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Nanorobot-Cell Communication via In Situ Generation of Biochemical Signals: Toward Regenerative Therapies

ACS nano 2025年第25期19卷 2025 Jun 17页

作者： Roshan Velluvakandy Xiaohui Ju Martin Pumera Future Energy and Innovation Laboratory Central European Institute of Technology Brno University of Technology Purkyňova 123 61200 Brno Czech Republic. Advanced Nanorobots & Multiscale Robotics Laboratory Faculty of Electrical Engineering and Computer Science VSB - Technical University of Ostrava 17. listopadu 2172/15 70800 Ostrava Czech Republic. Department of Medical Research China Medical University Hospital China Medical University No. 91 Hsueh-Shih Road 40402 Taichung Taiwan.

Achieving precise control of cellular processes drives possibilities for next-generation therapeutic approaches. However, existing technologies for influencing cell behavior primarily rely on specific drug delivery, limiting their ability to mimic natural cellular communication processes. In this work, we developed glucose-powered gold-silica (Au-SiO) nanorobots that induce cell migration by generating steady-state hydrogen peroxide (HO) as a biochemical signaling molecule to mimic natural cellular communication with high spatial resolution. These nanorobots leverage the unique 2-in-1 catalytic activity of gold nanoparticles for glucose oxidation and HO decomposition, allowing for precise control over the generation of steady-state HO concentration and enhanced diffusion powered by glucose within the cellular microenvironment. We further demonstrated that at low dosages of nanorobots, the steady-state HO generation promotes cell migration and proliferation, while higher dosages of nanorobots slow down cell proliferation. The proposed design of this biocompatible nanorobot is intended to enable communication with the environment and provide a noninvasive, biochemical command system for regulating cellular behavior. Additionally, we show proof of principle of a method by which nanorobots can augment wound healing and similar regenerative therapies.

关键词： cell signaling communication enhanced diffusion nanorobot steady-state

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Hierarchic Stabilization of Flying Convex-Path-Following Formations Part II: Underactuated Agents

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IFAC-PapersOnLine 2019年第12期52卷 352-357页

作者： Mohamed I. El-Hawwary Department of Electrical Power Engineering Faculty of Engineering Cairo University Giza 12613 Egypt Division of Decision and Control Systems School of Electrical Engineering & Computer Science KTH Royal Institute of Technology SE-100 44 Stockholm Sweden

In this paper the flying convex-path-following formations problem (FCxPFF) is solved for two cases of underactuated rigid bodies. In the first case the the rigid bodies have a single degree of underactuation with two thrusts and three torques. In the second, they have two degrees of underactuation with a single thrust. The solution builds on the one developed for fully-actuated agents in Part I of the paper. In addition, the way the solution is tailored for underactuation relies on further utilization of hierarchic set stabilization, and reduction. Additional remarks on the benefits of the approach, and simulation results of the proposed solutions are presented.

关键词： Formation control distributed stabilization underactuated systems hierarchical control reduction

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DEPLOY Tool: Incrementally Planning Marginless Elastic Optical Networks 20

DEPLOY Tool: Incrementally Planning Marginless Elastic Optic...

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20th International Conference on Transparent Optical Networks, ICTON 2018

作者： Kretsis, Aristotelis Soumplis, Polizois Christodoulopoulos, Kostas Varvarigos, Emmanouel Manos Department of Electrical and Computer Engineering National Technical University of Athens Greece Computer Technology Institute and Press - Diophantus Patras Greece Department of Electrical and Computer Systems Engineering Monash University Australia

ISBN: (纸本)9781538666043

Currently, the hardware (equipment) and software (including planning and operation tools) are both provided by optical equipment vendors, leading to the so called vendor lock. We present DEPLOY, a tool for planning and operating optical networks that uses generic vendor-agnostic models. We demonstrate its capabilities through the use case of incrementally planning an optical network over multiple periods under evolving traffic and physical layer conditions. Using DEPLOY we can evaluate the benefits of planning with reduced as opposed to planning with end-of-life margins. © 2018 IEEE.

关键词： Fiber optic networks

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Linear System Identification Under Multiplicative Noise from Multiple Trajectory Data

Linear System Identification Under Multiplicative Noise from...

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American Control Conference

作者： Yu Xing Ben Gravell Xingkang He Karl Henrik Johansson Tyler Summers Key Lab of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences and School of Mathematical Sciences University of Chinese Academy of Sciences Beijing P. R. China Department of Mechanical Engineering The University of Texas at Dallas Richardson TX USA Division of Decision and Control Systems School of Electrical Engineering and Computer Science KTH Royal Institute of Technology Stockholm Sweden

ISBN: (数字)9781538682661

ISBN: (纸本)9781538682678

The study of multiplicative noise models has a long history in control theory but is re-emerging in the context of complex networked systems and systems with learning-based control. We consider linear system identification with multiplicative noise from multiple state-input trajectory data. We propose exploratory input signals along with a least-squares algorithm to simultaneously estimate nominal system parameters and multiplicative noise covariance matrices. The asymptotic consistency of the least-squares estimator is demonstrated by analyzing first and second moment dynamics of the system. The results are illustrated by numerical simulations.

关键词： Trajectory Covariance matrices Linear systems Heuristic algorithms Optimal control Mathematical model

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The Robot Self-Efficacy Scale: Robot Self-Efficacy, Likability and Willingness to Interact Increases After a Robot-Delivered Tutorial

The Robot Self-Efficacy Scale: Robot Self-Efficacy, Likabili...

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IEEE International Workshop on Robot and Human Communication (ROMAN)

作者： Nicole L. Robinson Teah-Neal Hicks Gavin Suddrey David J. Kavanagh Department of Electrical and Computer Systems Engineering Monash University Clayton VIC Australia Science and Engineering Faculty Queensland University of Technology Brisbane QLD Australia Health Faculty Queensland University of Technology Institute of Health and Biomedical Innovation Centre for Children’s Health Research Brisbane QLD Australia

ISBN: (数字)9781728160757

ISBN: (纸本)9781728160764

An individual's self-efficacy to interact with a robot has important implications around the content, utility and success of the interaction. Individuals need to achieve a high level of self-efficacy in human robot-interaction in a reasonable time-frame for positive effects to occur in shortterm human-robot scenarios. This trial explored the impact of a 2-minute automated robot-delivered tutorial designed to teach people from the general public how to use the robot as a method to increase robot self-efficacy scores. This trial assessed scores before (T1) and after (T2) an interaction with the robot to investigate changes in self-efficacy, likability and willingness to use it. The 40 participants recruited had on average very low level of robotic experience. After the tutorial, people reported significantly higher robot self-efficacy with very large effect sizes to operate a robot and apply the robot to a task (η 2 p = 0.727 and 0.660). Significant increases in likability and willingness to interact with the robot were also found (η2p = 0.465 and 0.480). Changes in likability and self-efficacy contributed to 64% of the variance in changes to willingness to use the robot. Initial differences were found in robot self-efficacy for older people and those with less robotics and programming experience compared with other participants, but scores across these subgroups were similar after completion of the tutorial. This demonstrated that high levels of self-efficacy, likeability and willingness to use a social robot can be reached in a very short time, and on comparable levels, regardless of age or prior robotics experience. This outcome has significant implications for future trials using social robots, since these variables can strongly influence experimental outcomes.

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An eikonal equation approach to thermodynamics and the gradient flows in information geometry

arXiv

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arXiv 2020年

作者： Wada, Tatsuaki Scarfone, Antonio M. Matsuzoe, Hiroshi Region of Electrical and Electronic Systems Engineering Ibaraki University Nakanarusawa-cho Hitachi316-8511 Japan c/o Politecnico di Torino Torino10129 Italy Department of Computer Science and Engineering Nagoya Institute of Technology Gokiso-cho Showa-ku Nagoya466-8555 Japan

We can incorporate a"time" evolution into thermodynamics as a Hamilton-Jacobi dynamics. A set of the equations of states in thermodynamics is considered as the generalized eikonal equation, which is equivalent to Hamilton-Jacobi equation. We relate the Hamilton-Jacobi dynamics of a simple thermodynamic system to the gradient flows in information geometry. Copyright © 2020, The Authors. All rights reserved.

关键词： Geometrical optics

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Network-level optimal control for public bus operation

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IFAC-PapersOnLine 2020年第2期53卷 15003-15010页

作者： Balázs Varga Tamás Péni Balázs Kulcsár Tamás Tettamanti Budapest University of Technology and Economics Faculty of Transportation Engineering and Vehicle Engineering Department of Control for Transportation and Vehicle Systems Hungary H-1111 Budapest Műegyetem rkp. 3 Institute for Computer Science and Control (SZTAKI) Hungary H-1111 Budapest. Kende u. 13-17 Department of Electrical Engineering Chalmers University of Technology Hörsalsvägen 9-11 SE-412-96 Gothenburg Sweden

The paper presents modeling, control and analysis of an urban public transport network. First, a centralized system description is given, built up from the dynamics of individual buses and bus stops. Aiming to minimize three conflicting goals (equidistant headways, timetable adherence, and minimizing passenger waiting times), a reference tracking model predictive controller is formulated based on the piecewise-affine system model. The closed-loop system is analyzed with three methods. Numerical simulations on a simple experimental network showed that the temporal evolution of headways and passenger numbers could maintain their periodicity with the help of velocity control. With the help of randomized simulation scenarios, sensitivity of the system is analyzed. Finally, infeasible regions for the bus network control was sought using by formulating an explicit model predictive controller.

关键词： Urban systems Public transport Centralised control Model predictive control Piecewise-affine systems Scenario based methods Set theory

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Enhancing image quality in fast neutron-based range verification of proton therapy using a deep learning-based prior in LM-MAP-EM reconstruction

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Physics in medicine and biology 2025年第12期70卷 2025 Jun 5页

作者： Lena Marie Setterdahl Kyrre Skjerdal Hunter Nathaniel Ratliff Kristian Smeland Ytre-Hauge William R B Lionheart Sean Holman Helge Egil Seime Pettersen Francesco Blangiardi Danny Lathouwers Ilker Meric Department of Computer science Electrical engineering and Mathematical sciences Western Norway University of Applied Sciences Inndalsveien 28 Bergen Hordaland 5063 NORWAY. Department of Physics and Technology University of Bergen Allégaten 55 Bergen Hordaland 5007 NORWAY. Department of Mathematics The University of Manchester Alan Turing Building Upper Brook St Manchester England M13 9SR UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND. Department of Oncology and Medical Physics Haukeland Universitetssjukehus Jonas Lies veg 65 Postboks 1400 Bergen Hordaland 5021 NORWAY. Technology Methods and Systems Data Based Methods Fraunhofer Institute for Electronic Nano Systems ENAS Technologie-Campus 3 Chemnitz SN 09126 GERMANY. Department of Radiation Science and Technology Delft University of Technology Mekelweg 15 Delft 2629 JD NETHERLANDS. Department of Computer Science Electrical Engineering and Mathematical Sciences Western Norway University of Applied Sciences Inndalsveien 28 Bergen Hordaland 5063 NORWAY.

This study investigates the use of list-mode (LM) maximum a posteriori (MAP) expectation maximization (EM) incorporating prior information predicted by a convolutional neural network for image reconstruction in fast neutron (FN)-based proton therapy range verification. Approach. A conditional generative adversarial network (pix2pix) was trained on progressively noisier data, where detector resolution effects were introduced gradually to simulate realistic conditions. FN data were generated using Monte Carlo simulations of an 85 MeV proton pencil beam in a computed tomography (CT)-based lung cancer patient model, with range shifts emulating weight gain and loss. The network was trained to estimate the expected two-dimensional (2D) ground truth FN production distribution from simple back-projection images. Performance was evaluated using mean squared error (MSE), structural similarity index (SSIM), and the correlation between shifts in predicted distributions and true range shifts. Main results. Our results show that pix2pix performs well on noise-free data but suffers from significant degradation when detector resolution effects are introduced. Among the LM-MAP-EM approaches tested, incorporating a mean prior estimate into the reconstruction process improved performance, with LM-MAP-EM using a mean prior estimate outperforming naïve LM maximum likelihood EM (LM-MLEM) and conventional LM-MAP-EM with a smoothing quadratic energy function in terms of SSIM. Significance. Findings suggest that deep learning techniques can enhance iterative reconstruction for range verification in proton therapy. However, the effectiveness of the model is highly dependent on data quality, limiting its robustness in high-noise scenarios. .

关键词： LM-MAP-EM Monte Carlo simulation fast neutron imaging generative adversarial network organic scintillators proton therapy range verification

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Reciprocity of thermal diffusion in time-modulated systems

arXiv

引用

arXiv 2021年

作者： Li, Jiaxin Li, Ying Cao, Pei-Chao Zheng, Xu Peng, Yu-Gui Li, Baowen Zhu, Xue-Feng Alù, Andrea Qiu, Cheng-Wei Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore School of Mechatronics Engineering Harbin Institute of Technology Harbin150001 China Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China ZJU-Hangzhou Global Science and Technology Innovation Center Key Lab. of Advanced Micro Nano Electronic Devices & Smart Systems of Zhejiang Zhejiang University Hangzhou310027 China International Joint Innovation Center ZJU-UIUC Institute Electromagnetics Academy at Zhejiang University Zhejiang University Haining314400 China School of Physics and Innovation Institute Huazhong University of Science and Technology Wuhan430074 China Department of Physics University of Colorado BoulderCO80309 United States Department of Electrical Engineering City University of New York New YorkNY10031 United States Department of Mechanical Engineering University of Colorado BoulderCO80309 United States

The reciprocity principle governs the symmetry in transmission of electromagnetic and acoustic waves, as well as the diffusion of heat between two points in space, with important consequences for thermal management and energy harvesting. There has been significant recent interest in materials with time-modulated properties, which have been shown to efficiently break reciprocity for light, sound, and even charge diffusion. Quite surprisingly, here we show that, from a practical point of view, time modulation cannot generally be used to break reciprocity for thermal diffusion. We establish a theoretical framework to accurately describe the behavior of diffusive processes under time modulation, and prove that thermal reciprocity in dynamic materials is generally preserved by the continuity equation, unless some external bias or special material is considered. We then experimentally demonstrate reciprocal heat transfer in a time-modulated device. Our findings correct previous misconceptions regarding reciprocity breaking for thermal diffusion, revealing the generality of symmetry constraints in heat transfer, and clarifying its differences from other transport processes in what concerns the principles of reciprocity and microscopic reversibility. © 2021, CC BY.

关键词： Energy harvesting

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Codes with Hierarchical Locality from Covering Maps of Curves

Codes with Hierarchical Locality from Covering Maps of Curve...

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作者： Ballentine, Sean Barg, Alexander Vladut, Serge Department of Mathematics University of Maryland at College Park College ParkMD20742 United States Department of Electrical and Computer Engineering Institute for Systems Research University of Maryland at College Park College ParkMD20742 United States Russian Academy of Sciences Institute for Problems of Information Transmission Moscow13453 Russia

Locally recoverable (LRC) codes provide ways of recovering erased coordinates of the codeword without having to access each of the remaining coordinates. A subfamily of LRC codes with hierarchical locality (H-LRC codes) provides added flexibility to the construction by introducing several tiers of recoverability for correcting different numbers of erasures. We present a general construction of codes with 2-level hierarchical locality from maps between algebraic curves and specialize it to several code families obtained from quotients of curves by a subgroup of the automorphism group, including rational, elliptic, Kummer, and Artin-Schreier curves. We further address the question of H-LRC codes with availability, and suggest a general construction of such codes from fiber products of curves. Detailed calculations of parameters for H-LRC codes with availability are performed for Reed-Solomon- and Hermitian-like code families. Finally, we construct asymptotically good families of H-LRC codes from curves related to the Garcia-Stichtenoth tower. © 1963-2012 IEEE.

关键词： Reed-Solomon codes

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