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Model Structure Validation of Cell Signaling Pathways Using Colored Petri nets *

IFAC Proceedings Volumes 2012年第15期45卷 463-468页

作者： Dvid Csercsik Katalin M. Hangos Process Control Research Group Systems and Control Laboratory Computer and Automation Research Institute Hungarian Academy of Sciences P.O. Box 63 H-1518 Budapest Hungary

In this paper we propose a novel colored timed Petri net modelling approach for model structure validation of cell signaling pathways. The aim is to distinguish between models of different structures based on typically qualitative, roughly detailed measurement data. In this approach, tokens are present all the time at all of the places, and their color corresponds to the actual quantized activation state of the signaling component. The activation states are updated according to the progression of the signal through the signaling network. We demonstrate the results on a signaling network, which describes the interaction of fast (G protein coupled) and slow ( β -arrestin coupled) transmission.

关键词： Modeling and Identification control Applications in Biological processes

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Assessment of two pressure-velocity coupling strategies for local meshless numerical method

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9th International Conference on Advances in Fluid Mechanics - Advances in Fluid Mechanics IX, AFM 2012

作者： Kosec, G. Vertnik, R. Šarler, B. Jožef Stefan Institute Laboratory for Parallel and Distributed Computing Slovenia University of Nova Gorica Laboratory for Multiphase Processes Slovenia Štore steel d.o.o. Research Slovenia Centre of Excellence for Biosensors Automation and Process Control Laboratory for Advanced Materials Systems Slovenia

ISBN: (纸本)9781845646004

The performance of two pressure-velocity coupling strategies, associated with the primitive variable solution of incompressible Newtonian fluid with the meshless Local Radial Basis Function Collocation Method (LRBFCM), is compared with respect to computational efficiency, stability, accuracy and spatial convergence. The LRBFCM is structured with multiquadrics on five noded support domains. The explicit time stepping is used. The Backward- Facing Step problem (BFS) has been selected as a benchmark problem, previously tackled by several numerical methods. The semi-local fractional step method (FSM) and completely local pressure-velocity couplings (LPVC) are compared. The numerical results are validated against previously published data. The results are represented and compared in terms of a convergence plot of the reattachment position. We show that both approaches provide reasonable results;however, LVPC is less computationally complex and less stable in comparison to FSM. © 2012 WIT Press.

关键词： Computational efficiency

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An entropy approach to filtering for networked control systems

An entropy approach to filtering for networked control syste...

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作者： Zhang, Jianhua Du, Lilong Wang, Aiping Wang, Hong School of Control and Computer Engineering North China Electric Power University Beijing 102206 China Institute of Computing Sciences Anhui University Hefei China Control Systems Centre University of Manchester Manchester M601QD United Kingdom Key Laboratory of Integrated Automation of Process Industry Ministry of Education and Research Center of Automation Northeastern University Shenyang China

This paper is concerned with minimum error entropy filter design for non-linear Networked control systems (NCSs) with multiple-packet transmission mechanism. Since the error of the filter in NCSs is generally non-Gaussian, the filter is designed under the information theoretic learning frame. The convergent condition of the proposed filter is established. A simulation example shows that the proposed approach is feasible and effective. Copyright © 2012 Inderscience Enterprises Ltd.

关键词： Entropy

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Assessment of two pressure-velocity coupling strategies for local meshless numerical method

Assessment of two pressure-velocity coupling strategies for ...

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作者： Kosec, G. Vertnik, R. Šarler, B. Jožef Stefan Institute Laboratory for Parallel and Distributed Computing Slovenia University of Nova Gorica Laboratory for Multiphase Processes Slovenia Štore Steel D.o.o. Research Slovenia Centre of Excellence for Biosensors Automation and Process Control Laboratory for Advanced Materials Systems Slovenia

The performance of two pressure-velocity coupling strategies, associated with the primitive variable solution of incompressible Newtonian fluid with the meshless Local Radial Basis Function Collocation Method (LRBFCM), is compared with respect to computational efficiency, stability, accuracy and spatial convergence. The LRBFCM is structured with multiquadrics on five noded support domains. The explicit time stepping is used. The Backward-Facing Step problem (BFS) has been selected as a benchmark problem, previously tackled by several numerical methods. The semi-local fractional step method (FSM) and completely local pressure-velocity couplings (LPVC) are compared. The numerical results are validated against previously published data. The results are represented and compared in terms of a convergence plot of the reattachment position. We show that both approaches provide reasonable results;however, LVPC is less computationally complex and less stable in comparison to FSM. © 2012 WIT Press.

关键词： Computational efficiency

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Optimal solutions to robust stabilization problem for a class of systems with parametric uncertainty

Optimal solutions to robust stabilization problem for a clas...

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7th IFAC Symposium on Robust control Design, ROCOND'12

作者： Wu, Qinghe Xu, Li Mansour, Mohamed School of Automation Beijing Institute of Technology Beijing 100081 China Faculty of System Science and Technology Dept. of Electronics and Information Systems Akita Prefectural University Akita 015-0055 Japan Automatic Control Laboratory Swiss Federal Institute of Technology Zurich ETH Zentrum CH-8092 Zürich Switzerland

ISBN: (纸本)9783902823038

This paper tackles the robust stabilization problem for the plant family described by the transfer function set P(s, δ, δ) whose coefficients of the denominator and the numerator polynomials are affine in a real uncertain parameter vector δ satisfying the norm constraint δp ≤ δ for p ≥ 1. It is shown that there exists a fixed controller robustly stabilizing all the members of P(s, δ, δ) if and only if its every member plant is free of unstable pole-zero cancelation. The optimal robust stabilizer is characterized in terms of a three dimensional frequency dependent Hahn-Banach minimizer. Classes of P(s, δ, δ) are characterized using Nevanlinna-Pick interpolation theory. For these classes optimal robust stabilizers can be obtained in closed forms using H ∞-optimization technique. © 2012 IFAC.

关键词： Stabilization

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Dissipativity-based Distributed Nonlinear Predictive control for Cascaded systems

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IFAC Proceedings Volumes 2012年第15期45卷 439-444页

作者： P. Varutti B. Kern R. Findeisen P.Varutti B.Kern and R.Findeisen are with the Laboratory for Systems Theory and Automatic Control Institute of Automation Engineering Otto-von-Guericke University Magdeburg 39016 Magdeburg Germany

Developing centralized controllers for large-scale systems, e.g. complex chemical processes, electrical power networks, is an important, yet challenging problem. Typically, it would be of advantage if one could divide the problem into smaller parts (or subproblems), and to opt for a decentralized or distributed alternative. On the other hand, due to physical interconnections between subsystems, it is often complicated to find such a solution. Additionally, performance loss or even instability of the overall system can arise if the decentralization is not done properly. It is, therefore, fundamental to develop suitable distributed/decentralized techniques in order to avoid these issues. In this paper, we propose a decentralized dissipativity-based nonlinear model predictive control strategy for cascades of physically interconnected systems, e.g cascades of hydroelectric power plants, multi-cell batteries. Under mild assumptions, we prove that the control method guarantees overall stability by independently enforcing stability of the local subsystems. This allows for efficient decentralized solutions. Furthermore, the local controllers only exchange limited information and no model of the neighbor systems is required, facilitating decoupled local controller design. Two interconnected water tanks are used to demonstrate the effectiveness of our approach.

关键词： distributed control nonlinear predictive control dissipativity-based control continuous time systems

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An overview of agent-based evacuation models for building fires

An overview of agent-based evacuation models for building fi...

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IEEE International Conference on Networking, Sensing and control

作者： Yuling Hu Xiwei Liu Feiyue Wang Changjian Cheng Beijing Key Laboratory of Automatic Control System School of Automation Beijing Institute of Technology. and School of Electric and Information Engineering Beijing University of Civil Engineering and Architecture China State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences China

Agent-based evacuation modeling approach is gained more and more attention for investigating human cognitive capabilities and social behaviors in building fires. This paper mainly overviews the research about various agent-based evacuation models. For the decision-making reflects the intelligence of agent individual, we define three types of behavior decision-making models for agent individual based on the collected literatures and sum up the characteristics of each type. Aiming at crowd' important influence on evacuation processes, we also sum up two types of agent-based crowd modeling approaches to simulate crowd evacuation processes and give corresponding cases. Finally, after summing up the existing problems, the outlooks of the research from computational experiments point of view is proposed.

关键词： Computational modeling Fires Biological system modeling Buildings Decision making Humans Adaptation models

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Dynamical equivalence and linear conjugacy of biochemical reaction network models

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IFAC Proceedings Volumes 2012年第18期45卷 125-130页

作者： G. Szederkényi Z.A. Tuza K.M. Hangos Process Control Research Group Systems and Control Laboratory Computer and Automation Research Institute (MTA SZTAKI) Hungarian Academy of Sciences P.O. Box 63 H-1518 Budapest Hungary Faculty of Information Technology Péter Pázmány Catholic University H-1083 Budapest Práter u. 50/a

The distinguishability and identifiability of biological network models are key properties influencing the reliability of structural and parametric identification of such models. Recently, several new results have been published about dynamically equivalent and linearly conjugate reaction networks. In this paper, the notion and importance of dynamical equivalence and linear conjugacy of biochemical network models obeying the mass action law is shown. For this, new concepts in the form of core complexes and core reactions for linearly conjugate networks are introduced. Two examples illustrate the developed computation methods.

关键词： biological systems chemical reaction networks optimization

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Fault-tolerant control of an electro-hydraulic servo axes with a duplex-valve-system

Fault-tolerant control of an electro-hydraulic servo axes wi...

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作者： Beck, Mark Schwung, Andreas Muenchhof, Marco Isermann, Rolf TU Darmstadt Institute of Automatic Control Laboratory for Control Systems and Process Automation 64283 Darmstadt Germany TU Darmstadt Institute of Automatic Control Laboratory for Control Theory and Robotics 64283 Darmstadt Germany

ISBN: (纸本)9783902661937

This paper presents fault detection, fault diagnosis, the fault-tolerant control of an electro-hydraulic servo axes with a duplex-valve-system. The fault detection is based on parity equations and is load independent. The semi-physical models allow the detection of even small faults in the hydraulic system. The fault diagnosis used at the testbed is based on fuzzy-logic. In order to tolerate a faulty hydraulic proportional valve, a duplex-valve-system built up with standard proportional valves is applied. The fault management module allows the supervision of the hydraulic servo axes and decides on the reconfiguration of the control-loop. An Internal Model control (IMC)-tracking control structure for bumpless transfer between controllers is presented. Experimental results show the industrial applicability of the approach. © 2011 IFAC.

关键词： Fault detection

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Optimal Solutions to Robust Stabilization Problem for a Class of systems with Parametric Uncertainty

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IFAC Proceedings Volumes 2012年第13期45卷 156-161页

作者： Qinghe Wu Li Xu Mohamed Mansour School of Automation Beijing Institute of Technology Beijing 100081 China Faculty of System Science and Technology Dept. of Electronics and Information Systems Akita Prefectural University Akita 015-0055 Japan Automatic Control Laboratory Swiss Federal Institute of Technology Zurich ETH Zentrum CH-8092 Zürich Switzerland

This paper tackles the robust stabilization problem for the plant family described by the transfer function set P ( s, δ , δ ) whose coefficients of the denominator and the numerator polynomials are affine in a real uncertain parameter vector δ satisfying the norm constraint || δ || p ≤ δ for p ≥ 1. It is shown that there exists a fixed controller robustly stabilizing all the members of P ( s, δ , δ ) if and only if its every member plant is free of unstable pole-zero cancelation. The optimal robust stabilizer is characterized in terms of a three dimensional frequency dependent Hahn-Banach minimizer. Classes of P ( s, δ , δ ) are characterized using Nevanlinna-Pick interpolation theory. For these classes optimal robust stabilizers can be obtained in closed forms using ℋ ∞ -optimization technique.

关键词： real parameter uncertainty parametric robust stabilization stabilizability radius stability radius ℋ ∞ -optimization

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