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Energy recovery from syngas and pyrolysis wastewaters with anaerobic mixed cultures

Bioresources and Bioprocessing 2024年第1期11卷 1011-1025页

作者： Alberto Robazza Anke Neumann Institute of Process Engineering in Life Sciences 2:Electro Biotechnology Karlsruhe Institute of TechnologyKIT76131 KarlsruheGermany

The anaerobic digestion of aqueous condensate from fast pyrolysis is a promising technology for enhancing carbon and energy recovery from ***,another pyrolysis product,could be integrated as a co-substrate to improve process ***,limited knowledge exists on the co-fermentation of pyrolysis syngas and aqueous condensate by anaerobic cultures and the effects of substrate *** work investigates the ability of mesophilic and thermophilic anaerobic mixed cultures to co-ferment syngas and the aqueous condensate from either sewage sludge or polyethylene plastics pyrolysis in semi-batch bottle *** identifies inhibitory concentrations for carboxydotrophic and methanogenic reactions,examines specific component removal and assesses energy recovery *** results show successful co-fermentation of syngas and aqueous condensate components like phenols and ***,the characteristics and load of the aqueous condensates affected process performance and product *** toxicity,likely resulting from the synergistic effect of multiple toxicants,depended on the PACs’*** 37°C,concentrations of 15.6 gCOD/gVSS and 7.8 gCOD/gVSS of sewage sludge-derived aqueous condensate inhibited by 50%carboxydotrophic and methanogenic activity,*** 55°C,loads between 3.9 and 6.8 gCOD/gVSS inhibited by 50%both *** plastics condensate showed higher toxicity,with 2.8 gCOD/gVSS and 0.3 gCOD/gVSS at 37°C decreasing carboxydotrophic and methanogenic rates by 50%.At 55°C,0.3 gCOD/gVSS inhibited by 50%CO uptake rates and *** PAC loads reduced methane production and promoted short-chain carboxylates *** recalcitrant components in sewage sludge condensate hindered e-mol recovery,while plastics condensate showed high e-mol recoveries despite the stronger *** with challenges posed by substrate toxicity and composition variations,the successful conversion of sy

关键词： Pyrolysis wastewater Phenolics Nitrogen heterocycles Open cultures Volatile fatty acids Sewage sludge Polyethylene Energy recovery Carbon capture

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Anti-fatigue activity and mechanism of crocetin loaded nanoliposome in acute exercise-treated mice

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Food Science and Human Wellness 2024年第6期13卷 3361-3370页

作者： Jian Nan Jinglei Li Haishan Wu Haoran Cheng Hyun Jin Park Qingsheng Zhao Liu Yang School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Engineering Research Center of Bio-process Ministry of EducationHefei University of TechnologyHefei 230009China School of Life Sciences and Biotechnology Korea UniversitySeoul 02841South of Korea National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Crocetin displays strong antioxidant,anti-inflammatory and anti-depression activity which is promising to relieve symptoms of *** a carotenoid,crocetin is difficult to dissolve in water and highly unstable against many environmental *** is used to encapsulate crocetin to improve its water *** the present study,the antifatigue activities and potential mechanism of crocetin loaded nanoliposome(CLN)was extensively *** potential antifatigue pathway of CLN was ***,impact of CLN on the gut microbiota structure was examined which contributes to its antifatigue *** significantly increases exhaustive swimming time of fatigue mice,decreases the blood contents of lactic,blood urea nitrogen(BUN)and malondialdehyde(MDA).At the same time,CLN improves the activity of glutathione peroxidase(GSH-Px)and succinate dehydrogenase(SDH)enzyme,attenuates the oxidant stress in *** activates the adenosine monophosphate-activated kinase(AMPK)/peroxisome proliferator-activated receptor gamma coactivator-1α(PGC-1α)signaling pathway of fatigue mice,increases the mRNA expression of ATP *** also increases mRNA expression of mitochondrial transcription factor A(TFAM)which promotes mitochondrial ***,CLN ameliorates the gut microbiota structure by increasing the abundance of genus such as Lactobacillus in fatigue *** summary,CLN exerts strong anti-fatigue properties by decreasing the oxidant stress and the contents of harmful metabolites,augmenting the production of ATP,and potentially ameliorating the gut microbiota structure.

关键词： Crocetin Nanoliposome Fatigue AMPK/PGC-1αpathway Gut microbiota

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Separation of chitin from shrimp shells enabled by transition metal salt aqueous solution and ionic liquid

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Chinese Journal of Chemical engineering 2023年第1期53卷 133-141页

作者： Mi Feng Bin He Xinyan Chen Junli Xu Xingmei Lu Cai Jia Jian Sun Key Laboratory of Molecular Medicine and Biotherapy Ministry of Industry and Information TechnologySchool of Life SciencesBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologyAdvanced Research Institute of Multidisciplinary ScienceBeijing Institute of TechnologyBeijing 100081China CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex SystemsState Key Laboratory of Biochemical EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical and Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Chitin is a widely used important industrial polymer mainly from shrimp shells, but its commercial preparation is under the great challenge of serious pollution due to the requirement of HCl and Na ***, we demonstrated that high purity chitin can be obtained from waste shrimp shells(WSSs) by cascade separation with transition metal salt aqueous solution and ionic liquid(IL). Firstly, calcium carbonate of WSSs was effectively removed in the metal salt aqueous solution driven by the ion exchange interaction. Subsequently, 1-butyl-3-methylimidazolium chloride([Bmim]Cl) had bifunctional abilities to remove residual protein and introduced metal salts simultaneously by hydrogen bonding and coordination interactions. The key experimental factors affecting the separation process were systematically studied, including the type of metal salts, temperature, and [Bmim]Cl loading. After sequential treatment with a 20%(mass) Ni SO4aqueous solution at 130 ℃ and [Bmim]Cl at 150 ℃, the purity of a-chitin can be up to 96.5%(mass) that meets commercial requirements. The use of metal salts with higher coordination ability makes the preparation of chitin no longer depend on the commonly acid-base reaction, which is conducive to the preservation of chitin structure.

关键词： Chitin Ionic liquids Transition metal salts Separation Sustainability

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Biochemical methane potential of three-phase olive mill solid waste:Influence of temperature and supplemental enzymes

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Carbon Resources Conversion 2022年第3期5卷 248-254页

作者： Rafat Al Afif Christoph Pfeifer Institute of Chemical and Energy Engineering Department of Material Sciences and Process EngineeringUniversity of Natural Resources and Life SciencesViennaMuthgasse 1071190 ViennaAustria

Methane potential of three-phase olive mill solid waste(3POMSW)was evaluated by biochemical methane potential(BMP)tests at temperatures of 37.5◦C and 55◦*** results have shown,that thermophilic processing has a higher methane and biogas yield by 10%and 17.2%,respectively,compared to mesophilic *** thermophilic conditions of 3POMSW results in higher conversion of the feedstock into *** result of addition of enzymes(MethaPlus,Hemicellulase,PectinaseL,Amylase S and Lipase)and their mixtures to 3POMSW at 55◦C has shown that the optimum mixture of enzymes was Metha Plus and Hemicellulase,which resulted in an increase of methane yield by 1.3%compared to the base case without addition of *** model equations were developed based on first-order kinetic in order to calculate the biogas yield versus the time as a function of reaction rate constant(k)and the maximum biogas yield(ymax).In this study,results have shown two different reaction rates obtained for the mixtures of enzymes with 3POMSW of 0.130 d^(-1) from t=0…14 days and 0.034 d^(-1) from t=28…63 *** developed simple model equations can be applied for calculating the biogas yield at the time and by optimizing the process improving biological nutrient removal.

关键词： Three-phase olive mill solid waste Biochemical methane potential Mesophilic Thermophilic Anaerobic digestion

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Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation

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Green Energy & Environment 2022年第4期7卷 840-853页

作者： Liteng Li Xiaofang Li Susu Zhang Hongyuan Yan Xiaoqiang Qiao Hongyan He Tao Zhu Baokun Tang College of Pharmaceutical Science Institute of Life Science and Green DevelopmentKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of EducationHebei UniversityBaoding071002China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing010190China

Acrylic acid(AA)is an important and widely used industrial chemical,but its high toxicity renders its use incompatible with the concept of green *** leveraging its terminal carboxyl group and unsaturated bond,we designed and explored a new strategy to increase the greenness of AA via its eutectic melting using a quaternary ammonium salt(choline chloride)to form a deep eutectic solvent(DES),followed by polymerisation of the DES to form a polymer(poly(DES)).The greenness of AA,DES,and poly(DES)was evaluated via an in vitro test using MGC80-3 cells and an in vivo test using Kunming *** toxicity improved from Grade 2(moderately toxic)for AA to Grade 1(slightly toxic)for DESs and Grade 0(non-toxic)for poly(DES)in the in vitro ***,the poly(DES)s showed a lower toxicity in mice than the DESs in the in vivo ***,greenness enhancement was successfully achieved,with the greenness following the order AA

关键词： Greenness Deep eutectic solvent Polymer Toxicity Application

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Innovative Technologies for Improving the Sustainability of the Food Drying Industry

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Current Food Science and Technology Reports 2024年第2期2卷 231-239页

作者： Nowacka, Małgorzata Matys, Aleksandra Witrowa-Rajchert, Dorota Department of Food Engineering and Process Management Institute of Food Sciences Warsaw University of Life Sciences Warsaw Poland

Drying as a preservation method for plant materials improves microbial and nutritional quality, however, such processing needs a lot of energy. Thus, different approaches are described as the use of the nonthermal processing (pulsed electric field, ultrasound, high-pressure processing, ethanol application) to reduce drying time and obtain a higher quality of final product. There are given several examples for nonthermal processing, which highlight the positive impact on drying time, bioactive compounds content, and energy consumption for different food products. Also, the other aspects are described of the use of conventional drying methods, including hot-air drying, freeze-drying, microwave drying, infrared drying, and vacuum drying, emphasizing their advantages and limitations. Furthermore, the concept of hybrid drying technologies, integrating various methods is described. Additionally, the importance of solar drying is presented as an eco-friendly method, and the growing interest in combined drying methods. Also, a practical example of a mobile drying unit project is presented, showcasing its potential for versatile use in different locations and farms. However, for scaling up the processing, the optimization of the drying process in the laboratory scale into industrial scales is done through methods like Response Surface Methodology (RSM) and others. This paper presents a brief overview of developing drying technologies according to the sustainable approach in the food industry. In the aim of sustainability and efficiency in food science, innovative pretreatments coupled with hybrid drying methods, play a crucial role in producing high-quality products with lower energy consumption and reduced investment costs, emphasizing the importance of incorporating renewable energy in new drying solutions.

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Breaking down barriers: comprehensive functional analysis of the Aspergillus niger chitin synthase repertoire

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Fungal Biology and Biotechnology 2024年第1期11卷 3页

作者： Barthel, Lars Cairns, Timothy Duda, Sven Müller, Henri Dobbert, Birgit Jung, Sascha Briesen, Heiko Meyer, Vera Chair of Applied and Molecular Microbiology Institute of Biotechnology Technische Universität Berlin Berlin Germany School of Life Sciences Weihenstephan Chair of Process Systems Engineering Technical University of Munich Freising Germany

Background: Members of the fungal kingdom are heterotrophic eukaryotes encased in a chitin containing cell wall. This polymer is vital for cell wall stiffness and, ultimately, cell shape. Most fungal genomes contain numerous putative chitin synthase encoding genes. However, systematic functional analysis of the full chitin synthase catalogue in a given species is rare. This greatly limits fundamental understanding and potential applications of manipulating chitin synthesis across the fungal kingdom. Results: In this study, we conducted in silico profiling and subsequently deleted all predicted chitin synthase encoding genes in the multipurpose cell factory Aspergillus niger. Phylogenetic analysis suggested nine chitin synthases evolved as three distinct groups. Transcript profiling and co-expression network construction revealed remarkably independent expression, strongly supporting specific role(s) for the respective chitin synthases. Deletion mutants confirmed all genes were dispensable for germination, yet impacted colony spore titres, chitin content at hyphal septa, and internal architecture of submerged fungal pellets. We were also able to assign specific roles to individual chitin synthases, including those impacting colony radial growth rates (ChsE, ChsF), lateral cell wall chitin content (CsmA), chemical genetic interactions with a secreted antifungal protein (CsmA, CsmB, ChsE, ChsF), resistance to therapeutics (ChsE), and those that modulated pellet diameter in liquid culture (ChsA, ChsB). From an applied perspective, we show chsF deletion increases total protein in culture supernatant over threefold compared to the control strain, indicating engineering filamentous fungal chitin content is a high priority yet underexplored strategy for strain optimization. Conclusion: This study has conducted extensive analysis for the full chitin synthase encoding gene repertoire of A. niger. For the first time we reveal both redundant and non-redundant functional roles o

关键词： Aspergillus niger Biotechnology Cell wall Chitin Macromorphology Pellet Protein secretion µCT

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Flurbiprofen microneedle patches for the management of acute postoperative pain

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Nano Research 2024年第8期17卷 7493-7503页

作者： Huaqing Chu Yanyan Zhang Yuan Yang Jiangtao Xue Cong Li Wei Zhang Zhou Li Hui Zheng National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases School of Integrated Chinese and Western MedicineHunan University of Chinese MedicineChangsha 410208China School of Life Science Institute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China

Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are *** study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel).By adding varying amounts of genipin to modulate the crosslinking degree of cGel,the drug release behavior of the drug-loaded MNs in the skin can be *** crosslinking parameters that meet therapeutic requirements are selected,thus providing rapid and longlasting analgesic *** solutions were successfully cross-linked,altering matrix material microstructure,confirmed by scanning electron microscope imaging and fourier transform infrared *** demonstrated increasing mechanical strength with higher *** release rates were rapid initially,then slowed,exhibiting a characteristic of decreased release rates with increasing degrees of *** vivo,FBP/cGel MNs significantly reduced allodynia and hyperalgesia post-surgery,with the greatest effect observed at 2–3 h post-surgery,and can maintain analgesia for up to 6 *** tests confirmed good ***/cGel MNs effectively penetrate the stratum corneum,safely delivering drugs with significant analgesic effects,excellent mechanical properties,and good biocompatibility,representing a promising strategy for managing acute postoperative pain.

关键词： microneedle postoperative pain flurbiprofen non-steroid anti-inflammatory drug cross-linked gelatin

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“Wood-nacre”:Development of a Bio-inspired Wood-Based Composite for Beam and 3D-Surface Elements with Improved Failure Mechanisms

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Journal of Bionic engineering 2023年第4期20卷 1701-1711页

作者： Ulrich Müller Peter Halbauer Alexander Stadlmann Maximilian Grabner Hajir Al-musawi Bernhard Ungerer Maximilian Pramreiter Department of Material Science and Process Engineering Institute of Wood Technology and Renewable MaterialsUniversity of Natural Resources and Life SciencesKonrad-Lorenz-Straße 243430Tulln an der DonauAustria Hycobility Engineering&Technologies GmbH Stadiongasse 6-8/Top281010ViennaAustria

Following the natural structure of the nacre,the material studied consists of a multitude of hexagonal tiles that are glued together in an offset manner with a ductile *** so-called“wood nacre”consists of macroscopic tiles of birch wood veneer with a thickness of 0.8 mm and a size of 20 or 10 mm in diameter in order to mimic the aragonite tiles and the ductile PUR-adhesive corresponds to the layers of collagen in between.E-modulus(MOE),bending strength(MOR)and impact bending strength of the samples were determined and compared with reference samples of birch laminated *** hierarchical layered structure of the tiles does not cause any relevant loss in *** nacre,“wood nacre”also shows tough fracture behaviour and a high homogenization ***,strain hardening and high fracture toughness of the natural model could not be fully *** reason for this is the insufficient ratio between the strength and stiffness of the veneer layers and the *** adjusting the size of the tiles,increasing the strength and surface roughness of the veneers,*** densification,and using more ductile adhesives that can be applied in smaller layer thicknesses,it should be possible to better reproduce the natural ratios of nacre and thus achieve a significant improvement in the material properties of“wood nacre”.In addition to the mechanical properties,the high potential of the new material lies in the possibility of producing 3D shell-shaped elements for lightweight wood hybrid construction.

关键词： Bio-inspired Damage tolerance Failure behaviour Hierarchical structure Nacre Work of fracture

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Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration

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Translational Neurodegeneration 2024年第1期13卷 530-546页

作者： Ling-Jie Li Xiao-Ying Sun Ya-Ru Huang Shuai Lu Yu-Ming Xu Jing Yang Xi-Xiu Xie Jie Zhu Xiao-Yun Niu Dan Wang Shi-Yu Liang Xiao-Yu Du Sheng-Jie Hou Xiao-Lin Yu Rui-Tian Liu State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Neurology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China College of Life Science Ningxia UniversityYinchuan 750021China Department of BigData Beijing Medintell Bioinformatic Technology Co.LTDBeijing 100081China

Background Deoxyribonuclease 2(DNaseⅡ)plays a key role in clearing cytoplasmic double-stranded DNA(dsDNA).Deficiency of DNaseⅡleads to DNA accumulation in the *** dsDNA in neurons is an early pathological hallmark of senescence and neurodegenerative diseases including Alzheimer’s disease(AD).However,it is not clear how DNaseⅡand neuronal cytoplasmic dsDNA influence *** hyperphosphorylation is a key factor for the pathogenesis of *** effect of DNaseⅡand neuronal cytoplasmic dsDNA on neuronal tau hyperphosphorylation remains *** The levels of neuronal DNaseⅡand dsDNA in WT and Tau-P301S mice of different ages were measured by immunohistochemistry and immunolabeling,and the levels of DNaseⅡin the plasma of AD patients were measured by *** investigate the impact of DNaseⅡon tauopathy,the levels of phosphorylated tau,phosphokinase,phosphatase,synaptic proteins,gliosis and proinflammatory cytokines in the brains of neuronal DNaseⅡ-deficient WT mice,neuronal DNaseⅡ-deficient Tau-P301S mice and neuronal DNaseⅡ-overexpressing Tau-P301S mice were evaluated by immunolabeling,immunoblotting or *** performance was determined using the Morris water maze test,Y-maze test,novel object recognition test and open field *** The levels of DNaseⅡwere significantly decreased in the brains and the plasma of AD ***Ⅱalso decreased age-dependently in the neurons of WT and Tau-P301S mice,along with increased dsDNA accumulation in the *** DNA accumulation induced by neuronal DNaseⅡdeficiency drove tau phosphorylation by upregulating cyclin-dependent-like kinase-5(CDK5)and calcium/calmodulin activated protein kinaseⅡ(CaMKⅡ)and downregulating phosphatase protein phosphatase 2A(PP2A).Moreover,DNaseⅡknockdown induced and significantly exacerbated neuron loss,neuroinflammation and cognitive deficits in WT and Tau-P301S mice,respectively,while overexpression of neuronal DNaseⅡexhibited therapeutic ben

关键词： DNaseⅡ Alzheimer’s disease Double-stranded DNA Tau phosphorylation Tauopathy

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