检索结果-内蒙古大学图书馆

Signaling interactions among neurons impact cell fitness and death in Alzheimer's disease

Neural Regeneration Research 2023年第4期18卷 784-789页

作者： Catherine Yeates Prajakta Deshpande Madhuri Kango-Singh Amit Singh Department of Biology University of DaytonDaytonOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA The Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

The pathology of Alzheimer’s disease involves a long preclinical period,where the characteristic clinical symptoms of the changes in the brain are *** the preclinical period,homeostatic mechanisms may help prevent widespread cell *** has pointed towards selective cell death of diseased neurons playing a potentially protective *** the disease progresses,dysregulation of signaling pathways that govern cell death contributes to *** activation of the c-Jun N-terminal kinase pathway has been established in human and animal models of Alzheimer’s disease caused by amyloid-beta 42-or tau-mediated *** mosaic studies in Drosophila that examine amyloid-beta 42 in a subset of neurons suggest complex interplay between amyloid-beta 42-expressing and wild-type *** review examines the role of c-Jun N-terminal kinase signaling in the context of cell competition and short-range signaling interactions between amyloid-beta 42-expressing and wild-type *** competition is a conserved phenomenon regulating tissue integrity by assessing the fitness of cells relative to their neighbors and eliminating suboptimal *** clones of amyloid-beta 42 that juxtapose genetically distinct neuronal cell populations show promise for studying *** genetic mosaics with labeled clones of amyloid-beta 42-or tau-expressing and wild-type neurons will allow us to understand how short-range signaling alterations trigger cell death in neurons and thereby contribute to the progression of Alzheimer’s *** approaches have the potential to uncover biomarkers for early Alzheimer’s disease detection and new therapeutic targets for intervention.

关键词： Alzheimer’s disease amyloid-beta 42 mediated neurodegeneration cell competition Drosophila c-Jun N-terminal kinase signaling suboptimal cell super competition super competitor cell two clone-approach wild type cell

来源：评论

学校读者我要写书评

暂无评论

Nanoconfinement effect of nanoporous carbon electrodes for ionic liquid-based aluminum metal anode

引用

Journal of Energy Chemistry 2022年第11期31卷 121-127,I0005页

作者： Juhee Yoon Seongbak Moon Son Ha Hyung-Kyu Lim Hyoung-Joon Jin Young Soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheon 22212South Korea Department of Polymer Science and Engineering Inha UniversityIncheon 22212South Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841South Korea Division of Chemical Engineering and Bioengineering Kangwon National UniversityGangwon-do 24341South Korea Department of Integrative Energy Engineering Korea UniversitySeoul 02841South Korea

Rechargeable aluminum batteries(RABs),which use earth-abundant and high-volumetric-capacity metal anodes(8040 m Ah cm-3),have great potential as next-generation power sources because they use cheaper resources to deliver higher energies,compared to current lithium ion ***,the mechanism of charge delivery in the newly developed,ionic liquid-based electrolytic system for RABs differs from that in conventional organic ***,targeted research efforts are required to address the large overpotentials and cycling decay encountered in the ionic liquid-based electrolytic *** this study,a nanoporous carbon(NPC)electrode with well-developed nanopores is used to develop a high-performance aluminum *** negatively charged nanopores can provide quenched dynamics of electrolyte molecules in the aluminum deposition process,resulting in an increased collision *** fast chemical equilibrium of anionic species induced by the facilitated anionic collisions leads to more favorable reduction reactions that form aluminum *** nanoconfinement effect causes separated nucleation and growth of aluminum nanoparticles in the multiple confined nanopores,leading to higher coulombic efficiencies and more stable cycling performance compared with macroporous carbon black and 2D stainless steel electrodes.

关键词： Nanoconfinement effect Nanoporous carbon Ionic liquid electrolyte Metal anode Aluminum batteries Multivalent batteries

来源：评论

学校读者我要写书评

暂无评论

The important role of distortion recognition in student advocacy leadership development

引用

New directions for student leadership 2024年第182期2024卷 187-197页

作者： Yamanaka, Aoi Hassell-Goodman, Sharrell Athanasiou, Janet Arminio, Jan School of Integrative Studies George Mason University Fairfax VA United States Volgenau School of Engineering George Mason University Fairfax VA United States School of Advanced International Studies John Hopkins University Baltimore MD United States Higher Education Program George Mason University Fairfax VA United States

Though promoting student advocacy has become an essential part of leadership education, few studies explore development of advocacy in leadership education. This article offers how distortions, an aspect of a Black feminist reframing of dissonance, is related to existing leadership education literature. It then introduces students' voices demonstrating the importance of the realization of distortions in student advocacy development and links distortions with how power communicates and upholds systemic oppression. Finally, we offer practical recommendations based on a case scenario that utilize Black feminist perspectives of dissonance in refining student advocacy leadership education. Such insight prompts more effective strategies in student advocate development. © 2024 The Authors. New Directions for Student Leadership published by Wiley Periodicals LLC.

关键词：

来源：评论

学校读者我要写书评

暂无评论

First Demonstration of HZO-LNOI Integrated Ferroelectric Electro-Optic Modulator and Memory to Enable Reconfigurable Photonic Systems

First Demonstration of HZO-LNOI Integrated Ferroelectric Ele...

引用

2023 International Electron Devices Meeting, IEDM 2023

作者： Xu, Zefeng Chen, Chun-Kuei Lin, Hong-Lin Gao, Yuan Ke, Wei Xu, Baochang Dmitriev, Pavel Arbiz, Carlan Zamburg, Evgeny Touzard, Steven Cai, Xinlun Lee, James Venkatesan, Suresh Danner, Aaron Thean, Aaron Voon-Yew Department of Electrical and Computer Engineering Singapore Nus Graduate School Integrative Sciences and Engineering Program Singapore 117583 Singapore School of Electronics and Information Technology 117583 Singapore Centre for Quantum Technologies Nus Singapore Poet Technologies Canada Sun Yat-Sen University 510275 China

ISBN: (纸本)9798350327670

We have successfully demonstrated, for the first time, an innovative back-end-of-line (BEOL) compatible electro-optic modulator and memory (EOMM) based on Lithium Niobate on Insulator (LNOI) micro-ring resonator (MRR) integrated with Ferroelectric Hafnium Zirconate Hf0.5Zr0.5O (HZO) non-volatile analog memory. High non-volatile memory and modulation performances are both achieved in a single compact device, exhibiting high extinction ratio of 13.3 dB, excellent efficiency of 66pm/V, stable nine-state switching, record-high endurance exceeding 109 cycles. This is accomplished by utilizing Pockels effect in LNOI, induced by electric-field effect from remnant HZO ferroelectric polarization. We studied the system implementation of reconfigurable chiplet-interposer photonic interconnect, enabled by the EOMM and EOMM with hybrid thermal-optical modulation. Our model shows a potential 70% energy efficiency improvement over conventional electrical interposer interconnect. We have also tested the integration of the EOMM with POET technologies' 400G Tx/Rx optical interposer chip and studied a limited scale demonstration of the EOMM device. © 2023 IEEE.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Motor clustering enhances kinesin-driven vesicle transport

引用

Biophysical Journal 2025年第12期124卷 2033-2040页

作者： Jiang, Rui Feng, Qingzhou Nong, Daguan Kang, You Jung Sept, David Hancock, William O. Intercollege Program in Integrative and Biomedical Physiology Pennsylvania State University University Park PA United States Department of Biomedical Engineering Pennsylvania State University University Park PA United States Molecular Cellular and Integrative Biomedical Sciences Program Pennsylvania State University University Park PA United States Department of Biomedical Engineering University of Michigan Ann Arbor MI United States Department of Chemistry Pennsylvania State University University Park Pennsylvania United States

Intracellular vesicles are typically transported by a small number of kinesin and dynein motors. However, the slow microtubule binding rate of kinesin-1 observed in in vitro biophysical studies suggests that long-range transport may require a high number of motors. To address the discrepancy in motor requirements between in vivo and in vitro studies, we reconstituted motility of 120-nm-diameter liposomes driven by multiple GFP-labeled kinesin-1 motors. Consistent with predictions based on previous binding rate measurements, we found that long-distance transport requires a high number of kinesin-1 motors. We hypothesized that this discrepancy from in vivo observations may arise from differences in motor organization and tested whether motor clustering can enhance transport efficiency using a DNA scaffold. Clustering just three motors increased liposome travel distances across a wide range of motor numbers. Our findings demonstrate that, independent of motor number, the arrangement of motors on a vesicle regulates transport distance, suggesting that differences in motor organization may explain the disparity between in vivo and in vitro motor requirements for long-range transport. © 2025 Biophysical Society

关键词：

来源：评论

学校读者我要写书评

暂无评论

Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

引用

Genes & Diseases 2022年第4期9卷 841-844页

作者： Shang Jiunn Chuah Chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen Wong Asher Ah Tong Lim Sai Kiang Lim Wei Seong Toh Faculty of Dentistry National University of Singapore119085Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore117583Singapore Tissue Engineering Program Life Sciences InstituteNational University of Singapore117456Singapore Integrative Sciences and Engineering Program NUS Graduate SchoolNational University of Singapore119077Singapore

Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical *** MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.

关键词： healing clinical macrophage

来源：评论

学校读者我要写书评

暂无评论

High-performance solid-solution potassium-ion intercalation mechanism of multilayered turbostratic graphene nanosheets

引用

Journal of Energy Chemistry 2022年第4期31卷 814-823页

作者： Jiae Um Seung Uk Yoon Hoseong Kim Beom Sik Youn Hyoung-Joon Jin Hyung-Kyu Lim Young Soo Yun Program in Environmental and Polymer Engineering Inha Universityncheon 22212 South Korea Department of Polymer Science and Engineering Inha UniversityIncheon 22212South Korea Division of Chemical Engineering and Bioengineering Kangwon National University Chuncheon Gangwon-do 24341 South Korea KU-KIST Graduate School of Converging Science and Technologyea University 145 Anam-roSeongbuk-guSoul02841 South Korea Department of Integrative Energy Engineering 145 Anam-roSongbuk-guKorea UniversitySeoul 02841 South Korea

The solid-solution reaction between an alkali cation and an active host material is known as a singlephase redox mechanism,and it is typically accompanied by a continuous voltage *** is distinct from the typical alkali cation intercalation reaction at an equivalent site of the active host material,which exhibits a voltage ***,we report an unusual solid-solution potassium-ion intercalation mechanism with a low-voltage plateau capacity on multilayered turbostratic graphene nanosheets(T-GNSs).Despite the disordered graphitic structure with a broad range of d-spacings(3.65–4.18À),the T-GNSs showed a reversible plateau capacity of~200 m A h g^(-1),which is higher than that of a well-ordered graphite nanoplate(~120 m A h g^(-1)).In addition,a sloping capacity of~220 m A h g^(-1)was delivered with the plateau capacity,and higher rate capabilities,better reversibility,and a more stable cycling performance were confirmed on the turbostratic ***-principles calculations suggest that the multitudinous lattice domains of the T-GNSs contain diverse intercalation sites with strong binding energies,which could be the origin of the high-performance solid-solution potassium-ion intercalation behavior when the turbostratic graphene stacks have a d-spacing smaller than that of equilibrium potassium–graphite intercalation compounds(5.35À).

关键词： Turbostratic graphite Graphene nanosheet Defective carbon Anode Potassium-ion batteries

来源：评论

学校读者我要写书评

暂无评论

Superabsorbent Ternary Composite Desiccants Towards Energy-Efficient Dehumidification in Cooling Systems

Superabsorbent Ternary Composite Desiccants Towards Energy-E...

引用

Electric And Power engineering (EPEi), IEEE International Conference And Exposition On

作者： Mei Gui Vanessa Wee Amutha Chinnappan Seeram Ramakrishna Integrative Sciences and Engineering Program NUS Graduate School National University of Singapore Singapore Singapore Department of Mechanical Engineering: College of Design and Engineering Centre for Nanotechnology and Sustainability National University of Singapore Singapore Singapore

ISBN: (数字)9798350356199

ISBN: (纸本)9798350356205

Desiccant-coated heat exchangers (DCHEs) enable energy-efficient dehumidification, alleviating the overall heat load on vapor compression refrigeration systems. However, conventional desiccants have limited water uptake capacities and high regeneration temperature requirements. This work presents ternary composite desiccants comprising the metal-organic framework, MIL-101(Cr) (where MIL denotes Materials Institute Lavoisier), the superabsorbent polymer polyvinyl alcohol (PVA), and hygroscopic salts for enhanced moisture sorption. Gravimetric water sorption analyses revealed that desiccants containing lithium chloride ($\mathbf{L i C l}$) attained water uptakes greater than their calcium chloride- and copper (II) sulfate-containing counterparts. Subsequent cyclic tests identified the optimal MIL-101(Cr)/PVA/LiCl composite that adsorbed and desorbed moisture readily. From its water sorption isotherm, the 3MIL-101(Cr)/1PVA/1 LiCl desiccant has a water uptake capacity of $2.49 \mathrm{~g}_{\text {water }} \mathbf{g}_{\text {desiccant }}{ }^{-1}$ - nearly double that of MIL-101(Cr) and more than nine times that of silica gel. When coated onto a prototype heat exchanger, the 3MIL-101(Cr)/1PVA/1 LiCl composite demonstrated a gravimetric water uptake more than double that of the silica gel-coated control across three adsorption-desorption cycles. Moreover, low-grade waste heat of $50^{\circ} \mathrm{C}$ could partially regenerate these DCHEs, leaving behind residual moisture of less than $0.5 \mathbf{g}_{\text {water }}$ $\mathbf{g}_{\text {desiccant }}{ }^{-1}$. Consequently, the 3MIL-101(Cr)/1PVA/1LiCl-coated heat exchangers are effective dehumidifiers for addressing the latent heat load towards energy savings in cooling systems.

关键词： Salt Power engineering Heat engines Moisture Water heating Prototypes Energy efficiency Waste heat Refrigeration Resistance heating

来源：评论

学校读者我要写书评

暂无评论

Development of Hair Follicle Dermal Papilla Spheroids Encapsulated in Alginate Hydrogel with Extracellular Matrix Protein

Development of Hair Follicle Dermal Papilla Spheroids Encaps...

引用

Biomedical engineering International Conference (BMEiCON)

作者： Phasin Srinualchai Thanchanok Khorporn Patsawee Sriboonaied Peerapat Thongnuek Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok Thailand Biomedical Materials and Devices for Revolutionary Integrative Systems Engineering (BMD-RISE) Research Unit Faculty of Engineering Biomedical Engineering Research Center Chulalongkorn University Bangkok Thailand

ISBN: (数字)9798331505431

ISBN: (纸本)9798331505448

Hair follicles (HF) are important anatomical structures that are responsible for maintenance of the hair cycle. However, hair disease can affect the hair follicle directly with the modern treatment still riddled with side effects due to lack of full understanding of hair nature. The study aimed to investigate the effect of alginate hydrogel with extracellular matrix (ECM) protein encapsulation on activity of dermal papilla (DP) spheroids. The DP cells were aggregated to mimic its native spherical structure and introduced into alginate solution mixed with ECM. The mixture was then crosslinked with calcium chloride to form hydrogel. The encapsulation elevated alkaline phosphatase (ALP) activity, which is a DP molecular marker. This work demonstrates that DP encapsulation in alginate with ECM can manipulate DP spheroid activity.

关键词： Encapsulation Proteins Protein engineering Three-dimensional displays Hydrogels Peptides Hafnium Hair follicle Maintenance Extracellular

来源：评论

学校读者我要写书评

暂无评论

Extraction of c- F os Protein Regions from Mouse Brain Slice Images using Multi-channelization, 1 x 1 Convolution and U -Net

Extraction of c- F os Protein Regions from Mouse Brain Slice...

引用

International Symposium on Soft Computing and Intelligent Systems (SCIS)

作者： Ziyue Wang Hibiki Okamura Shijie Luo Yu Hayashi Hotaka Takizawa Master's Program in Computer Science University of Tsukuba Tsukuba Japan Ph.D. Program in Humanics International Institute for Integrative Sleep Medicine University of Tsukuba Tsukuba Japan International Institute for Integrative Sleep Medicine University of Tsukuba Tsukuba Japan Institute of Systems and Information Engineering Academic Computing & Communications Center University of Tsukuba Tsukuba Japan

ISBN: (数字)9798350373332

ISBN: (纸本)9798350373349

This study proposed a novel extraction method of c-Fos protein regions in DAB(3,3‘-diaminobenzidine)-stained mouse brain slice images using the U-Net model combined with the multi-channelization and $1\times 1$ convolution techniques. Our U-Net m odel, called $1\times 1$ conv U-Net, was applied to three DAB- strainedmouse slice images whose resolutions were $1000\mathrm{x}1000$ pixels. The experimental results demonstrated that the $1\times 1$ conv U-Net outperformed the conventional U-Net.

关键词： Proteins Visualization Image resolution Image analysis Convolution Feature extraction Brain modeling Biology Biomedical imaging

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：