Traditional visual surveillance systems have blind spots, resulting in a lack of information about the location and behavior of the surveillance target, while the lack of collaboration of a single visual sensor in tra...
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Generating novel molecules to satisfy specific properties is a challenging task in modern drug discovery,which requires the optimization of a specific objective based on satisfying chemical ***,we aim to optimize the ...
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Generating novel molecules to satisfy specific properties is a challenging task in modern drug discovery,which requires the optimization of a specific objective based on satisfying chemical ***,we aim to optimize the properties of a specific molecule to satisfy the specific properties of the generated *** Matched Molecular Pairs(MMPs),which contain the source and target molecules,are used herein,and logD and solubility are selected as the optimization *** main innovative work lies in the calculation related to a specific transformer from the perspective of a matrix *** intervals and state changes are then used to encode logD and solubility for subsequent *** the experiments,we screen the data based on the proportion of heavy atoms to all atoms in the groups and select 12365,1503,and 1570 MMPs as the training,validation,and test sets,*** models are compared with the baseline models with respect to their abilities to generate molecules with specific *** show that the transformer model can accurately optimize the source molecules to satisfy specific properties.
Vibration-induced bias deviation,which is generated by intensity fluctuations and additional phase differences,is one of the vital errors for fiber optic gyroscopes(FOGs)operating in vibration environment and has seve...
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Vibration-induced bias deviation,which is generated by intensity fluctuations and additional phase differences,is one of the vital errors for fiber optic gyroscopes(FOGs)operating in vibration environment and has severely restricted the applications of high-precision *** conventional methods for suppressing vibration-induced errors mostly concentrate on reinforcing the mechanical structure and optical path as well as the compensation under some specific operation parameters,which have very limited effects for high-precision FOGs maintaining performances under *** this work,a technique of suppressing the vibration-induced bias deviation through removing the part related to the varying gain from the rotation-rate output is put ***,the loop gain is extracted out by adding a gain-monitoring *** demodulating the loop gain and the rotation rate simultaneously under distinct frequencies and investigating their quantitative relationship,the vibrationinduced bias error is compensated without limiting the operating parameters or environments,like the applied modulation *** experimental results show that the proposed method has achieved the reduction of bias error from about 0.149°/h to0.014°/h during the random vibration with frequencies from20 Hz to 2000 *** technique provides a feasible route for enhancing the performances of high-precision FOGs heading towards high environmental adaptability.
Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
Nonstationary time series are ubiquitous in almost all natural and engineering *** the time-varying signatures from nonstationary time series is still a challenging problem for data *** Time-Frequency Distribution(TFD...
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Nonstationary time series are ubiquitous in almost all natural and engineering *** the time-varying signatures from nonstationary time series is still a challenging problem for data *** Time-Frequency Distribution(TFD)provides a powerful tool to analyze these ***,they suffer from Cross-Term(CT)issues that impair the readability of ***,to achieve high-resolution and CT-free TFDs,an end-to-end architecture termed Quadratic TF-Net(QTFN)is proposed in this *** by classic TFD theory,the design of this deep learning architecture is heuristic,which firstly generates various basis functions through ***,more comprehensive TF features can be extracted by these basis ***,to balance the results of various basis functions adaptively,the Efficient Channel Attention(ECA)block is also embedded into ***,a new structure called Muti-scale Residual Encoder-Decoder(MRED)is also proposed to improve the learning ability of the model by highly integrating the multi-scale learning and encoder-decoder ***,although the model is only trained by synthetic signals,both synthetic and real-world signals are tested to validate the generalization capability and superiority of the proposed QTFN.
This paper focuses on the effective utilization of data augmentation techniques for 3Dlidar point clouds to enhance the performance of neural network *** point clouds,which represent spatial information through a coll...
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This paper focuses on the effective utilization of data augmentation techniques for 3Dlidar point clouds to enhance the performance of neural network *** point clouds,which represent spatial information through a collection of 3D coordinates,have found wide-ranging *** augmentation has emerged as a potent solution to the challenges posed by limited labeled data and the need to enhance model generalization *** of the existing research is devoted to crafting novel data augmentation methods specifically for 3D lidar point ***,there has been a lack of focus on making the most of the numerous existing augmentation *** this deficiency,this research investigates the possibility of combining two fundamental data augmentation *** paper introduces PolarMix andMix3D,two commonly employed augmentation techniques,and presents a new approach,named *** of using a fixed or predetermined combination of augmentation methods,RandomFusion randomly chooses one method from a pool of options for each instance or *** innovative data augmentation technique randomly augments each point in the point cloud with either PolarMix or *** crux of this strategy is the random choice between PolarMix and Mix3Dfor the augmentation of each point within the point cloud data *** results of the experiments conducted validate the efficacy of the RandomFusion strategy in enhancing the performance of neural network models for 3D lidar point cloud semantic segmentation *** is achieved without compromising computational *** examining the potential of merging different augmentation techniques,the research contributes significantly to a more comprehensive understanding of how to utilize existing augmentation methods for 3D lidar point *** data augmentation technique offers a simple yet effective method to leverage the diversity of augmentation techniques and boost the ro
Kernel is a kind of data summary which is elaborately extracted from a large *** a problem,the solution obtained from the kernel is an approximate version of the solution obtained from the whole dataset with a provabl...
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Kernel is a kind of data summary which is elaborately extracted from a large *** a problem,the solution obtained from the kernel is an approximate version of the solution obtained from the whole dataset with a provable approximate *** is widely used in geometric optimization,clustering,and approximate query processing,etc.,for scaling them up to massive *** this paper,we focus on the minimumε-kernel(MK)computation that asks for a kernel of the smallest size for large-scale data *** the open problem presented by Wang et *** whether the minimumε-coreset(MC)problem and the MK problem can be reduced to each other,we first formalize the MK problem and analyze its *** to the NP-hardness of the MK problem in three or higher dimensions,an approximate algorithm,namely Set Cover-Based Minimumε-Kernel algorithm(SCMK),is developed to solve *** prove that the MC problem and the MK problem can be Turing-reduced to each ***,we discuss the update of MK under insertion and deletion operations,***,a randomized algorithm,called the Randomized Algorithm of Set Cover-Based Minimumε-Kernel algorithm(RA-SCMK),is utilized to further reduce the complexity of *** efficiency and effectiveness of SCMK and RA-SCMK are verified by experimental results on real-world and synthetic *** show that the kernel sizes of SCMK are 2x and 17.6x smaller than those of an ANN-based method on real-world and synthetic datasets,*** speedup ratio of SCMK over the ANN-based method is 5.67 on synthetic ***-SCMK runs up to three times faster than SCMK on synthetic datasets.
The increasing prevalence of drones has raised significant concerns regarding their potential for misuse in activities such as smuggling, terrorism, and unauthorized access to restricted airspace. Consequently, the de...
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Being able to safely land on the surface is one of the primary challenges when a probe exploring an asteroid. In order to ensure landing safety, the landing location planning needs to comprehensively consider the terr...
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Automatic path planning is very important for many applications such as robots exploring unknown environments and logistics delivery. In this paper, we propose a discrete multi-population fruit fly optimization algori...
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