The authors propose a new defined tensile stress distribution for steel fiber reinforced concrete (SFRC) to evaluate the flexural strength of SFRC beams. It is a simplified formula based on the SFRC tensile stress – ...
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Bispecific antibodies(bsAbs)hold promises for enhanced therapeutic potential surpassing that of their parental monoclonal ***,bsAbs pose great challenges in their manufacturing,and one of the common reasons is their s...
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Bispecific antibodies(bsAbs)hold promises for enhanced therapeutic potential surpassing that of their parental monoclonal ***,bsAbs pose great challenges in their manufacturing,and one of the common reasons is their susceptibility to *** on previous studies demonstrating the functionality and potential manufacturability of Fab-scFv format bsAb,this investigation delved into the impact of environmental factors-such as pH,buffer types,ionic strength,protein concentrations,and temperatures-on its stability and the reversal of its self-associated *** acidic,low-salt conditions were found optimal,ensuring bsAb stability for 30 days even at elevated temperature of 40°***,these conditions facilitated the reversal of its self-associated aggregates to monomers during the initial 7-day incubation *** findings underscore the robustness and resilience of Fab-scFv format bsAb,further confirming its potential manufacturability despite its current absence as commercial products.
Impulsively generated focused jets play a significant role in various applications, including inkjet printing, needle-free drug delivery, and microfluidic devices. As the demand for generating jets and droplets from m...
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Impulsively generated focused jets play a significant role in various applications, including inkjet printing, needle-free drug delivery, and microfluidic devices. As the demand for generating jets and droplets from medium to highly viscous liquids increases, understanding the role of viscosity in jetting dynamics becomes crucial. While previous studies have examined the viscous effects on walls, the impact on free surfaces has not been thoroughly understood. This study aims to bridge this gap by integrating experiments with numerical simulations to investigate the viscous effects on focused jet formation. We demonstrate that mass and momentum transfer along the tangential direction of the free surface contribute to focused jet formation, and viscosity plays a key role in this transfer process. The viscosity-induced diffusion of the shear flow and vorticity near the free surface reduces the jet speed. Based on experimental observations and simulation results, we propose an equation to predict the viscous jet velocity. These findings offer new perspectives on viscous interface dynamics in advanced manufacturing and biomedical applications.
The use of biodiesel mixtures has become a part of everyday life. The current implementation of B7 biodiesel at the pump and the premise that the near future will make B20 biodiesel compulsory leads to the necessity o...
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Nowadays, heavy metal pollution is considered one of the most important environmental issues. Thereby, this paper proposes a novel approach towards obtaining biofriendly hybrid composite beads based on sodium alginate...
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The L1_(2)-strengthened Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3)medium-entropy alloy(MEA)with precipitations of grain boundaries has been developed through selective laser melting(SLM)followed by cold rolling and annealing,e...
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The L1_(2)-strengthened Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3)medium-entropy alloy(MEA)with precipitations of grain boundaries has been developed through selective laser melting(SLM)followed by cold rolling and annealing,exhibiting excellent strength-ductility *** as-printed alloy exhibits low yield strength(YS)of~384 MPa,ultimate tensile strength(UTS)of~453 MPa,and uniform elongation(UE)of 1.5%due to the existence of the SLM-induced *** cold rolling and annealing,the YS,UTS,and UE are significantly increased to~739 MPa,~1230 MPa,and~47%,*** enhancement primarily originates from the refined grain structure induced by cold rolling and *** presence of coherent sphericalγ'precipitates(L1_(2)phases)and Al/Ti-rich precipitates at the grain boundaries,coupled with increased lattice defects such as dislocations,stacking faults,and ultrafine deformation twins,further contribute to the property’s *** study highlights the potential of SLM in producing high-strength and ductile MEA with coherent L1_(2)nanoprecipitates,which can be further optimized through subsequent rolling and annealing *** findings offer valuable insights for the development of high-performance alloys for future engineering applications.
This paper aims to analyze the evolution of wind turbines in the last decade and place it in the context of environmental changes that have occurred in recent years. The use of artificial intelligence, genetic algorit...
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The biomimetic hydrophobic surface is a potentially efficient underwater drag reduction method and the drag reduction mechanism of this kind of surface comes from the interfacial *** now,it is a hotspot to grasp the s...
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The biomimetic hydrophobic surface is a potentially efficient underwater drag reduction method and the drag reduction mechanism of this kind of surface comes from the interfacial *** now,it is a hotspot to grasp the slippage characteristic and explore slippage enhancement *** paper not only summarizes our numerical simulation and experimental results of slippage characteristic at the solid-liquid interface(SLI)of hydrophobic surfaces(HS)and the gas-liquid interface(GLI)of superhydrophobic surfaces(SHS)in recent years,but also introduces some innovative methods that can effectively improve the gas film stability and drag reduction effect of ***,we used the molecular dynamics(MD)simulation method to figure out the effect of the solid-liquid interaction strength,the system temperature and the shear rate on the slippage of SLI,and expound their action mechanism from molecular ***,by MD and multibody dissipative particle dynamics(MDPD)method,the slippage behavior at the GLI was studied under the influence of the microstructure size and the flow driving *** proposed a new kind of hybrid slip boundary condition model to describe the slippage characteristic on *** addition,we found through experiment that a three-dimensional backflow will appear on the GLI under the interfacial adsorption of surfactants,and the backflow direction will reverse with the change of GLI ***,we put forward the wettability step structure and gas injection method to enhance the stability and drag reduction effect of the gas film on SHS.
Taking CL-20(Hexanitrohexaazaisowurtzitane)-based aluminized explosives with high gurney energy as the research object, this research experimentally investigates the work capability of different aluminized explosive f...
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Taking CL-20(Hexanitrohexaazaisowurtzitane)-based aluminized explosives with high gurney energy as the research object, this research experimentally investigates the work capability of different aluminized explosive formulations when driving metal flyer plates in the denotation wave propagation *** research results showed that the formulations with 43 μm aluminum(Al) powder particles(The particle sizes of Al powder were in the range of 2~43 μm) exhibited the optimal performance in driving flyer plates along the denotation wave propagation direction. Compared to the formulations with Al powder 13 μm, the formulations with Al powder 2 μm delivered better performance in accelerating metal flyer plates in the early stage, which, however, turned to be poor in the later stage. The CL-20-based explosives containing 25% Al far under-performed those containing 15% Al. Based on the proposed quasi-isentropic hypothesis, relevant isentropy theories, and the functional relationship between detonation parameters and entropy as well as Al reaction degree, the characteristic lines of aluminized explosives in accelerating flyer plates were theoretically studied, a quasi-isentropic theoretical model for the aluminized explosive driving the flyer plate was built and the calculation methods for the variations of flyer plate velocity, Al reaction degree, and detonation product parameters with time and axial positions were developed. The theoretical model built is verified by the experimental results of the CL-20-based aluminized explosive driving flyer plate. It was found that the model built could accurately calculate the variations of flyer plate velocity and Al reaction degree over time. In addition, how physical parameters including detonation product pressure and temperature varied with time and axial positions was identified. The action time of the positive pressure after the detonation of aluminized explosives was found prolonged and the downtrend of the temperature was
The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 *** study aims to fill the gap in the experimental and analytical s...
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The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 *** study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic *** the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/*** erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered *** examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration ***,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation ***,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present *** upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or *** to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit.
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