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Medicine-engineering interdisciplinary researches for addiction: Opportunities and challenges

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Meta-Radiology

Meta-Radiology 2023年第2期1卷

作者： Wen, Xinwen Du, Zhe Wang, Zhen Xu, Yu Wang, Kunhua Yu, Dahua Liu, Jun Yuan, Kai School of Life Science and Technology Xidian University Shaanxi Xi'an 710126 China Yunnan University Yunnan Kunming 650500 China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing School of Information Engineering Inner Mongolia University of Science and Technology Inner Mongolia Baotou 014010 China Department of Radiology Second Xiangya Hospital Central South University Changsha 410011 China Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Shaanxi Xi'an 710126 China Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information School of Life Science and Technology Xidian University Shaanxi Xi'an 710126 China

Advances in neuroscience have suggested that addiction is not only an ongoing dynamic transaction between the person, their behavior, and the environment, but a disturbance of neurotransmitters in neurons involved in reward, memory, and cognitive control. Although the neural mechanism of addiction is complex and heterogeneous, previous addiction recovery and treatment studies have proven that addiction is amenable to treatment and recovery. At present, addiction treatment faces great challenges as well as many opportunities. The field of biomedical engineering is and will be at the forefront of these accelerating disciplines based on advances in imaging, genomics, systems medicine, molecular and cellular engineering, and other biomedical sciences. Thus, we propose several perspectives to accelerate the development of advanced and scientific approaches for addiction treatment: early prevention is better than cure and addiction treatment should focus on individualized regulation, whole-body interaction and the translation of effective animal models to human. © 2023 The Authors

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Reward processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker

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BIOLOGICAL PSYCHIATRY 2021年第8期90卷 529-539页

作者： Qi, Shile Schumann, Gunter Bustillo, Juan Turner, Jessica A. Jiang, Rongtao Zhi, Dongmei Fu, Zening Mayer, Andrew R. Vergara, Victor M. Silva, Rogers F. Iraji, Armin Chen, Jiayu Damaraju, Eswar Ma, Xiaohong Yang, Xiao Stevens, Michael Mathalon, Daniel H. Ford, Judith M. Voyvodic, James Mueller, Bryon A. Belger, Aysenil Potkin, Steven G. Preda, Adrian Zhuo, Chuanjun Xu, Yong Chu, Congying Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Quinlan, Erin Burke Desrivieres, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Martinot, Jean-Luc Martinot, Marie-Laure Paillere Artiges, Eric Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomas Poustka, Luise Hohmann, Sarah Frohner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Calhoun, Vince D. Sui, Jing [a]Tri-institutional Center for Translational Research in Neuroimaging and Data Science Georgia State University Georgia Institute Technology and Emory University Atlanta Georgia [b]Department of Psychiatry University of New Mexico Albuquerque New Mexico [c]Department of Psychology Georgia State University Atlanta Georgia [d]Olin Neuropsychiatry Research Center Hartford Connecticut [e]Department of Psychiatry University of California San Francisco San Francisco California [f]Department of Radiology Duke University Durham North Carolina [g]Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill North Carolina [h]Department of Psychiatry University of Minnesota Minneapolis Minnesota [i]Department of Psychiatry University of California Irvine Irvine California [j]Departments of Psychiatry and Psychology University of Vermont Burlington Vermont [k]Centre for Population Neuroscience and Stratified Medicine Institute for Science and Technology of Brain-Inspired Intelligence Fudan University Shanghai China [l]University of Chinese Academy of Sciences Beijing China [dd]Department of Computer Science and Engineering Nanjing University of Aeronautics and Astronautics Nanjing China [m]Brainnetome Center and National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing China [ee]State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China [n]Psychiatric Laboratory and Mental Health Center the State Key Laboratory of Biotherapy West China Hospital of Sichuan University Chengdu China [o]Department of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory Nankai University Affiliated Anding Hospital Tianjin China [p]Department of Humanities and Social Science Shanxi Medical University Taiyuan China [q]Department of Psychiatry and Psychotherapy Charité – Universitätsmedizin Berlin Campus Charité Mitte corporate member of Freie Universität Berlin Humboldt-Univers

BACKGROUND: Dysfunctional reward processing is implicated in multiple mental disorders. Novelty seeking (NS) assesses preference for seeking novel experiences, which is linked to sensitivity to reward environmental cues. METHODS: A subset of 14-year-old adolescents (imageN) with the top 20% ranked high-NS scores was used to identify high-NS-associated multimodal components by supervised fusion. These features were then used to longitudinally predict five different risk scales for the same and unseen subjects (an independent dataset of subjects at 19 years of age that was not used in predictive modeling training at 14 years of age) (within imageN, n z 1100) and even for the corresponding symptom scores of five types of patient cohorts (non-imageN), including drinking (n = 313), smoking (n = 104), attention-deficit/hyperactivity disorder (n = 320), major depressive disorder (n = 81), and schizophrenia (n = 147), as well as to classify different patient groups with diagnostic labels. RESULTS: Multimodal biomarkers, including the prefrontal cortex, striatum, amygdala, and hippocampus, associated with high NS in 14-year-old adolescents were identified. The prediction models built on these features are able to longitudinally predict five different risk scales, including alcohol drinking, smoking, hyperactivity, depression, and psychosis for the same and unseen 19-year-old adolescents and even predict the corresponding symptom scores of five types of patient cohorts. Furthermore, the identified reward-related multimodal features can classify among attention-deficit/hyperactivity disorder, major depressive disorder, and schizophrenia with an accuracy of 87.2%. CONCLUSIONS: Adolescents with higher NS scores can be used to reveal brain alterations in the reward-related system, implicating potential higher risk for subsequent development of multiple disorders. The identified high-NS- associated multimodal reward-related signatures may serve as a transdiagnostic neuroimaging bi

关键词： ADHD Attention-deficit/hyperactivity disorder Major depressive disorders MDD Novelty seeking Reward processing Schizophrenia Substance use

Efficient image Super-Resolution with Feature Interaction Weighted Hybrid Network

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arXiv 2022年

作者： Li, Wenjie Li, Juncheng Gao, Guangwei Deng, Weihong Yang, Jian Qi, Guo-Jun Lin, Chia-Wen Pattern Recognition and Intelligent System Laboratory School of Artificial Intelligence Beijing University of Posts and Telecommunications Beijing100080 China Intelligent Visual Information Perception Laboratory Institute of Advanced Technology Nanjing University of Posts and Telecommunications Nanjing210046 China Key Laboratory of Artificial Intelligence Ministry of Education Shanghai200240 China Provincial Key Laboratory for Computer Information Processing Technology Soochow University Suzhou215006 China School of Communication and Information Engineering Shanghai University Shanghai200444 China School of Computer Science and Technology Nanjing University of Science and Technology Nanjing210094 China Research Center for Industries of the Future the School of Engineering Westlake University Hangzhou310024 China OPPO Research SeattleWA98101 United States Department of Electrical Engineering National Tsing Hua University Hsinchu30013 Taiwan

Lightweight image super-resolution aims to reconstruct high-resolution images from low-resolution images using low computational costs. However, existing methods result in the loss of middle-layer features due to activation functions. To minimize the impact of intermediate feature loss on reconstruction quality, we propose a Feature Interaction Weighted Hybrid Network (FIWHN), which comprises a series of Wide-residual Distillation Interaction Block (WDIB) as the backbone. Every third WDIB forms a Feature Shuffle Weighted Group (FSWG) by applying mutual information shuffle and fusion. Moreover, to mitigate the negative effects of intermediate feature loss, we introduce Wide Residual Weighting units within WDIB. These units effectively fuse features of varying levels of detail through a Wide-residual Distillation Connection (WRDC) and a Self-Calibrating Fusion (SCF). To compensate for global feature deficiencies, we incorporate a Transformer and explore a novel architecture to combine CNN and Transformer. We show that our FIWHN achieves a favorable balance between performance and efficiency through extensive experiments on low-level and high-level tasks. Codes will be available at https://***/IVIPLab/FIWHN. Copyright © 2022, The Authors. All rights reserved.

关键词： image reconstruction

NTIRE 2021 Challenge on image Deblurring

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arXiv 2021年

作者： Nah, Seungjun Son, Sanghyun Lee, Suyoung Timofte, Radu Lee, Kyoung Mu Chen, Liangyu Zhang, Jie Lu, Xin Chu, Xiaojie Chen, Chengpeng Xiong, Zhiwei Xu, Ruikang Xiao, Zeyu Huang, Jie Zhang, Yueyi Xi, Si Wei, Jia Bai, Haoran Cheng, Songsheng Wei, Hao Sun, Long Tang, Jinhui Pan, Jinshan Lee, Donghyeon Lee, Chulhee Kim, Taesung Wang, Xiaobing Zhang, Dafeng Pan, Zhihong Lin, Tianwei Wu, Wenhao He, Dongliang Li, Baopu Li, Boyun Xi, Teng Zhang, Gang Liu, Jingtuo Han, Junyu Ding, Errui Tao, Guangpin Chu, Wenqing Cao, Yun Luo, Donghao Tai, Ying Lu, Tong Wang, Chengjie Li, Jilin Huang, Feiyue Chen, Hanting Chen, Shuaijun Guo, Tianyu Wang, Yunhe Zamir, Syed Waqas Arora, Aditya Khan, Salman Hayat, Munawar Khan, Fahad Shahbaz Shao, Ling Zuo, Yushen Ou, Yimin Chai, Yuanjun Shi, Lei Liu, Shuai Lei, Lei Feng, Chaoyu Zeng, Kai Yao, Yuying Liu, Xinran Zhang, Zhizhou Huang, Huacheng Zhang, Yunchen Jiang, Mingchao Zou, Wenbin Miao, Si Kim, Yangwoo Sun, Yuejin Deng, Senyou Ren, Wenqi Cao, Xiaochun Wang, Tao Suin, Maitreya Rajagopalan, A.N. Duong, Vinh Van Nguyen, Thuc Huu Yim, Jonghoon Jeon, Byeungwoo Li, Ru Xie, Junwei Han, Jong-Wook Choi, Jun-Ho Kim, Jun-Hyuk Lee, Jong-Seok Zhang, Jiaxin Peng, Fan Svitov, David Pakulich, Dmitry Kim, Jaeyeob Jeong, Jechang Department of ECE ASRI SNU Korea Republic of Computer Vision Lab ETH Zurich Switzerland University of Science and Technology of China China Megvii China Fudan University China Peking University China Netease Games AI Lab Nanjing University of Science and Technology China Guilin University of Electronic Technology China Samsung Electronics Co. Ltd Sunmoon University Asan Korea Republic of Samsung Research China Beijing China Baidu Research United States Department of Computer Vision Technology Baidu Inc China Fudan University China Megvii China Nanjing University China Tencent Noah's Ark Lab Huawei Technologies Co. Ltd Inception Institute of Artificial Intelligence Tsinghua University Beijing China North China University of Technology China Xiaomi South China University of Technology China Lab of Image Science and Technology Southeast University China China Design Group Co. Ltd China JOYY AI GROUP Fujian Normal University China Shanghai Advanced Research Institute Chinese Academy of Sciences China Institute of Information Engineering Chinese Academy of Sciences China Huawei Noah's Ark Lab Indian Institute of Technology Madras India Department of ECE Sungkyunkwan University Korea Republic of Fuzhou University China Imperial Vision Co. Ltd School of Integrated Technology Yonsei University Korea Republic of Expasoft LLC Institute of Automation and Electrometry The SB RAS Image Communication & Signal Processing Laboratory Hanyang University Korea Republic of

Motion blur is a common photography artifact in dynamic environments that typically comes jointly with the other types of degradation. This paper reviews the NTIRE 2021 Challenge on image Deblurring. In this challenge report, we describe the challenge specifics and the evaluation results from the 2 competition tracks with the proposed solutions. While both the tracks aim to recover a high-quality clean image from a blurry image, different artifacts are jointly involved. In track 1, the blurry images are in a low resolution while track 2 images are compressed in JPEG format. In each competition, there were 338 and 238 registered participants and in the final testing phase, 18 and 17 teams competed. The winning methods demonstrate the state-of-the-art performance on the image deblurring task with the jointly combined artifacts. © 2021, CC BY-NC-ND.

关键词： image enhancement

Acceptance and generation of general wave by a natural observation filter

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ELECTRONICS AND COMMUNICATIONS IN JAPAN PART III-FUNDAMENTAL ELECTRONIC SCIENCE 1995年第11期78卷 1-8页

作者： Iijima, T Honorary Member Japan Advanced Institute of Science and Technology Ishikawa Japan 923-12 Taizo lijima:graduated with a B.E. degree from the Tokyo Institute of Technology in 1948 and received his Ph.D. degree later. He joined the Electro-Technical Laboratories in 1948and since then has been involved in research on electromagnetic theory pattern recognition theory image processing voice recognition and research and development of OCR etc. After serving as the head of Iijima Special Research Laboratories he became Professorat the Tokyo Institute of Technology in 1972. Later he became the Professor Emeritus of that Institute in 1986. He became a Professor at Tokyo Engineering University and Professor Emeritus of that University in 1991. In 1991 he became Professor at the Japan Advanced Institute of Science and Technology and was appointed Vice President of that Institute in 1992. He served successively as editor examiner secretary of general affairs inspector councilor committee-head of pattern recognition and specialized studies head of Tokyo chapter and vice president of this Institute. In 1991 he became the Honorary Member.He received the Paper Award from the Institute four times and the literary works Award once. He received the Achievement Award and the Distinguished Service Award in 1976 and 1989 respectively. He received the Purple Ribbon Medal from the Emperor in 1988.

During the past few years, there has been a series of papers published on the theory of the natural observation method. As one of the important applications of this theory, the problems of acceptance and generation of a general waveform are discussed here. The case of polynomial waveforms and its corresponding theory was published previously. A great extension of that theory which covers general waveforms is presented here and its full picture is clarified.

关键词： natural observation filter acceptance of a wave generation of a wave theory of natural observation of the normal type

Design and implementation of a clock recovery circuit for fast Ethernet applications

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Chinese Journal of Systems Engineering and Electronics 2004年第4期000卷

A circuit architechure to realize clock recovery for fast Ethernet applications is presented, whick includies system architecture, modified Mueller Muller algorithm for 100BASE-TX, phase detector for 100BASE-TX and multiple output charge pump PLL. The clock recovery circuit is verified by TSMC 0.35um 1P5M CMOS process. The results show that this clock recovery circuit exactly extracts the timing information. It has advantages over others for simple and easy implementation.

关键词： clock recovery phase locked loop adaptive equalizer

Overview of the CCKS 2019 knowledge graph evaluation track: Entity, relation, event and QA

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arXiv 2020年

作者： Han, Xianpei Wang, Zhichun Zhang, Jiangtao Wen, Qinghua Li, Wenqi Tang, Buzhou Wang, Qi Feng, Zhifan Zhang, Yang Lu, Yajuan Wang, Haitao Chen, Wenliang Shao, Hao Chen, Yubo Liu, Kang Zhao, Jun Wang, Taifeng Zhang, Kezun Wang, Meng Jiang, Yinlin Qi, Guilin Zou, Lei Hu, Sen Zhang, Minhao Lin, Yinnian Chinese Information Processing Laboratory Institute of Software Chinese Academy of Sciences Beijing100190 China School of Artificial Intelligence Beijing Normal University Beijing100875 China 305 Hospital of People’s Liberation Army Beijing100017 China Department of Computer Science and Technology Tsinghua University Beijing100084 China Yidu Cloud Beijing100000 China Harbin Institute of Technology Shenzhen Guangdong518055 China Baidu Beijing100193 China School of Computer Science & Technology Soochow University Suzhou Jiangsu215006 China Gowild Suzhou Jiangsu215002 China National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing100190 China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing100049 China Ant Financial Hangzhou Zhejiang310000 China School of Computer Science and Engineering Southeast University Nanjing Jiangsu211189 China Key Laboratory of Computer Network Information Integration Southeast University Nanjing Jiangsu211189 China Peking University Beijing100871 China

Knowledge graph models world knowledge as concepts, entities, and the relationships between them, which has been widely used in many real-world tasks. CCKS 2019 held an evaluation track with 6 tasks and attracted more than 1,600 teams. In this paper we give an overview of the knowledge graph evaluation tract at CCKS 2019. By reviewing the task definition, successful methods, useful resources, good strategies and research challenges associated with each task in CCKS 2019, this paper can provide a helpful reference for developing knowledge graph applications and conducting future knowledge graph researches. Copyright © 2020, The Authors. All rights reserved.

关键词： Knowledge graph

Addendum to “Hum-PLoc: A novel ensemble classifier for predicting human protein subcellular localization” [Biochem. Biophys. Res. Commun. 347 (2006) 150–157]

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Biochemical and Biophysical Research Communications 2006年第4期348卷 1479-1479页

作者： Kuo-Chen Chou Hong-Bin Shen Gordon Life Science Institute 13784 Torrey Del Mar Drive San Diego CA 92130 USA Institute of Image Processing and Pattern Recognition Shanghai Jiaotong University 1954 Hua-Shan Road Shanghai 200030 China

REFUGE2 CHALLENGE: A TREASURE TROVE FOR MULTI-DIMENSION ANALYSIS AND EVALUATION IN GLAUCOMA SCREENING

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arXiv 2022年

作者： Fang, Huihui Li, Fei Wu, Junde Fu, Huazhu Sun, Xu Son, Jaemin Yu, Shuang Zhang, Menglu Yuan, Chenglang Bian, Cheng Lei, Baiying Zhao, Benjian Xu, Xinxing Li, Shaohua Fumero, Francisco Sigut, José Almubarak, Haidar Bazi, Yakoub Guo, Yuanhao Zhou, Yating Baid, Ujjwal Innani, Shubham Guo, Tianjiao Yang, Jie Orlando, José Ignacio Bogunović, Hrvoje Zhang, Xiulan Xu, Yanwu The REFUGE2 Challenge Australia State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Intelligent Healthcare Unit Baidu Inc. Beijing China The Institute of High Performance Computing Agency for Science Technology and Research Singapore Yatiris Group PLADEMA Institute CONICET UNICEN Tandil Argentina Christian Doppler Lab for Artificial Intelligence in Retina Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria VUNO Inc Seoul Korea Republic of Tencent HealthCare Tencent Shenzhen China Computer Vision Institute College of Computer Science and Software Engineering of Shenzhen University Shenzhen China School of Biomedical Engineering Health Science Center Shenzhen University China Xiaohe Healthcare ByteDance Guangdong Guangzhou510000 China School of Biomedical Engineering Shenzhen University China College of Computer Science & Software Engineering Shenzhen University China Department of Computer Science and Systems Engineering Universidad de La Laguna Spain Saudi Electronic University Saudi Arabia King Saud University Saudi Arabia Institute of Automation Chinese Academy of Sciences Beijing China University of Chinese Academy of Sciences Beijing China SGGS Institute of Engineering and Technology India Institute of Medical Robotics Shanghai Jiao Tong University China Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University China

With the rapid development of artificial intelligence (AI) in medical image processing, deep learning in color fundus photography (CFP) analysis is also evolving. Although there are some open-source, labeled datasets of CFPs in the ophthalmology community, large-scale datasets for screening only have labels of disease categories, and datasets with annotations of fundus structures are usually small in size. In addition, labeling standards are not uniform across datasets, and there is no clear information on the acquisition device. Here we release a multi-annotation, multi-quality, and multi-device color fundus image dataset for glaucoma analysis on an original challenge-Retinal Fundus Glaucoma Challenge 2nd Edition (REFUGE2). The REFUGE2 dataset contains 2000 color fundus images with annotations of glaucoma classification, optic disc/cup segmentation, as well as fovea localization. Meanwhile, the REFUGE2 challenge sets three sub-tasks of automatic glaucoma diagnosis and fundus structure analysis and provides an online evaluation framework. Based on the characteristics of multi-device and multi-quality data, some methods with strong generalizations are provided in the challenge to make the predictions more robust. This shows that REFUGE2 brings attention to the characteristics of real-world multi-domain data, bridging the gap between scientific research and clinical application. © 2022, CC BY-NC-ND.

关键词： Color