作者:
Zhou, YanXiong, YonghuaSchool of Automation
China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Wuhan430074 China
The widespread application of unmanned aerial vehicle (UAV) has made the coverage path planning problem for multiple UAV systems a research hotspot. In this paper, we propose a multi-UAV solution to achieve complete c...
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作者:
Tao, ZixingCao, WeihuaGan, Chao
Wuhan China
School of Future Technology School of Automation Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan China
Air quality data exhibit nonlinearity, sensitivity to environmental factors, and long-term dependencies. Numerous factors influence air quality, making accurate predictions based on a single-dimensional dataset imprac...
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This study explores the trajectory tracking control problem of a free-flying space manipulator subject to parametric uncertainties, external disturbance, and actuator saturation. An adaptive control strategy, employin...
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Summary What is already known about this topic?The recurrence of tuberculosis(TB)following successful treatment presents a significant *** is added by this report?Achieving the global End TB Strategy milestones and ta...
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Summary What is already known about this topic?The recurrence of tuberculosis(TB)following successful treatment presents a significant *** is added by this report?Achieving the global End TB Strategy milestones and targets with the current strategies in China is ***,interventions following recovery to prevent recurrence,in conjunction with preventive treatment for latent TB infection(LTBI),will aid in meeting these objectives.
This paper investigates the cooperative output regulation problem of heterogeneous linear multi-agent systems over directed graphs with the constraint of communication *** that there exists an exosystem whose state in...
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This paper investigates the cooperative output regulation problem of heterogeneous linear multi-agent systems over directed graphs with the constraint of communication *** that there exists an exosystem whose state information is not available to all agents,the authors develop distributed adaptive event-triggered observers for the followers based on relative information between neighboring *** should be pointed out that,two kinds of time-varying gains are introduced to avoid relying on any global information associated with the network,and dynamic triggering conditions are designed to get rid of continuous *** the basis of the designed observers,the authors devise a local controller for each *** with the existing related works,the main contribution of the current paper is that the cooperative output regulation problem for general directed graphs is solved requiring neither global information nor continuous communications.
The article poses and solves the problem of creating an experiment processing method that is compact, high-precision and convenient for use as part of an adaptive controller. These requirements are met by the author...
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Objective To establish and modify quantitative real-time polymerase chain reaction(qPCR)-based serotyping assays to distinguish 97 pneumococcal *** A database of capsular polysaccharide(cps)loci sequences was generate...
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Objective To establish and modify quantitative real-time polymerase chain reaction(qPCR)-based serotyping assays to distinguish 97 pneumococcal *** A database of capsular polysaccharide(cps)loci sequences was generated,covering 97 pneumococcal *** analyses were performed to identify the cps loci structure and target genes related to different pneumococcal serotypes with specific SNPs.A total of 27 novel qPCR serotyping assay primers and probes were established based on qPCR,while 27 recombinant plasmids containing serotype-specific DNA sequence fragments were constructed as reference target sequences to examine the specificity and sensitivity of the qPCR assay.A panel of pneumococcal reference strains was employed to evaluate the capability of pneumococcal *** A total of 97 pneumococcal serotyping assays based on qPCR were established and modified,which included 64 serotypes previously reported as well as an additional 33 ***-seven novel qPCR serotyping target sequences were implemented in the pneumococcal qPCR serotyping system.A total of 97 pneumococcal serotypes,which included 52 individual serotypes and 45 serotypes belonging to 20 serogroups,could not be identified as individual *** sensitivity of qPCR assays based on 27 target sequences was 1–100 copies/μ*** specificity of the qPCR assays was 100%,which were tested by a panel of 90 serotypes of the pneumococcal reference *** A total of 27 novel qPCR assays were established and modified to analyze 97pneumococcal serotypes.
The authors propose a multimodal control system for an unmanned quadcopter integrating various information input, processing, and transmission methods, as well as the methods of geometrical and smart control. The smar...
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The problem of optimizing the load on an operator of unmanned aerial vehicles (UAVs), which performs real-time tasks of researching and monitoring territories in an unstable environment is considered. Working load dep...
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The Mpox virus(MPXV) has emerged as a formidable orthopoxvirus, posing an immense challenge to global public health. An understanding of the regulatory mechanisms of MPXV infection, replication and immune evasion will...
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The Mpox virus(MPXV) has emerged as a formidable orthopoxvirus, posing an immense challenge to global public health. An understanding of the regulatory mechanisms of MPXV infection, replication and immune evasion will benefit the development of novel antiviral strategies. Despite the involvement of G-quadruplexes(G4s) in modulating the infection and replication processes of multiple viruses, their roles in the MPXV life cycle remain largely unknown. Here, we found a highly conservative and stable G4 in MPXV that acts as a positive regulatory element for viral immunodominant protein ***, by screening 42 optically pure chiral metal complexes, we identified the Λ enantiomer of a pair of chiral helical compounds that can selectively target m RNA G4 and enhance expression of the 39-k Da core protein encoded by the MPXV A5L gene. Mechanistically, RNA G4-specific helicase DHX36 inhibits A5L protein expression by unwinding G4s. In contrast, MH3 Λ enhanced m RNA stability by specifically targeting G4 structures and subsequently increased protein expression. Furthermore, given the pivotal role of the 39-k Da core protein in activating immune responses and facilitating virion maturation, modulation of MPXV G4 folding by MH3 Λ exhibited inhibitory effects on MPXV replication through enhancing the immune response. Our findings underscore the critical involvement of G4 in the MPXV life cycle and offer potential avenues for developing antiviral drugs that target G4.
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