensus sequence of the repeat unit of this family for short sequences which would become, with one base change, recognition sites for various restriction endonucleases. To do this, we have designed a pair of programs to search DNA sequences of any length for sets of related short sequences, allowing user-specified mismatches in the short sequence. Since putative regulatory regions are generally short sequences, these programs are also useful for locating all possible versions of such sequences in any given DNA. We describe the programs, and present results of searches using the programs.
The genus Rattus has two related families of satellite DNA: Satellite I consists of tandem arrays of a 370 base pair repeat unit which is a dimer of two 185 base pair portions (a, b) which are about 60% homologous. Sa...
The genus Rattus has two related families of satellite DNA: Satellite I consists of tandem arrays of a 370 base pair repeat unit which is a dimer of two 185 base pair portions (a, b) which are about 60% homologous. Satellite I' consists of tandem arrays of a 185 base pair repeat unit (a') which is about 85% homologous to a and 60% homologous to b. R. norvegicus contains only satellite I but R. rattus contains both satellites I and I'. We examined certain aspects of satellite DNA evolution by comparing the spacing at which variant repeat units of each satellite have spread among non-variant repeat units in these two species. With but one exception, in R. rattus, 15 different variant repeat units have spread among non-variant repeat units of satellite I, with a spacing equal to the length of the (a,b) dimer. Similarly, fourteen different variant repeat units of the monomeric satellite I' have mixed among non-variant repeat units with a spacing equal to the length of the (a') monomer. These results suggest that a mechanism involving homologous interaction among satellite sequences could account for the spread of variant family members. We also found that a sequence variant present in certain portions of the dimeric repeat unit of satellite I is more efficiently amplified (or less efficiently corrected) than variants occurring in other regions. This was not true for the monomeric repeat unit of satellite I'.
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