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Digital twins for the era of personalized surgery

npj Digital Medicine 2025年第1期8卷 1-8页

作者： Mekki, Yosra Magdi Luijten, Gijs Hagert, Elisabet Belkhair, Sirajeddin Varghese, Chris Qadir, Junaid Solaiman, Barry Bilal, Muhammad Dhanda, Jaghtar Egger, Jan Deng, Jun Khanduja, Vikas Frangi, Alejandro F. Zughaier, Susu M. Stotland, Mitchell A. College of Medicine Qatar University QU Health Doha Qatar Essen Germany Institute of Computer Graphics and Vision Graz University of Technology Graz Austria Essen Germany Aspetar Orthopedic- and Sports Medicine Hospital Doha Qatar Karolinska Institutet Department of Clinical Science and Education Stockholm Sweden Department of Neurosurgery Neuroscience Institute Hamad Medical Corporation Doha Qatar Weill Cornell Medicine - Qatar Doha Qatar Department of Surgery University of Auckland Auckland New Zealand College of Engineering Qatar University Doha Qatar Doha Qatar Faculty of Business Law and Social Sciences Birmingham City University Birmingham United Kingdom Head & Neck Unit Queen Victoria Hospital NHS Foundation Trust Grinstead West Sussex United Kingdom Essen Germany Department of Therapeutic Radiology Yale University New HavenCT United States Addenbrooke’s—Cambridge University Hospitals NHS Trust Cambridge United Kingdom University of Manchester Manchester United Kingdom Department of Computer Science School of Engineering University of Manchester Manchester United Kingdom NIHR Manchester Biomedical Research Centre Manchester Academic Health Sciences Centre University of Manchester Manchester United Kingdom Department of Cardiovascular Sciences KU Leuven Leuven Belgium KU Leuven Leuven Belgium The Christabel Pankhurst Institute The University of Manchester ManchesterM13 9PL United Kingdom Sidra Medicine Doha Qatar

Digital twins can aid surgeons in training and in performing interventions with greater awareness and precision. The range and variety of digital twins in surgery are described, and their use across perioperative care is discussed. While largely experimental, they are beginning to show promise for the enhancement of personalized, adaptive, and data-driven surgical care. Issues relevant to the greater adoption and deployment of digital twins are all considered. © The Author(s) 2025.

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Communication pattern based performance prediction on the NCUBE 2 multiprocessor system 3rd

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3rd Joint International Conference on Vector and Parallel Processing, CONPAR 1994 - VAPP VI

作者： Wabnig, H. Haring, G. Kranzlmüller, D. Volkert, J. University of Vienna Institute of Applied Computer Science and Information Systems Dept of Advanced Computer Engineering Lenaugasse 2/8 ViennaA-1080 Austria University Linz Institute of Computer Science Dept of Graphics and Parallel Processing Altenbergerstr. 69 LinzA-4040 Austria

ISBN: (纸本)9783540584308

This paper shows the usage of the PAPS toolset for performance prediction on the nCUBE 2 multiprocessor system. Two Petri net models for communication on the nCUBE 2 with different levels of accuracy are developed and investigated. The representation of network contention within the Petri net models is validated for the message broadcast communication pattern. Parameter values for communication are determined for the nCUBE 2 machine. A parallel implementation of the Gaussian elimination algorithm is used to investigate the accuracy of the predicted absolute execution time depending on the choosen Petri net communication model. © Springer-Verlag Berlin Heidelberg 1994.

关键词： Petri nets

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Providing high-level control and expert assistance in the user interface presentation design 93

Providing high-level control and expert assistance in the us...

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Proceedings of the INTERCHI '93 Conference on Human Factors in Computing Systems

作者： Kim, Won Chul Foley, James D. Department of Electrical Engineering and Computer Science The George Washington University Washington DC Graphics Visualization and Usability Center College of Computing Georgia Institute of Technology Atlanta GA

ISBN: (纸本)9051991339

Current user interface builders provide only low-level assistance, because they have knowledge of neither the application, nor the principles by which interface elements are combined effectively. We have developed a framework that unites the knowledge components essential for effective user interface presentation design. The framework consists of an application model (both a data model and a control model), a design process model that supports top-down iterative development, and graphic design knowledge that is used both to place dialog box elements such that their application dependent logical relationships are visually reinforced and to control design symmetry and balance. To demonstrate the framework's viability, we have constructed a tool based on encapsulated design knowledge that establishes high-level style preferences and provides expert assistance for the dialog box presentation design and menu structuring.

关键词： UI design process

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Surface deformation with low shape error

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Journal of Information and Computational Science 2012年第16期9卷 4681-4689页

作者： Liu, Jiongzhou Li, Jituo Lu, Guodong Wang, Bei Institute of Engineering and Computer Graphics Department of Mechanical Engineering Zhejiang University Hangzhou 310027 China

Realistic surface deformation is extremely important for animation and virtual design. In this paper, a practicable approach for deforming mesh surface with low shape error is proposed. The low shape error deformation is obtained by preserving both the edge lengths and inner angles of the mesh elements, which can be achieved by minimizing a carefully designed constrained deformation energy. The deformation energy is minimized by solving a linear equation system. Experiments show that our approach yields natural deformation results in a high efficiency. © 2012 Binary Information Press.

关键词： Deformation

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Robust computation of subcortical functional connectivity guided by quantitative susceptibility mapping: An application in Parkinson's disease diagnosis

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NeuroImage 2025年 314卷 121256-121256页

作者： Qin, Jianmei Wu, Haoting Wu, Chenqing Guo, Tao Zhou, Cheng Duanmu, Xiaojie Tan, Sijia Wen, Jiaqi Zheng, Qianshi Yuan, Weijin Zhu, Zihao Chen, Jingwen Wu, Jingjing He, Chenyu Ma, Yiran Liu, Chunlei Xu, Xiaojun Guan, Xiaojun Zhang, Minming Department of Radiology the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Joint Laboratory of Clinical Radiology the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China State Key Laboratory of Computer-aided Design & Computer Graphics Zhejiang University College of Computer Science and technology Hangzhou China State Key Laboratory of Industrial Control Technology Zhejiang University College of Control Science and Engineering Hangzhou China Department of Electrical Engineering and Computer Sciences University of California Berkeley CA United States Helen Wills Neuroscience Institute University of California Berkeley CA United States

Previous resting state functional MRI (rs-fMRI) analyses of the basal ganglia in Parkinson's disease heavily relied on T1-weighted imaging (T1WI) atlases. However, subcortical structures are characterized by subtle contrast differences, making their accurate delineation challenging on T1WI. In this study, we aimed to introduce and validate a method that incorporates quantitative susceptibility mapping (QSM) into the rs-fMRI analytical pipeline to achieve precise subcortical nuclei segmentation and improve the stability of RSFC measurements in Parkinson's disease. A total of 321 participants (148 patients with Parkinson's Disease and 173 normal controls) were enrolled. We performed cross-modal registration at the individual level for rs-fMRI to QSM (FUNC2QSM) and T1WI (FUNC2T1), *** consistency and accuracy of resting state functional connectivity (RSFC) measurements in two registration approaches were assessed by intraclass correlation coefficient and mutual information. Bootstrap analysis was performed to validate the stability of the RSFC differences between Parkinson's disease and normal controls. RSFC-based machine learning models were constructed for Parkinson's disease classification, using optimized hyperparameters (RandomizedSearchCV with 5-fold cross-validation). The consistency of RSFC measurements between the two registration methods was poor, whereas the QSM-guided approach showed better mutual information values, suggesting higher registration accuracy. The disruptions of RSFC identified with the QSM-guided approach were more stable and reliable, as confirmed by bootstrap analysis. In classification models, the QSM-guided method consistently outperformed the T1WI-guided method, achieving higher test-set ROC-AUC values (FUNC2QSM: 0.87–0.90, FUNC2T1: 0.67–0.70). The QSM-guided approach effectively enhanced the accuracy of subcortical segmentation and the stability of RSFC measurement, thus facilitating future biomarker development in Parkinso

关键词： Parkinson's disease Quantitative susceptibility mapping Resting-state functional connectivity Subcortical nuclei

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Modeling mechanical CAD data with data abstraction and object-oriented techniques 2

Modeling mechanical CAD data with data abstraction and objec...

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2nd IEEE International Conference on Data engineering, COMPDEC 1986

作者： Spooner, David L. Milicia, Michael A. Faatz, Donald B. Center for Interactive Computer Graphics Rensselaer Polytechnic Institute TroyNY12180 United States Computer Science Department Rensselaer Polytechnic Institute TroyNY12180 United States Electrical Computer and Systems Engineering Department Rensselaer Polytechnic Institute TroyNY12180 United States

This paper focuses on the problem of management of CAD data by investigating the use of the software engineering principles of data abstraction and object-oriented programming as means for managing the volume and complexity of design data. It discusses how a data management system which manages abstract data types provides a framework for integrating a CAD environment by providing a single mechanism to manage data, programs, and the manipulation of the data with the programs. It also shows how two forms of abstraction, aggregation and generalization, can be used to model hierarchies of parts and components, and multiple design alternatives, respectively. These abstractions are then used to model the geometrical and topological data required to describe three-dimensional mechanical parts. © 1986 IEEE.

关键词： computer aided design

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Constrained optimization applied to the parameter setting problem for analog circuits 91

Constrained optimization applied to the parameter setting pr...

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Proceedings of the 5th International Conference on Neural Information Processing Systems

作者： David Kirk Kurt Fleischer Lloyd Watts Alan Barr Computer Graphics California Institute of Technology Pasadena CA Computer Graphics California Institute of Technology Pasadena CA and Dept of Electrical Engineering

ISBN: (纸本)9781558602229

We use constrained optimization to select operating parameters for two circuits: a simple 3-transistor square root circuit, and an analog VLSI artificial cochlea. This automated method uses computer controlled measurement and test equipment to choose chip parameters which minimize the difference between the actual circuit's behavior and a specified goal behavior. Choosing the proper circuit parameters is important to compensate for manufacturing deviations or adjust circuit performance within a certain range. As biologically-motivated analog VLSI circuits become increasingly complex, implying more parameters, setting these parameters by hand will become more cumbersome. Thus an automated parameter setting method can be of great value [Fleischer 90]. Automated parameter setting is an integral part of a goal-based engineering design methodology in which circuits are constructed with parameters enabling a wide range of behaviors, and are then "tuned" to the desired behaviors automatically.

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A Web adaptive educational system for people with hearing difficulties

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Education and Information Technologies 2000年第3期5卷 189-200页

作者： Markellou, Penelope Rigou, Maria Sirmakessis, Spiros Tsakalidis, Athanasios Computer Engineering and Informatics Department Multimedia Graphics and GIS Lab. University of Patras Patras 26500 Greece Internet and Multimedia Technologies Research Unit Computer Technology Institute Patras 26221 61 Riga Feraiou Str. Greece

In this paper we present a web adaptive educational tool for the Greek Sign Language. The design and the implementation of the tool were partially funded by national bodies. The paper presents the architecture of the tool, in an abstract way and briefly describes its functionality. The interaction process followed is also presented. © 2000 Kluwer Academic Publishers.

关键词： Architecture Hearing difficulties Interactive learning Sign language

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A Three-Dimensional Edge Operator

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IEEE Transactions on Pattern Analysis and Machine Intelligence 1981年第3期PAMI-3卷 324-331页

作者： Zucker, Steven W. Hummel, Robert A. Computer Vision and Graphics Laboratory Department of Electrical Engineering McGill University Montreal P.Q. Canada Courant Institute New York University New York NY 10003 United States

Modern scanning techniques, such as computed tomography, have begun to produce true three-dimensional imagery of internal structures. The first stage in finding structure in these images, like that for standard two-dimensional images, is to evaluate a local edge operator over the image. If an edge segment in two dimensions is modeled as an oriented unit line segment that separates unit squares (Le., pixels) of different intensities, then a three-dimensional edge segment is an oriented unit plane that separates unit volumes (i.e., voxels) of different intensities. In this correspondence we derive an operator that finds the best oriented plane at each point in the image. This operator, which is based directly on the 3-D problem, complements other approaches that are either interactive or heuristic extensions of 2-D techniques. Copyright © 1981 by The institute of Electrical and Electronics Engineers, Inc.

关键词： computerized tomography (CT) edge detection feature detection three-dimensional edge operators three-dimensional modeling

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A variational method for accurate distance function estimation 9th

A variational method for accurate distance function estimati...

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9th International Conference on Numerical Geometry, Grid Generation, and Scientific Computing, celebrating the 150th anniversary of Georgy F. Voronoi, NUMGRID 2018

作者： Belyaev, Alexander G. Fayolle, Pierre-Alain Institute of Sensors Signals and Systems School of Engineering & Physical Sciences Heriot-Watt University Edinburgh United Kingdom Computer Graphics Laboratory University of Aizu Aizu-Wakamatsu Japan

Variational problems for accurate approximation of the distance from the boundary of a domain are studied. It is demonstrated that the problems can be efficiently solved by ADMM. Advantages of the proposed distance fu... 详细信息

ISBN: (纸本)9783030234355

关键词： Numerical methods

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