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Correction: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

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Journal of neuroengineering and rehabilitation 2024年第1期21卷 71页

作者： M Encarna Micó-Amigo Tecla Bonci Anisoara Paraschiv-Ionescu Martin Ullrich Cameron Kirk Abolfazl Soltani Arne Küderle Eran Gazit Francesca Salis Lisa Alcock Kamiar Aminian Clemens Becker Stefano Bertuletti Philip Brown Ellen Buckley Alma Cantu Anne-Elie Carsin Marco Caruso Brian Caulfield Andrea Cereatti Lorenzo Chiari Ilaria D'Ascanio Bjoern Eskofier Sara Fernstad Marcel Froehlich Judith Garcia-Aymerich Clint Hansen Jeffrey M Hausdorff Hugo Hiden Emily Hume Alison Keogh Felix Kluge Sarah Koch Walter Maetzler Dimitrios Megaritis Arne Mueller Martijn Niessen Luca Palmerini Lars Schwickert Kirsty Scott Basil Sharrack Henrik Sillén David Singleton Beatrix Vereijken Ioannis Vogiatzis Alison J Yarnall Lynn Rochester Claudia Mazzà Silvia Del Din Translational and Clinical Research Institute Faculty of Medical Sciences Newcastle University Newcastle Upon Tyne UK. Department of Mechanical Engineering and Insigneo Institute for in Silico Medicine The University of Sheffield Sheffield UK. Laboratory of Movement Analysis and Measurement Ecole Polytechnique Federale de Lausanne Lausanne Switzerland. Machine Learning and Data Analytics Lab Department of Artificial Intelligence in Biomedical Engineering Friedrich-Alexander-Universität Erlangen Nürnberg Erlangen Germany. Center for the Study of Movement Cognition and Mobility Neurological Institute Tel Aviv Sourasky Medical Center Tel Aviv Israel. Department of Biomedical Sciences University of Sassari Sassari Italy. Department of Electronics and Telecommunications Politecnico di Torino Turin Italy. National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC) Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne UK. Robert Bosch Gesellschaft für Medizinische Forschung Stuttgart Germany. The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne UK. School of Computing Newcastle University Newcastle Upon Tyne UK. Barcelona Institute for Global Health (ISGlobal) Barcelona Spain. Universitat Pompeu Fabra Barcelona Catalonia Spain. CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain. Insight Centre for Data Analytics University College Dublin Dublin Ireland. School of Public Health Physiotherapy and Sports Science University College Dublin Dublin Ireland. Department of Electrical Electronic and Information Engineering «Guglielmo Marconi» University of Bologna Bologna Italy. Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV) University of Bologna Bologna Italy. Grünenthal GmbH Aachen Germany. Department of Neurology University Medical Center Schleswig-Holstein Campus Kiel Kiel Germany. Sagol School of Neuroscien

Ti interstitial flows giving rutile TiO2 reoxidation process enhanced in (001) surface

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arXiv 2019年

作者： Ichibha, Tom Benali, Anouar Hongo, Kenta Maezono, Ryo School of Information Science JAIST 1-1 Asahidai NomiIshikawa923-1292 Japan Computational Science Division Argonne National Laboratory 9700 Cass Avenue LemontIL60439 United States Research Center for Advanced Computing Infrastructure JAIST 1-1 Asahidai NomiIshikawa923-1292 Japan Center for Materials Research by Information Integration Research and Services Division of Materials Data and Integrated System National Institute for Materials Science 1-2-1 Sengen Tsukuba305-0047 Japan PRESTO Japan Science and Technology Agency 4-1-8 Honcho Kawaguchi-shi Saitama322-0012 Japan Computational Engineering Applications Unit RIKEN 2-1 Hirosawa Wako Saitama351-0198 Japan

We revisited ab initio evaluations of the energy barriers along the possible diffusion paths of the defects in rutile TiO2. By using a method carefully considering the cancellation of the self-interaction, Ti interstitials hopping along c-axis are identified as the major diffusion directing to [001] surface. The conclusion is contradicting to any of previous theoretical works, and the discrepancy is explained by the overestimation of the radius of defects due to the poor cancellations in the previous works. The updated prediction here can explain the superior photocatalysis activity in [001] surface to [110]. Copyright © 2019, The Authors. All rights reserved.

关键词： Titanium dioxide

Mars-Crossing Minor Planet 2018 VL10: a Jupiter-family Comet Discovery via Citizen science

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Research Notes of the AAS 2023年第12期7卷 279-279页

作者： Colin Orion Chandler William J. Oldroyd Chadwick A. Trujillo Henry H. Hsieh William A. Burris Jay K. Kueny Jarod A. DeSpain Nima Sedaghat Kennedy A. Farrell Mark Jesus Mendoza Magbanua Scott S. Sheppard Michele T. Mazzucato Milton K. D. Bosch Tiffany Shaw-Diaz Virgilio Gonano Al Lamperti José A. da Silva Campos Brian L. Goodwin Ivan A. Terentev Charles J. A. Dukes Dept. of Astronomy & the DiRAC Institute University of Washington 3910 15th Ave NE Seattle WA 98195 USA coc123@uw.edu LSST Interdisciplinary Network for Collaboration and Computing 933 N. Cherry Avenue Tucson AZ 85721 USA Dept. of Astronomy & Planetary Science Northern Arizona University PO Box 6010 Flagstaff AZ 86011 USA Raw Data Speaks Initiative Planetary Science Institute 1700 East Fort Lowell Rd. Suite 106 Tucson AZ 85719 USA Institute of Astronomy and Astrophysics Academia Sinica P.O. Box 23-141 Taipei 10617 Taiwan Dept. of Physics San Diego State University 5500 Campanile Drive San Diego CA 92182 USA University of Arizona Dept. of Astronomy and Steward Observatory 933 North Cherry Avenue Rm. N204 Tucson AZ 85721 USA Lowell Observatory 1400 W Mars Hill Rd Flagstaff AZ 86001 USA Dept. of Laboratory Medicine University of California San Francisco 2340 Sutter Street San Francisco CA 94143 USA Dept. of Terrestrial Magnetism Carnegie Institution for Science 5241 Broad Branch Road. NW Washington DC 20015 USA Active Asteroids Citizen Scientist Royal Astronomical Society Burlington House Piccadilly London W1J 0BQ UK Physical Sciences Group Siena Academy of Sciences Piazzetta Silvio Gigli 2 I-53100 Siena Italy Delaware Valley Amateur Astronomers 112 Pebble Beach Drive Royersford PA 19468 USA Astronomical Society of Southern Africa P.O. Box 9 Observatory 7935 Cape Town South Africa

We announce the discovery of cometary activity emitting from minor planet 2018 VL10 in Dark Energy Camera images spanning from UT 2018 December 31 to UT 2019 March 3. The activity was identified by volunteers of our N...

We announce the discovery of cometary activity emitting from minor planet 2018 VL₁₀ in Dark Energy Camera images spanning from UT 2018 December 31 to UT 2019 March 3. The activity was identified by volunteers of our NASA Partner program Active Asteroids, a Zooniverse-hosted Citizen science project designed to find previously unknown activity in known minor planets. Notably, 2018 VL₁₀ crosses the orbits of Mars and Jupiter, and experiences close approaches of less than 0.5 au with both Earth and Jupiter. We classify 2018 VL₁₀ as a member of the Jupiter-family comets, a group of objects especially important to understand because they hold important clues about the solar system volatile distribution, past and present.

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Quantum supremacy circuit simulation on sunway taihulight

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arXiv 2018年

作者： Li, Riling Wu, Bujiao Ying, Mingsheng Sun, Xiaoming Yang, Guangwen Department of Computer Science & Technology Tsinghua University Beijing China CAS Key Lab of Network Data Science and Technology Institute of Computing Technology Chinese Academy of Sciences Beijing China Centre for Quantum Software and Information University of Technology Sydney Sydney Australia State Key Lab of Computer Science Institute of Software Chinese Academy of Sciences Department of Computer Science & Technology Tsinghua University Beijing China

With the rapid progress made by industry and academia, quantum computers with dozens of qubits or even larger size are being realized. However, the fidelity of existing quantum computers often sharply decreases as the circuit depth increases. Thus, an ideal quantum circuit simulator on classical computers, especially on high-performance computers, is needed for benchmarking and validation. We design a large-scale simulator of universal random quantum circuits, often called "quantum supremacy circuits", and implement it on Sunway TaihuLight. The simulator can be used to accomplish the following two tasks: 1) computing a complete output state-vector;2) Calculating one or a few amplitudes. We target the simulation of 49-qubit circuits. For task 1), we successfully simulate such a circuit of depth 39, and for task 2) we reach the 55-depth level. To the best of our knowledge, both of the simulation results reach the largest depth for 49-qubit quantum supremacy circuits. Copyright © 2018, The Authors. All rights reserved.

关键词： Circuit simulation

Creating bus timetables with maximal synchronization by a new algorithm based on the PSO 17

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Creating bus timetables with maximal synchronization by a ne...

17th COTA International Conference of Transportation Professionals: Transportation Reform and Change - Equity, Inclusiveness, Sharing, and Innovation, CICTP 2017

作者： Tian, Daxin Liu, Wenhao Guo, Peng Rong, Hui Wang, Wenyang Gong, Jinfeng Wang, Yunpeng Liu, He Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang Univ. Beijing100191 China Beijing Key Laboratory for Cooperative Vehicle Infrastructure Systems and Safety Control School of Transportation Science and Engineering Beihang Univ. Beijing100191 China Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies Nanjing210096 China Quartermaster Equipment Institute of the General Logistics Dept. of CPLA Beijing100010 China

ISBN: (数字)9780784480915

ISBN: (纸本)9780784480915

This paper addresses the problem of receiving a timetable for a settled network with maximal synchronization. In this paper, a model has been developed to solve the problem which attaches importance to creating a timetable for maximizing their synchronization and enables the transfer of passengers from one route to another with least waiting times at transfer nodes. Next, this problem is formulated as a mixed integer linear programming problem, and a new algorithm based on the traditional particle swarm optimization (PSO) has been developed to solve the problem in a short time. Finally, the relationship of iterative time and the complexity of the given network is qualitatively established. © ASCE.

关键词： Synchronization

Segregated interactions in urban and online spaces

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arXiv 2019年

作者： Dong, Xiaowen Morales, Alfredo J. Jahani, Eaman Moro, Esteban Lepri, Bruno Bozkaya, Burcin Sarraute, Carlos Bar-Yam, Yaneer Pentland, Alex Department of Engineering Science University of Oxford Oxford United Kingdom MIT Media Lab CambridgeMA United States New England Complex Systems Institute CambridgeMA United States MIT Institute for Data Systems and Society CambridgeMA United States Department of Mathematics and GISC Universidad Carlos III de Madrid Leganés Spain Mobile and Social Computing Lab Fondazione Bruno Kessler Trento Italy Behavioral Analytics & Visualization Lab Sabancı University Istanbul Turkey New College of Florida SarasotaFL United States Grandata Labs Buenos Aires Argentina

Urban income segregation is a widespread phenomenon that challenges societies across the globe. Classical studies on segregation have largely focused on the geographic distribution of residential neighborhoods rather than on patterns of social behaviors and interactions. In this study, we analyze segregation in economic and social interactions by observing credit card transactions and Twitter mentions among thousands of individuals in three culturally different metropolitan areas. We show that segregated interaction is amplified relative to the expected effects of geographic segregation in terms of both shopping activity and online communication. Furthermore, we find that segregation increases with difference in socio-economic status but is asymmetric, i.e., the amount of interaction from poorer to wealthier neighborhoods is considerably larger than vice versa. Our results provide novel insights into the understanding of behavioral segregation in human interactions with significant socio-political and economic implications. Copyright © 2019, The Authors. All rights reserved.

关键词： Geographical distribution

Euclid preparation. XXXIX. The effect of baryons on the Halo Mass Function

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arXiv 2023年

作者： Castro, T. Borgani, S. Costanzi, M. Dakin, J. Dolag, K. Fumagalli, A. Ragagnin, A. Saro, A. Le Brun, A.M.C. Aghanim, N. Amara, A. Andreon, S. Auricchio, N. Baldi, M. Bardelli, S. Bodendorf, C. Bonino, D. Branchini, E. Brescia, M. Brinchmann, J. Camera, S. Capobianco, V. Carbone, C. Carretero, J. Casas, S. Castellano, M. Cavuoti, S. Cimatti, A. Congedo, G. Conselice, C.J. Conversi, L. Copin, Y. Corcione, L. Courbin, F. Courtois, H.M. Cropper, M. Da Silva, A. Degaudenzi, H. Di Giorgio, A.M. Dinis, J. Dubath, F. Duncan, C.A.J. Dupac, X. Farina, M. Farrens, S. Ferriol, S. Frailis, M. Franceschi, E. Fumana, M. Galeotta, S. Gillis, B. Giocoli, C. Grazian, A. Grupp, F. Haugan, S.V.H. Holmes, W. Hormuth, F. Hornstrup, A. Jahnke, K. Keihänen, E. Kermiche, S. Kiessling, A. Kilbinger, M. Kubik, B. Kunz, M. Kurki-Suonio, H. Ligori, S. Lilje, P.B. Lindholm, V. Lloro, I. Maiorano, E. Mansutti, O. Marggraf, O. Markovic, K. Martinet, N. Marulli, F. Massey, R. Maurogordato, S. Medinaceli, E. Meneghetti, M. Merlin, E. Meylan, G. Moresco, M. Moscardini, L. Munari, E. Niemi, S.-M. Padilla, C. Paltani, S. Pasian, F. Pettorino, V. Pires, S. Polenta, G. Poncet, M. Popa, L.A. Pozzetti, L. Raison, F. Rebolo, R. Renzi, A. Rhodes, J. Riccio, G. Romelli, E. Roncarelli, M. Saglia, R. Sapone, D. Sartoris, B. Schneider, P. Schrabback, T. Secroun, A. Seidel, G. Serrano, S. Sirignano, C. Sirri, G. Stanco, L. Starck, J.-L. Tallada-Crespí, P. Taylor, A.N. Tereno, I. Toledo-Moreo, R. Torradeflot, F. Tutusaus, I. Valentijn, E.A. Valenziano, L. Vassallo, T. Veropalumbo, A. Wang, Y. Weller, J. Zacchei, A. Zamorani, G. Zoubian, J. Zucca, E. Biviano, A. Bozzo, E. Cerna, C. Colodro-Conde, C. Di Ferdinando, D. Mauri, N. Neissner, C. Sakr, Z. Scottez, V. Tenti, M. Viel, M. Wiesmann, M. Akrami, Y. Anselmi, S. Baccigalupi, C. Ballardini, M. Borlaff, A.S. Bruton, S. Burigana, C. Cabanac, R. Cappi, A. Carvalho, C.S. INAF-Osservatorio Astronomico di Trieste Via G. B. Tiepolo 11 Trieste34143 Italy INFN Sezione di Trieste Via Valerio 2 TS Trieste34127 Italy IFPU Institute for Fundamental Physics of the Universe via Beirut 2 Trieste34151 Italy ICSC - Centro Nazionale di Ricerca in High Performance Computing Big Data e Quantum Computing Via Magnanelli 2 Bologna Italy Dipartimento di Fisica - Sezione di Astronomia Università di Trieste Via Tiepolo 11 Trieste34131 Italy Institute for Computational Science University of Zurich Winterthurerstrasse 190 Zurich8057 Switzerland Universitäts-Sternwarte München Fakultät für Physik Ludwig-Maximilians-Universität München Scheinerstrasse 1 München81679 Germany INAF-Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Via Piero Gobetti 93/3 Bologna40129 Italy Dipartimento di Fisica e Astronomia "Augusto Righi" Alma Mater Studiorum Università di Bologna via Piero Gobetti 93/2 Bologna40129 Italy Laboratoire Univers et Théorie Observatoire de Paris Université PSL Université Paris Cité CNRS Meudon92190 France Université Paris-Saclay CNRS Institut d'astrophysique spatiale Orsay91405 France Institute of Cosmology and Gravitation University of Portsmouth PortsmouthPO1 3FX United Kingdom INAF-Osservatorio Astronomico di Brera Via Brera 28 Milano20122 Italy Dipartimento di Fisica e Astronomia Università di Bologna Via Gobetti 93/2 Bologna40129 Italy INFN-Sezione di Bologna Viale Berti Pichat 6/2 Bologna40127 Italy Max Planck Institute for Extraterrestrial Physics Giessenbachstr. 1 Garching85748 Germany Pino Torinese10025 Italy Dipartimento di Fisica Università di Genova Via Dodecaneso 33 Genova16146 Italy INFN-Sezione di Genova Via Dodecaneso 33 Genova16146 Italy Department of Physics "E. Pancini" University Federico II Via Cinthia 6 Napoli80126 Italy INAF-Osservatorio Astronomico di Capodimonte Via Moiariello 16 Napoli80131 Italy INFN section of Naples Via Cinthia 6 Napoli80126 Italy Instit

The Euclid photometric survey of galaxy clusters stands as a powerful cosmological tool, with the capacity to significantly propel our understanding of the Universe. Despite being subdominant to dark matter and dark energy, the baryonic component of our Universe holds substantial influence over the structure and mass of galaxy clusters. This paper presents a novel model that can be used to precisely quantify the impact of baryons on the virial halo masses of galaxy clusters using the baryon fraction within a cluster as a proxy for their effect. Constructed on the premise of quasi-adiabaticity, the model includes two parameters, which are calibrated using non-radiative cosmological hydrodynamical simulations, and a single large-scale simulation from the Magneticum set, which includes the physical processes driving galaxy formation. As a main result of our analysis, we demonstrate that this model delivers a remarkable 1% relative accuracy in determining the virial dark matter-only equivalent mass of galaxy clusters starting from the corresponding total cluster mass and baryon fraction measured in hydrodynamical simulations. Furthermore, we demonstrate that this result is robust against changes in cosmological parameters and against variation of the numerical implementation of the subresolution physical processes included in the simulations. Our work substantiates previous claims regarding the impact of baryons on cluster cosmology studies. In particular, we show how neglecting these effects would lead to biased cosmological constraints for a Euclid-like cluster abundance analysis. Importantly, we demonstrate that uncertainties associated with our model arising from baryonic corrections to cluster masses are subdominant when compared to the precision with which mass-observable (i.e. richness) relations will be calibrated using Euclid and to our current understanding of the baryon fraction within galaxy clusters. Copyright © 2023, The Authors. All rights reserved.

关键词： Galaxies

SNe Ia from double detonations: Impact of core-shell mixing on the carbon ignition mechanism

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arXiv 2020年

作者： Gronow, Sabrina Collins, Christine Ohlmann, Sebastian T. Pakmor, Rüdiger Kromer, Markus Seitenzahl, Ivo R. Sim, Stuart A. Röpke, Friedrich K. Heidelberger Institut für Theoretische Studien Schloss-Wolfsbrunnenweg 35 Heidelberg69118 Germany Zentrum für Astronomie der Universität Heidelberg Astronomisches Rechen-Institut Mönchhofstr. 12-14 Heidelberg69120 Germany Astrophysics Research Center School of Mathematics and Physics Queen's University Belfast Belfast Northern IrelandBT7 1NN United Kingdom Max Planck Computing and Data Facility Gießenbachstraße 2 Garching85748 Germany Max Planck Institute for Astrophysics Karl-Schwarzschild-Straße 1 Garching85748 Germany Zentrum für Astronomie der Universität Heidelberg Institut für Theoretische Astrophysik Philosophenweg 12 Heidelberg69120 Germany School of Science University of New South Wales Australian Defence Force Academy CanberraACT2600 Australia

Sub-Chandrasekhar mass white dwarfs accreting a helium shell on a carbon-oxygen core are potential progenitors of normal Type Ia supernovae. This work focuses on the details of the onset of the carbon detonation in the double detonation sub-Chandrasekhar model. In order to simulate the influence of core-shell mixing on the carbon ignition mechanism, the helium shell and its detonation are followed with an increased resolution compared to the rest of the star treating the propagation of the detonation wave more accurately. This significantly improves the predictions of the nucleosynthetic yields from the helium burning. The simulations were carried out with the Arepo code. A carbon-oxygen core with a helium shell was set up in one dimension and mapped to three dimensions. We ensured the stability of the white dwarf with a relaxation step before the hydrodynamic detonation simulation started. Synthetic observables were calculated with the radiative transfer code Artis. An ignition mechanism of the carbon detonation was observed, which received little attention before. In this "scissors mechanism", the impact the helium detonation wave has on unburnt material when converging opposite to its ignition spot is strong enough to ignite a carbon detonation. This is possible in a carbon enriched transition region between the core and shell. The detonation mechanism is found to be sensitive to details of the core-shell transition and our models illustrate the need to consider core-shell mixing taking place during the accretion process. Even though the detonation ignition mechanism differs form the converging shock mechanism, the differences in the synthetic observables are not significant. Though they do not fit observations better than previous simulations, they illustrate the need for multi-dimensional simulations. Copyright © 2020, The Authors. All rights reserved.

关键词： Hydrodynamics

Comprehensive proteomics metadata and integrative web portals facilitate sharing and integration of LINCS multiomics data

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Molecular & cellular proteomics : MCP 2025年 100947页

作者： Dušica Vidović Behrouz Shamsaei Stephan C Schürer Phillip Kogan Szymon Chojnacki Michal Kouril Mario Medvedovic Wen Niu Evren U Azeloglu Marc R Birtwistle Yibang Chen Tong Chen Jens Hansen Bin Hu Ravi Iyengar Gomathi Jayaraman Hong Li Tong Liu Eric A Sobie Yuguang Xiong Matthew J Berberich Gary Bradshaw Mirra Chung Robert A Everley Ben Gaudio Marc Hafner Marian Kalocsay Caitlin E Mills Maulik K Nariya Peter K Sorger Kartik Subramanian Chiara Victor Maria Banuelos Victoria Dardov Ronald Holewinski Danica-Mae Manalo Berhan Mandefro Andrea D Matlock Loren Ornelas Dhruv Sareen Clive N Svendsen Vineet Vaibhav Jennifer E Van Eyk Vidya Venkatraman Steve Finkbiener Ernest Fraenkel Jeffrey Rothstein Leslie Thompson Jacob Asiedu Steven A Carr Karen E Christianson Desiree Davison Deborah O Dele-Oni Katherine C DeRuff Shawn B Egri Alvaro Sebastian Vaca Jacome Jacob D Jaffe Daniel Lam Lev Litichevskiy Xiaodong Lu James Mullahoo Adam Officer Malvina Papanastasiou Ryan Peckner Caidin Toder Joel Blanchard Michael Bula Tak Ko Li-Huei Tsai Jennie Z Young Vagisha Sharma Ajay Pillai Jarek Meller Michael J MacCoss BD2K-LINCS DCIC Department of Molecular and Cellular Pharmacology University of Miami Miami FL 33146 Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami FL 33146. BD2K-LINCS DCIC Department of Environmental and Public Health Sciences University of Cincinnati Cincinnati OH 45220. Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami FL 33146 BD2K-LINCS DCIC Institute for Data Science and Computing University of Miami FL 33146. DToxS Department of Pharmacological Sciences Icahn School of Medicine at Mount Sinai New York NY 10029. DToxS Department of Pharmacological Sciences Icahn School of Medicine at Mount Sinai New York NY 10029 DToxS Center for Advanced Proteomics Research Rutgers University New Jersey Medical School Newark NJ 07103. HMS LINCS Center Harvard Medical School Boston MA 02115. NeuroLINCS Cedars-Sinai Medical Center Los Angeles CA 90048. NeuroLINCS Gladstone Institute of Neurological Disease and the Departments of Neurology and Physiology University of California San Francisco San Francisco CA 94158. NeuroLINCS Department of Biological Engineering MIT Cambridge MA 02142. NeuroLINCS Department of Neuroscience Johns Hopkins University Baltimore MD 21205. NeuroLINCS Departments of Psychiatry and Human Behavior and Neurobiology and Behavior University of California Irvine Irvine CA 92697. PCCSE The Broad Institute of Harvard and MIT Cambridge MA 02142. PCCSE Picower Institute for Learning and Memory Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA 02139. PCCSE Department of Genome Sciences University of Washington Seattle WA 98195. NIH Bethesda MD 20892. BD2K-LINCS DCIC Department of Environmental and Public Health Sciences University of Cincinnati Cincinnati OH 45220. Electronic address: mellerj@ucmail.uc.edu. PCCSE Department of Genome Sciences University of Washington Seattle WA 98195. Electronic address: maccoss@uw.edu.

The Library of Integrated Network-based Cellular Signatures (LINCS), an NIH Common Fund program, has cataloged and analyzed cellular function and molecular activity profiles in response to >80,000 perturbing agents that are potentially disruptive to cells. Because of the importance of proteins and their modifications to the response of specific cellular perturbations, four of the six LINCS centers have included significant proteomics efforts in the characterization of the resulting phenotype. This manuscript aims to describe this effort and the data harmonization and integration of the LINCS proteomics data discussed in recent LINCS papers.

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