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Statistical analysis of retinal tomographic pseudo images for diagnostic purpose

Journal of Mathematical Modelling and Algorithms 2010年第3期9卷 257-273页

作者： Bruni, C. de Juan, J. Ferrone, C. Giannini, D. Grzywacz, N.M. Huang, D. Koch, G. Russo, V. Tan, O. D.I.S. Department University La Sapienza 00185 Rome Via Ariosto 25 Italy Department of Biotechnology University of Alicante Alicante Spain Departments of Biomedical and Electrical Engineering Neuroscience Graduate Program Center for Vision Science and Technology University of Southern California Los Angeles United States Department of Ophthalmology and Doheny Eye Institute University of Southern California Los Angeles United States

The majority of visual impairments are related to retinal disorders. Therefore, techniques useful for early detection of retinal anomalies are of great interest for diagnosis and treatment of related pathologies. Optical Coherence Tomography (OCT) is a non-invasive technique that is becoming increasingly important in the analysis of human retina. This technique produces sections of a three dimensional reflectance map, which are pseudo-images of the retinal structure. In these pseudo-images, early pathologies may produce local modifications of reflectance, which visually, appear as blots. Consequently, automatic procedures for detection of such blots may be of help in the diagnosis of many retinal diseases. Due to the complexity of the measurement technique and of the retinal structure, the pseudo-images produced by OCT can be modeled as 2D random signals: the above pathological blots correspond to sudden changes in the distribution of such OCT signals. In this work, we performed a statistical analysis of retinal OCT data. We found that the so-called stretched-exponential distribution, a two-parameter probability density function, provides a model that describes the data in a satisfactory way. In addition, we analyzed spatial-reflectance interdependence by studying the autocorrelation function;this analysis showed a significant correlation between contiguous pixels about 5 μm apart. We then developed a procedure to obtain the maximum-likelihood estimate of distribution parameters along the retinal pseudo-image. With this procedure, we analyzed their spatial dependence both along and across retinal layers. We observed that along suitable thin layers, the two parameters were statistically constant. By exploiting this result, a statistical procedure was developed for automatic detection of parameter variations due to retinal pathological blots. Some first results are reported for detection of diabetic retinopathy. © 2010 Springer Science+Business Media B.V.

关键词： Diabetic retinopathy Optical coherence tomography Retinal pseudo-images Statistical analysis

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UAV relay network to support WSN connectivity

UAV relay network to support WSN connectivity

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International Conference on Ultra Modern Telecommunications and Workshops (ICUMT)

作者： Edison Pignaton de Freitas Tales Heimfarth Ivayr Farah Netto Carlos Eduardo Lino Carlos Eduardo Pereira Armando Morado Ferreira Flávio Rech Wagner Tony Larsson IDE Halmstad University Halmstad Sweden Institute of Informatics Federal University of Rio Grande do Sul Porto Alegre Brazil Computer Science Department Federal University of Lavras Lavras Brazil Defense Engineering Graduate Program Military Institute of Engineering Rio de Janeiro Brazil

An important problem in Wireless Sensor Networks (WSN) is the occurrence of failures that lead to the disconnection of parts of the network, compromising the final results achieved by the WSN operation. A way to overcome such problem is to provide a reliable connection to support the connectivity via other types of nodes that communicate with the sensor nodes. This paper proposes the usage of a network composed by Unmanned Aerial Vehicles (UAVs) as a relay network to guarantee the delivery of data produced by WSN nodes on the ground to the users. Results from simulations of the proposed technique are provided and discussed.

关键词： Base stations Unmanned aerial vehicles Mobile communication Wireless sensor networks Peer to peer computing Mobile computing Relays

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A multi-source micro power generator employing thermal and vibration energy harvesting

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Procedia engineering 2010年 5卷 1176-1179页

作者： Hakan Töreyin Emre Topal Haluk Külah Middle East Technical University Department of Electrical and Electronics Engineering Ankara Turkey Middle East Technical University Micro and Nano Technologies Graduate Program Ankara Turkey METU-MEMS Research and Application Center Ankara TURKEY * Currently with School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta U.S.A.

This paper introduces a new cantilever type multi-source energy harvester generating electric power from both ambient heat and vibration. Harvesting energy from vibration was realized by electromagnetic conversion, whereas the energy generation from heat was supplied by making use of Seebeck effect of Cr–Al thermocouples implemented on the microcantilevers. The measured average Seebeck coefficient is 12 μV/K per thermocouple. A total voltage of 3.3 mV was generated from the thermoelectric part and 13.4 mV from the electromagnetic part of the device. Measured total power from the fabricated chip is 1.91 nW (1.12 nW from vibration, 0.79 nW from thermoelectric).

关键词： Energy harvesting Thermoelectric, electromagnetic Vibration Micro power generation

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Chi-Huang Chen Sheau-Ling Hsieh Yung-Ching Weng Wen-Yung Chang Feipei Lai Department of Electrical Engineering National Taiwan University Taipei Taiwan EECS International Graduate Program Institute IT Center National Chiao Tung University Hsinchu Taiwan Department of Computer Science and Engineering National Taiwan University Taiwan Institute of Computer Science and Engineering College of Computer Science National Chiao Tung University Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taiwan

Semantic similarity measure plays an essential role in Information Retrieval and Natural Language Processing. In this paper we propose a page-count-based semantic similarity measure and apply it in biomedical domains. Previous researches in semantic web related applications have deployed various semantic similarity measures. Despite the usefulness of the measurements in those applications, measuring semantic similarity between two terms remains a challenge task. The proposed method exploits page counts returned by the Web Search Engine. We define various similarity scores for two given terms P and Q, using the page counts for querying P, Q and P AND Q. Moreover, we propose a novel approach to compute semantic similarity using lexico-syntactic patterns with page counts. These different similarity scores are integrated adapting support vector machines, to leverage the robustness of semantic similarity measures. Experimental results on two datasets achieve correlation coefficients of 0.798 on the dataset provided by A. Hliaoutakis, 0.705 on the dataset provide by T. Pedersen with physician scores and 0.496 on the dataset provided by T. Pedersen et al. with expert scores.

关键词： Semantics Biomedical measurements Correlation Kernel Training Medical services Support vector machine classification

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3D Parallel Conjugate Gradient Solver Optimized for GPUs

3D Parallel Conjugate Gradient Solver Optimized for GPUs

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Biennial institute of electrical and Electronics Engineers Conference on Electomagnetic Field Computation

作者： Rogerio F. Carvalho Carlos A. P. S. Martins Rose M. S. Batalha Ana F. P. Camargos Graduate Program in Electrical Engineering Pontifical Catholic University of Minas Gerais Federal Institute of Minas Gerais

ISBN: (纸本)9781424470594

Conjugate gradient (CG) solver implementations optimized for GPUs are developed and applied to a 3D finite element (FEM) problem. Results show that our GPUs implementations have a superior improvement in computational performance than cluster and other GPU implementations, due to algorithm and other architecture dependent optimizations.

关键词： Solvers computational performance conjugate gradient

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State Observation For Non-Linear Switched Systems Using Non-Homogeneous HOSM Observers

State Observation For Non-Linear Switched Systems Using Non-...

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2010 49th IEEE Conference on Decision and Control

作者： Hector Rios Jorge Davila Leonid Fridman Program of Mastery and Doctorate in Electrical Engineering Engineering Faculty National Autonomous University of Mexico C.P. 04510 Mexico D.F. Section of Graduate Studies and Research ESIME-UPT National Polytechnic Institute C.P. 07340 Mexico D.F. Department of Control Division of Electrical Engineering Engineering Faculty National Autonomous University of Mexico C.P. 04510 Mexico D.F.

ISBN: (纸本)9781424477456

This article presents the problem of finite time reconstruction of the state and operating mode for a class of non-linear switched systems. The proposed method is based on the non-homogeneous high-order sliding mode approach and it is able to reconstruct both the state and operating mode of the switched system based only on measurable outputs. The observability is derived in terms of certain geometric restrictions on the vector fields of the switched system that require the availability of all its modes. The method does not require the system to be transformed to any normal form. Simulation results support the proposed method.

关键词： High-order Sliding Modes Non-Linear Ob-servers Switched Systems

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Metabolomics as molecular analysis tool in cell culture engineering

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IFAC Proceedings Volumes 2010年第6期43卷 491-495页

作者： S.I. Vernardis P.K. Chrysanthopoulos C.T. Goudar M.I. Klapa Metabolic Engineering and Systems Biology Laboratory Institute of Chemical Engineering and High-Temperature Chemical Processes Foundation for Research and Technology-Hellas Patras GR- 265 04 Greece Cell Culture Development Global Biological Development Bayer HealthCare 800 Dwight Way Berkeley CA 94710 Interdepartmental Graduate Program in “Informatics in Life Sciences” Medical School University of Patras Greece Departments of Chemical & Biomolecular Engineering and Bioengineering University of Maryland College Park MD 20742 USA

So far, cell culture engineering has used the high-throughput transcriptional and more recently protein profiling techniques attempting to further understand and resolve significant issues regarding the cell culture performance and its optimization. At the metabolic level, flux analysis has been used to monitor changes in the metabolic state that could affect the successful outcome of cell cultures. Metabolomics, referring to the simultaneous quantification of the (relative) concentration of the free small metabolites, is the most recently introduced high-throughput method for the measurement of the metabolic fingerprint of a biological system. Considering the role of metabolism in the context of the overall cellular function, it is easily understandable why quantifying a complete and accurate metabolomic profile is foreseen to have a major positive impact in cell culture engineering research. We will present application of Gas Chromatorgaphy-Mass Spectrometry metabolomics to monitor and analyze mammalian cell culture systems. Specifically, two bioreactor processes will be discussed in which baby hamster kidney cells were cultivated in high-cell density perfusion reactors at both laboratory and manufacturing scales and samples were analyzed over the course of the cultivation. Metabolomics enabled the differentiation between cell cultures based on bioreactor type, and stage of cell growth. Multivariate statistical analysis enabled the identification of the metabolites whose change in concentration was characteristic of the modification in any of these macroscopic parameters. The acquired results support the usefulness of metabolomics as a molecular analysis tool in cell culture engineering.

关键词： bioprocess development and optimization cell culture Gas Chromatography-Mass Spectrometry (GC-MS) high-cell density perfusion system high-throughput biomolecular analysis

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Web-based healthcare Hand Drawing Management System

Web-based healthcare Hand Drawing Management System

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Sheau-Ling Hsieh Yung-Ching Weng Chi-Huang Chen Kai-Ping Hsu Jeng-Wei Lin Feipei Lai EECS International Graduate Program Institute IT Center National Chiao Tung University Hsinchu Taiwan Taiwan University Taipei Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Computer and Information Networking Center National Taiwan University Taipei Taiwan Department of Information Management Tunghai University Taichung Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan

The paper addresses Medical Hand Drawing Management System architecture and implementation. In the system, we developed four modules: hand drawing management module; patient medical records query module; hand drawing editing and upload module; hand drawing query module. The system adapts windows-based applications and encompasses web pages by *** hosting mechanism under web services platforms. The hand drawings implemented as files are stored in a FTP server. The file names with associated data, e.g. patient identification, drawing physician, access rights, etc. are reposited in a database. The modules can be conveniently embedded, integrated into any system. Therefore, the system possesses the hand drawing features to support daily medical operations, effectively improve healthcare qualities as well. Moreover, the system includes the printing capability to achieve a complete, computerized medical document process. In summary, the system allows web-based applications to facilitate the graphic processes for healthcare operations.

关键词： Medical services Biomedical imaging Printing Conferences Web services Graphics Databases

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A Nonlinear Underactuated Controller for 3D-Trajectory Tracking with a Miniature Helicopter

A Nonlinear Underactuated Controller for 3D-Trajectory Track...

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2010 IEEE International Conference on Industrial Technology (ICIT 2010)

作者： A. S. Brandao M. Sarcinelli-Filho R. Carelli Graduate Program on Electrical Engineering Federal University of Espirito Santo Vitoria ES Brazil Institute of Automatics National University of San Juan San Juan (Capital) Argentine

ISBN: (纸本)9781424456956

This work proposes a nonlinear controller for an autonomous helicopter, to track a given 3D trajectory. The starting point is a dynamic model obtained using the Euler-Lagrange formulation, considering the aircraft as a rigid body. The first contribution is the proposal of a suitable control law considering the nonlinear model, with no linearization strategy, and a proof of the stability of the closed-loop system that embeds such controller. The second contribution is the fact that the proposed controller is based on the inverse dynamics, focusing on its underactuated-system character. Finally, simulation results are presented and discussed, which validate the proposed controller.

关键词： Controllers autonomous helicopters trajectory tracking Lagrange formulation inverse kinematics Nonlinear Models control law Closed loop systems Helicopters Aircraft Miniature Proof nonlinearity Simulation results

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Ontology engineering

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Nature Biotechnology 2010年第2期28卷 128-130页

作者： Alterovitz, Gil Xiang, Michael Hill, David P. Lomax, Jane Liu, Jonathan Cherkassky, Michael Dreyfuss, Jonathan Mungall, Chris Harris, Midori A. Dolan, Mary E. Blake, Judith A. Ramoni, Marco F. Children's Hospital Informatics Program Harvard-MIT Division of Health Sciences and Technology Harvard Medical School Boston MA United States Partners Healthcare Center for Personalized Genetic Medicine Boston MA United States Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA United States Jackson Laboratory Bar Harbor ME United States EMBL-EBI Wellcome Trust Genome Campus Hinxton United Kingdom Department of Biology Massachusetts Institute of Technology Cambridge MA United States Lawrence Berkeley National Laboratory Berkeley CA United States

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