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BioTIME 2.0: Expanding and Improving a Database of Biodiversity Time Series

Global Ecology and Biogeography 2025年第5期34卷

作者： Maria Dornelas Laura H. Antão Amanda E. Bates Viviana Brambilla Jonathan M. Chase Cher F. Y. Chow Ada Fontrodona-Eslava Anne E. Magurran Inês S. Martins Faye Moyes Alban Sagouis Samuel Adu-Acheampong Daniel Acquah-Lamptey Dušan Adam Penelope A. Ajani Aitor Albaina Pablo Almaraz Jeongseop An Roger Sigismund Anderson Madelaine Jean Robertson Anderson Alexsander Z. Antunes Ivan Arismendi Linda Armbrecht Pedro Aros-Mardones Sreejith Kalpuzha Ashtamoorthy Narayanan Ayyappan Gal Badihi Joseph J. Bailey Andrew H. Baird Mark Edward Baird Sreekumar Vadakkethil Balakrishnan José António L. Barão-Nóbrega Adi Barash Miguel Barbosa Jos Barlow Claus Bässler Matthieu Beaumont Natalie Beenaerts Tiago Octavio Begot Wallace Beiroz Ricardo Beldade David M. Bell Alecia Bellgrove Jonathan Belmaker Lisandro Benedetti-Cecchi Cassandra E. Benkwitt Pamela Medina-van Berkum Brandon T. Bestelmeyer Matthew G. Betts Maxwell Kelvin Billah Anne D. Bjorkman Magdalena Błażewicz Christopher P. Bloch Shane A. Blowes Antonio Bode Juliano A. Bogoni Thomas Bolger Timothy C. Bonebrake Erik Bonsdorff Roberta Bottarin Luke N. Brokensha Rob W. Brooker Andrew J. Brooks Helge Bruelheide Thiago Almeida Bueno Claire Laguionie Mariana Lopes Campagnoli James Cant Erica Pellegrini Caramaschi Alexandre Caron Tadhg Carroll Tancredi Caruso Juan Carvajal-Quintero Giuseppe Castaldelli Edward Castañeda-Moya Pedro V. Castilho Sonia Zanini Cechin Shahar Chaikin Uchangi Manjunatha Chandrashekara Tory J. Chase Chaolun Allen Chen Jorge José Cherem Sei-Woong Choi Erica M. Christensen Alexander V. Christianini Jackson Wing Four Chu Peter Coad Carl Van Colen Lise Comte Elisabeth J. Cooper J. Hans C. Cornelissen Eddy Cosson Unai Cotano Luc Crevecoeur Shannan Kyle Crow Graeme S. Cumming Vanessa S. Daga Gabriella Damasceno Gergana N. Daskalova Claire H. Davies Robert A. Davis Frank P. Day Sussy De-La-Zerda Amy Elizabeth Deacon Indradatta de Castro-Arrazola Steven Degraer Kharran Deonarinesingh Juan C. Diaz-Ricaurte Christopher R. Dickman Tara Dirilgen Ciaran John Dolan J. Emmet Centre for Biological Diversity School of Biology University of St Andrews Fife UK MARE—Centro de Ciências do Mar e do Ambiente Faculdade de Ciências Universidade de Lisboa Lisboa Portugal Research Centre for Ecological Change Organismal and Evolutionary Biology Research Programme Faculty of Biological and Environmental Sciences University of Helsinki Helsinki Finland Department of Biology University of Victoria Victoria British Columbia Canada German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig Leipzig Germany Department of Computer Science Martin Luther University Halle-Wittenberg Halle (Saale) Germany Leverhulme Centre for Anthropocene Biodiversity Department of Biology University of York York UK Department of Animal Biology and Conservation Science University of Ghana Accra Ghana Philipps Universität Marburg Marburg Germany Department of Forest Ecology Silva Tarouca Research Institute Brno Czech Republic School of Life Sciences University of Technology Sydney Sydney New South Wales Australia Zoology and Animal Cell Biology Department University of the Basque Country (UPV/EHU) Leioa Spain Grupo de Oceanografía de Ecosistemas Instituto de Ciencias Marinas de Andalucía CSIC Campus Universitario de Puerto Real Puerto Real Spain National Institute of Ecology Seocheon Republic of Korea African Regional Postgraduate Programme in Insect Science University of Ghana Accra Ghana Département de Biologie Université de Sherbrooke Sherbrooke Quebec Canada Núcleo de Conservação da Biodiversidade Instituto de Pesquisas Ambientais Secretaria de Meio Ambiente Infraestrutura e Logística do Estado de São Paulo São Paulo Brazil Department of Fisheries Wildlife and Conservation Sciences Oregon State University Corvallis Oregon USA Institute for Marine and Antarctic Studies Ecology & Biodiversity Centre University of Tasmania Hobart Tasmania Australia Graduate Program in Oceanography Department of Oceanography Faculty of Natural Scienc

Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R package (BioTIMEr) to facilitate use of the database. Main Types of Variables Included The database is composed of one main data table containing the abundance records and 11 metadata tables. The data are organised in a hierarchy of scales where 11,989,233 records are nested in 1,603,067 sample events, from 553,253 sampling locations, which are nested in 708 studies. A study is defined as a sampling methodology applied to an assemblage for a minimum of 2 years. Spatial Location and Grain Sampling locations in BioTIME are distributed across the planet, including marine, terrestrial and freshwater realms. Spatial grain size and extent vary across studies depending on sampling methodology. We recommend gridding of sampling locations into areas of consistent size. Time Period and Grain The earliest time series in BioTIME start in 1874, and the most recent records are from 2023. Temporal grain and duration vary across studies. We recommend doing sample-level rarefaction to ensure consistent sampling effort through time before calculating any diversity metric. Major Taxa and Level of Measurement The database includes any eukaryotic taxa, with a combined total of 56,400 taxa. Software Format csv and. SQL.

关键词： assemblage biodiversity community database ecoinformatics species taxa time

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Consensus on the definitions and descriptions of the domains of the OMERACT Core Outcome Set for shared decision making interventions in rheumatology trials

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SEMINARS IN ARTHRITIS AND RHEUMATISM 2024年 65卷 152381-152381页

作者： Decary, Simon de Wit, Maarten Naye, Florian Barton, Jennifer L. Fraenkel, Liana Li, Linda C. Brooks, Peter Stacey, Dawn Maxwell, Lara J. Campbell, Willemina Hofstetter, Cathie Voshaar, Marieke Meara, Alexa Christensen, Robin Boonen, Annelies Suarez-Almazor, Maria E. Meade, Tanya March, Lyn Jull, Janet Elizabeth Alten, Rieke Morgan, Esi M. Hazlewood, Glen Stewart Barber, Claire E. H. Guillemin, Francis El-Miedany, Yasser Mittoo, Shikha Robertson, Tiffany Westrich Bartlett, Susan J. Singh, Jasvinder A. Mannion, Melissa Nasef, Samah Ismail Boel, Anne Adebajo, Adewale Arnaud, Laurent Gill, Tiffany K. Moholt, Ellen Burt, Jennifer Jayatilleke, Arundathi Hmamouchi, Ihsane Berthelsen, Dorthe B. Blanco, Francisco J. Mather, Kate Maharaj, Ajesh Sharma, Saurab Caso, Francesco Beaton, Dorcas Shea, Beverly Fong, Christopher Fernandez, Anthony P. Mackie, Sarah Nikiphorou, Elena Jones, Allyson Greer-Smith, Regina Sloan, Victor S. Akpabio, Akpabio Strand, Vibeke Lee, Rebecca R. Umaefulam, Valerie Monti, Sara Abaza, Nouran Schultz, Grayson Stones, Simon Gossec, Laure Nielsen, Sabrina Mai Cavallo, Sabrina Srinivasalu, Hemalatha Constien, Deb Evans, Vicki Tugwell, Peter Toupin-April, Karine Univ Sherbrooke Sch RehabilFac Med & Hlth Sci Res CtrCHUS CIUSSS EstrieCHUS Sherbrooke PQ Canada Patient Res Partner Amsterdam Netherlands Oregon Hlth & Sci Univ VA Portland Hlth Care Syst Portland OR USA Yale Univ Dept Internal Med New Haven CT USA Univ British Columbia Dept Phys Therapy Vancouver BC Canada Arthrit Res Canada Vancouver BC Canada Univ Melbourne Sch Populat & Global Hlth Melbourne Australia Northern Hlth Melbourne Australia Univ Ottawa Sch Nursing Ottawa ON Canada Ottawa Hosp Res Inst Ottawa ON Canada Univ Ottawa Ottawa Hosp Res Inst Ctr Practice Changing Res Ottawa ON Canada Univ Ottawa Fac Med Ottawa ON Canada Toronto Western Hosp Univ Hlth Network Patient Res Partner Toronto ON Canada Sint Maartenskliniek Dept Pharm Nijmegen Netherlands Sint Maartenskliniek Dept Res Innovat Nijmegen Netherlands Radboud Univ Nijmegen Dept Pharm Med Ctr Nijmegen Netherlands Ohio State Univ Div Rheumatol Columbus OH USA Bispebjerg & Frederiksberg Hosp Parker Inst Musculoskeletal Stat Unit Copenhagen Denmark Odense Univ Hosp Dept Rheumatol Odense Denmark Maastricht Univ Div Rheumatol Dept Internal Med Med Ctr Maastricht Netherlands Maastricht Univ Caphri Res Inst Maastricht Netherlands Univ Texas MD Anderson Canc Ctr Sect Rheumatol & Clin Immunol Dept Gen Internal Med Houston TX USA Western Sydney Univ Sydney NSW Australia Royal North Shore Hosp Univ Sydney Dept Rheumatol Sydney Australia Queens Univ Sch Rehabil Therapy Kingston ON Canada Univ Med Berlin Dept Internal Med 2 Schlosspark KlinRheumatol Res Ctr Clin Immunol Osteol Phys Therapy & Sports Med Berlin Germany Univ Washington Seattle Childrens Hosp Dept Pediat Div Rheumatol Seattle WA USA Univ Calgary Dept Med Calgary AB Canada Univ Calgary Cumming Sch Med Dept Med Dept Community Hlth Sci Calgary AB Canada Univ Lorraine INSPIIRE INSERM Nancy France Canterbury Kings Coll London Canterbury Kent England Kings Coll London London England Vansha

Objective: To gain consensus on the definitions and descriptions of the domains of the Outcome Measures in Rheumatology (OMERACT) core domain set for rheumatology trials evaluating shared decision making (SDM) interventions. Methods: Following the OMERACT Handbook methods, our Working Group (WG), comprised of 90 members, including 17 patient research partners (PRPs) and 73 clinicians and researchers, had six virtual meetings in addition to email exchanges to develop draft definitions and descriptions. The WG then conducted an international survey of its members to gain consensus on the definitions and descriptions. Finally, the WG members had virtual meetings and e-mail exchanges to review survey results and finalize names, definitions and descriptions of the domains. Results: WG members contributed to developing the definitions. Fifty-two members representing four continents and 13 countries completed the survey, including 15 PRPs, 33 clinicians and 37 researchers. PRPs and clinicians/ researchers agreed with all definitions and descriptions with agreements ranging from 87% to 100%. Respondents suggested wording changes to the names, definitions and descriptions to better reflect the domains. Discussions led to further simplification and clarification to address common questions/concerns about the domains. Conclusion: Our WG reached consensus on the definitions and descriptions of the domains of the core domain set for rheumatology trials of SDM interventions. This step is crucial to understand each domain and provides the foundation to identify instruments to measure each domain for inclusion in the Core Outcome Measurement Set. Clinical significance: The current study provides consensus-based definitions and descriptions for the domains of the OMERACT core domain set for shared decision making interventions from patients/caregivers, clinicians and researchers. This is a crucial step to understand each domain and provides the foundation to identify instruments to

关键词： OMERACT Rheumatology Shared decision making Core domain set Consensus-building Survey

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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

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NATURE COMMUNICATIONS 2018年第1期9卷 1-16页

作者： Davies, Gail Lam, Max Harris, Sarah E. Trampush, Joey W. Luciano, Michelle Hill, W. David Hagenaars, Saskia P. Ritchie, Stuart J. Marioni, Riccardo E. Fawns-Ritchie, Chloe Liewald, David C. M. Okely, Judith A. Ahola-Olli, Ari V. Barnes, Catriona L. K. Bertram, Lars Bis, Joshua C. Burdick, Katherine E. Christoforou, Andrea DeRosse, Pamela Djurovic, Srdjan Espeseth, Thomas Giakoumaki, Stella Giddaluru, Sudheer Gustavson, Daniel E. Hayward, Caroline Hofer, Edith Ikram, M. Arfan Karlsson, Robert Knowles, Emma Lahti, Jari Leber, Markus Li, Shuo Mather, Karen A. Melle, Ingrid Morris, Derek Oldmeadow, Christopher Palviainen, Teemu Payton, Antony Pazoki, Raha Petrovic, Katja Reynolds, Chandra A. Sargurupremraj, Muralidharan Scholz, Markus Smith, Jennifer A. Smith, Albert V. Terzikhan, Natalie Thalamuthu, Anbupalam Trompet, Stella van der Lee, Sven J. Ware, Erin B. Windham, B. Gwen Wright, Margaret J. Yang, Jingyun Yu, Jin Ames, David Amin, Najaf Amouyel, Philippe Andreassen, Ole A. Armstrong, Nicola J. Assareh, Amelia A. Attia, John R. Attix, Deborah Avramopoulos, Dimitrios Bennett, David A. Boehmer, Anne C. Boyle, Patricia A. Brodaty, Henry Campbell, Harry Cannon, Tyrone D. Cirulli, Elizabeth T. Congdon, Eliza Conley, Emily Drabant Corley, Janie Cox, Simon R. Dale, Anders M. Dehghan, Abbas Dick, Danielle Dickinson, Dwight Eriksson, Johan G. Evangelou, Evangelos Faul, Jessica D. Ford, Ian Freimer, Nelson A. Gao, He Giegling, Ina Gillespie, Nathan A. Gordon, Scott D. Gottesman, Rebecca F. Griswold, Michael E. Gudnason, Vilmundur Harris, Tamara B. Hartmann, Annette M. Hatzimanolis, Alex Heiss, Gerardo Holliday, Elizabeth G. Joshi, Peter K. Kahonen, Mika Kardia, Sharon L. R. Karlsson, Ida Kleineidam, Luca Knopman, David S. Kochan, Nicole A. Konte, Bettina Kwok, John B. Le Hellard, Stephanie Lee, Teresa Lehtimaki, Terho Li, Shu-Chen Liu, Tian Koini, Marisa London, Edythe Longstreth, Will T., Jr. Lopez, Oscar L. Loukola, Anu Luck, Tobias Lundervold, Astri J. Lundquist, Anders Lyytikainen, Leo-Pekka Martin, Nicholas G. Montgom Univ Edinburgh Ctr Cognit Ageing & Cognit Epidemiol Dept Psychol Sch Philosophy Psychol & Language Sci Edinburgh EH8 9JZ Midlothian Scotland Inst Mental Hlth Singapore 539747 Singapore Univ Edinburgh Western Gen Hosp MRC Inst Genet & Mol Med Med Genet SectCtr Genom & Expt Med Edinburgh EH4 2XU Midlothian Scotland BrainWorkup LLC Los Angeles CA 90033 USA Univ Southern Calif Keck Sch Med Dept Psychiat & Behav Sci Los Angeles CA 90033 USA Kings Coll London Inst Psychiat Psychol & Neurosci Social Genet & Dev Psychiat Ctr De Crespigny PkDenmark Hill London SE5 8AF England Univ Turku Res Ctr Appl & Prevent Cardiovasc Med Turku 20520 Finland Satakunta Cent Hosp Dept Internal Med Pori 28100 Finland Univ Edinburgh Usher Inst Populat Hlth Sci & Informat Ctr Global Hlth Res Teviot Pl Edinburgh EH8 9AG Midlothian Scotland Max Planck Inst Mol Genet D-14195 Berlin Germany Univ Washington Dept Med Cardiovasc Hlth Res Unit Seattle WA 98101 USA Icahn Sch Med Mt Sinai Dept Psychiat New York NY 10029 USA James J Peters VA Med Ctr Mental Illness Res Educ & Clin Ctr VISN 3 Bronx NY 10468 USA Harvard Med Sch Brigham & Womens Hosp Dept Psychiat Boston MA 02115 USA Univ Bergen Dept Clin Sci KG Jebsen Ctr Psychosis Res NORMENT N-5021 Bergen Norway Haukeland Hosp Dr Einar Martens Res Grp Biol Psychiat Ctr Med Genet & Mol Med N-5020 Bergen Norway Feinstein Inst Med Res Ctr Psychiat Neurosc Manhasset NY 11030 USA Univ Bergen Oslo Univ Hosp Dept Med Genet N-0424 Oslo Norway Univ Oslo Dept Psychol N-0373 Oslo Norway Oslo Univ Hosp Div Mental Hlth & Addict N-0315 Oslo Norway Univ Crete Dept Psychol GR-74100 Iraklion Greece Univ Calif San Diego Dept Psychiat San Diego CA 92093 USA Univ Calif San Diego Ctr Behav Genet Aging San Diego CA 92093 USA Univ Edinburgh Inst Genet & Mol Med Med Res Council Human Genet Unit Edinburgh EH4 2XU Midlothian Scotland Univ Edinburgh Ctr Genom & Expt Med Generat Scotland Edinburgh EH4 2XU Midlothian Scotland Med Univ

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486;age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.

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Author Correction: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

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Nature communications 2021年第1期12卷 1166页

作者： Ditte Demontis Raymond K Walters Veera M Rajagopal Irwin D Waldman Jakob Grove Thomas D Als Søren Dalsgaard Marta Ribasés Jonas Bybjerg-Grauholm Maria Bækvad-Hansen Thomas Werge Merete Nordentoft Ole Mors Preben Bo Mortensen Bru Cormand David M Hougaard Benjamin M Neale Barbara Franke Stephen V Faraone Anders D Børglum The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Aarhus Denmark. ditte@biomed.au.dk. Center for Genomics and Personalized Medicine Aarhus Denmark. ditte@biomed.au.dk. Department of Biomedicine - Human Genetics Aarhus University Aarhus Denmark. ditte@biomed.au.dk. Analytic and Translational Genetics Unit Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA. Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA USA. The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Aarhus Denmark. Center for Genomics and Personalized Medicine Aarhus Denmark. Department of Biomedicine - Human Genetics Aarhus University Aarhus Denmark. Department of Psychology Emory University Atlanta GA USA. Bioinformatics Research Centre Aarhus University Aarhus Denmark. National Centre for Register-Based Research Aarhus University Aarhus Denmark. Psychiatric Genetics Unit Group of Psychiatry Mental Health and Addiction Vall d'Hebron Research Institute (VHIR) Universitat Autònoma de Barcelona Barcelona Catalonia Spain. Department of Psychiatry Hospital Universitari Vall d'Hebron Barcelona Catalonia Spain. Biomedical Network Research Center on Mental Health (CIBERSAM) Instituto de Salud Carlos III Madrid Spain. Departament de Genètica Microbiologia i Estadística Facultat de Biologia Universitat de Barcelona Barcelona Catalonia Spain. Center for Neonatal Screening Department for Congenital Disorders Statens Serum Institut Copenhagen Denmark. GLOBE Institute Center for GeoGenetics University of Copenhagen Copenhagen Denmark. Institute of Biological Psychiatry MHC Sct. Hans Mental Health Services Copenhagen Roskilde Denmark. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark. Copenhagen University Hospital Mental Health Centre Copenhagen Mental Health Services in the Capital Region of Denmark Hellerup Denmark. Department of

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BIOM-51. MOLECULAR SUBTYPES, CLINICAL CHARACTERISTICS, AND THERAPEUTIC IMPLICATIONS FOR CNS TUMORS WITHBCOR/BCORL1FUSION/INTERNAL TANDEM DUPLICATION

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Neuro-Oncology 2024年第SUPPLEMENT_8期26卷 viii31-viii31页

作者： Gojo, Johannes Federico, Aniello Geisemeyer, Neal Schmitt-Hoffner, Felix Mauermann, Monika Sill, Martin Bruckner, Katharina Korshunov, Andrey Stichel, Damian Capper, David Tauziede-Espariat, Arnault Varlet, Pascale Aldape, Kenneth Abdullaev, Zied Donson, Andrew M Pahnke, Jens Schüller, Ulrich Galbraith, Kristyn Snuderl, Matija Alexandrescu, Sanda Filbin, Mariella Gramatzki, Dorothee Urbanic-Purkart, Tadeja Ziad, Fouzia Toledano, Helen Kerl, Kornelius Hasselblatt, Martin Papusha, Ludmila Brandner, Sebastian Łastowska, Maria Miele, Evelina Lugt, Jasper v d Bunt, Jens Kramm, Christof André, Nicolas Appay, Romain Bouchoucha, Yassine Hansford, Jordan Zapotocky, Michal Kranendonk, Mariette E Nobusawa, Sumihito Solomon, David Haberler, Christine Jones, Barbara Sturm, Dominik Sahm, Felix Jäger, Natalie Pfister, Stefan M Hoff, Katja v Kool, Marcel Department of Pediatrics and Adolescent Medicine Comprehensive Center for Pediatrics and Comprehensive Cancer Center Medical University of Vienna Vienna Austria Hopp Children’s Cancer Center (KITZ) Heidelberg Germany Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Research Consortium (DKTK) Heidelberg Germany Department of Neuropathology University Hospital Heidelberg (DKFZ) Heidelberg Germany Clinical Cooperation Unit Neuropathology German Cancer Research Center (DKFZ) Heidelberg Germany Department of Neuropathology Charité Universitätsmedizin Berlin Berlin Germany Department of Neuropathology GHU Paris Psychiatry and Neurosciences Sainte-Anne Hospital Paris France Laboratory of Pathology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda USA Morgan Adams Foundation Pediatric Brain Tumor Research Program Department of Pediatrics University of Colorado School of Medicine Aurora USA Department of Pathology (PAT) Clinics for Laboratory Medicine (KLM) Oslo University Hospital (OUS) Oslo Norway Department of Pediatric Hematology and Oncology University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Pathology New York University School of Medicine New York USA Department of Pathology Boston Children’s Hospital Harvard Medical School Boston USA Department of Pediatric Oncology Dana-Farber Boston Children’s Cancer and Blood Disorders Center Boston USA Department of Neurology Clinical Neuroscience Center University Hospital and University of Zurich Zurich Switzerland Department of Neurology and Neuroradiology Vascular and Interventional Radiology Auenbruggerplatz 22 8036 Graz Medical University of Graz Graz Austria Department of Pathology Waikato Hospital Hamilton New Zealand Faculty of Medicine Tel Aviv University Tel Aviv Israel Department of Pediatric Hematology-Oncology Schneider Children’s Medical Center Petah Tikva Tel Aviv Israel Department of Pedia

Central nervous system (CNS) tumors with eitherBCORinternal tandem duplication (BCORITD) or gene fusions involvingBCOR/BCORL1(BCORFUS) are recognized as tumor types with characteristic molecular and clinical features but lacking clear therapeutic guidance. In an extensive international effort, we compiled a retrospective cohort of 229 (148BCORITD, 81BCORFUS) unique cases via molecular profiling of CNS tumors. By analyzing DNA methylation patterns of 220 tumors we confirmed distinct epigenetic profiles ofBCORITD versusBCORFUS. The majority (91 percent) ofBCORFUS primary tumors was localized in the supratentorial region whereasBCORITD were localized across all anatomical CNS compartments. Median patient age at diagnosis was 20 years forBCORFUS and 4 years forBCORITD. Metastatic disease was rare inBCORFUS patients but more common inBCORITD tumors where 10 percent presented with metastatic disease and one third showed CNS or (rarely) extra-CNS metastasis in the course of disease. This was also reflected in clinical outcome as 5-year overall survival (OS) was 89 percent in BCOR FUS but 61 percent inBCORITD. In contrast, 5-year progression-free survival (PFS) was comparable reaching 27 percent inBCORFUS and 30 percent inBCORITD. Integrating treatment details we found a trend towards benefit of gross-total resection on OS (BCORFUS, n=18, p<0.08;BCORITD, n=67, p<0.12) but not for PFS (BCORFUS, n=16, p<0.33;BCORITD, n=64, p<0.59). Radiotherapy was associated with improved PFS (BCORFUS, n=18, p<0.01;BCORITD, n=70, p<0.001) and OS (BCORFUS, n=20, p<0.01;BCORITD, n=73, p<0.001). Further in-depth analyses of clinical outcome parameters (primary metastatic disease, radiotherapy approach, chemotherapy type, patient age) are currently ongoing. In summary, we provide first robust annotation of CNSBCORtumor types, clinical outcomes and therapy.

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World Congress Integrative Medicine & Health 2017: Part one: Berlin, Germany. 3-5 May 2017

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BMC Complement Altern Med 2017年第SUPPL 1期17卷 322-322页

作者： Benno Brinkhaus Torkel Falkenberg Aviad Haramati Stefan N. Willich Josephine P. Briggs Merlin Willcox Klaus Linde Töres Theorell Lisa M. Wong Jeffrey Dusek Darong Wu David Eisenberg Bettina Berger Kathi Kemper Beate Stock-Schröer Hedda Sützl-Klein Rosaria Ferreri Gary Kaplan Harald Matthes Gabriele Rotter Elad Schiff Zahi Arnon Eckhard Hahn Christina M. Luberto David Martin Silke Schwarz Diethard Tauschel Andrew Flower Harsha Gramminger Hedwig H. Gupta S. N. Gupta Annette Kerckhoff Christian S. Kessler Andreas Michalsen Eun S. Kim Eun H. Jang Rana Kim Sae B. Jan Martin Mittwede Wiebke Mohme Eran Ben-Arye Massimo Bonucci Bashar Saad Thomas Breitkreuz Elio Rossi Rejin Kebudi Michel Daher Samaher Razaq Nahla Gafer Omar Nimri Mohamed Hablas Gunver Sophia Kienle Noah Samuels Michael Silbermann Lena Bandelin Anna-Lena Lang Eva Wartner Christoph Holtermann Maxwell Binstock Robert Riebau Edin Mujkanovic Holger Cramer Romy Lauche Andres Michalsen Lesley Ward Dominik Irnich Wolfram Stör Geoffrey Burnstock Hans-Georg Schaible Thomas Ots Jost Langhorst Tobias Sundberg Catherina Amarell Melanie Anheyer Marion Eckert Mercedes Ogal Annette Schönauer Birgit Reisenberger Bernhard Brand Dennis Anheyer Gustav Dobos Matthias Kroez Aldo Ammendola Jun J. Mao Claudia Witt Yufei Yang Miriam Oritz Markus Horneber Petra Voiß Alexandra von Rosenstiel Catharina Amarell Friedemann Schad Marc Schläppi Matthias Kröz Arndt Büssing Gil Bar-Sela David Avshalomov Samuel Attias Sian Cotton Miek Jong Mats Jong Christian Scheffer Friedrich Edelhäuser Abdullah AlBedah Myeong Soo Lee Mohamed Khalil Keiko Ogawa Yoshiharu Motoo Junsuke Arimitsu Masao Ogawa Genki Shimizu Rainer Stange Karin Kraft Kenny Kuchta Kenji Watanabe D Bonin Harald Gruber Sabine Koch Urs Pohlmann Christine Caldwell Barbara Krantz Ria Kortum Lily Martin Lisa S. Wieland Ben Kligler Susan Gould-Fogerite Yuqing Zhang John J. Riva Michael Lumpkin Emily Ratner Liu Ping Pei Jian Gesa-Meyer Hamme Xiaosong Mao Han Chouping Sven Schröder Josef Hummelsberger Michael Wullinger Marc Brodzky Chr Institute for Social Medicine Epidemiology and Health Economics Charité – Universitätsmedizin Berlin Berlin Germany Department of Neurobiology Care Sciences and Society Division of Nursing Research Group Integrative Care Karolinska Institutet Stockholm Sweden I C – The Integrative Care Science Center Järna Sweden Department of Biochemistry Molecular and Cellular Biology Georgetown University Medical Center Washington DC USA Department of Medicine Georgetown University Medical Center Washington DC USA NCCIH NIH Bethesda MD USA Department of Primary Care and Population Sciences University of Southampton Aldermoor Health Centre Coxford Rd Southampton 2016 5ST UK Institute of General Practice Technical University Munich Munich Germany Department of Neuroscience Karolinska Institute Stockholm Sweden Stress Research Institute Stockholm University Stockholm Sweden Arts and Humanities Initiative Harvard Medical School Boston MA 02115 USA Psychosomatic medicine Neuropsychology Allina Health Minneapolis MN USA nd Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China Department of Nutrition Harvard University T H Chan School of Public Health Boston MA 02115 USA Department of Health University of Witten/Herdecke Witten/Herdecke Germany OSU Blacklick OH USA Carstens-Foundation and FORUM D-45276 Essen Germany ESIHR (European Society for Integrative Health Care) A-1070 Vienna Austria Hospital Centre of Integrated Medicine Hospital of Pitiglian o ASL SudEst Toscana Grosseto Italy The Kaplan Center for Integrative Medicine Georgetown University McLean VA USA Hospital Havelhöhe Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité University Hospital Berlin Germany Internal medicine and Complementary medicine service Bnai Zion Medical Center Haifa Israel Complementary-Integrative Surgery Service Bnai Zion Medical Center Haifa Israel The Emek Yezreel Academic College Yezreel Valley Israel Medicine

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Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

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Nature communications 2019年第1期10卷 2068页

作者： Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Sim Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology School of Philosophy Psychology and Language Sciences The University of Edinburgh Edinburgh EH8 9JZ UK. Institute of Mental Health Singapore 539747 Singapore. Medical Genetics Section Centre for Genomic & Experimental Medicine MRC Institute of Genetics & Molecular Medicine University of Edinburgh Western General Hospital Edinburgh EH4 2XU UK. BrainWorkup LLC Los Angeles 90033 CA USA. Department of Psychiatry and Behavioral Sciences Keck School of Medicine University of Southern California Los Angeles 90033 CA USA. Social Genetic and Developmental Psychiatry Centre Institute of Psychiatry Psychology & Neuroscience King's College London De Crespigny Park Denmark Hill London SE5 8AF UK. Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Turku 20520 Finland. Department of Internal Medicine Satakunta Central Hospital Pori 28100 Finland. Centre for Global Health Research Usher Institute of Population Health Sciences and Informatics University of Edinburgh Teviot Place Edinburgh EH8 9AG Scotland. Max Planck Institute for Molecular Genetics Berlin 14195 Germany. Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle 98101 Washington USA. Department of Psychiatry Icahn School of Medicine at Mount Sinai New York 10029 NY USA. Mental Illness Research Education and Clinical Center (VISN 3) James J. Peters VA Medical Center Bronx 10468 NY USA. Department of Psychiatry Brigham and Women's Hospital Harvard Medical School Boston 02115 MA USA. NORMENT K.G. Jebsen Centre for Psychosis Research Department of Clinical Science University of Bergen Bergen 5021 Norway. Dr. Einar Martens Research Group for Biological Psychiatry Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen 5020 Norway. Center for Psychiatric Neuroscience Feinstein Institute for Medical Resea

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions...

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Proceedings of the Frontiers of Retrovirology Conference 2016

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Retrovirology 2016年第1期13卷 1-40页

作者： Irena Zurnic Sylvia Hütter Nicole Stanke Tobias Kern Fabian Lindel Gesche Gerresheim Martin Hamann Erik Müllers Dirk Lindemann Ute Lehmann Juliane Reh Paul Lesbats Peter Cherepanov Melanie Mann Erik Serrao Alan Engelman Claire Da Silva Santos Kevin Tartour Andrea Cimarelli Rya Burdick Jianbo Chen Jaya Sastri Wei-Shau Hu Vinay Pathak Oliver T. Keppler Patrícia de Sousa-Pereira Hanna-Mari Baldauf Marcel Stern Karine Pradeau Sylvia Eiler Nicolas Levy Marc Ruff Sarah Lennon Sarah Cianferani Stéphane Emiliani Vincent Parissi Sylvie Rato Miguel Munoz Angela Ciuffi Antonio Rausell Amalio Telenti Alexander Zhyvoloup Ian Anderson Chen- Hsuin Lee Ariberto Fassati Anat Melamed Delphine Planas Petronela Ancuta Yuwei Zhang Huicheng Chen Annie Bernier Annie Gosselin Janos Kriston-Vizi Robin Ketteler Andy Merritt Charles Bangham Jocelyn Turpin Anthony Rodari Benoit Van Driessche Mathilde Galais Nadége Delacourt Sylvain Fauquenoy Caroline Vanhulle Anna Kula Carine Van Lint Ernst J. Wolvetang Arsène Burny Olivier Rohr Thijs van Montfort Renee van der Sluis Ben Berkhout Dave Speijer Gang Wang Na Zhao Atze T. Das Mirte Scherpenisse Bo Meng Andrzej Rutkowski Lars Dölken Andrew Lever Neil Berry Claire Ham Neil Almond Hoi Ping Mok Nicholas Norton Axel Fun Jack Hirst Mark Wills Chris Hellmund Harriet Groom Thomas Schuster Benedikt Asbach Ralf Wagner Christine Gross Martina Kalmer Andrea K. Thoma-Kress Norbert Donhauser Sebastian Millen Sandra M. Müller-Schmucker Veit Wiesmann Thomas Wittenberg Jan Gettemans Minghua Li Shan-Lu Liu Eric O. Freed Janis Müller Jan Münch Simone Joas Clement Wesley Gnanadurai Edina Lump Christina M. Stürzel Daniel Sauter Frank Kirchhoff Katharina Mack Kathrin Starz Christina Stürzel Xaver Sewald Nasim Motamedi Pradeep Uchil Ruoxi Pi Christin Herrmann Walther Mothes Mark Ladinsky Pamela Bjorkman Jagadish Beloor Priti Kumar Thomas Murooka Thorsten Mempel Michael Brehm Dale Greiner Erica Parrish Nicholas F. Parrish Beatrice H. Hahn Frederic Bibollet-Ruche Ulrike Sauermann Katharina Töpfer Tina Schultheiss Chris Molecular Virology and Gene Therapy Molecular Medicine Leuven Belgium Molecular Virology Technical University Dresden Dresden Germany Center for Regenerative Therapies Dresden Dresden Germany Potsdam University Potsdam Germany The Francis Crick Institute London Great Britain Institute of Clinical and Molecular Virology Friedrich-Alexander-Universität Erlangen-Nuremberg Erlangen Germany Dana Farber Cancer Institute Boston MA United States CIRI Lyon France National Cancer Institute Frederick MD United States Virology Max von Pettenkofer-Institut LMU Munich Munich Germany Institute of Medical Virology University of Frankfurt Frankfurt a. M. Germany German Center for Infection Research Munich Germany Institute of Medical Virology University Hospital Frankfurt Frankfurt a. M. Germany CIBIO/InBIO University of Porto Vairão Portugal Faculty of Sciences University of Porto Porto Portugal Virology Max von Pettenkofer Institute LMU Munich Germany Institute for Medical Virology Frankfurt a. M. Germany Integrative structural Biology IGBMC Illkirch France Institut Pluridisciplinaire Hubert Curien Strasbourg France Institut Cochin Paris France CNRS UMR5234 MFP Lab Bordeaux France Associated International Laboratory (LIA) Microbiology and Immunology CNRS/Université de Bordeaux/Heinrich Pette Institute-Leibniz Institute for Experimental Virology Bordeaux/Hamburg France Institute of Microbiology University Hospital Center and University of Lausanne Lausanne Switzerland Imagine Institute Paris Descartes University Paris France J. Craig Venter Institute La Jolla CA United States Infection University College London London Great Britain Medicine Imperial College London Great Britain Microbiology & Infection University of Montreal Montreal Great Britain CRCHUM Montreal Canada University College London LMCB London Great Britain MRC Technology Centre for Therapeutic Discovery London Great Britain Section of Virology Department of Medicine Imperial Co

Oral presentationsSession 1: Entry & uncoatingO1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replicationIrena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Re... 详细信息

Oral presentations

Session 1: Entry & uncoating

O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication

Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann

O2 A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV-1 infection

Claire Da Silva Santos, Kevin Tartour, Andrea Cimarelli

O3 Dynamics of nuclear envelope association and nuclear import of HIV-1 complexes

Rya Burdick, Jianbo Chen, Jaya Sastri, Wei-Shau Hu, Vinay Pathak

O4 Human papillomavirus protein E4 potently enhances the susceptibility to HIV infection

Oliver T. Keppler

Session 2: Reverse transcription & integration

O5 Structure and function of HIV-1 integrase post translational modifications

Karine Pradeau, Sylvia Eiler, Nicolas Levy, Sarah Lennon, Sarah Cianferani, Stéphane Emiliani, Marc Ruff

O6 Regulation of retroviral integration by RNA polymerase II associated factors and chromatin structure

Vincent Parissi

Session 3: Transcription and latency

O7 A novel single-cell analysis pipeline to identify specific biomarkers of HIV permissiveness

Sylvie Rato, Antonio Rausell, Miguel Munoz, Amalio Telenti, Angela Ciuffi

O8 A capsid-dependent integration program linking T cell activation to HIV-1 gene expression

Alexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Janos Kriston-Vizi, Robin Ketteler, Chen-Hsuin Lee, Andy Merritt, Petronela Ancuta, Charles Bangham, Ariberto Fassati

O9 Characterisation of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome

Anthony Rodari, Benoit Van Driessche, Mathilde Galais, Nadége Delacourt, Sylv

关键词： Human Immunodeficiency Virus Infection Simian Immunodeficiency Virus Feline Immunodeficiency Virus Bovine Leukemia Virus Prototype Foamy Virus

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Abstracts for the 6th Congress of Asian Sleep Research Society

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Sleep and Biological Rhythms 2009年第4期7卷 A1-A49页

作者： Seog Ju Kim In Kyoon Lyoo Yu-Jin Lee Do-Un Jeong Hirohiko Kanai Masanori Ookubo Atsushi Yoshimura Masako Okawa Noto Yamada Takeshi Munezawa Yoshitaka Kaneita Yoneatsu Osaki Hideyuki Kanda Tadahiro Ohtsu Masumi Minowa Kenji Suzuki Susumu Hijuchi Hiroyuki Suzuki Takashi Ohida Takashi Abe Yoko Komada Shoichi Asaoka Yuichi Inoue Jin-Seong Lee Sang-Yong Cho Deependra Kumar Hruda N. Mallick Velayudhan M. Kumar Mahesh K. Kaushik Akihiro Karashima Noiihiro Katayama Mitsuyuki Nakao Ravindra P. Nagendra Sathiamma Sulekha Sathyaprabha T. Narasappa Pradhan Nityanadan Bindu M. Kutty M. Nirmala P. N. Ravindra Basavaraj Ramappa Tubaki T. N. Sathyaprabha D. Sudhakar G. S. Lavekar C. R. Chandrashekar Kazuyoshi Kitaoka Mika Shimizu Sachiko Chikahisa Kazuo Yoshizaki Hiroyoshi Sei Jong-Won Kim Misa Takegami Shin Yamazaki Yasuaki Hayashino Rei Ono Koji Otani Miho Sekiguchi Shinichi Konno Shunichi Fukuhara Antonia J. Jakobson Paul Fitzgerald Russell Conduit Xin Shirley Li Siu Ping Joyce Lam Wai Man Mandy Yu Yun Kwok Wing Kazue Okamoto-Mizuno Koh Mizuno Mituaki Yamamoto Shuichiro Shirakawa Hirokazu Doi Mikako Kato Kazuyuki Shinohara Masako Tamaki Shiori Matsuda Katsuo Yamazaki Tadao Hori Keiko Ogawa Kazumi Takahashi Kunio Kitahama Katuo Yamazaki Yoshimasa Koyama Kohei Shioda Yugo Ueda Yukiko Nakamura Clara Inoue Kazushige Goto Sunao Uchida Yuko Morita Yoshiko Honda Tohru Kodama Mari Hagihara Toru Nakajima Masato Saito Yoshihiko Koga Shinichiro Tanaka Hiroshi Yamadera Madoka Takahara Sachiko Suwa Minoru Onozuka Sadao Sato Fumiharu Togo Taiki Komatsu Takeshi Mitani Jongbae Choi Bin Zhang Taeko Sasai Hiromi Mitsubayashi Mitsuhiro Ohtsu Isao Hasegawa Tatsuya Ishii Akira Komori Asami Suzuki Yue Nakahara Mitsuyasu Hiroki Mariko Nakauma Nobuo Someya Tomomasa Ochiai Shouhei Komori Rayleigh Ping-Ying Chiang Zai-Ting Yeh Seong T. Kim Seung H. Yoon Jeong S. Kwon Jong H. Choi Hyung J. Ahn Youngsoo Kim Bolortuya Yunren Lichao Chen Radhika Basheer Robert W. Mccarley Robert E. Strecker Makoto Honda Tetsuaki Arai Miyuki Fukazawa Yutaka Honda Kuniaki T Department of Psychiatry Gachon University of Medicine and Science Incheon Republic of Korea Department of Psychiatry Seoul National University Seoul Republic of Korea Department of Neuropsychiatry and Center for Sleep and Chronobiology Seoul National University Hospital Seoul Republic of Korea Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea Seoul National University Hospital Seoul Republic of Korea Department of Psychiatry Shiga University of Medical Science Otsu Japan Division of Public Health Department of Social Medicine Nihon University School of Medicine Tokyo Japan Department of Public Health Nihon University School of Medicine Tokyo Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan Department of Public Health Showa University School of Medicine Tokyo Japan Faculty of Humanities Seitoku University Matsudo Japan Section on Behavioral Science Division of Clinical Research National Hospital Organization Kurihama Alcoholism Center Yokosuka Japan Department of Otolaryngology Second Hospital Fujita Health University Nagoya Japan National Hospital Organization Kurihama Alcoholism Center Kanagawa Japan Metropolitan Police Department Criminal Investigation Laboratory Tokyo Japan Japan Somnology Center Neuropsychiatrie Research Institute Tokyo Japan Department of Somnology Tokyo Medical University Tokyo Japan Japan Somnology Center Neuropsychiatric Research Institute Tokyo Japan Department of Somnology Tokyo Medical and Dental University Tokyo Japan Center for Sleep and Chronobiology Department of Psychiatry and Behavioral Science Seoul National University College of Medicine Seoul Republic of Korea Department of Psychiatry and Behavioral Science Center for Sleep and Chronobiology Seoul Republic of Korea Department of Physiology Al

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ESICM LIVES 2016: part two

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Intensive Care Medicine Experimental 2016年第1期4卷 205-404页

作者： S. Sivakumar F. S. Taccone K. A. Desai C. Lazaridis M. Skarzynski M. Sekhon W. Henderson D. Griesdale L. Chapple A. Deane L. Williams R. Strickland K. Lange D. Heyland M. Chapman M. J. Rowland P. Garry J. Westbrook R. Corkill C. A. Antoniades K. T. Pattinson G. Fatania A. J. Strong R. B. Myers C. M. Jermaine C. S. Robertson C. G. Rusin J. Hofmeijer L. Sondag M. C. Tjepkema-Cloostermans A. Beishuizen F. H. Bosch M. J. A. M. van Putten L. Carteron C. Patet D. Solari M. Oddo M. A. Ali C. Dias R. Almeida A. Vaz-Ferreira J. Silva E. Monteiro A. Cerejo A. P. Rocha A. A. Elsayed A. M. Abougabal B. N. Beshey K. M. Alzahaby S. Pozzebon A. Blandino Ortiz S. Cristallini O. Lheureux A. Brasseur J. L. Vincent J. Creteur M. Hravnak K. Yousef Y. Chang E. Crago R. M. Friedlander S. A. Abdelmonem S. A. Tahon T. A. Helmy H. S. Meligy F. Puig I. Dunn-Siegrist J. Pugin S. Gupta D. Govil S. Srinivasan S. J. Patel J. K. N A. Gupta D. S. Tomar M. Shafi R. Harne D. P. Arora N. Talwar S. Mazumdar E. E. Papakrivou D. Makris E. Manoulakas B. Tsolaki B. Karadodas E. Zakynthinos I. Palacios Garcia A. Diaz Martin V. Sanchez Encinares M. Pachón Ibañez J. Garnacho Montero G. Labrador T. Cebrero Cangueiro V. Poulose J. Koh J. W. Kam H. Yeter A. Kara O. Aktepe A. Topeli I. Tsolakoglou G. Intas P. Stergiannis A. A. Kolaros E. Chalari E. Athanasiadou A. Martika G. Fildisis V. Faivre C. Mengelle B. Favier D. Payen A. Poppe M. S. Winkler E. Mudersbach J. Schreiber M. L. Wruck E. Schwedhelm S. Kluge C. Zöllner T. Tavladaki A. M. Spanaki H. Dimitriou E. Kondili C. Choulaki E. Meleti D. Kafetzopoulos D. Georgopoulos G. Briassoulis A. García-de la Torre M. V. de la Torre-Prados T. Tsvetanova-Spasova P. Nuevo-Ortega C. Rueda-Molina A. Fernández-Porcel E. Camara-Sola L. Salido-Díaz A. García-Alcántara D. E. Meleti B. Suberviola J. Riera L. Rellan M. Sanchez J. C. Robles E. Lopez R. Vicente E. Miñambres M. Santibañez M. Le Guen J. Moore N. Mason M. Windpassinger O. Plattner E. Mascha D. I. Sessler Outcomes Research U. Melia J. Fontanet J. P. van den Berg M. Baylor College of Medicine Neurology/Neurocritical Care Houston USA Erasmus Hospital Intensive Care Medicine Brussels Belgium Centre Hospitalier Régional Orléans Réaimation Médicale Orléans France University of British Columbia Vancouver Canada University of Adelaide Discipline of Acute Care Medicine Adelaide Australia Royal Adelaide Hospital Intensive Care Adelaide Australia Griffith University Menzies Health Institute of Queensland Gold Coast Australia University of Adelaide Discipline of Medicine Adelaide Australia Kingston General Hospital Clinical Evaluation Research Unit Kingston Canada University of Oxford Nuffield Department of Clinical Neurosciences Oxford UK Oxford University Hospitals NHS Foundation Trust Neurosciences Intensive Care Unit Oxford UK King’s College Hospital Department of Neurosurgery London UK King’ College London Institute of Psychiatry Psychology and Neuroscience Department of Clinical Neuroscience London UK Rice University Computer Science Houston USA Baylor College of Medicine Neurosurgery Houston USA Baylor College of Medicine Pediatric Cardiology Houston USA University of Twente Clinical Neurophysiology Enschede Netherlands Rijnstate Hospital Neurology Arnhem Netherlands Medical Spectrum Twente Clinical Neurophysiology Enschede Netherlands Medical Spectrum Twente Intensive Care Enschede Netherlands Rijnstate Hospital Intensive Care Arnhem Netherlands CHUV Department of Intensive Care Medicine Neuroscience Critical Care Research Group Lausanne Switzerland Aga Khan University Hospital Anaesthesiology Karachi Pakistan Centro Hospitalar São João Intensive Care Porto Portugal Faculty of Medicine University of Porto Medicine Porto Portugal Faculdade de Ciências Universidade do Porto Departamento de Matemática Porto Portugal Centro de Matemática Universidade do Porto Porto Portugal The Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine Zaragoza Spain Centro Hospitalar

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