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Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair

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Bioactive Materials 2024年第10期40卷 306-317页

作者： Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul08826South Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826South Korea Department of Biomedical Engineering Dongguk UniversitySeoul10326South Korea Soonchunhyang Institute of Medi-bio Science(SIMS) Soonchunhyang UniversityCheonan31151South Korea Department of Integrated Biomedical Science Soonchunhyang UniversityAsan31538South Korea Department of Orthopaedic Surgery Konkuk University Chungju HospitalKonkuk University School of MedicineChungju27376South Korea BioMAX Institute Seoul National UniversitySeoul08826South Korea

Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage *** or gradient scaffolds,often in conjunction with stem cells and growth factors,have been developed to mimic the respective layers for osteochondral defect *** this study,we designed a hyaline cartilage-hypertrophic cartilage bilayer graft(RGD/RGDW)with ***,we demonstrated that RGD peptide-modified chondroitin sulfate cryogel(RGD group)is chondro-conductive and capable of hyaline cartilage ***,we incorporated whitlockite(WH),a Mg^(2+)-containing calcium phosphate,into RGD cryogel(RGDW group)to induce chondrocyte hypertrophy and form collagen X-rich hypertrophic *** is the first study to use WH to produce hypertrophic ***-laden RGDW cryogel exhibited significantly upregulated expression of hypertrophy markers in vitro and formed ectopic hypertrophic cartilage in vivo,which mineralized into calcified cartilage in bone ***,RGD cryogel and RGDW cryogel were combined into bilayer(RGD/RGDW group)and implanted into rabbit osteochondral defect,where RGD layer supports hyaline cartilage regeneration and bioceramic-containing RGDW layer promotes calcified cartilage *** the RGD group(monolayer)formed hyaline-like neotissue that extends into the subchondral bone,the RGD/RGDW group(bilayer)regenerated hyaline cartilage tissue confined to its respective layer and promoted osseointegration for integrative defect repair.

关键词： Bioceramic Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair

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Economic and Sensitivity Analyses for an Optimal Hybrid Power Generation for Stand-Alone Power Systems: Case of Klongrua, Phato, Chumphon, Thailand

Economic and Sensitivity Analyses for an Optimal Hybrid Powe...

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2022 International Electrical engineering Congress, iEECON 2022

作者： Jeenthanom, Pathumwadee Saelao, Jeerawan Muangjai, Worrajak Thongporn, Jutturit Panlawan, Nattawat Somsak, Teerasak Rajamangala University of Technology Lanna Electrical Engineering Program Faculty of Engineering Chiang Mai Thailand Maejo University Division of Mathematics Faculty of Science Chiangmai Thailand Rajamangala University of Technology Lanna Collage of Integrated of Science and Technology Chiang Mai Thailand

ISBN: (纸本)9781665402064

This paper analyzes a hybrid power system for an independent power system for Baan Khlongrua community, which is a village far from the transmission line system so that the community has electricity available all the time. The designed system consists of solar cells, batteries, inverters and small power turbines. Therefore, this research assesses the economic value and analyzes the system's sensitivity. It is assumed that the electricity demand will increase by 4.25% per year. The analysis data found that in the first year, the cost of energy (COE) was 0.137 /kWh, the second year was 0.132 /kWh, and the third year was 0.127 /kWh. Year 1 has a high COE due to system design being approximately 10% larger than current demand, and in years 4, 5, 6, COE will increase. As a result of the designed system, it will not produce enough electricity to meet the electrical load of the village. Therefore, a diesel generator compensates during the power shortage, causing the CO2 value in the year 4,5,6 to 3,780 kg/yr 2,898 kg/yr 3,265 kg/yr increased. This CO2 value, therefore, affects the COE increase, and COE decreases from 0.137 to 0.127 /kWh. the payback period of the system can be quickly achieved. © 2022 IEEE.

关键词： Sensitivity analysis

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Directly and instantly seeing through random diffusers by self-imaging in scattering speckles

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PhotoniX 2023年第1期4卷 674-687页

作者： Jietao Liu Wenhong Yang Guofeng Song Qiaoqiang Gan Laboratory of Photonic Integrated Circuits Xiong’an Institute of InnovationChinese Academy of SciencesXiong’an New AreaBeijing 071700Hebei ProvinceChina 2 Sustainability&Photonics Energy Research LaboratoryMaterial Science Engineering programDivision of Physical Science&EngineeringKing Abdullah University of Science and TechnologyThuwalSaudi Arabia

Imaging through scattering medium is challenging but important for different *** advances rely on computational image reconstruction from scattering *** these conventional investigations,speckles were always treated as scrambled grainy *** seeing through scattering diffusers has never been ***,we report a new strategy to see through random diffusers directly using self-imaging of *** analyzing the physics,a direct observation strategy through scattering media is reported with improved image *** this method,we experimentally demonstrated reconstruction-free real-time imaging of static and moving objects with their actual orientation information under single-wavelength and white light *** also proposed a modified speckle autocorrelation imaging(SAI)method inspired by the self-imaging ***,our strategy requires no pre-calibration or acquisition of point-spread-function,no active control of wavefronts or complicated equipment,nor iterations or carefully adjusted parameters,paving the way towards rapid and high-quality imaging through scattering diffusers.

关键词： speckle random instant

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Projection of climate change effects on flood inundation in the Gin River basin, Sri Lanka 9

Projection of climate change effects on flood inundation in ...

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9th International Conference on Flood Management, ICFM 2023

作者： Jayapadma, Jayapadma Mudalige Miyuru Uthpala Souma, Kazuyoshi Ishidaira, Hiroshi Magome, Jun Wickramaarachchi, Thushara Navodani Special Educational Program on River Basin Environmental Science Integrated Graduate School of Medicine Engineering and Agricultural Sciences University of Yamanashi 4-3-11 Takeda Yamanashi Kofu400-8511 Japan Interdisciplinary Centre for River Basin Environment University of Yamanashi 4-3-11 Takeda Yamanashi Kofu400-8511 Japan Department of Civil and Environmental Engineering Faculty of Engineering University of Ruhuna Galle Hapugala Sri Lanka

Human-induced climate change has altered the frequency and severity of heavy precipitation, droughts, and floods worldwide. Sri Lanka, a developing country in the Indian Ocean, has suffered frequent floods, affecting over 64 % of the population in the past decade. The Gin River, the primary drinking water source of the densely populated Galle district with over 1 million residents, faces recurrent flood disasters. Therefore, this study employed a multi-model ensemble to simultaneously simulate the impact of climate change on both river flow and inundation extent in the frequently flooded Gin River basin located in humid tropical monsoon region. Bias-corrected climate projections of an ensemble of five General Circulation Models (GCMs) from the Coupled Model Inter-comparison Project Phase 5 (CMIP5) under Representative Concentration Pathway (RCP) 4.5 emission scenario were used to project future river flow and flood inundation in the Gin River basin, Sri Lanka. The validated Rainfall-Runoff-Inundation (RRI) model projected a 5 % increase in high flows (flows exceeding a 5 % probability of exceedance ( Copyright © 2024 Jayapadma Mudalige Miyuru Uthpala Jayapadma et al.

关键词： Floods

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Solution-processable electrode-material embedding in dynamically inscribed nanopatterns(SPEEDIN)for continuous fabrication of durable flexible devices

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Microsystems & Nanoengineering 2021年第5期7卷 173-181页

作者： Wonseok Lee Hyoungseok Chae Dong Kyo Oh Minyoung Lee Hyunsoo Chun Gyubeom Yeon Jaewon Park Joohoon Kim Hongseok Youn Junsuk Rho Jong G.Ok Department of Mechanical and Automotive Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Graduate Program of Energy Technology School of Integrated TechnologyInstitute of Integrated TechnologyGwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Mechanical Engineering Hanbat National UniversityDaejeon 34158Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea

A facile and scalable lithography-free fabrication technique,named solution-processable electrode-material embedding in dynamically inscribed nanopatterns(SPEEDIN),is developed to produce highly durable *** uniquely utilizes a single continuous flow-line manufacturing process comprised of dynamic nanoinscribing and metal nanoparticle solution coating with selective ***-and/or micro-trenches are inscribed into arbitrary polymers,and then an Ag nanoparticle solution is dispersed,soft-baked,doctor-bladed,and hard-baked to embed Ag micro-and nanowire structures into the *** to lithographically embossed metal structures,the embedded SPEEDIN architectures can achieve higher durability with comparable optical and electrical properties and are robust and power-efficient even under extreme stresses such as scratching and *** one tangible application of SPEEDIN,we demonstrate a flexible metal electrode that can operate at 5 V at temperatures up to 300℃even under the influence of harsh external *** can be applied to the scalable fabrication of diverse flexible devices that are reliable for heavy-duty operation in harsh environments involving high temperatures,mechanical deformations,and chemical hazards.

关键词： electrode process embedding

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MODELING THE HODGKIN-HUXLEY NEURON TO DETERMINE NEURONAL ENERGY CONSUMPTION EFFICIENCY AND OXYGEN CONSUMPTION VALUES

Biomedical Sciences Instrumentation

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Biomedical sciences Instrumentation 2022年第2期58卷 50-58页

作者： Enochson, Avery Ewert, Daniel Mitar, Dipankar Striker, Ryan Cleveland, Jerika Wolf, Henry Gieser, Anna Braaten, Ben Allen, Jeffery Allen, Monica Department of Integrated Engineering at Iron Range Engineering Program of Minnesota State University Mankato MN United States Department of Computer Science and Computer Engineering University of Wisconsin – La Crosse La CrosseWI United States Department of Electrical and Computer Engineering North Dakota State University FargoND United States Air Force Research Laboratory Munitions Directorate Eglin Air Force Base Eglin AFB FL United States

Understanding neuronal structure and function is essential to studying the human brain. The goal of this project was to create a model of human brain neurons that accurately reflects neuronal function, energy consumption, and oxygen consumption. Extensive work has been performed on the Hodgkin-Huxley model of neurons to accurately model neuronal firing. This study focuses on the creation of a model of the Hodgkin-Huxley neuron in MATLAB with the assistance of the DynaSim toolbox. This model was used to compute values and using another model the energy efficiency of the neuron was calculated and related to oxygen consumption, which then corresponds to Blood Oxygenation Level Dependent (BOLD) imaging in fMRI. The results of this study provide detailed visual and technical information about how the brain neurons function, which is crucial to the further development in brain imaging techniques and to further our understanding of why and how our complex brains function. © 2022 IAE All rights reserved.

关键词： Neurons

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Modeling the Self-Capacitance of Individual Plates in a Multi-Conductor System using PEEC 5

Modeling the Self-Capacitance of Individual Plates in a Mult...

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5th IEEE Research and Applications of Photonics in Defense Conference, RAPID 2022

作者： Wolf, Henry Striker, Ryan Cleveland, Jerika Gieser, Anna Braaten, Benjamin D. Enochson, Avery Ewert, Daniel Mitra, Dipankar Allen, Jeffery Allen, Monica Vitola, Sabina North Dakota State University Department of Electrical and Computer Engineering Fargo United States Program of Minnesota State University Department of Integrated Engineering at Iron Range Engineering MankatoMN United States University of Wisconsin - la Crosse Department of Computer Science and Computer Engineering La CrosseWI United States Eglin Air Force Base Eglin Afb Air Force Research Laboratory Munitions Directorate FL32542 United States Minnesota State University Bell Program Department of Integrated Engineering MankatoMN United States

ISBN: (数字)9781665402231

ISBN: (纸本)9781665402231

In many areas of electronics design, it is necessary to understand the different aspects of capacitance associated with various conducting surfaces in a particular layout. This is because as operating frequencies increase and dimensions decrease, capacitive coupling can become the dominant means in which noise is induced in a design. Therefore, having the ability to extract an equivalent circuit for modeling capacitive coupling and understanding the coupling can be very important, and challenging. This paper presents insight on capacitive coupling by evaluating the capacitance between two parallel plates, with particular attention paid to the self-capacitance (with a reference at infinity) of each of the individual plates. More specifically, the Partial Element Equivalent Circuit (PEEC) method is used to compute the self-capacitance of each individual plate in the parallel plate capacitor problem, and results are verified by comparison to values from James C. Maxwell's original works and the electrostatic solver ANSYS Maxwell 3D. Overall, it is shown how the self-capacitance of each individual plate changes as a function of distance between the parallel plates. © 2022 IEEE.

关键词： Capacitance

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Neuronal Modeling Tool Using DynaSim 5

Neuronal Modeling Tool Using DynaSim

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5th IEEE Research and Applications of Photonics in Defense Conference, RAPID 2022

作者： Gieser, Anna Vitola, Sabina Enochson, Avery Wolf, Henry Striker, Ryan Cleveland, Jerika Braaten, Benjamin D. Ewert, Daniel Mitra, Dipankar Allen, Jeffery Allen, Monica North Dakota State University Department of Electrical and Computer Engineering Fargo United States Minnesota State University Bell Program Department of Integrated Engineering MankatoMN United States Program of Minnesota State University Department of Integrated Engineering at Iron Range Engineering MankatoMN United States University of Wisconsin - la Crosse Department of Computer Science and Computer Engineering La CrosseWI United States Munitions Directorate Air Force Research Laboratory Eglin Air Force Base FL32542 United States

ISBN: (数字)9781665402231

ISBN: (纸本)9781665402231

Human cognitive processes remain an area of strong interest and ongoing research. One tool to gain greater insight into this process is neuronal modeling. The following features are desirable in a neuronal modeling tool: a library of known parameters for different neurons and species, the ability to select the neuron and species of interest, the ability to quickly simulate neuronal behavior, and the ability to calculate metabolic requirements and efficiencies for various neuronal activity. Many of these can be found in software today, but not all elements can be found in one entity. The goal of this work is to develop a neuronal modeling tool that incorporates these features. © 2022 IEEE.

关键词： Neurons

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Plasmonic gold nanoisland on TiO2: effect of dewetting temperature

Plasmonic gold nanoisland on TiO2: effect of dewetting tempe...

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Frontiers in Optics, FiO 2022

作者： Chowdhury, Aminur Rashid Luk, Ting Shan Hutter, Tanya Materials Science and Engineering Program Texas Materials Institute The University of Texas at Austin Texas AustinTX78712 United States Center for Integrated Nanotechnology Sandia National Laboratories New Mexico AlbuquerqueNM87123 United States

ISBN: (纸本)9781557528209

Here we report the effect of annealing/dewetting temperature on the development of plasmonic gold (Au) nanoislands on anatase titanium dioxide (TiO2) film. A 140 nm thick TiO2 film was deposited using atomic layer deposition (ALD) and 6 nm Au was deposited using e-beam sputtering. Samples were annealed at 100, 150, 200, 250, 300 and 350 ∘C for 3 minutes and analyzed using ellipsometer, scanning electron microscope (SEM) and ultraviolet-visible (UV-VIS) spectroscopy. Plasmonic Au nanoislands formed at annealing conditions of temperature above 200 ∘C for 3 minutes. Also, no phase change of anatase TiO2 was found for annealing temperatures below 350 ∘C for a heating period of 3 minutes. © 2022 The Author(s)

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New microbial electrosynthesis system for methane production from carbon dioxide coupled with oxidation of sulfide to sulfate

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Journal of Environmental sciences 2023年第3期125卷 786-797页

作者： Hiromi Kambara Ha T.T.Dinh Shuji Matsushita Yoshiteru Aoi Tomonori Kindaichi Noriatsu Ozaki Akiyoshi Ohashi Department of Civil and Environmental Engineering Graduate School of EngineeringHiroshima University1–4–1KagamiyamaHigashi-HiroshimaHiroshima 739–8527Japan Faculty of Environment Ho Chi Minh City University of Natural Resources and Environment236 Le Van Sy1 WardTan Binh DistrictHo Chi Minh CityVietnam Agricultural Technology Research Center Hiroshima Prefectural Technology Research Institute6869HaraHachihonmatsuHigashihiroshimaHiroshima 739–0151Japan Program of Biotechnology Graduate School of Integrated Sciences for LifeHiroshima University1–3–1KagamiyamaHigashi-HiroshimaHiroshima 739–8530Japan Department of Civil and Environmental Engineering Graduate School of Advanced Science and EngineeringHiroshima University1–4–1KagamiyamaHigashi-HiroshimaHiroshima 739–8527Japan

Microbial electrosynthesis system (MES) is a promising method that can use carbon dioxide,which is a greenhouse gas,to produce methane which acts as an energy source,without using organic ***,this bioelectrical reduction reaction can proceed at a certain high applied voltage when coupled with water oxidation in the anode coated with metallic *** coupled with the oxidation of HS–to SO_(4)^(2-),methane production is thermodynamically more feasible,thus implying its production at a considerably lower applied *** this study,we demonstrated the possibility of electrotrophic methane production coupled with HS–oxidation in a cost-effective bioanode chamber in the MES without organic substrates at a low applied voltage of 0.2 *** addition,microbial community analyses of biomass enriched in the bioanode and biocathode were used to reveal the most probable pathway for methane production from HS–*** the bioanode,electroautotrophic SO_(4)^(2-)production accompanied with electron donation to the electrode is performed mainly by the following two steps:first,incomplete sulfide oxidation to sulfur cycle intermediates (SCI) is performed;then the produced SCI are disproportionated to HS^(–)and SO_(4)^(2-).In the biocathode,methane is produced mainly via H_(2)and acetate by electronaccepting syntrophic bacteria,homoacetogens,and acetoclastic ***,a new ecofriendly MES with biological H_(2)S removal is established.

关键词： Microbial electrosynthesis system Low applied voltage Organic substrates Methane production Sulfur oxidation

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