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Electrochemical performance of sodium titanate nanorods for sodium-ion battery anode applications

AIP Conference Proceedings 2023年第1期2480卷

作者： Zikri Noer Siti Utari Rahayu Hilda Ayu Marlina Fauzi Handoko Susanto Sigit Rahardi Rifki Septawendar Bambang Sunendar Department of Physics Faculty of Mathematics and Natural Sciences Universitas Sumatera Utara Jl. Bioteknologi No.1 Medan Indonesia 20155 Integrated Research Laboratory Universitas Sumatera Utara Jl. Tridarma No. 8 Medan Sumatera Utara Indonesia 20155 Balai Besar Bahan dan Barang Teknik (B4T) Ministry of Industry of Indonesia Jl. Sangkuriang No.14 Bandung Jawa Barat Indonesia 40135 Center for Ceramics Ministry of Industry of Indonesia Jl. Akhmad Yani 392 Bandung Jawa Barat Indonesia 40272 Engineering Physics Study Program Faculty of Industrial Technology Institut Teknologi Bandung Jl. Ganesha 10 Bandung Jawa Barat Indonesia 40132

In this study, the electrochemical performance of sodium titanate nanorods for sodium-ion battery anode applications was analyzed. Sodium titanate has been successfully prepared from the titanium (IV) Isopropoxide (TTIP) and sodium chloride (NaCl) precursor assisted by organic templates (ethylene glycol and citric acid) through a simple and hydrothermal template method, sodium titanate has been used to function in sodium-ion battery anodes. Manufacture of sodium titanate which is more environmentally friendly without the use of peroxides. Sodium titanate was initially prepared by mixing a solution of sodium precursor with a solution of titanium precursor at a stoichiometric mole ratio of 1.6: 1. Then, it was preheated through the hydrothermal method at 150°C for 6 hours, then calcined at 800°C for 1 hour in two burning situations which are different, namely reduction and oxidation. The same process is carried out in the synthesis of other samples without preheating treatment. Performance tests were carried out on sodium-ion batteries with calcined sodium titanate as the base ingredient. Preheating and combustion treatments in a reduced atmosphere are the optimum conditions for the formation of sodium titanate which produces sodium titanate type Na2Ti6O13. Galvanostatic charge/discharge performance produces a capacity of 43 mAh after 10 cycles.

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A mountable toilet system for personalized health monitoring via the analysis of excreta (vol 15, pg 561, 2020)

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NATURE BIOMEDICAL engineering 2020年第6期4卷 662-662页

作者： Park, Seung-min Won, Daeyoun D. Lee, Brian J. Escobedo, Diego Esteva, Andre Aalipour, Amin Ge, T. Jessie Kim, Jung Ha Suh, Susie Choi, Elliot H. Lozano, Alexander X. Yao, Chengyang Bodapati, Sunil Achterberg, Friso B. Kim, Jeesu Park, Hwan Choi, Youngjae Kim, Woo Jin Yu, Jung Ho Bhatt, Alexander M. Lee, Jong Kyun Spitler, Ryan Wang, Shan X. Gambhir, Sanjiv S. Department of Radiology Stanford University School of Medicine Stanford CA USA Molecular Imaging Program at Stanford Stanford University School of Medicine Stanford CA USA Department of Surgery Seoul Song Do Hospital Seoul Republic of Korea Cancer Immunology Laboratory Seoul Song Do Hospital Seoul Republic of Korea Department of Surgery Leiden University Medical Center Leiden the Netherlands Department of Creative IT Engineering Pohang University of Science and Technology (POSTECH) Pohang Republic of Korea Precision Health and Integrated Diagnostic Center (PHIND) Stanford University School of Medicine Palo Alto CA USA Department of Materials Science and Engineering Stanford University Stanford CA USA Department of Bioengineering Stanford University Stanford CA USA Canary Center at Stanford for Cancer Early Detection Stanford University School of Medicine Palo Alto CA USA Salesforce Research Palo Alto CA USA Department of Urology Stanford University School of Medicine Stanford CA USA Department of Pharmacology Case Western Reserve University School of Medicine Cleveland OH USA Faculty of Medicine University of Toronto Toronto Ontario Canada Department of Electrical Engineering Stanford University Stanford CA USA College of Medicine The Catholic University of Korea Seoul Republic of Korea

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词： Diagnosis

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Densification of single-walled carbon nanotube films: Mesoscopic distinct element method simulations and experimental validation

arXiv

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arXiv 2020年

作者： Drozdov, Grigorii Ostanin, Igor Xu, Hao Wang, Yuezhou Dumitrică, Traian Grebenko, Artem Tsapenko, Alexey P. Gladush, Yuriy Ermolaev, Georgy Volkov, Valentyn S. Eibl, Sebastian Rüde, Ulrich Nasibulin, Albert G. Scientific Computation Program University of Minnesota Twin CitiesMN55455 United States Multi-Scale Mechanics Faculty of Engineering Technology MESA+ University of Twente Enschede7500 AE Netherlands Skolkovo Institute of Science and Technology Nobel St. 3 Moscow Russia Department of Aerospace Engineering and Mechanics University of Minnesota Twin CitiesMN55455 United States Integrated Engineering Minnesota State University MankatoMN56001 United States Department of Mechanical Engineering University of Minnesota Twin CitiesMN55455 United States Moscow Institute of Physics and Technology Institute Lane 9 Dolgoprudniy Russia Department of Applied Physics Aalto University School of Science AaltoFI-00076 Finland Center for Photonics and 2D Materials Moscow Institute of Physics and Technology Dolgoprudny141700 Russia Friedrich-Alexander University Erlangen-Nuremberg Cauerstr.11 Erlangen91052 Germany Aalto University Department of Materials Science and Engineering Aalto00076 Finland

Nanometer thin single-walled carbon nanotube (CNT) films collected from the aerosol chemical deposition reactors have gathered attention for their promising applications. Densification of these pristine films provides an important way to manipulate the mechanical, electronic, and optical properties. To elucidate the underlying microstructural level restructuring, which is ultimately responsible for the change in properties, we perform large scale vector-based mesoscopic distinct element method simulations in conjunction with electron microscopy and spectroscopic ellipsometry characterization of pristine and densified films by drop-cast volatile liquid processing. Matching the microscopy observations, pristine CNT films with finite thickness are modeled as self-assembled CNT networks comprising entangled dendritic bundles with branches extending down to individual CNTs. Simulations of the film under uniaxial compression uncover an ultra-soft densification regime extending to a ~75% strain, which is likely accessible with the surface tensional forces arising from liquid surface tension during the evaporation. When removing the loads, the pre-compressed samples evolve into homogeneously densified films with thickness values depending on both the pre-compression level and the sample microstructure. The significant reduction in thickness, confirmed by our spectroscopic ellipsometry, is attributed to the underlying structural changes occurring at the 100 nm scale, including the zipping of the thinnest dendritic branches. Copyright © 2020, The Authors. All rights reserved.

关键词： Carbon films

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Public Health Microbiome Curriculum: Looking Below the Tip of the Iceberg for Approaches to Population Health

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Microbial biotechnology 2025年第6期18卷 e70160页

作者： Melissa K Melby Swapna Mylabathula Meghan B Azad Sarah Turner Naama Geva-Zatorsky Carolina Tropini Melissa B Manus Martin Blaser Mark Nichter CIFAR Humans & the Microbiome Program Toronto Canada. Department of Anthropology University of Delaware Newark Delaware USA. Temerty Faculty of Medicine University of Toronto Toronto Canada. Department of Pediatrics and Child Health University of Manitoba Winnipeg Canada. Manitoba Interdisciplinary Lactation Centre (MILC) Children's Hospital Research Institute of Manitoba Winnipeg Canada. Department of Community Health Sciences University of Manitoba Winnipeg Manitoba Canada. Department of Cell Biology and Cancer Science Rappaport Faculty of Medicine Rappaport Technion Integrated Cancer Center (RTICC) Technion-Israel Institute of Technology Haifa Israel. Department of Microbiology and Immunology University of British Columbia Vancouver Canada. School of Biomedical Engineering University of British Columbia Vancouver Canada. Department of Anthropology University of Texas at San Antonio San Antonio Texas USA. Departments of Medicine and Pathology & Laboratory Medicine RBHS Robert Wood Johnson Medical School Rutgers University Rutgers New Jersey USA. School of Anthropology University of Arizona Tucson Arizona USA.

We discuss the opportunity for public health microbiome curricula to bridge the gaps in knowledge that exist between microbiome researchers and the lay public. We propose equipping public health professionals, important facilitators of public outreach and behaviour change, with three public health curriculum modules focused on breastfeeding, antibiotics and diet. These modules shift the focus from microbes as pathogens to potential partners in promoting health across the life course. Current public health messages cover only the 'tip of the iceberg' in exploring mechanisms, and this microbiome curriculum dives below the surface to provide fresh perspectives. These microbiome insights allow us to move beyond a focus on microbes as pathogens to understand the numerous collaborative roles played by the microbiome in producing health, and the upstream factors influencing the microbiome, thereby offering mechanistic insights that can be harnessed for public health education.

关键词： antibiotics breastfeeding diet microbiome public health

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Potassium Batteries: Dendrite‐Free Potassium Metal Anodes in a Carbonate Electrolyte (Adv. Mater. 7/2020)

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Advanced Materials 2020年第7期32卷

作者： Pengcheng Liu Yixian Wang Qilin Gu Jagjit Nanda John Watt David Mitlin Materials Science and Engineering Program and Texas Materials Institute The University of Texas at Austin Austin TX 78712‐1591 USA Department of Materials Science and Engineering Faculty of Engineering National University of Singapore Singapore 117574 Singapore Chemical Sciences Division Oak Ridge National Laboratory Oak Ridge TN 37830 USA Center for Integrated Nanotechnologies Los Alamos National Laboratory Los Alamos NM 87545 USA

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TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A (vol 603, pg 131, 2022)

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NATURE 2024年第8020期631卷 E7-E7页

作者： Brown, Anna-Leigh Wilkins, Oscar G. Keuss, Matthew J. Hill, Sarah E. Zanovello, Matteo Lee, Weaverly Colleen Bampton, Alexander Lee, Flora C. Y. Masino, Laura Qi, Yue A. Bryce-Smith, Sam Gatt, Ariana Hallegger, Martina Fagegaltier, Delphine Phatnani, Hemali Phatnani, Hemali Newcombe, Jia Gustavsson, Emil K. Seddighi, Sahba Reyes, Joel F. Coon, Steven L. Ramos, Daniel Schiavo, Giampietro Fisher, Elizabeth M. C. Raj, Towfique Secrier, Maria Lashley, Tammaryn Ule, Jernej Buratti, Emanuele Humphrey, Jack Ward, Michael E. Fratta, Pietro UCL Queen Square Motor Neuron Disease Centre Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology UCL London UK The Francis Crick Institute London UK UK Dementia Research Institute University College London London UK Department of Molecular Biology and Nanobiotechnology National Institute of Chemistry Ljubljana Slovenia National Institute of Neurological Disorders and Stroke NIH Bethesda MD USA Medical Scientist Training Program Johns Hopkins University School of Medicine Baltimore MD USA Center for Alzheimer’s and Related Dementias National Institutes of Health Bethesda MD USA Queen Square Brain Bank UCL Queen Square Institute of Neurology University College London London UK Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology University College London London UK Great Ormond Street Institute of Child Health Genetics and Genomic Medicine University College London London UK Center for Genomics of Neurodegenerative Disease New York Genome Center (NYGC) New York NY USA NeuroResource Department of Neuroinflammation UCL Queen Square Institute of Neurology London UK Molecular Genomics Core Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH Bethesda MD USA Nash Family Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA Ronald M. Loeb Center for Alzheimer’s Disease Icahn School of Medicine at Mount Sinai New York NY USA Department of Pathology Fishberg Department of Neuroscience Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai New York NY USA Estelle and Daniel Maggin Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics Evolution and Environment UCL Genetics Institute University College London London UK Mole

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Detection of Adhesion Molecules on Inflamed Macrophages at Early-Stage Using SERS Probe Gold Nanorods

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Nano-Micro Letters 2017年第1期9卷 113-121页

作者： Dakrong Pissuwan Yusuke Hattori World Premier International Immunology Frontier Research Center Osaka UniversityOsaka 5650871Japan Materials Science and Engineering Program Multidisciplinary UnitFaculty of ScienceMahidol UniversityBangkok 10400Thailand Research Institute of Pharmaceutical Sciences Musashino UniversityTokyo 2028585Japan

In recent years, it has been shown that inflammatory biomarkers can be used as an effective signal for disease diagnoses. The early detection of these signals provides useful information that could prevent the occurrence of severe diseases. Here, we employed surface-enhanced Raman scattering(SERS) probe gold nanorods(GNRs) as a tool for the early detection of inflammatory molecules in inflamed cells. A murine macrophage cell line(Raw264.7) stimulated with lipopolysaccharide(LPS) was used as a model in this study. The prepared SERS probe GNRs containing 4-mercaptobenzoic acid as a Raman reporter to generate SERS signals were used for detection of intracellular adhesion molecule-1(ICAM-1) in macrophages after treatment with LPS for varying lengths of time. Our results show that SERS probe GNRs could detect significant differences in the expression of ICAM-1 molecules in LPS-treated macrophages compared to those in untreated macrophages after only 1 h of LPS treatment. In contrast, when using fluorescent labeling or enzyme-linked immunosorbent assays(ELISA) to detect ICAM-1, significant differences between inflamed and un-inflamed macrophages were not seen until the cells had been treated with LPS for 5 h. These results indicate that our SERS probe GNRs provide a higher sensitivity for detecting biomarker molecules in inflamed macrophages than the conventional fluorescence and ELISA techniques, and could therefore be useful as a potential diagnostic tool for managing disease risk.

关键词： Gold nanorod SERS Inflamed cell Macrophage ICAM-1

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Effects of carbon fiber on mechanical and electrical properties of fly ash geopolymer composite

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Materials Today: Proceedings 2018年第6期5卷 14017-14025页

作者： Panjasil Payakaniti Supree Pinitsoonthorn Prasit Thongbai Vittaya Amornkitbamrung Prinya Chindaprasirt Materials Science and Nanotechnology Program Department of Physics Faculty of Science Khon Kaen University Khon Kaen 40002 Thailand Integrated Nanotechnology Research Center Department of Physics Faculty of Science Khon Kaen University Khon Kaen 40002 Thailand Nanotec-KKU Center of Excellence on Advanced Nanomaterials for Energy Production and Storage Khon Kaen University Khon Kaen 40002 Thailand Sustainable Infrastructure Research and Development Center Department of Civil Engineering Faculty of Engineering Khon Kaen University Khon Kaen 40002 Thailand

High calcium fly ash geopolymer composite was prepared by incorporating short carbon fiber in the geopolymer matrix. The carbon fiber (CF) content was varied from 0 to 1%, the liquid to ash ratio was controlled at 0.5. The workability, mechanical and electrical properties of the geopolymer composites were examined. The result showed that the incorporation of 0.5%CF and above resulted in the ductile failure of specimen. The increasing CF content also resulted in decreasing workability and mechanical strength. The electrical resistivity was also reduced and was more stable to the curing age and temperature. The cyclic voltammetry (CV) curve of 60°C curing provided less peaks than that of 25°C.

关键词： Geopolymer Alkaline activated binder Mechanical Properties Electrical properties

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients

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Cancer Cell 2025年第3期43卷 361-379.e10页

作者： Chen, Jianzhou Levy, Antonin Tian, Ai-Ling Huang, Xuehan Cai, Guoxin Fidelle, Marine Rauber, Conrad Ly, Pierre Pizzato, Eugénie Sitterle, Lisa Piccinno, Gianmarco Liu, Peng Durand, Sylvère Mao, Misha Zhao, Liwei Iebba, Valerio Felchle, Hannah Mallard de La Varende, Anne-Laure Fischer, Julius Clemens Thomas, Simon Greten, Tim F. Jones, Jennifer C. Monge, Cecilia Demaria, Sandra Formenti, Silvia Belluomini, Lorenzo Dionisi, Valeria Massard, Christophe Blanchard, Pierre Robert, Charlotte Quevrin, Clément Lopes, Eloise Clémenson, Céline Mondini, Michele Meziani, Lydia Zhan, Yizhou Zeng, Chengbing Cai, Qingxin Morel, Daphne Sun, Roger Laurent, Pierre-Antoine Mangoni, Monica Di Cataldo, Vanessa Arilli, Chiara Trommer, Maike Wegen, Simone Neppl, Sebastian Riechelmann, Rachel P. Camandaroba, Marcos P. Neto, Elson Santos Fournier, Pierre-Edouard Segata, Nicola Holicek, Peter Galluzzi, Lorenzo Buqué, Aitziber Alves Costa Silva, Carolina Derosa, Lisa Kroemer, Guido Chen, Chuangzhen Zitvogel, Laurence Deutsch, Eric Gustave Roussy Cancer Campus (GRCC) Clinicobiome Villejuif Cedex 94805 France Faculté de Médecine Université Paris-Saclay Kremlin-Bicêtre 94270 France Institut National de la Santé Et de la Recherche Médicale (INSERM) UMR 1015 Equipe Labellisée—Ligue Nationale contre le Cancer Villejuif 94805 France CICBT1428 Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France Department of Radiation Oncology Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France INSERM U1030 Radiothérapie Moléculaire et Innovations Thérapeutiques Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France Metabolomics and Cell Biology Platforms UMS AMMICa Gustave Roussy Cancer Campus Villejuif 94805 France Centre de Recherche des Cordeliers INSERM U1138 Équipe Labellisée – Ligue Nationale contre le Cancer Université Paris Cité Sorbonne Université Paris 75006 France Institut du Cancer Paris CARPEM Department of Biology Hôpital Européen Georges Pompidou AP-HP Paris 75015 France Department of Radiation Oncology Cancer Hospital of Shantou University Medical College Shantou 515031 China Department of Gastroenterology and Infectious Diseases University Hospital Heidelberg Heidelberg 69120 Germany Department of Computational Cellular and Integrative Biology University of Trento Trento 38123 Italy Department of Radiation Oncology Weill Cornell Medicine New York 10065 NY United States Drug Development Department (DITEP) Gustave Roussy Cancer Campus Villejuif 94805 France Department of Radiation Oncology Cyberknife and Radiotherapy Faculty of Medicine and University Hospital Cologne Cologne 50937 Germany Center for Integrated Oncology (CIO) Faculty of Medicine and University Hospital Cologne University of Cologne Cologne 50937 Germany Center for Molecular Medicine Cologne University of Cologne Cologne 50931 Germany Olivia Newton-John Cancer Wellness & Research Centre Austin Health Department of Radiation Oncology Heidelberg Melbourne 3084 VIC Australia Departme

The mechanisms governing the abscopal effects of local radiotherapy in cancer patients remain an open conundrum. Here, we show that off-target intestinal low-dose irradiation (ILDR) increases the clinical benefits of immune checkpoint inhibitors or chemotherapy in eight retrospective cohorts of cancer patients and in tumor-bearing mice. The abscopal effects of ILDR depend on dosimetry (≥1 and ≤3 Gy) and on the metabolic and immune host-microbiota interaction at baseline allowing CD8⁺ T cell activation without exhaustion. Various strains of Christensenella minuta selectively boost the anti-cancer efficacy of ILDR and PD-L1 blockade, allowing emigration of intestinal PD-L1-expressing dendritic cells to tumor-draining lymph nodes. An interventional phase 2 study provides the proof-of-concept that ILDR can circumvent resistance to first- or second-line immunotherapy in cancer patients. Prospective clinical trials are warranted to define optimal dosimetry and indications for ILDR to maximize its therapeutic potential. © 2025 The Author(s)

关键词： bile acids cancer Christensenella minuta dendritic cells gut microbiota metabolomics radiotherapy tumor immunosurveillance

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